RS58974B1 - 4-(3-pirazolilamino)-benzimidazol derivat kao jak1 inhibitor za tretiranje kancera - Google Patents

4-(3-pirazolilamino)-benzimidazol derivat kao jak1 inhibitor za tretiranje kancera

Info

Publication number
RS58974B1
RS58974B1 RS20190876A RSP20190876A RS58974B1 RS 58974 B1 RS58974 B1 RS 58974B1 RS 20190876 A RS20190876 A RS 20190876A RS P20190876 A RSP20190876 A RS P20190876A RS 58974 B1 RS58974 B1 RS 58974B1
Authority
RS
Serbia
Prior art keywords
pyrazolylamino
treating cancer
benzimidazole derivative
jak1 inhibitor
jak1
Prior art date
Application number
RS20190876A
Other languages
English (en)
Inventor
Joshua Ryan Clayton
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of RS58974B1 publication Critical patent/RS58974B1/sr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
RS20190876A 2015-08-04 2016-07-28 4-(3-pirazolilamino)-benzimidazol derivat kao jak1 inhibitor za tretiranje kancera RS58974B1 (sr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562200684P 2015-08-04 2015-08-04
EP16750326.7A EP3331873B1 (en) 2015-08-04 2016-07-28 A 4-(3-pyrazolylamino)-benzimidazole derivative as jak1 inhibitor for treating cancer
PCT/US2016/044410 WO2017023672A1 (en) 2015-08-04 2016-07-28 4-(3-pyrazolylamino)-benzimidazole compounds and their use as jak1 inhibitors

Publications (1)

Publication Number Publication Date
RS58974B1 true RS58974B1 (sr) 2019-08-30

Family

ID=56618268

Family Applications (1)

Application Number Title Priority Date Filing Date
RS20190876A RS58974B1 (sr) 2015-08-04 2016-07-28 4-(3-pirazolilamino)-benzimidazol derivat kao jak1 inhibitor za tretiranje kancera

Country Status (27)

Country Link
US (1) US9556153B1 (sr)
EP (1) EP3331873B1 (sr)
JP (1) JP6470869B2 (sr)
KR (1) KR102032792B1 (sr)
CN (1) CN108026076B (sr)
AR (1) AR105400A1 (sr)
AU (1) AU2016302748B2 (sr)
BR (1) BR112017028240B1 (sr)
CA (1) CA2990471C (sr)
CY (1) CY1121909T1 (sr)
DK (1) DK3331873T3 (sr)
EA (1) EA033572B1 (sr)
ES (1) ES2743499T3 (sr)
HR (1) HRP20191227T1 (sr)
HU (1) HUE047037T2 (sr)
LT (1) LT3331873T (sr)
MA (1) MA44383B1 (sr)
MD (1) MD3331873T2 (sr)
ME (1) ME03451B (sr)
MX (1) MX2018001306A (sr)
NZ (1) NZ738247A (sr)
PL (1) PL3331873T3 (sr)
PT (1) PT3331873T (sr)
RS (1) RS58974B1 (sr)
SI (1) SI3331873T1 (sr)
TW (1) TW201718555A (sr)
WO (1) WO2017023672A1 (sr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3030697C (en) 2016-07-14 2021-02-23 Eli Lilly And Company Pyrazolylaminobenzimidazole derivatives as jak inhibitors
GB201717260D0 (en) * 2017-10-20 2017-12-06 Galapagos Nv Novel compounds and pharma ceutical compositions thereof for the treatment of inflammatory disorders

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013025628A1 (en) * 2011-08-15 2013-02-21 Ligand Pharmaceuticals Incorporated Janus kinase inhibitor compounds and methods
EP2861231B1 (en) * 2012-06-14 2016-08-31 Eli Lilly and Company Inhibitor of jak1 and jak2
GB201401086D0 (en) * 2014-01-23 2014-03-12 Galapagos Nv Novel compounds and pharmaceutical compositions thereof for the treatment of inflammatory disorders

Also Published As

Publication number Publication date
JP6470869B2 (ja) 2019-02-13
MA44383A (fr) 2019-01-23
JP2018524384A (ja) 2018-08-30
CY1121909T1 (el) 2020-10-14
PL3331873T3 (pl) 2019-11-29
ME03451B (me) 2020-01-20
BR112017028240A2 (pt) 2018-09-04
CA2990471A1 (en) 2017-02-09
US20170037034A1 (en) 2017-02-09
EP3331873A1 (en) 2018-06-13
MD3331873T2 (ro) 2019-11-30
HRP20191227T1 (hr) 2019-10-18
CA2990471C (en) 2020-01-07
KR20180022966A (ko) 2018-03-06
AU2016302748B2 (en) 2019-02-28
AR105400A1 (es) 2017-09-27
MX2018001306A (es) 2018-05-17
ES2743499T3 (es) 2020-02-19
EA033572B1 (ru) 2019-11-06
CN108026076A (zh) 2018-05-11
BR112017028240B1 (pt) 2023-04-11
WO2017023672A1 (en) 2017-02-09
US9556153B1 (en) 2017-01-31
EA201792676A1 (ru) 2018-07-31
AU2016302748A1 (en) 2018-01-04
DK3331873T3 (da) 2019-08-12
EP3331873B1 (en) 2019-06-26
KR102032792B1 (ko) 2019-10-16
NZ738247A (en) 2019-06-28
MA44383B1 (fr) 2019-08-30
SI3331873T1 (sl) 2019-08-30
LT3331873T (lt) 2019-08-26
PT3331873T (pt) 2019-09-12
HUE047037T2 (hu) 2020-04-28
CN108026076B (zh) 2020-07-10
TW201718555A (zh) 2017-06-01

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