RS58972B1 - Karbidopa i l-dopa prolekovi i njihova primena za lečenje parkinsonove bolesti - Google Patents

Karbidopa i l-dopa prolekovi i njihova primena za lečenje parkinsonove bolesti

Info

Publication number: RS58972B1
Authority: RS; Serbia
Prior art keywords: carbidopa; disease; treat parkinson; dopa prodrugs; dopa
Prior art date: 2014-10-21

Application number

RS20190854A

Other languages

English (en)

Inventor

Benoit Cardinal-David

Vincent S Chan

Kassibla E Dempah

Brian P Enright

Rodger F Henry

Raimundo Ho

Ye Huang

Alexander D Huters

Russell C Klix

Scott W Krabbe

Philip R Kym

Yanbin Lao

Xiaochun Lou

Sean E Mackey

Mark A Matulenko

Peter T Mayer

Christopher P Miller

James Stambuli

Eric A Voight

Zhi Wang

Geoff G Zhang

Valentino J Stella

Original Assignee

Abbvie Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2014-10-21

Filing date

2015-10-21

Publication date

2019-08-30

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=54478240&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=RS58972(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2015-10-21 Application filed by Abbvie Inc filed Critical Abbvie Inc

2019-08-30 Publication of RS58972B1 publication Critical patent/RS58972B1/sr

Links

WTDRDQBEARUVNC-LURJTMIESA-N L-DOPA Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-LURJTMIESA-N 0.000 title 1
WTDRDQBEARUVNC-UHFFFAOYSA-N L-Dopa Natural products OC(=O)C(N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-UHFFFAOYSA-N 0.000 title 1
208000018737 Parkinson disease Diseases 0.000 title 1
229960004205 carbidopa Drugs 0.000 title 1
TZFNLOMSOLWIDK-JTQLQIEISA-N carbidopa (anhydrous) Chemical compound NN[C@@](C(O)=O)(C)CC1=CC=C(O)C(O)=C1 TZFNLOMSOLWIDK-JTQLQIEISA-N 0.000 title 1
229940002612 prodrug Drugs 0.000 title 1
239000000651 prodrug Substances 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
- A61K31/6615—Compounds having two or more esterified phosphorus acid groups, e.g. inositol triphosphate, phytic acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C281/00—Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
- C07C281/02—Compounds containing any of the groups, e.g. carbazates
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/01—Sulfonic acids
- C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
- C07C309/24—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of a carbon skeleton containing six-membered aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C47/00—Compounds having —CHO groups
- C07C47/20—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms
- C07C47/277—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms containing ether groups, groups, groups, or groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/094—Esters of phosphoric acids with arylalkanols
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Psychology (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

RS20190854A 2014-10-21 2015-10-21 Karbidopa i l-dopa prolekovi i njihova primena za lečenje parkinsonove bolesti RS58972B1 (sr)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US201462066771P	2014-10-21	2014-10-21
EP15791424.3A EP3209302B1 (en)	2014-10-21	2015-10-21	Carbidopa and l-dopa prodrugs and their use to treat parkinson's disease
PCT/US2015/056686 WO2016065019A1 (en)	2014-10-21	2015-10-21	Carbidopa and l-dopa prodrugs and their use to treat parkinson's disease

Publications (1)

Publication Number	Publication Date
RS58972B1 true RS58972B1 (sr)	2019-08-30

Family

ID=54478240

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
RS20190854A RS58972B1 (sr)	2014-10-21	2015-10-21	Karbidopa i l-dopa prolekovi i njihova primena za lečenje parkinsonove bolesti

Country Status (35)

Country	Link
US (7)	US9446059B2 (sr)
EP (3)	EP3569587A1 (sr)
JP (5)	JP6567049B2 (sr)
KR (2)	KR20230066484A (sr)
CN (4)	CN107206013A (sr)
AR (1)	AR102389A1 (sr)
AU (3)	AU2015335941B2 (sr)
BR (1)	BR112017008198B1 (sr)
CA (1)	CA2965379A1 (sr)
CY (1)	CY1121826T1 (sr)
DK (1)	DK3209302T3 (sr)
ES (1)	ES2739536T3 (sr)
FI (1)	FIC20230014I1 (sr)
FR (1)	FR23C1035I1 (sr)
HR (1)	HRP20191285T1 (sr)
HU (2)	HUE044115T2 (sr)
IL (3)	IL251829B (sr)
LT (2)	LT3209302T (sr)
MX (2)	MX2021003840A (sr)
MY (1)	MY189519A (sr)
NL (1)	NL301224I2 (sr)
NO (1)	NO2023013I1 (sr)
PH (1)	PH12017500746B1 (sr)
PL (1)	PL3209302T3 (sr)
PT (1)	PT3209302T (sr)
RS (1)	RS58972B1 (sr)
RU (2)	RU2743347C2 (sr)
SA (1)	SA521421115B1 (sr)
SG (1)	SG11201703170RA (sr)
SI (1)	SI3209302T1 (sr)
TR (1)	TR201908296T4 (sr)
TW (2)	TWI755257B (sr)
UA (1)	UA120437C2 (sr)
WO (1)	WO2016065019A1 (sr)
ZA (1)	ZA201702760B (sr)

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RU2743347C2 (ru) *	2014-10-21	2021-02-17	Эббви Инк.	Пролекарства карбидопа и l-dopa и их применение для лечения болезни паркинсона
EP4295909A2 (en) *	2016-04-20	2023-12-27	AbbVie Inc.	Carbidopa and l-dopa prodrugs and methods of use
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WO2018154447A1 (en) *	2017-02-21	2018-08-30	Neuroderm Ltd	Dopa decarboxylase inhibitor compositions
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US11104697B2 (en)	2019-05-20	2021-08-31	H. Lundbeck A/S	Process for the manufacture of (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4AR,10AR)-7-hydroxy-1- propyl-1,2,3,4,4A,5,10,10A-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid
US11168056B2 (en)	2019-05-20	2021-11-09	H. Lundbeck A/S	Process for the manufacturing of (6aR,10aR)-7-propyl-6,6a,7,8,9,10,10a,11-octahydro-[1,3]dioxolo[4′,5′:5,6]benzo[1,2-G]quinoline and (4aR,10aR)-1-propyl-1,2,3,4,4a,5,10,10a-octahydro-benzo[G]quinoline-6,7-diol
CN113727974A (zh)	2019-05-21	2021-11-30	H.隆德贝克有限公司	用于治疗帕金森病的新儿茶酚胺前药
US11331293B1 (en)	2020-11-17	2022-05-17	Neuroderm, Ltd.	Method for treatment of Parkinson's disease
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US11213502B1 (en)	2020-11-17	2022-01-04	Neuroderm, Ltd.	Method for treatment of parkinson's disease
EP4223288B1 (en)	2022-02-07	2024-03-06	Berlirem GmbH	Novel kit of pharmaceutical preparations for the treatment of parkinson's disease

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RU2743347C2 (ru)	2014-10-21	2021-02-17	Эббви Инк.	Пролекарства карбидопа и l-dopa и их применение для лечения болезни паркинсона
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2015
- 2015-10-21 RU RU2017117413A patent/RU2743347C2/ru active
- 2015-10-21 CN CN201580069519.8A patent/CN107206013A/zh active Pending
- 2015-10-21 MX MX2021003840A patent/MX2021003840A/es unknown
- 2015-10-21 TW TW110101738A patent/TWI755257B/zh active
- 2015-10-21 DK DK15791424.3T patent/DK3209302T3/da active
- 2015-10-21 TR TR2019/08296T patent/TR201908296T4/tr unknown
- 2015-10-21 UA UAA201704815A patent/UA120437C2/uk unknown
- 2015-10-21 RS RS20190854A patent/RS58972B1/sr unknown
- 2015-10-21 EP EP19164151.3A patent/EP3569587A1/en not_active Withdrawn
- 2015-10-21 CN CN202010250046.4A patent/CN111454290B/zh active Active
- 2015-10-21 EP EP22204022.2A patent/EP4186510A1/en active Pending
- 2015-10-21 US US14/919,418 patent/US9446059B2/en active Active
- 2015-10-21 PT PT15791424T patent/PT3209302T/pt unknown
- 2015-10-21 CN CN202010250040.7A patent/CN111494395A/zh active Pending
- 2015-10-21 MY MYPI2017701367A patent/MY189519A/en unknown
- 2015-10-21 KR KR1020237015051A patent/KR20230066484A/ko not_active Application Discontinuation
- 2015-10-21 CA CA2965379A patent/CA2965379A1/en not_active Abandoned
- 2015-10-21 ES ES15791424T patent/ES2739536T3/es active Active
- 2015-10-21 SG SG11201703170RA patent/SG11201703170RA/en unknown
- 2015-10-21 HU HUE15791424 patent/HUE044115T2/hu unknown
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LTPA2023519I1 (sr)	2023-06-26
IL268885B (en)	2020-08-31
AU2015335941A1 (en)	2017-05-04
CY1121826T1 (el)	2020-07-31
RU2021103000A (ru)	2021-03-01
MX2017005236A (es)	2017-07-26
US20160106765A1 (en)	2016-04-21
HRP20191285T1 (hr)	2019-10-18
LT3209302T (lt)	2019-06-10
JP6567049B2 (ja)	2019-08-28
KR20170071599A (ko)	2017-06-23
CN111454290A (zh)	2020-07-28
IL251829A0 (en)	2017-06-29
FIC20230014I1 (fi)	2023-03-31
JP6932227B2 (ja)	2021-09-08
KR20230066484A (ko)	2023-05-15
CA2965379A1 (en)	2016-04-28
AU2023210650A1 (en)	2023-08-24
NO2023013I1 (no)	2023-03-20
TR201908296T4 (tr)	2019-06-21
KR102537018B1 (ko)	2023-05-30
PL3209302T3 (pl)	2019-10-31
NL301224I1 (sr)	2023-03-29
WO2016065019A1 (en)	2016-04-28
US20160362431A1 (en)	2016-12-15
CN111362980A (zh)	2020-07-03
PT3209302T (pt)	2019-07-19
US10730895B2 (en)	2020-08-04
PH12017500746A1 (en)	2017-10-30
JP2017537066A (ja)	2017-12-14
BR112017008198A2 (pt)	2017-12-26
FR23C1035I1 (fr)	2023-12-08
US20200262852A1 (en)	2020-08-20
TW202131931A (zh)	2021-09-01
RU2017117413A3 (sr)	2019-05-30
AU2021201414B2 (en)	2023-05-11
PH12017500746B1 (en)	2017-10-30
HUE044115T2 (hu)	2019-10-28
JP6750076B2 (ja)	2020-09-02
TWI718999B (zh)	2021-02-21
US20220153765A1 (en)	2022-05-19
ES2739536T3 (es)	2020-01-31
JP2019218356A (ja)	2019-12-26
US20190375770A1 (en)	2019-12-12
BR112017008198B1 (pt)	2021-02-09
IL276493A (en)	2020-09-30
TW201630924A (zh)	2016-09-01
AR102389A1 (es)	2017-02-22
TWI755257B (zh)	2022-02-11
EP3209302B1 (en)	2019-04-24
SG11201703170RA (en)	2017-05-30
SI3209302T1 (sl)	2019-06-28
AU2015335941B2 (en)	2021-04-01
US20230106081A1 (en)	2023-04-06
RU2017117413A (ru)	2018-11-26
EP3569587A1 (en)	2019-11-20
UA120437C2 (uk)	2019-12-10
CN111454290B (zh)	2022-12-23
US11091507B2 (en)	2021-08-17
US9446059B2 (en)	2016-09-20
IL268885A (en)	2019-10-31
EP4186510A1 (en)	2023-05-31
CN111362980B (zh)	2022-10-18
JP2023174770A (ja)	2023-12-08
NL301224I2 (nl)	2023-08-16
JP2021183628A (ja)	2021-12-02
DK3209302T3 (da)	2019-05-13
JP2020189864A (ja)	2020-11-26
IL251829B (en)	2019-09-26
US20180079762A1 (en)	2018-03-22
MY189519A (en)	2022-02-16
RU2743347C2 (ru)	2021-02-17
MX2021003840A (es)	2022-06-30
SA521421115B1 (ar)	2022-03-01
CN107206013A (zh)	2017-09-26
AU2021201414A1 (en)	2021-03-25
HUS2300009I1 (hu)	2023-03-28
CN111494395A (zh)	2020-08-07
US10174061B2 (en)	2019-01-08
ZA201702760B (en)	2022-05-25
EP3209302A1 (en)	2017-08-30

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