RS52767B - Novel aminoindazole derivatives as medicines and pharmaceutical compositions containing same - Google Patents

Novel aminoindazole derivatives as medicines and pharmaceutical compositions containing same

Info

Publication number
RS52767B
RS52767B YU20050165A YUP16505A RS52767B RS 52767 B RS52767 B RS 52767B YU 20050165 A YU20050165 A YU 20050165A YU P16505 A YUP16505 A YU P16505A RS 52767 B RS52767 B RS 52767B
Authority
RS
Serbia
Prior art keywords
alkyl
aryl
heteroaryl
nhc
trifluoromethoxy
Prior art date
Application number
YU20050165A
Other languages
Serbian (sr)
Inventor
Dominique Lesuisse
Gilles Dutruc-Rosset
Franck Halley
Didier Babin
Thomas Rooney
Original Assignee
Aventis Pharma S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma S.A. filed Critical Aventis Pharma S.A.
Priority claimed from PCT/FR2003/002633 external-priority patent/WO2004022544A1/en
Publication of RS20050165A publication Critical patent/RS20050165A/en
Publication of RS52767B publication Critical patent/RS52767B/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Jedinjenja formule (I):u kojojR3 je (1-6C)alkil, aril, aril(1-6C)alkil, heteroaril, heteroaril(1-6C)alkil, aril ili heteroaril radikal kondenzovan sa (1-10C)cikloalkilom, heterociklom, heterocikloalkilom, cikloalkilom, adamantilom, policikloalkilom, alkenilom, alkinilom, CONR1R2, CSNR1R2, COOR1, SO2R1 ili C(=NH)NR1; ovi su po izboru supstituisani jednim ili više supstituenata odabranih od halogena, CN, NO2, NH2, OH, OR1, COOH, C(O)OR1, -O-C(O)R1, NR1R2, NHC(O)R1, C(O)NR1R2, SRl, S(O)R1, SO2R1, NHSO2R1, SO2NR1R2, C(S)NR1R2, NHC(S)R1, -O-SO2R1, -SO2-O-R1, aril, heteroaril, formil, okso, trifluormetil, trifluormetilsulfanil, trifluormetoksi i (1-6C)alkil;R5 je aril po izboru supstituisan jednim ili više supstituenata odabranih od halogena, CN, NO2, NH2, OH, OR10, COOH, C(O)OR10, -O-C(O)R10, NR10R11, NHC(O)R10, C(O)NR10R11, NHC(S)R10, C(S)NR10R11, SR10, S(O)R10, SO2R10, NHSO2R10, SO2NR10R11, -O-SO2R10, -SO2-O-R10, aril, heteroaril, formil, trifluormetil, trifluormetoksi i (1-6C)alkil;R6 je halogen, metil, ciklopropil, CN, OH, metoksi, trifluormetil, etilenil, acetilenil, trifluormetoksi, NO2, NH2 or NMe2 radikal;R1 R2, R10 i R11 su, nezavisno jedan od drugog, vodonik, (1-6C)alkil, aril, alkenil, alkinil ili heteroaril, koji sami po izboru supstituisani jednim ili više supstituenata odabranih od halogena, (1-6C)alkil, (1-6C)alkoksi, CN, NO2, NH2, OH, COOH, COOalkil, CONH2, formil, okso, trifluormetil i trifluormetoksi;njihovi racemati, enantiomeri i diastereoizomeri i njihove smeše, njihovi tautomeri i farmaceutski prihvatljive soli.Prijava sadrži još 12 patentnih zahteva.Compounds of formula (I): wherein R 3 is (1-6C) alkyl, aryl, aryl (1-6C) alkyl, heteroaryl, heteroaryl (1-6C) alkyl, aryl or heteroaryl radical fused to (1-10C) cycloalkyl, heterocycle , heterocycloalkyl, cycloalkyl, adamantyl, polycycloalkyl, alkenyl, alkynyl, CONR1R2, CSNR1R2, COOR1, SO2R1 or C (= NH) NR1; these are optionally substituted by one or more substituents selected from halogen, CN, NO2, NH2, OH, OR1, COOH, C (O) OR1, -OC (O) R1, NR1R2, NHC (O) R1, C (O) NR1R2, SR1, S (O) R1, SO2R1, NHSO2R1, SO2NR1R2, C (S) NR1R2, NHC (S) R1, -O-SO2R1, -SO2-O-R1, aryl, heteroaryl, formyl, oxo, trifluoromethyl, trifluoromethylsulfanyl, trifluoromethoxy and (1-6C) alkyl, R5 is aryl optionally substituted with one or more substituents selected from halogen, CN, NO2, NH2, OH, OR10, COOH, C (O) OR10, -OC (O) R10, NR10R11, NHC (O) R10, C (O) NR10R11, NHC (S) R10, C (S) NR10R11, SR10, S (O) R10, SO2R10, NHSO2R10, SO2NR10R11, -O-SO2R10, -SO2-O- R10, aryl, heteroaryl, formyl, trifluoromethyl, trifluoromethoxy and (1-6C) alkyl, R6 is halogen, methyl, cyclopropyl, CN, OH, methoxy, trifluoromethyl, ethylene, acetylenyl, trifluoromethoxy, NO2, NH2 or NMe2 radical, R1 R2 , R 10 and R 11 are, independently of one another, hydrogen, (1-6C) alkyl, aryl, alkenyl, alkynyl or heteroaryl, which are themselves optionally substituted by one or more substituents selected from halogen on, (1-6C) alkyl, (1-6C) alkoxy, CN, NO2, NH2, OH, COOH, COOalkyl, CONH2, formyl, oxo, trifluoromethyl and trifluoromethoxy, their racemates, enantiomers and diastereoisomers and mixtures thereof, their tautomers and pharmaceutically acceptable salts. The application comprises a further 12 claims.

YU20050165A 2002-09-05 2003-09-03 Novel aminoindazole derivatives as medicines and pharmaceutical compositions containing same RS52767B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR0210962A FR2844267B1 (en) 2002-09-05 2002-09-05 NOVEL DERIVATIVES OF AMINOINDAZOLES AS MEDICAMENTS AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM
US41996502P 2002-10-22 2002-10-22
PCT/FR2003/002633 WO2004022544A1 (en) 2002-09-05 2003-09-03 Novel aminoindazole derivatives as medicines and pharmaceutical compositions containing same

Publications (2)

Publication Number Publication Date
RS20050165A RS20050165A (en) 2007-08-03
RS52767B true RS52767B (en) 2013-10-31

Family

ID=31725841

Family Applications (1)

Application Number Title Priority Date Filing Date
YU20050165A RS52767B (en) 2002-09-05 2003-09-03 Novel aminoindazole derivatives as medicines and pharmaceutical compositions containing same

Country Status (9)

Country Link
CN (1) CN1982316A (en)
AR (1) AR041131A1 (en)
FR (1) FR2844267B1 (en)
ME (1) MEP25708A (en)
MY (1) MY146796A (en)
PE (1) PE20040995A1 (en)
RS (1) RS52767B (en)
TW (2) TWI353978B (en)
ZA (1) ZA200501427B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102007002717A1 (en) 2007-01-18 2008-07-24 Merck Patent Gmbh Heterocyclic indazole derivatives
DE102007022565A1 (en) 2007-05-14 2008-11-20 Merck Patent Gmbh Heterocyclic indazole derivatives

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2422367C (en) * 2000-09-15 2010-05-18 Vertex Pharmaceuticals Incorporated Pyrazole compounds useful as protein kinase inhibitors
KR100947185B1 (en) * 2000-12-21 2010-03-15 버텍스 파마슈티칼스 인코포레이티드 Pyrazole compounds useful as protein kinase inhibitors and compositions comprising said compounds

Also Published As

Publication number Publication date
FR2844267A1 (en) 2004-03-12
RS20050165A (en) 2007-08-03
MEP25708A (en) 2010-06-10
CN1982316A (en) 2007-06-20
TWI353245B (en) 2011-12-01
FR2844267B1 (en) 2008-02-15
MY146796A (en) 2012-09-28
TWI353978B (en) 2011-12-11
PE20040995A1 (en) 2005-01-28
TW200820967A (en) 2008-05-16
TW200413325A (en) 2004-08-01
ZA200501427B (en) 2006-04-26
AR041131A1 (en) 2005-05-04

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