RS50342B - Postupak za radioobeležavanje proteina sa itrijumom-90 - Google Patents
Postupak za radioobeležavanje proteina sa itrijumom-90Info
- Publication number
- RS50342B RS50342B YUP-617/01A YUP61701A RS50342B RS 50342 B RS50342 B RS 50342B YU P61701 A YUP61701 A YU P61701A RS 50342 B RS50342 B RS 50342B
- Authority
- RS
- Serbia
- Prior art keywords
- peptide
- protein
- chelator
- patient
- further purification
- Prior art date
Links
- 108090000623 proteins and genes Proteins 0.000 title abstract 5
- 102000004169 proteins and genes Human genes 0.000 title abstract 5
- 238000000034 method Methods 0.000 title abstract 2
- 238000000163 radioactive labelling Methods 0.000 title abstract 2
- VWQVUPCCIRVNHF-OUBTZVSYSA-N Yttrium-90 Chemical compound [90Y] VWQVUPCCIRVNHF-OUBTZVSYSA-N 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 4
- 238000000746 purification Methods 0.000 abstract 2
- 230000002285 radioactive effect Effects 0.000 abstract 2
- 239000002738 chelating agent Substances 0.000 abstract 1
- 230000001419 dependent effect Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
- G01N33/532—Production of labelled immunochemicals
- G01N33/534—Production of labelled immunochemicals with radioactive label
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1027—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against receptors, cell-surface antigens or cell-surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1093—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Optics & Photonics (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Microbiology (AREA)
- Analytical Chemistry (AREA)
- Cell Biology (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Food Science & Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Postupak za radioobeležavanje helator-konjugovanog proteina ili peptida sa Y za dobijanje radioobeleženog proteina ili peptida koji se može davati direktno pacijentu bez daljeg prečišćavanja od neugrađenog radioaktivnog obeleživača, naznačen time što sadrži,: (i) mešanje helator-konjugovanog proteina ili peptida sa rastvorom koji sadrži 90Y ili njegovu so u prihvatljivom puferu; i (ii) inkubiranje mešavine manje od 8 minuta, na temperaturi između 25°C do 43°, na pH od 3 do 6 tako da se produkuje protein ili peptid obeležen sa 90Y koji ima radiohemijsku čistoću veću od 95%, specifičnu aktivnost najmanje 5 mCi/mg, specifičnost vezivanja od najmanje 50%, i može se davati direktno pacijentu bez daljeg prečišćavanja od neugrađenog radioaktivnog obeleživača. Prijava sadrži još 11 zavisnih patentnih zahteva.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US25933899A | 1999-03-01 | 1999-03-01 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| YU61701A YU61701A (sh) | 2004-05-12 |
| RS50342B true RS50342B (sr) | 2009-11-10 |
Family
ID=22984528
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| YUP-617/01A RS50342B (sr) | 1999-03-01 | 2000-02-29 | Postupak za radioobeležavanje proteina sa itrijumom-90 |
Country Status (36)
| Country | Link |
|---|---|
| US (3) | US6994840B1 (sr) |
| EP (2) | EP2011520A1 (sr) |
| JP (1) | JP4558947B2 (sr) |
| KR (1) | KR100734023B1 (sr) |
| CN (1) | CN1251767C (sr) |
| AT (1) | ATE428446T1 (sr) |
| AU (1) | AU780311B2 (sr) |
| BG (1) | BG65568B1 (sr) |
| BR (1) | BR0008635A (sr) |
| CA (1) | CA2362908C (sr) |
| CY (1) | CY1109211T1 (sr) |
| CZ (1) | CZ20013127A3 (sr) |
| DE (2) | DE60042014D1 (sr) |
| DK (1) | DK1156835T3 (sr) |
| EE (1) | EE05582B1 (sr) |
| ES (1) | ES2165830T3 (sr) |
| GR (1) | GR20010300078T1 (sr) |
| HK (1) | HK1045656B (sr) |
| HR (1) | HRP20010713A2 (sr) |
| HU (1) | HU227986B1 (sr) |
| IL (2) | IL145112A0 (sr) |
| ME (1) | ME00783B (sr) |
| MX (1) | MXPA01008745A (sr) |
| MY (1) | MY133346A (sr) |
| NO (1) | NO330728B1 (sr) |
| NZ (1) | NZ513667A (sr) |
| PL (1) | PL204239B1 (sr) |
| PT (1) | PT1156835E (sr) |
| RS (1) | RS50342B (sr) |
| RU (1) | RU2221807C2 (sr) |
| SI (1) | SI1156835T1 (sr) |
| SK (1) | SK287650B6 (sr) |
| TW (1) | TWI283178B (sr) |
| UA (1) | UA75036C2 (sr) |
| WO (1) | WO2000052031A2 (sr) |
| ZA (1) | ZA200106945B (sr) |
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| PT1680141E (pt) | 2003-11-04 | 2010-12-20 | Novartis Vaccines & Diagnostic | Métodos terapêuticos para tumores sólidos que expressam o antigénio de superfície celular cd40 |
| EP2243492A1 (en) | 2003-11-04 | 2010-10-27 | Novartis Vaccines and Diagnostics, Inc. | Use of antagonist anti-cd40 monoclonal antibodies for treatment of multiple myeloma |
| PT1682177E (pt) | 2003-11-04 | 2010-11-29 | Xoma Technology Lt | Utilização de anticorpos antagonistas anti-cd40 para o tratamento da leucemia linfocítica crónica |
| EP1682178B8 (en) | 2003-11-04 | 2010-09-01 | Novartis Vaccines and Diagnostics, Inc. | Methods of therapy for cancers expressing the cd40 antigen |
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| PL3418300T3 (pl) | 2011-07-18 | 2021-05-04 | Institute For Research In Biomedicine | Neutralizujące przeciwciała przeciwko wirusowi grypy A i ich zastosowania |
| BR112014023063A2 (pt) | 2012-03-20 | 2017-07-18 | Corti Davide | anticorpos que neutralizam rsv, mpv e pvm e usos dos mesmos |
| RU2537175C2 (ru) * | 2013-03-26 | 2014-12-27 | Российская Федерация, От Имени Которой Выступает Министерство Образования И Науки Российской Федерации | Способ получения радиоиммунного препарата для диагностики и терапии онкологических заболеваний |
| CN112142845A (zh) | 2013-08-13 | 2020-12-29 | 赛诺菲 | 纤溶酶原激活剂抑制剂-1(pai-1)的抗体及其用途 |
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