RS49954B - Postupak za sintezu inhibitora hiv proteaze - Google Patents
Postupak za sintezu inhibitora hiv proteazeInfo
- Publication number
- RS49954B RS49954B YUP-559/00A YU55900A RS49954B RS 49954 B RS49954 B RS 49954B YU 55900 A YU55900 A YU 55900A RS 49954 B RS49954 B RS 49954B
- Authority
- RS
- Serbia
- Prior art keywords
- compound
- synthesis
- protease inhibitors
- hiv protease
- formula
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/20—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Communicable Diseases (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Furan Compounds (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
Postupak dobijanja jedinjenja formule (I) naznačen time, što: i) reaguje p-nitrofenilsulfonil grupa sa jedinjenjem formule (A) gde je P aminska zaštitna grupa; ii) deprotektuje se jedinjenje nastalo u koraku i); iii) reaguje jedinjenje nastalo u koraku ii) sa tetrahidrofuriloksikarbonil grupom; ili reaguje jedinjenje nastalo u koraku ii) sa fozgenom, ili ekvivalentom, pa nastali intermedijar reaguje sa (S)-tetrahidro-3-furanolom; i iv) redukuje se jedinjenjenastalo u koraku iii) uz formiranje jedinjenja formule (I).Prijava sadrži još 11 patentnih zahteva.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9805898.5A GB9805898D0 (en) | 1998-03-20 | 1998-03-20 | Process for the sythesis of hiv protease inhibitors |
Publications (2)
Publication Number | Publication Date |
---|---|
YU55900A YU55900A (sh) | 2003-02-28 |
RS49954B true RS49954B (sr) | 2008-09-29 |
Family
ID=10828884
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
YUP-559/00A RS49954B (sr) | 1998-03-20 | 1999-03-18 | Postupak za sintezu inhibitora hiv proteaze |
Country Status (32)
Country | Link |
---|---|
US (1) | US6281367B1 (sr) |
EP (1) | EP1066276B1 (sr) |
JP (1) | JP3363439B2 (sr) |
KR (1) | KR100555278B1 (sr) |
CN (1) | CN1308319C (sr) |
AP (1) | AP1226A (sr) |
AT (1) | ATE242772T1 (sr) |
AU (1) | AU751534B2 (sr) |
BR (1) | BR9908970A (sr) |
CA (1) | CA2324217C (sr) |
CZ (1) | CZ299193B6 (sr) |
DE (1) | DE69908761T2 (sr) |
DK (1) | DK1066276T3 (sr) |
EA (1) | EA003022B1 (sr) |
EE (1) | EE04750B1 (sr) |
ES (1) | ES2203090T3 (sr) |
GB (1) | GB9805898D0 (sr) |
HK (1) | HK1032047A1 (sr) |
HR (1) | HRP20000609B1 (sr) |
HU (1) | HUP0105439A3 (sr) |
ID (1) | ID26587A (sr) |
IL (1) | IL138127A (sr) |
IS (1) | IS2273B (sr) |
NO (1) | NO317648B1 (sr) |
NZ (1) | NZ506563A (sr) |
PL (1) | PL201810B1 (sr) |
PT (1) | PT1066276E (sr) |
RS (1) | RS49954B (sr) |
SK (1) | SK283939B6 (sr) |
TR (1) | TR200002698T2 (sr) |
WO (1) | WO1999048885A1 (sr) |
ZA (1) | ZA200004482B (sr) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PT810209E (pt) | 1992-08-25 | 2002-09-30 | Searle & Co | Hidroxietilamino-sulfonamidas de alfa- e beta-aminoacidos uteis como inibidores de protease retroviral |
WO2001046120A1 (en) * | 1999-12-23 | 2001-06-28 | Aerojet Fine Chemicals Llc | Improved preparation of 2s,3s-n-isobutyl-n-(2-hydroxy-3-amino-4-phenylbutyl)-p-nitrobenzenesulfonylamide hydrochloride and other derivatives of 2-hydroxy-1,3-diamines |
US6548706B2 (en) * | 1999-12-23 | 2003-04-15 | Aerojet Fine Chemicals Llc | Preparation of 2S,3S-N-isobutyl-N-(2-hydroxy-3-amino-4-phenylbutyl) -p-nitrobenzenesulfonylamide hydrochloride and other derivatives of 2-hydroxy-1,3-diamines |
SI2767539T1 (sl) | 2002-05-16 | 2017-10-30 | Janssen Sciences Ireland Uc | Psevdopolimorfne oblike inhibitorja proteaze HIV |
US7772411B2 (en) | 2003-12-23 | 2010-08-10 | Tibotec Pharmaceuticals Ltd. | Process for the preparation of (3R,3aS,6aR)-hexahydrofuro [2,3-b] furan-3-yl (1S,2R)-3[[(4-aminophenyl) sulfonyl] (isobutyl) amino]-1-benzyl-2-hydroxypropylcarbamate |
AR073248A1 (es) | 2008-09-01 | 2010-10-20 | Tibotec Pharm Ltd | Proceso para la preparacion de (1s, 2r)-3- ((4-aminofenil) sulfonil) ( isobutil) amino)-1- bencil-2- hidroxipropilcarbamato de (3r, 3as,6ar)- hexahidrofuro-(2,3-b) furan-3- ilo (darunavir) y compuestos intermediarios utiles en dicho proceso. |
US20120295898A1 (en) | 2010-01-27 | 2012-11-22 | Mark Richard Underwood | Antiviral Therapy |
US8877947B2 (en) | 2010-09-10 | 2014-11-04 | Lupin Limited | Process for preparation of substantially pure fosamprenavir calcium and its intermediates |
CN111233794A (zh) * | 2020-03-27 | 2020-06-05 | 江巨东 | 一种安普那韦的精制方法 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1071930A (zh) * | 1991-07-10 | 1993-05-12 | 伊莱利利公司 | 用作治疗艾滋病的人免疫缺陷病毒蛋白酶的抑制剂 |
PT810209E (pt) * | 1992-08-25 | 2002-09-30 | Searle & Co | Hidroxietilamino-sulfonamidas de alfa- e beta-aminoacidos uteis como inibidores de protease retroviral |
US5723490A (en) * | 1992-09-08 | 1998-03-03 | Vertex Pharmaceuticals Incorporated | THF-containing sulfonamide inhibitors of aspartyl protease |
IS2334B (is) * | 1992-09-08 | 2008-02-15 | Vertex Pharmaceuticals Inc., (A Massachusetts Corporation) | Aspartyl próteasi hemjari af nýjum flokki súlfonamíða |
-
1998
- 1998-03-20 GB GBGB9805898.5A patent/GB9805898D0/en not_active Ceased
-
1999
- 1999-03-18 KR KR1020007010359A patent/KR100555278B1/ko not_active IP Right Cessation
- 1999-03-18 CN CNB998042242A patent/CN1308319C/zh not_active Expired - Fee Related
- 1999-03-18 CA CA002324217A patent/CA2324217C/en not_active Expired - Fee Related
- 1999-03-18 BR BR9908970-0A patent/BR9908970A/pt not_active Application Discontinuation
- 1999-03-18 US US09/646,277 patent/US6281367B1/en not_active Expired - Lifetime
- 1999-03-18 ID IDW20001857A patent/ID26587A/id unknown
- 1999-03-18 DE DE69908761T patent/DE69908761T2/de not_active Expired - Lifetime
- 1999-03-18 TR TR2000/02698T patent/TR200002698T2/xx unknown
- 1999-03-18 PT PT99910543T patent/PT1066276E/pt unknown
- 1999-03-18 CZ CZ20003457A patent/CZ299193B6/cs not_active IP Right Cessation
- 1999-03-18 HU HU0105439A patent/HUP0105439A3/hu unknown
- 1999-03-18 PL PL342602A patent/PL201810B1/pl not_active IP Right Cessation
- 1999-03-18 AU AU29475/99A patent/AU751534B2/en not_active Ceased
- 1999-03-18 AT AT99910543T patent/ATE242772T1/de not_active IP Right Cessation
- 1999-03-18 AP APAP/P/2000/001911A patent/AP1226A/en active
- 1999-03-18 WO PCT/GB1999/000852 patent/WO1999048885A1/en active IP Right Grant
- 1999-03-18 IL IL13812799A patent/IL138127A/xx not_active IP Right Cessation
- 1999-03-18 EP EP99910543A patent/EP1066276B1/en not_active Expired - Lifetime
- 1999-03-18 ES ES99910543T patent/ES2203090T3/es not_active Expired - Lifetime
- 1999-03-18 DK DK99910543T patent/DK1066276T3/da active
- 1999-03-18 RS YUP-559/00A patent/RS49954B/sr unknown
- 1999-03-18 EA EA200000859A patent/EA003022B1/ru unknown
- 1999-03-18 JP JP2000537868A patent/JP3363439B2/ja not_active Expired - Lifetime
- 1999-03-18 EE EEP200000568A patent/EE04750B1/xx not_active IP Right Cessation
- 1999-03-18 NZ NZ506563A patent/NZ506563A/en unknown
- 1999-03-18 SK SK1373-2000A patent/SK283939B6/sk not_active IP Right Cessation
-
2000
- 2000-08-29 IS IS5605A patent/IS2273B/is unknown
- 2000-08-29 ZA ZA200004482A patent/ZA200004482B/en unknown
- 2000-09-15 HR HR20000609A patent/HRP20000609B1/xx not_active IP Right Cessation
- 2000-09-19 NO NO20004664A patent/NO317648B1/no not_active IP Right Cessation
-
2001
- 2001-03-30 HK HK01102333A patent/HK1032047A1/xx not_active IP Right Cessation
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
NZ514453A (en) | Novel sulfonamide compounds and uses thereof | |
CA2238978A1 (en) | Retroviral protease inhibiting compounds | |
ATE226199T1 (de) | Antithrombotische organische nitrate | |
RS65604A (en) | Novel fluorene carboxylic acid esters, methods for the production thereof, and use of the same as pharmaceuticals | |
AU6464998A (en) | Synthesis of 2-alkoxyestradiols | |
RS49954B (sr) | Postupak za sintezu inhibitora hiv proteaze | |
TR200101800T2 (tr) | Korumalı bir 4-aminometil-pirrolidin-3-on hazırlama prosesi. | |
NO890638D0 (no) | Nye karbamater, deres fremstilling og anvendelse som drivstoffadditiver. | |
EP0190356A4 (en) | AMIDINE COMPOUNDS. | |
DZ1724A1 (fr) | Nouvelles azétidinones substituées comme agents anti-inflammatoires et anti-dégénérescence. | |
BG60267B1 (bg) | Метод за получаване на производни на амидоксим | |
EP1310495A3 (en) | Glycidyl amines and their use in the preparation of HIV protease inhibitors | |
WO1995002584A3 (en) | Process for making hiv protease inhibitors | |
JO2433B1 (en) | Preparation of heterocyclic lindane landscapes | |
PT832067E (pt) | Processo para a conversao de 2,4-dicloropiridinas a 2-ariloxi-4-cloropiridinas | |
TW339325B (en) | Novel azepane derivatives, process for the preparation thereof and pharmaceutical composition containing the same | |
JPS6413083A (en) | Streptonigrin derivative and medicinal composition | |
DE60043228D1 (de) | Herstellungsverfahren von 2-cyanopyridinen | |
DK0971907T3 (da) | Fremgangsmåde til fremstilling af 1,3-disubstituerede 2-nitroguanidiner | |
TW344741B (en) | Process for the preparation of alkylimidazolidone (meth)acrylates | |
CA2375631A1 (en) | Process for production of amic acid ester | |
ES8606269A1 (es) | Procedimiento para preparar un derivado de pirrolidina | |
SE9802939D0 (sv) | New process | |
BR0312773A (pt) | Método para produzir um composto altamente puro | |
MX9702486A (es) | La fabricacion de levobupivacaina y sus analogos de l-lisina. |