RO84256B - Procedeu de preparare a unor iminohalogenuri de cefalosporina - Google Patents
Procedeu de preparare a unor iminohalogenuri de cefalosporinaInfo
- Publication number
- RO84256B RO84256B RO108361A RO10836180A RO84256B RO 84256 B RO84256 B RO 84256B RO 108361 A RO108361 A RO 108361A RO 10836180 A RO10836180 A RO 10836180A RO 84256 B RO84256 B RO 84256B
- Authority
- RO
- Romania
- Prior art keywords
- general formula
- thienylacetic
- defined above
- chlorine
- cephalosporin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/59—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3 with hetero atoms directly attached in position 3
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01L—SEMICONDUCTOR DEVICES NOT COVERED BY CLASS H10
- H01L24/00—Arrangements for connecting or disconnecting semiconductor or solid-state bodies; Methods or apparatus related thereto
- H01L24/74—Apparatus for manufacturing arrangements for connecting or disconnecting semiconductor or solid-state bodies
- H01L24/78—Apparatus for connecting with wire connectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01L—SEMICONDUCTOR DEVICES NOT COVERED BY CLASS H10
- H01L2224/00—Indexing scheme for arrangements for connecting or disconnecting semiconductor or solid-state bodies and methods related thereto as covered by H01L24/00
- H01L2224/74—Apparatus for manufacturing arrangements for connecting or disconnecting semiconductor or solid-state bodies and for methods related thereto
- H01L2224/78—Apparatus for connecting with wire connectors
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01L—SEMICONDUCTOR DEVICES NOT COVERED BY CLASS H10
- H01L2924/00—Indexing scheme for arrangements or methods for connecting or disconnecting semiconductor or solid-state bodies as covered by H01L24/00
- H01L2924/0001—Technical content checked by a classifier
- H01L2924/00014—Technical content checked by a classifier the subject-matter covered by the group, the symbol of which is combined with the symbol of this group, being disclosed without further technical details
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Communicable Diseases (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Oncology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Manufacturing & Machinery (AREA)
- Computer Hardware Design (AREA)
- Microelectronics & Electronic Packaging (AREA)
- Power Engineering (AREA)
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pyrrole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Inventia se refera la un procedeu de preparare a unor iminohalogenuri de cefalosporine cu formula generala I: (vezi form. in desc.) în care X reprezinta clor sau brom R reprezinta o grupa de protectie a radicalului carboxilic, R1 reprezinta hidrogen sau grupa metoxi R2 reprezinta un radical acil al unui acid carboxilic ales dintre acid acetic fenoxiacetic benzilic benzoic 2-tienilacetic, 2-cloracetoxi-2-fenilacetic si 4 -clorbenzenzoic constand din aceea ca se trateaza o cefalosporina cu formula generala II: (vezi form. in desc.) în care R, R1 si R2 au semnificatiile de mai sus cu 2....3 echivalenti de complex triarilfosfit-halogen cu formula generala III: (vezi form. in desc.) în care x are semnificatia de mai sus si Z reprezinta hidrogen sau o grupa alchil cu 1.....4 atomi de carbon obtinut în mod cunoscut din cantitati echivalente din trifenilfosfitul corespunzator si clor sau brom reactia între compusii II si III avînd rol în mediul anhidru într-un solvent ales dintre o hidrocarbura alifatica halogenata si acetonitril la o temperatura cuprinsa între -15 si 30 degree C în prezenta unei amine tertiare aleasa între piridina chinolina si dimetilanilina, în raport molar de 1,0....1,2:1 fata de compusul cu formula III.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/008,647 US4226986A (en) | 1979-02-01 | 1979-02-01 | Process for halogenation of β-lactam compounds |
Publications (2)
Publication Number | Publication Date |
---|---|
RO84256A RO84256A (ro) | 1984-05-23 |
RO84256B true RO84256B (ro) | 1984-07-30 |
Family
ID=21732838
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RO108361A RO84256B (ro) | 1979-02-01 | 1980-02-01 | Procedeu de preparare a unor iminohalogenuri de cefalosporina |
Country Status (22)
Country | Link |
---|---|
US (1) | US4226986A (ro) |
EP (1) | EP0014566B1 (ro) |
JP (1) | JPS55104289A (ro) |
KR (2) | KR830001892B1 (ro) |
BE (1) | BE881426A (ro) |
BG (1) | BG35896A3 (ro) |
CA (1) | CA1150725A (ro) |
CH (1) | CH642971A5 (ro) |
CS (1) | CS275604B6 (ro) |
DE (1) | DE3063395D1 (ro) |
ES (2) | ES8104302A1 (ro) |
FR (1) | FR2447926A1 (ro) |
GB (1) | GB2041374B (ro) |
HU (1) | HU182065B (ro) |
IE (1) | IE49503B1 (ro) |
IL (1) | IL59266A (ro) |
IT (1) | IT1130240B (ro) |
LU (1) | LU82121A1 (ro) |
MX (1) | MX6576E (ro) |
PH (2) | PH14774A (ro) |
RO (1) | RO84256B (ro) |
ZM (1) | ZM1280A1 (ro) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1148938A (en) * | 1979-05-08 | 1983-06-28 | John R. Corfield | Preparation of cephalosporins and intermediates employed therein |
US4281117A (en) * | 1980-09-04 | 1981-07-28 | Eli Lilly And Company | Process for 3-chloro cephalosporin nucleus |
IN181695B (ro) * | 1992-08-10 | 1998-09-05 | Ranbaxy Lab Ltd | |
US5604222A (en) * | 1993-12-27 | 1997-02-18 | Lupin Laboratories, Ltd. | Method for the preparation of 2-chloro sulfinyl azetidinones |
US5578721A (en) * | 1994-07-11 | 1996-11-26 | Lupin Laboratories Limited | Process for preparation of 3-exomethylene cepham sulfoxide esters |
JP6669831B2 (ja) * | 2018-10-02 | 2020-03-18 | 株式会社ユニバーサルエンターテインメント | 遊技機 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3925372A (en) * | 1973-02-23 | 1975-12-09 | Lilly Co Eli | Alpha-aminoacyl-3-halo cephalosporins |
US3962227A (en) * | 1973-02-23 | 1976-06-08 | Eli Lilly And Company | 3-halo cephalosporins |
GB1472869A (en) * | 1975-08-11 | 1977-05-11 | Farmaceutici Italia | Intermediates for cephalosporin synthesis |
IE45158B1 (en) * | 1976-08-16 | 1982-06-30 | Lilly Co Eli | 3-chloro-cephem synthesis |
GB1576219A (en) * | 1976-12-31 | 1980-10-01 | Connlab Holdings Ltd | Thiazoleneazetidinone derivatives |
-
1979
- 1979-02-01 US US06/008,647 patent/US4226986A/en not_active Expired - Lifetime
-
1980
- 1980-01-29 IL IL59266A patent/IL59266A/xx unknown
- 1980-01-29 HU HU80190A patent/HU182065B/hu unknown
- 1980-01-30 CA CA000344676A patent/CA1150725A/en not_active Expired
- 1980-01-30 BG BG046413A patent/BG35896A3/xx unknown
- 1980-01-30 BE BE1/9702A patent/BE881426A/fr not_active IP Right Cessation
- 1980-01-30 FR FR8001969A patent/FR2447926A1/fr active Granted
- 1980-01-31 CH CH79880A patent/CH642971A5/fr not_active IP Right Cessation
- 1980-01-31 IE IE187/80A patent/IE49503B1/en not_active IP Right Cessation
- 1980-01-31 LU LU82121A patent/LU82121A1/fr unknown
- 1980-01-31 IT IT19610/80A patent/IT1130240B/it active
- 1980-01-31 DE DE8080300283T patent/DE3063395D1/de not_active Expired
- 1980-01-31 EP EP80300283A patent/EP0014566B1/en not_active Expired
- 1980-01-31 JP JP1196380A patent/JPS55104289A/ja active Granted
- 1980-01-31 GB GB8003293A patent/GB2041374B/en not_active Expired
- 1980-01-31 CS CS80660A patent/CS275604B6/cs unknown
- 1980-02-01 MX MX808627U patent/MX6576E/es unknown
- 1980-02-01 PH PH23581A patent/PH14774A/en unknown
- 1980-02-01 ZM ZM12/80A patent/ZM1280A1/xx unknown
- 1980-02-01 KR KR1019800000398A patent/KR830001892B1/ko active
- 1980-02-01 KR KR1019800000400A patent/KR830001906B1/ko active
- 1980-02-01 ES ES488234A patent/ES8104302A1/es not_active Expired
- 1980-02-01 RO RO108361A patent/RO84256B/ro unknown
- 1980-09-16 ES ES495102A patent/ES8106530A1/es not_active Expired
-
1981
- 1981-01-15 PH PH25089A patent/PH17758A/en unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
RO78870B (ro) | Procedeu pentru prepararea unor derivati de mercaptoacilproline | |
RO79871B (ro) | Procedeu de preparare a unor fenonoxime aromatice substituite | |
RO82962B (ro) | Procedeu pentru prepararea unor derivati de cefalosporina | |
RO84021B (ro) | Procedeu pentru prepararea esterilor metilici ai unor n-fenil-furanoilanilide | |
RO91871B (ro) | Procedeu pentru prepararea unor derivati de 1,4-dihidro-4-oxonaftiridina | |
RO81944B (ro) | Procedeu de preparare a unor imidodisulfamide | |
RO84256B (ro) | Procedeu de preparare a unor iminohalogenuri de cefalosporina | |
RO96413B (ro) | Procedeu pentru prepararea unor derivati de tiadiazol | |
SE7602144L (sv) | Kvaternera imidazoliumforeningar | |
RO85818B (ro) | PROCEDEU PENTRU PREPARAREA ACIZILOR ALCANOICI SUBSTITUITI îN ALFA CU UN SUBSTITUENT AROMATIC SI A ESTERILOR ACESTORA | |
GB1511340A (en) | Thiophen saccharins | |
RO86646B (ro) | Procedeu pentru prepararea unor oximeteri | |
IN167606B (ro) | ||
RO81532B (ro) | Procedeu de preparare a unor fenoxiamine heterociclice | |
RO91422B (ro) | Procedeu pentru prepararea unor derivati de 1,3-oxazolidin-2-ona | |
RO86842B (ro) | Procedeu de preparare a unor fosforoditionati | |
IN165298B (ro) | ||
KR840001581A (ko) | 베타-락타마제 억제제 2-베타-치환-2-알파-메틸-(5r)펜임-3-알파카복실산 1,1-디옥사이드 및 그 중간체의 제조방법 | |
RO81212B (ro) | Procedeu pentru prepararea unor 2', 6'-dialchil-n-(alcoximetil)-2-cloracetanilide | |
HUP9901951A1 (hu) | Eljárás piridin-2,3-dikarboxilát-származékok előállítására és az eljárásban alkalmazott közbenső termékek | |
RO86277B (ro) | Procedeu de preparare a unor azolil-sililglicoeteri | |
US4429160A (en) | Polyoxaalkyl aminoalcohols | |
KR890002005A (ko) | 방향족 헤테로고리 퍼옥시카르복실산 | |
ES8400111A1 (es) | "un procedimiento para la preparacion de 6-(3,6-dihidro-1(2h)-piridil)primidin-3-oxidos 2,4-disubstituidos". | |
RO86858B (ro) | Procedeu pentru prepararea unor derivati de acid -2-fenoxipropionic ai pentitelor |