RO82214B - Procede pour la preparation des pyrimidones - Google Patents

Procede pour la preparation des pyrimidones

Info

Publication number
RO82214B
RO82214B RO105409A RO10540981A RO82214B RO 82214 B RO82214 B RO 82214B RO 105409 A RO105409 A RO 105409A RO 10540981 A RO10540981 A RO 10540981A RO 82214 B RO82214 B RO 82214B
Authority
RO
Romania
Prior art keywords
pyrimidones
alkyl
substituted
preparation
preparation des
Prior art date
Application number
RO105409A
Other languages
Romanian (ro)
Other versions
RO82214A (en
Inventor
David Gwyn Cooper
George Sideny Sach
Original Assignee
Smith Kline And French Laboratorie Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smith Kline And French Laboratorie Limited filed Critical Smith Kline And French Laboratorie Limited
Publication of RO82214B publication Critical patent/RO82214B/en
Publication of RO82214A publication Critical patent/RO82214A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Pyrrole Compounds (AREA)

Abstract

Inventia se refera la un propcedeu pentru prepararea unor pirimidoane cu formula generala I: (vezi formula) în care R1 si R2 sunt alchil cu 1...4 atomi de carbon, Y este metilen sau sulf, X este metilen, Z este hidrogen sau alchil cu 1...4 atomi de carbon, R3 este hidrogen, alchil cu 1...4 atomi de carbon sau gruparea -A-B în care A este alchilen cu 1...4 atomi de carbon si B este piridil sau N-oxopiridil, eventual substituit cu una sau mai multe grupe hidroxi, alchil inferior, furanil, tienil, 1,3-benzodioxolil, o grupa 2-furanil sau 2-tienil, substituita în pozitia 3 sau 4 prin -CH2NR1R2 sau o grupa 4-piridil substituita în pozitia 2 prin -CH2NR1R2 sau o grupa 2-piridil sibstituita în pozitia 4 sau 5 prin -CH2NR1R2, constînd din aceea ca o amina cu formula genrala II: (vezi formula)...The invention relates to a process for the preparation of pyrimidones of general formula I wherein R 1 and R 2 are C 1 to C 4 alkyl, Y is methylene or sulfur, X is methylene, Z is hydrogen or alkyl of 1-4 carbon atoms, R 3 is hydrogen, alkyl of 1-4 carbon atoms or the group -AB wherein A is C 1-4 alkylene and B is pyridyl or N- oxopyridyl optionally substituted with one or more hydroxy, lower alkyl, furanyl, thienyl, 1,3-benzodioxolyl, 2-furanyl or 2-thienyl group, substituted at the 3 or 4 position by -CH 2 NR 1 R 2 or a 4-pyridyl group substituted at the 2-position by -CH 2 NR 1 R 2 or a 2-pyridyl group substituted in the 4 or 5 position by -CH 2 NR 1 R 2, consisting of that an amine of the formula II: (see formula) ...

RO81105409A 1980-10-01 1981-09-26 PROCEDURE FOR PREPARING PIRIMODONE RO82214A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8031685 1980-10-01

Publications (2)

Publication Number Publication Date
RO82214B true RO82214B (en) 1983-06-30
RO82214A RO82214A (en) 1983-07-07

Family

ID=10516418

Family Applications (1)

Application Number Title Priority Date Filing Date
RO81105409A RO82214A (en) 1980-10-01 1981-09-26 PROCEDURE FOR PREPARING PIRIMODONE

Country Status (22)

Country Link
US (1) US4385058A (en)
EP (1) EP0049173B1 (en)
JP (1) JPS5791986A (en)
KR (1) KR830007630A (en)
AT (1) ATA420581A (en)
AU (1) AU547215B2 (en)
CA (1) CA1170261A (en)
DD (1) DD200469A5 (en)
DE (1) DE3171234D1 (en)
DK (1) DK435681A (en)
ES (1) ES8301966A1 (en)
FI (1) FI813054L (en)
GR (1) GR75783B (en)
IL (1) IL63913A0 (en)
NO (1) NO813326L (en)
PH (2) PH17950A (en)
PL (1) PL233256A1 (en)
PT (1) PT73691B (en)
RO (1) RO82214A (en)
YU (1) YU236881A (en)
ZA (1) ZA816794B (en)
ZW (1) ZW21281A1 (en)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT74865B (en) * 1981-05-27 1983-12-07 Smithkline Beckman Corp Process of preparing a 2-(pyridylbutylamino)-pyrimidone and of its pharmaceutically acceptable salts
ZA823149B (en) * 1981-05-27 1983-03-30 Smithkline Beckman Corp Chemical process
US4808589A (en) * 1982-02-20 1989-02-28 Smith Kline & French Laboratories Limited Pyrimidone derivatives
EP0089765A3 (en) * 1982-03-17 1984-05-23 Smith Kline & French Laboratories Limited Pyridine derivatives
DE3365869D1 (en) * 1982-07-30 1986-10-09 Smith Kline French Lab Amino pyrimidinones and their preparation
PT77287B (en) * 1982-10-01 1986-02-04 Smith Kline French Lab Compound
AU1956283A (en) * 1982-10-02 1984-04-05 Smith Kline & French Laboratories Limited 1-(3-(4-(substited aminomethyl)pyrid-2-yl-oxy)-prop-1-yl- amino) - 2-aminocyclobut-i-ene-3,4-diones
PT77623B (en) * 1982-11-25 1986-03-19 Smith Kline French Lab Process for the preparation of a small class of histamine h2-antagonists
JO1274B1 (en) * 1982-12-03 1985-04-20 سيدني ساخ جورج Puridone derivatives
DK584683A (en) * 1982-12-23 1984-06-24 Smith Kline French Lab pyridine derivatives
EP0112707B1 (en) * 1982-12-23 1987-11-04 Smith Kline & French Laboratories Limited Aminopyrimidinone derivatives as histamine h1-antagonists
GB8311443D0 (en) * 1983-04-27 1983-06-02 Smith Kline French Lab Chemical compounds
GB8318638D0 (en) * 1983-07-09 1983-08-10 Smith Kline French Lab Chemical compounds
GB8319874D0 (en) * 1983-07-23 1983-08-24 Smith Kline French Lab Compounds
GB8320505D0 (en) * 1983-07-29 1983-09-01 Smith Kline French Lab Chemical compounds
US4772704A (en) * 1983-09-21 1988-09-20 Bristol-Myers Company 2,5-disubstituted-4(3H)-pyrimidones having histamine H2 -receptor antagonist activity
GB8332091D0 (en) * 1983-12-01 1984-01-11 Smith Kline French Lab Chemical compounds
GB8421427D0 (en) * 1984-08-23 1984-09-26 Smith Kline French Lab Chemical compounds
CA1275097A (en) * 1984-10-02 1990-10-09 Fujio Nohara Pyridyloxy derivatives
GB8601816D0 (en) * 1986-01-25 1986-02-26 Smith Kline French Lab Pyridine derivatives
US4931452A (en) * 1987-11-10 1990-06-05 The Dow Chemical Company N-cyanomethyl-2-pyridinone insecticides
JP2807577B2 (en) * 1990-06-15 1998-10-08 エーザイ株式会社 Cyclic amide derivative
EP4196793A1 (en) 2020-08-11 2023-06-21 Université de Strasbourg H2 blockers targeting liver macrophages for the prevention and treatment of liver disease and cancer

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1419994A (en) * 1973-05-03 1976-01-07 Smith Kline French Lab Heterocyclicalkylaminotheterocyclic compounds methods for their preparation and compositions comprising them
US4145546A (en) * 1975-10-02 1979-03-20 Smith Kline & French Laboratories Limited 4-Pyrimidone compounds
US4218452A (en) * 1975-10-02 1980-08-19 Smith Kline & French Laboratories Limited Substituted 4-pyrimidone compounds, compositions and methods of use
IN146736B (en) * 1975-10-02 1979-08-25 Smith Kline French Lab
MW5076A1 (en) * 1975-12-29 1978-02-08 Smith Kline French Lab Pharmacologicalle active compounds
US4154834A (en) * 1975-12-29 1979-05-15 Smith Kline & French Laboratories Limited Substituted isocytosines having histamine H2 -antagonist activity
IN151188B (en) * 1978-02-13 1983-03-05 Smith Kline French Lab
US4227000A (en) * 1978-04-11 1980-10-07 Smith Kline & French Laboratories Limited Intermediates in the process for making histamine antagonists
IL57416A (en) * 1978-05-30 1983-03-31 Smith Kline French Lab Nitro compounds,processes for preparing them and compositions containing them
ZA793443B (en) * 1978-07-26 1980-12-31 Glaxo Group Ltd Heterocyclic derivatives
US4250316A (en) * 1978-11-24 1981-02-10 Bristol-Myers Company Pyridyl guanidine anti-ulcer agents
US4255428A (en) * 1979-03-24 1981-03-10 Smith Kline & French Laboratories Limited 5-(Hydroxypyridylalkyl)-4-pyrimidones
CA1140129A (en) * 1979-08-21 1983-01-25 Ronald J. King 4-pyrimidone derivatives

Also Published As

Publication number Publication date
AU7595181A (en) 1982-04-08
EP0049173A2 (en) 1982-04-07
AU547215B2 (en) 1985-10-10
FI813054L (en) 1982-04-02
JPS5791986A (en) 1982-06-08
PH17948A (en) 1985-02-11
DD200469A5 (en) 1983-05-04
EP0049173B1 (en) 1985-07-03
US4385058A (en) 1983-05-24
NO813326L (en) 1982-04-02
DK435681A (en) 1982-04-02
EP0049173A3 (en) 1982-06-30
CA1170261A (en) 1984-07-03
ES505898A0 (en) 1983-01-01
PH17950A (en) 1985-02-11
PL233256A1 (en) 1982-11-08
ES8301966A1 (en) 1983-01-01
ATA420581A (en) 1985-03-15
PT73691A (en) 1981-10-01
JPS6328069B2 (en) 1988-06-07
DE3171234D1 (en) 1985-08-08
KR830007630A (en) 1983-11-04
ZW21281A1 (en) 1981-11-18
GR75783B (en) 1984-08-02
PT73691B (en) 1982-12-10
RO82214A (en) 1983-07-07
YU236881A (en) 1984-02-29
ZA816794B (en) 1982-10-27
IL63913A0 (en) 1981-12-31

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