PT98858A - PROCESS FOR THE PREPARATION OF 3-QUINUCLIDYL BUTYANATES AND PROPANOATES - Google Patents

PROCESS FOR THE PREPARATION OF 3-QUINUCLIDYL BUTYANATES AND PROPANOATES

Info

Publication number
PT98858A
PT98858A PT98858A PT9885891A PT98858A PT 98858 A PT98858 A PT 98858A PT 98858 A PT98858 A PT 98858A PT 9885891 A PT9885891 A PT 9885891A PT 98858 A PT98858 A PT 98858A
Authority
PT
Portugal
Prior art keywords
carbon atom
group attached
adjacent carbon
het
halo
Prior art date
Application number
PT98858A
Other languages
Portuguese (pt)
Other versions
PT98858B (en
Inventor
Alan Stobie
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB909019472A external-priority patent/GB9019472D0/en
Priority claimed from GB919106733A external-priority patent/GB9106733D0/en
Application filed by Pfizer filed Critical Pfizer
Publication of PT98858A publication Critical patent/PT98858A/en
Publication of PT98858B publication Critical patent/PT98858B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

(* CHEMICAL STRUCTURE *) (I) 3-Quinuclidinyl butanoate and propanoate antimuscarinic bronchodilators, particularly useful in the treatment of chronic obstructive airways disease and asthma, of formula (1), and their pharmaceutically acceptable salts, wherein X is either (a) a phenyl group optionally substituted by one or two substituents each independently selected from halo. CF3, C1-C4 alkyl, C1-C4 alkoxy and hydroxy or (b) a thienyl group; and "Het" is either (a) a 5-membered nitrogen-containing heterocyclic group attached to the adjacent carbon atom either by a carbon or a ring nitrogen atom and which is selected from imidazolyl, pyrazolyl, triazolyl and tetrazolyl. (b) an oxadiazolyl or thiadiazolyl group attached to the adjacent carbon atom by a carbon atoms, or (c) a 6-membered nitrogen-containing heterocyclic group attached to the adjacent carbon atom by a carbon atom and selected from pyridinyl, pyrazinyl, pyrimidinyl and pyridazinyl, "Het" being optionally substituted by up to two substituents each independently selected from halo, CF3, C1-C4 alkyl, C1-C4 alkoxy, hydroxy, amino and azido; and m is 1 or 2.
PT98858A 1990-09-06 1991-09-04 PROCESS FOR THE PREPARATION OF 3-QUINUCLIDYL BUTYANATES AND PROPANOATES PT98858B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB909019472A GB9019472D0 (en) 1990-09-06 1990-09-06 Antimuscarinic bronchodilators
GB919106733A GB9106733D0 (en) 1991-03-28 1991-03-28 Antimuscarinic bronchodilators

Publications (2)

Publication Number Publication Date
PT98858A true PT98858A (en) 1992-07-31
PT98858B PT98858B (en) 1999-07-30

Family

ID=26297607

Family Applications (1)

Application Number Title Priority Date Filing Date
PT98858A PT98858B (en) 1990-09-06 1991-09-04 PROCESS FOR THE PREPARATION OF 3-QUINUCLIDYL BUTYANATES AND PROPANOATES

Country Status (12)

Country Link
US (1) US5292749A (en)
EP (1) EP0500864B1 (en)
JP (1) JPH0725756B2 (en)
AT (1) ATE205844T1 (en)
CA (1) CA2073005C (en)
DE (1) DE69132735T2 (en)
DK (1) DK0500864T3 (en)
ES (1) ES2161211T3 (en)
FI (1) FI97469C (en)
IE (1) IE913119A1 (en)
PT (1) PT98858B (en)
WO (1) WO1992004346A1 (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5264415A (en) * 1992-06-25 1993-11-23 Rohm And Haas Company Fungicidal and herbicidal triazoles
US5981549A (en) * 1997-02-14 1999-11-09 Synapse Pharmaceutical International Method for controlling or alleviating the symptoms of respiratory disease and allergies
US20020098109A1 (en) * 1997-09-17 2002-07-25 Jerry Nelson Method and apparatus for producing purified or ozone enriched air to remove contaminants from fluids
ES2165768B1 (en) 1999-07-14 2003-04-01 Almirall Prodesfarma Sa NEW DERIVATIVES OF QUINUCLIDINE AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM.
SK287414B6 (en) 2000-12-28 2010-09-07 Laboratorios Almirall, S.A. Quinuclidine derivatives and compositions contain thereof
AU2003269380A1 (en) * 2002-10-29 2004-05-25 Pharmacia & Upjohn Company Llc Quinuclidinium derivatives as antimuscarinic agents
CN101023062A (en) * 2004-06-30 2007-08-22 詹森药业有限公司 Alpha,beta-unsaturated esters and acids by stereoselective dehydration
EP2100598A1 (en) 2008-03-13 2009-09-16 Laboratorios Almirall, S.A. Inhalation composition containing aclidinium for treatment of asthma and chronic obstructive pulmonary disease
EP2100599A1 (en) 2008-03-13 2009-09-16 Laboratorios Almirall, S.A. Inhalation composition containing aclidinium for treatment of asthma and chronic obstructive pulmonary disease
EP2510928A1 (en) 2011-04-15 2012-10-17 Almirall, S.A. Aclidinium for use in improving the quality of sleep in respiratory patients
WO2013134562A1 (en) 2012-03-09 2013-09-12 Inception 2, Inc. Triazolone compounds and uses thereof
EP2935228B9 (en) 2012-12-20 2017-12-06 Inception 2, Inc. Triazolone compounds and uses thereof
CA2921420A1 (en) 2013-09-06 2015-03-12 Inception 2, Inc. Triazolone compounds and uses thereof

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3290316A (en) * 1962-08-03 1966-12-06 Hoffmann La Roche Alpha-3-pyridylmandelic acid and derivatives thereof
US3833592A (en) * 1966-05-31 1974-09-03 Little Inc A Tropanyl alpha,alpha-diphenyl-alpha-fluoroacetate esters
GB1219606A (en) * 1968-07-15 1971-01-20 Rech S Et D Applic Scient Soge Quinuclidinol derivatives and preparation thereof
US4431627A (en) * 1980-06-03 1984-02-14 Research Corporation Gamma-emitting receptor-binding 3-quinuclidinyl glycolates; methods of preparation thereof and imaging and assay methods utilizing same
US4644003A (en) * 1985-04-03 1987-02-17 Research Corporation 3-quinuclidinol esters, useful as antagonists of muscarinic acetylcholine receptors
US4843074A (en) * 1988-05-17 1989-06-27 Marion Laboratories, Inc. 1-azabicyclo[2.2.2]octan-3-yl 2-aryl-3-azacyclo-2-hydroxypropionates and their quaternary salts
EP0353189B1 (en) * 1988-07-28 1994-01-12 Ciba-Geigy Ag Copper and nickel dihalogenide complexes, process for their preparation and their use
IT1228288B (en) * 1989-01-09 1991-06-07 Zambon Spa COMPOUNDS WITH ANTI-SEROTONIN ACTIVITY
GB8923590D0 (en) * 1989-10-19 1989-12-06 Pfizer Ltd Antimuscarinic bronchodilators

Also Published As

Publication number Publication date
CA2073005C (en) 1998-11-10
FI97469B (en) 1996-09-13
JPH05502454A (en) 1993-04-28
DE69132735D1 (en) 2001-10-25
CA2073005A1 (en) 1992-03-07
JPH0725756B2 (en) 1995-03-22
PT98858B (en) 1999-07-30
US5292749A (en) 1994-03-08
DE69132735T2 (en) 2002-05-29
FI922013A (en) 1992-05-05
DK0500864T3 (en) 2001-11-12
WO1992004346A1 (en) 1992-03-19
IE913119A1 (en) 1992-03-11
FI922013A0 (en) 1992-05-05
ES2161211T3 (en) 2001-12-01
FI97469C (en) 1996-12-27
EP0500864B1 (en) 2001-09-19
EP0500864A1 (en) 1992-09-02
ATE205844T1 (en) 2001-10-15

Similar Documents

Publication Publication Date Title
AU616362B2 (en) Antimuscarinic bronchodilators
PT98858A (en) PROCESS FOR THE PREPARATION OF 3-QUINUCLIDYL BUTYANATES AND PROPANOATES
MX9603506A (en) Heteroaromatic oxazole compounds and use thereof.
IE892340L (en) 4-oxoquinoline-3-carboxylic acid derivatives, their¹preparation and their use
AU6858887A (en) Anti-dysrhythmia agent
MY131501A (en) Process for the prepration of clavulanic acid
IE832361L (en) Triazole antifungal agents.
EP0945426A4 (en) Nitrone derivatives
FI923759A0 (en) THERAPEUTIC BENSAZAPINFOERENINGAR.
CA2190130A1 (en) Thiadiazoles and their use as antipicornaviral agents
ES2112867T3 (en) SALTS OF ACIL- (2'-HIDROXIBIFENIL-2-IL) -PHOSPHINICS ACIDS, THEIR PRODUCTION AND THEIR USE.
IL105666A0 (en) Substituted pyridines,their preparation and pharmaceutical use
IE901104L (en) New bronchospasmolytic compounds and process for their¹preparation
GB9605705D0 (en) Therapeutic agents
DE69717277D1 (en) Imidazopyridine
HUP9900895A2 (en) 2-substituted benzimidazole derivatives as smooth muscle cell proliferation inhibitors
FR2372816A1 (en) N-Aminoalkyl-1,2-benzisothiazol-3-one derivs. - useful as thrombocyte aggregation inhibitors for humans and animals
BG50556A1 (en) Heterocyclic derivatives of 2- amino- 3- hydroxypyridine and method for their preparation
ES8402303A1 (en) Antibiotics, their preparation and use.

Legal Events

Date Code Title Description
BB1A Laying open of patent application

Effective date: 19920317

FG3A Patent granted, date of granting

Effective date: 19990414

MM3A Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 20031031