PT97096B - PROCESS FOR THE PREPARATION OF DETERGENT COMPOSITIONS WITH LOW IRRITATING EFFECT ON THE SKIN - Google Patents
PROCESS FOR THE PREPARATION OF DETERGENT COMPOSITIONS WITH LOW IRRITATING EFFECT ON THE SKIN Download PDFInfo
- Publication number
- PT97096B PT97096B PT9709691A PT9709691A PT97096B PT 97096 B PT97096 B PT 97096B PT 9709691 A PT9709691 A PT 9709691A PT 9709691 A PT9709691 A PT 9709691A PT 97096 B PT97096 B PT 97096B
- Authority
- PT
- Portugal
- Prior art keywords
- group
- alkyl
- diamine
- process according
- carbon atoms
- Prior art date
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- 239000000203 mixture Substances 0.000 title claims abstract description 99
- 238000000034 method Methods 0.000 title claims description 18
- 239000003599 detergent Substances 0.000 title claims description 14
- 238000002360 preparation method Methods 0.000 title claims description 8
- 230000000622 irritating effect Effects 0.000 title claims description 3
- 239000004094 surface-active agent Substances 0.000 claims abstract description 28
- 150000004985 diamines Chemical class 0.000 claims abstract description 8
- 125000002467 phosphate group Chemical class [H]OP(=O)(O[H])O[*] 0.000 claims abstract 3
- -1 aliphatic amines Chemical class 0.000 claims description 51
- 125000004432 carbon atom Chemical group C* 0.000 claims description 28
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 claims description 21
- 125000000217 alkyl group Chemical group 0.000 claims description 17
- 150000001412 amines Chemical class 0.000 claims description 14
- 125000003342 alkenyl group Chemical group 0.000 claims description 13
- 125000005263 alkylenediamine group Chemical group 0.000 claims description 12
- 125000005210 alkyl ammonium group Chemical group 0.000 claims description 11
- 239000007859 condensation product Substances 0.000 claims description 11
- QGZKDVFQNNGYKY-UHFFFAOYSA-O ammonium group Chemical group [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 claims description 10
- 239000000243 solution Substances 0.000 claims description 9
- 229910052783 alkali metal Inorganic materials 0.000 claims description 8
- 150000001340 alkali metals Chemical group 0.000 claims description 8
- 150000001875 compounds Chemical class 0.000 claims description 8
- 239000006071 cream Substances 0.000 claims description 8
- 150000003839 salts Chemical class 0.000 claims description 8
- 239000000344 soap Substances 0.000 claims description 8
- 125000001165 hydrophobic group Chemical group 0.000 claims description 7
- 239000000606 toothpaste Substances 0.000 claims description 7
- 125000002947 alkylene group Chemical group 0.000 claims description 6
- 150000003863 ammonium salts Chemical class 0.000 claims description 6
- 229910052739 hydrogen Inorganic materials 0.000 claims description 6
- 239000001257 hydrogen Substances 0.000 claims description 6
- 239000002453 shampoo Substances 0.000 claims description 6
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims description 5
- 229910052700 potassium Inorganic materials 0.000 claims description 5
- 239000011591 potassium Substances 0.000 claims description 5
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 4
- 239000002324 mouth wash Substances 0.000 claims description 4
- GETQZCLCWQTVFV-UHFFFAOYSA-N trimethylamine Chemical compound CN(C)C GETQZCLCWQTVFV-UHFFFAOYSA-N 0.000 claims description 4
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 3
- VMOWKUTXPNPTEN-UHFFFAOYSA-N n,n-dimethylpropan-2-amine Chemical compound CC(C)N(C)C VMOWKUTXPNPTEN-UHFFFAOYSA-N 0.000 claims description 3
- 229910052708 sodium Inorganic materials 0.000 claims description 3
- 239000011734 sodium Substances 0.000 claims description 3
- WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 claims description 2
- 230000000694 effects Effects 0.000 claims description 2
- 229910052744 lithium Inorganic materials 0.000 claims description 2
- DJEQZVQFEPKLOY-UHFFFAOYSA-N N,N-dimethylbutylamine Chemical compound CCCCN(C)C DJEQZVQFEPKLOY-UHFFFAOYSA-N 0.000 claims 2
- JQVDAXLFBXTEQA-UHFFFAOYSA-O dibutylazanium Chemical compound CCCC[NH2+]CCCC JQVDAXLFBXTEQA-UHFFFAOYSA-O 0.000 claims 2
- ZMANZCXQSJIPKH-UHFFFAOYSA-O triethylammonium ion Chemical compound CC[NH+](CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-O 0.000 claims 2
- 125000001931 aliphatic group Chemical group 0.000 claims 1
- 230000007794 irritation Effects 0.000 claims 1
- 238000005187 foaming Methods 0.000 abstract description 7
- 206010040880 Skin irritation Diseases 0.000 abstract description 2
- 239000004480 active ingredient Substances 0.000 abstract description 2
- 230000036556 skin irritation Effects 0.000 abstract description 2
- 231100000475 skin irritation Toxicity 0.000 abstract description 2
- 239000006260 foam Substances 0.000 description 34
- 210000003491 skin Anatomy 0.000 description 23
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 21
- 239000000194 fatty acid Substances 0.000 description 20
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 19
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 18
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 18
- 229910019142 PO4 Inorganic materials 0.000 description 16
- 235000014113 dietary fatty acids Nutrition 0.000 description 16
- 229930195729 fatty acid Natural products 0.000 description 16
- 235000021317 phosphate Nutrition 0.000 description 16
- 239000004166 Lanolin Substances 0.000 description 15
- 239000002253 acid Substances 0.000 description 15
- 239000004615 ingredient Substances 0.000 description 15
- 235000019388 lanolin Nutrition 0.000 description 15
- 229940039717 lanolin Drugs 0.000 description 15
- 239000003995 emulsifying agent Substances 0.000 description 14
- 235000019441 ethanol Nutrition 0.000 description 14
- 239000010452 phosphate Substances 0.000 description 14
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 13
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 10
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical class OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 9
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 9
- 235000011187 glycerol Nutrition 0.000 description 9
- 239000007787 solid Substances 0.000 description 9
- 239000002562 thickening agent Substances 0.000 description 9
- 238000004140 cleaning Methods 0.000 description 8
- 150000004665 fatty acids Chemical class 0.000 description 8
- 239000007788 liquid Substances 0.000 description 8
- MNNHAPBLZZVQHP-UHFFFAOYSA-N diammonium hydrogen phosphate Chemical class [NH4+].[NH4+].OP([O-])([O-])=O MNNHAPBLZZVQHP-UHFFFAOYSA-N 0.000 description 7
- 239000006210 lotion Substances 0.000 description 7
- MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 description 6
- 150000002430 hydrocarbons Chemical group 0.000 description 6
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 6
- 229920001223 polyethylene glycol Polymers 0.000 description 6
- 239000003380 propellant Substances 0.000 description 6
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 description 6
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 5
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 5
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 5
- 125000000129 anionic group Chemical group 0.000 description 5
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 5
- 125000003438 dodecyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 5
- 239000003974 emollient agent Substances 0.000 description 5
- 230000001815 facial effect Effects 0.000 description 5
- 150000002191 fatty alcohols Chemical class 0.000 description 5
- 239000003205 fragrance Substances 0.000 description 5
- 235000015110 jellies Nutrition 0.000 description 5
- POULHZVOKOAJMA-UHFFFAOYSA-N methyl undecanoic acid Natural products CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 description 5
- 239000003921 oil Substances 0.000 description 5
- 235000019198 oils Nutrition 0.000 description 5
- 235000013772 propylene glycol Nutrition 0.000 description 5
- 239000002904 solvent Substances 0.000 description 5
- 239000000600 sorbitol Substances 0.000 description 5
- 229940034610 toothpaste Drugs 0.000 description 5
- 238000011200 topical administration Methods 0.000 description 5
- 239000005639 Lauric acid Substances 0.000 description 4
- 239000004698 Polyethylene Substances 0.000 description 4
- ATUOYWHBWRKTHZ-UHFFFAOYSA-N Propane Chemical compound CCC ATUOYWHBWRKTHZ-UHFFFAOYSA-N 0.000 description 4
- GOOHAUXETOMSMM-UHFFFAOYSA-N Propylene oxide Chemical compound CC1CO1 GOOHAUXETOMSMM-UHFFFAOYSA-N 0.000 description 4
- 229920002125 Sokalan® Polymers 0.000 description 4
- NSOXQYCFHDMMGV-UHFFFAOYSA-N Tetrakis(2-hydroxypropyl)ethylenediamine Chemical compound CC(O)CN(CC(C)O)CCN(CC(C)O)CC(C)O NSOXQYCFHDMMGV-UHFFFAOYSA-N 0.000 description 4
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 4
- 239000000443 aerosol Substances 0.000 description 4
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Natural products C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 4
- 125000002768 hydroxyalkyl group Chemical group 0.000 description 4
- 229940051866 mouthwash Drugs 0.000 description 4
- 125000000913 palmityl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 4
- 229920000573 polyethylene Polymers 0.000 description 4
- 229920001451 polypropylene glycol Polymers 0.000 description 4
- 239000000047 product Substances 0.000 description 4
- 239000003981 vehicle Substances 0.000 description 4
- 244000060011 Cocos nucifera Species 0.000 description 3
- 235000013162 Cocos nucifera Nutrition 0.000 description 3
- 229920002472 Starch Polymers 0.000 description 3
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 3
- 235000021120 animal protein Nutrition 0.000 description 3
- 239000003945 anionic surfactant Substances 0.000 description 3
- 235000013871 bee wax Nutrition 0.000 description 3
- 239000012166 beeswax Substances 0.000 description 3
- 235000012000 cholesterol Nutrition 0.000 description 3
- 150000002148 esters Chemical class 0.000 description 3
- 238000009472 formulation Methods 0.000 description 3
- 229930195733 hydrocarbon Natural products 0.000 description 3
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 3
- 239000008274 jelly Substances 0.000 description 3
- 229940099367 lanolin alcohols Drugs 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 description 3
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 3
- 229960002216 methylparaben Drugs 0.000 description 3
- 231100000344 non-irritating Toxicity 0.000 description 3
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 description 3
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 3
- 229960003415 propylparaben Drugs 0.000 description 3
- 229920006395 saturated elastomer Polymers 0.000 description 3
- 235000019698 starch Nutrition 0.000 description 3
- 125000004079 stearyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 3
- 239000001993 wax Substances 0.000 description 3
- 229920001285 xanthan gum Polymers 0.000 description 3
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical class CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 2
- HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical compound NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 description 2
- RWLALWYNXFYRGW-UHFFFAOYSA-N 2-Ethyl-1,3-hexanediol Chemical compound CCCC(O)C(CC)CO RWLALWYNXFYRGW-UHFFFAOYSA-N 0.000 description 2
- MFICROQSAOKQAZ-UHFFFAOYSA-N 3-(2-aminoethylamino)propane-1,1,1,3-tetrol hexadecyl dihydrogen phosphate Chemical compound C(CCCCCCCCCCCCCCC)OP(=O)(O)O.OC(CC(O)(O)O)NCCN MFICROQSAOKQAZ-UHFFFAOYSA-N 0.000 description 2
- HBTAOSGHCXUEKI-UHFFFAOYSA-N 4-chloro-n,n-dimethyl-3-nitrobenzenesulfonamide Chemical compound CN(C)S(=O)(=O)C1=CC=C(Cl)C([N+]([O-])=O)=C1 HBTAOSGHCXUEKI-UHFFFAOYSA-N 0.000 description 2
- GJCOSYZMQJWQCA-UHFFFAOYSA-N 9H-xanthene Chemical compound C1=CC=C2CC3=CC=CC=C3OC2=C1 GJCOSYZMQJWQCA-UHFFFAOYSA-N 0.000 description 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- PIICEJLVQHRZGT-UHFFFAOYSA-N Ethylenediamine Chemical compound NCCN PIICEJLVQHRZGT-UHFFFAOYSA-N 0.000 description 2
- 239000004354 Hydroxyethyl cellulose Substances 0.000 description 2
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 2
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 2
- GQPLMRYTRLFLPF-UHFFFAOYSA-N Nitrous Oxide Chemical compound [O-][N+]#N GQPLMRYTRLFLPF-UHFFFAOYSA-N 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- 239000002202 Polyethylene glycol Substances 0.000 description 2
- 229920001214 Polysorbate 60 Polymers 0.000 description 2
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 229920002359 Tetronic® Polymers 0.000 description 2
- XEFQLINVKFYRCS-UHFFFAOYSA-N Triclosan Chemical compound OC1=CC(Cl)=CC=C1OC1=CC=C(Cl)C=C1Cl XEFQLINVKFYRCS-UHFFFAOYSA-N 0.000 description 2
- 239000004164 Wax ester Substances 0.000 description 2
- 239000003082 abrasive agent Substances 0.000 description 2
- 229940048299 acetylated lanolin alcohols Drugs 0.000 description 2
- 150000001298 alcohols Chemical class 0.000 description 2
- 150000008051 alkyl sulfates Chemical class 0.000 description 2
- 239000003242 anti bacterial agent Substances 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 239000002585 base Substances 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 125000002091 cationic group Chemical group 0.000 description 2
- 229920001577 copolymer Polymers 0.000 description 2
- 239000002537 cosmetic Substances 0.000 description 2
- JQVDAXLFBXTEQA-UHFFFAOYSA-N dibutylamine Chemical compound CCCCNCCCC JQVDAXLFBXTEQA-UHFFFAOYSA-N 0.000 description 2
- 150000005690 diesters Chemical class 0.000 description 2
- ZBCBWPMODOFKDW-UHFFFAOYSA-N diethanolamine Chemical compound OCCNCCO ZBCBWPMODOFKDW-UHFFFAOYSA-N 0.000 description 2
- 229940031578 diisopropyl adipate Drugs 0.000 description 2
- TVACALAUIQMRDF-UHFFFAOYSA-N dodecyl dihydrogen phosphate Chemical compound CCCCCCCCCCCCOP(O)(O)=O TVACALAUIQMRDF-UHFFFAOYSA-N 0.000 description 2
- 239000000975 dye Substances 0.000 description 2
- 239000000796 flavoring agent Substances 0.000 description 2
- 235000013355 food flavoring agent Nutrition 0.000 description 2
- 235000003599 food sweetener Nutrition 0.000 description 2
- 150000002334 glycols Chemical class 0.000 description 2
- ZUVCYFMOHFTGDM-UHFFFAOYSA-N hexadecyl dihydrogen phosphate Chemical compound CCCCCCCCCCCCCCCCOP(O)(O)=O ZUVCYFMOHFTGDM-UHFFFAOYSA-N 0.000 description 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 2
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 2
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000002480 mineral oil Substances 0.000 description 2
- 235000010446 mineral oil Nutrition 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 125000001421 myristyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 2
- 239000002736 nonionic surfactant Substances 0.000 description 2
- 125000001117 oleyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])/C([H])=C([H])\C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 2
- SSZBUIDZHHWXNJ-UHFFFAOYSA-N palmityl stearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCCCCCCCCCCCCCCCC SSZBUIDZHHWXNJ-UHFFFAOYSA-N 0.000 description 2
- 239000002304 perfume Substances 0.000 description 2
- 235000011007 phosphoric acid Nutrition 0.000 description 2
- 239000001294 propane Substances 0.000 description 2
- WBHHMMIMDMUBKC-QJWNTBNXSA-M ricinoleate Chemical compound CCCCCC[C@@H](O)C\C=C/CCCCCCCC([O-])=O WBHHMMIMDMUBKC-QJWNTBNXSA-M 0.000 description 2
- 229940066675 ricinoleate Drugs 0.000 description 2
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 2
- 230000005808 skin problem Effects 0.000 description 2
- 238000003892 spreading Methods 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 239000003765 sweetening agent Substances 0.000 description 2
- 230000000699 topical effect Effects 0.000 description 2
- 229930195735 unsaturated hydrocarbon Natural products 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- 235000019386 wax ester Nutrition 0.000 description 2
- JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical compound OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 description 1
- DSEKYWAQQVUQTP-XEWMWGOFSA-N (2r,4r,4as,6as,6as,6br,8ar,12ar,14as,14bs)-2-hydroxy-4,4a,6a,6b,8a,11,11,14a-octamethyl-2,4,5,6,6a,7,8,9,10,12,12a,13,14,14b-tetradecahydro-1h-picen-3-one Chemical compound C([C@H]1[C@]2(C)CC[C@@]34C)C(C)(C)CC[C@]1(C)CC[C@]2(C)[C@H]4CC[C@@]1(C)[C@H]3C[C@@H](O)C(=O)[C@@H]1C DSEKYWAQQVUQTP-XEWMWGOFSA-N 0.000 description 1
- 229940058015 1,3-butylene glycol Drugs 0.000 description 1
- JQJSFAJISYZPER-UHFFFAOYSA-N 1-(4-chlorophenyl)-3-(2,3-dihydro-1h-inden-5-ylsulfonyl)urea Chemical compound C1=CC(Cl)=CC=C1NC(=O)NS(=O)(=O)C1=CC=C(CCC2)C2=C1 JQJSFAJISYZPER-UHFFFAOYSA-N 0.000 description 1
- KYUPIHBUKDNZKE-UHFFFAOYSA-N 1-amino-3-methylbutan-2-ol Chemical compound CC(C)C(O)CN KYUPIHBUKDNZKE-UHFFFAOYSA-N 0.000 description 1
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 1
- SUQPHYAFSSXBNB-UHFFFAOYSA-N 16-methylheptadecyl dihydrogen phosphate Chemical compound CC(C)CCCCCCCCCCCCCCCOP(O)(O)=O SUQPHYAFSSXBNB-UHFFFAOYSA-N 0.000 description 1
- AZWJLPQNCPXJGB-UHFFFAOYSA-N 2,2,11-trimethyldodecan-3-yl dihydrogen phosphate Chemical compound CC(C)CCCCCCCC(C(C)(C)C)OP(O)(O)=O AZWJLPQNCPXJGB-UHFFFAOYSA-N 0.000 description 1
- XFOQWQKDSMIPHT-UHFFFAOYSA-N 2,3-dichloro-6-(trifluoromethyl)pyridine Chemical compound FC(F)(F)C1=CC=C(Cl)C(Cl)=N1 XFOQWQKDSMIPHT-UHFFFAOYSA-N 0.000 description 1
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- 235000011803 sesame oil Nutrition 0.000 description 1
- 229920002545 silicone oil Polymers 0.000 description 1
- 230000037394 skin elasticity Effects 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 235000002639 sodium chloride Nutrition 0.000 description 1
- 229910052938 sodium sulfate Inorganic materials 0.000 description 1
- 235000011152 sodium sulphate Nutrition 0.000 description 1
- 239000013042 solid detergent Substances 0.000 description 1
- 239000003549 soybean oil Substances 0.000 description 1
- 235000012424 soybean oil Nutrition 0.000 description 1
- 239000012177 spermaceti Substances 0.000 description 1
- 229940084106 spermaceti Drugs 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- SFVFIFLLYFPGHH-UHFFFAOYSA-M stearalkonium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1 SFVFIFLLYFPGHH-UHFFFAOYSA-M 0.000 description 1
- 235000003702 sterols Nutrition 0.000 description 1
- 150000003432 sterols Chemical class 0.000 description 1
- 150000005846 sugar alcohols Polymers 0.000 description 1
- 150000003467 sulfuric acid derivatives Chemical class 0.000 description 1
- 239000000271 synthetic detergent Substances 0.000 description 1
- 239000003760 tallow Substances 0.000 description 1
- BORJONZPSTVSFP-UHFFFAOYSA-N tetradecyl 2-hydroxypropanoate Chemical compound CCCCCCCCCCCCCCOC(=O)C(C)O BORJONZPSTVSFP-UHFFFAOYSA-N 0.000 description 1
- KRIXEEBVZRZHOS-UHFFFAOYSA-N tetradecyl dihydrogen phosphate Chemical compound CCCCCCCCCCCCCCOP(O)(O)=O KRIXEEBVZRZHOS-UHFFFAOYSA-N 0.000 description 1
- DZKXJUASMGQEMA-UHFFFAOYSA-N tetradecyl tetradecanoate Chemical compound CCCCCCCCCCCCCCOC(=O)CCCCCCCCCCCCC DZKXJUASMGQEMA-UHFFFAOYSA-N 0.000 description 1
- ICUTUKXCWQYESQ-UHFFFAOYSA-N triclocarban Chemical compound C1=CC(Cl)=CC=C1NC(=O)NC1=CC=C(Cl)C(Cl)=C1 ICUTUKXCWQYESQ-UHFFFAOYSA-N 0.000 description 1
- 229960003500 triclosan Drugs 0.000 description 1
- 125000002889 tridecyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
- 125000002948 undecyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 239000012178 vegetable wax Substances 0.000 description 1
- 239000004034 viscosity adjusting agent Substances 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/0005—Other compounding ingredients characterised by their effect
- C11D3/0094—High foaming compositions
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/11—Esters of phosphoric acids with hydroxyalkyl compounds without further substituents on alkyl
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
- C11D1/02—Anionic compounds
- C11D1/34—Derivatives of acids of phosphorus
- C11D1/345—Phosphates or phosphites
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/26—Organic compounds containing nitrogen
- C11D3/30—Amines; Substituted amines ; Quaternized amines
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Health & Medical Sciences (AREA)
- Cosmetics (AREA)
- Detergent Compositions (AREA)
- Emulsifying, Dispersing, Foam-Producing Or Wetting Agents (AREA)
Abstract
Description
CAMPO TÉCNICO presente invento refere-se a um processo para a preparação de novos agentes tensio-activos e composições tensio-activas com baixo efeito irritante da pele, que apresentam elevadas propriedades de produção de espuma contendo, como ingrediente activo, um sal de fosfato de monoalquilo diamina.TECHNICAL FIELD The present invention relates to a process for the preparation of new surfactants and surfactant compositions with a low skin irritating effect, which have high foaming properties containing, as an active ingredient, a phosphate salt of monoalkyl diamine.
ANTECEDENTES DO INVENTOBACKGROUND OF THE INVENTION
Sabões, detergentes e abrasivos tem, desde há muito, sido usados na limpeza do corpo. Os agentes tensio-activos tais como alquil sulfatos, polioxietileno alquil sulfatos, alquilbenzeno sulfonatose a-olefina sulfonatos têm sido largamente usados como componentes tensio-activas para muitos artigos de limpeza.Soaps, detergents and abrasives have long been used to cleanse the body. Surfactants such as alkyl sulfates, polyoxyethylene alkyl sulfates, alkylbenzene sulfonatose a-olefin sulfonates have been widely used as surfactant components for many cleaning articles.
Sabe-se que tais agentes tensio-activos aniónicos são absorvidos e por essa razão provocam secura e escamação da epiderme, bem como gretas e aspereza, se forem usados contínuamente. Assim, problemas da pele tais como aspereza das mãos podem ser provocados pela utilização de detergentes. A aspereza da pele pode provocar problemas graves de pele tal como equizema. Assim, existe uma necessidade urgente de eliminar essa desvantagem.Such anionic surfactants are known to be absorbed and for this reason cause dryness and scaling of the epidermis, as well as cracks and roughness, if used continuously. Thus, skin problems such as hand roughness can be caused by the use of detergents. The roughness of the skin can cause serious skin problems such as evenness. Thus, there is an urgent need to eliminate this disadvantage.
Os agentes tensio-activos não-iónicos provocam pouca ou nenhuma aspereza ou secura da pele. No entanto, nao possuem as mesmas propriedades vantajosas de formação de espuma e detergencia como os agentes tensio-activos aniónicos. Por isso, não tem sido adequado incorporar-se agentes tensio-activos não iónicos em composiçoes de limpeza como componentes detergentes primários.Nonionic surfactants cause little or no skin roughness or dryness. However, they do not have the same advantageous foaming and detergent properties as anionic surfactants. Therefore, it has not been suitable to incorporate nonionic surfactants into cleaning compositions as primary detergent components.
Os esteres fosfóricos ácidos tem sido reconhecidos como agentes tensio-activos aniónicos, geralmente como mono ou diesteres ou suas misturas. Não obstante, a sua solubilidade na água não é geralmente muito boa.Phosphoric acid esters have been recognized as anionic surfactants, generally as mono or diesters or mixtures thereof. However, its solubility in water is generally not very good.
A Patente Europeia N2 265 702 publicada em 4 de Maio, 1988 descreve composições cosméticas transparentes ou semitransparentes contendo um fosfato monoalquilo, água, óleo e um álcool para tratamento da pele. Os óleos e álcoois são utilizados para se obter limpidez. A Patente U.S. 4.573.749 atribuída a Mclntosh, emitida em 28 de Junho, 1988 descreve fosfatos de alquil monamina comEuropean Patent No. 265 702 published on May 4, 1988 describes transparent or semitransparent cosmetic compositions containing a monoalkyl phosphate, water, oil and an alcohol for skin treatment. Oils and alcohols are used to obtain clarity. U.S. Patent 4,573,749 issued to Mclntosh, issued June 28, 1988 describes alkyl monamine phosphates with
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actividade antimicrobiana. A Patente U.S. 4.290.904 atribuída a Poper e ai, emitida em 22 de Setembro, 1981, Patente U.K. Νθ 1.513.053, publicada em 7 de Junho, 1978 e Patente Europeia 023 978, publicado em 18 de Fevereiro, 1981, descrevem preparações cosméticas e de maquilhagem contendo alquileno diaminas alcoxiladas. As Patentes U.S. 4.476.043, 4.476.044 e 4.476.045 atribuídas a 0’Lenick, emitida em 16 de Outubro, 1984, descrevem agentes tensio-activos substancialmente não-aquosos contendo um sulfato orgânico, õleo mineral e uma amina alcoxilada. Nao obstante, nenhuma dessas referências descreve o uso de um agente tensio-activo de fosfato de diamino alquilo.antimicrobial activity. US Patent 4,290,904 issued to Poper et al, issued on September 22, 1981, UK Patent Νθ 1,513,053, published on June 7, 1978 and European Patent 023 978, published on February 18, 1981, describe preparations cosmetics and make-up containing alkylene alkoxylated diamines. U.S. Patents 4,476,043, 4,476,044 and 4,476,045 issued to O'Lenick, issued October 16, 1984, describe substantially non-aqueous surfactants containing an organic sulfate, mineral oil and an alkoxylated amine. However, none of these references describes the use of a diamino alkyl phosphate surfactant.
Sais de fosfato de monoalquilo foram igualmente descritos como úteis agentes tensio-activos na Patente U.S. 4.139.485 atribuída a Imokawa e al., emitida em 13 de Fevereiro, 1979. No entanto, essas superfícies formam soluções aquosas turvas a menos que contenham outros solventes (por exemplo, agentes solubilizantes). Além disso, a reologia desses sais limita a variedade de formulações que podem ser feitas com agradáveis caracteristicas estéticas.Monoalkyl phosphate salts have also been described as useful surfactants in US Patent 4,139,485 issued to Imokawa et al., Issued February 13, 1979. However, these surfaces form cloudy aqueous solutions unless they contain other solvents (for example, solubilizing agents). In addition, the rheology of these salts limits the variety of formulations that can be made with pleasant aesthetic characteristics.
Verificou-se que certos sais novos de fosfato de monoalquil^iiamina, bem como determinadas composições tensio-activas transparentes e estáveis contendo esses sais, facilmente permitem a preparação' de espumas estáveis, arejadas e não pressurizadas. Essas espumas possuem bom poder de lavagem e detergencia, são suaves e não irritantes e deixam, pouca ou nenhuma película residual na superfície limpa da pele. Estas composiçoes são de natureza homogénea, podem ser estruturadas para serem molhadas ou secas, estáveis ou rapidamente decomponíveis e são esteticamente adequadas para · utilização numa grande variedade de produtos de higiene pessoal.It has been found that certain new monoalkylamine phosphate salts, as well as certain transparent and stable surfactant compositions containing these salts, easily allow the preparation of stable, aerated and non-pressurized foams. These foams have good washing and detergent power, are smooth and non-irritating and leave little or no residual film on the clean skin surface. These compositions are homogeneous in nature, can be structured to be wet or dry, stable or rapidly decomposable and are aesthetically suitable for use in a wide variety of personal care products.
Um dos principais objectivos deste invento é descrever a preparaçao de uma composição para limpeza da pele feita a partir dos novos sais de fosfato de monoalquil diamina do presente invento, que produzirão uma espuma utilizável a partir de um dispositivo de aplicação de espuma manual e por aperto, bem como de um dispositivo de aerossol e que, além disso, nao tornará o dispositivo inútil devido a t;,©btrução do dispositivo, por exemplo.One of the main objectives of this invention is to describe the preparation of a skin cleansing composition made from the new monoalkyl diamine phosphate salts of the present invention, which will produce a foam that can be used from a hand-held foam device and an aerosol device and which, moreover, do not become useless due device at,, © btrução device, for example.
Outro objecto do presente invento é proporcionar agentes tensio-activos e composições tensio-activas produtoras deAnother object of the present invention is to provide surfactants and surfactant compositions producing
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espumas relativamente estáveis ou desintegráveis. Uma forma de realizaçao preferida do presente invento é proporcionar espumas de baixa densidade para limpeza da pele.relatively stable or disintegrable foams. A preferred embodiment of the present invention is to provide low density foams for cleaning the skin.
Outro objecto do presente invento é proporcionar um agente tensio-activo e uma composição tensio-activa suave e não irritante para a pele e olhos e que não necessita do uso de propulsores, evitando-se assim o perigo de explosão ou corrosão do contentor.Another object of the present invention is to provide a surfactant and a smooth surfactant composition that is non-irritating to the skin and eyes and does not require the use of propellants, thus avoiding the danger of explosion or corrosion of the container.
Ainda outro objecto do presente invento é proporcionar uma composição produtora de espuma tal, que se colocada num dispositivo aplicador de espuma manual com paredes deformáveis, a quantidade de força necessária para produzir a espuma nao é excessiva (isto é, menos do que cerca de 15 psi) e é facilmente utilizável pelo utilizador médio.Yet another object of the present invention is to provide a foam-producing composition such that if placed in a manual foam applicator device with deformable walls, the amount of force required to produce the foam is not excessive (that is, less than about 15 psi) and is easily usable by the average user.
Estes objectivos, bem como outros aparentes aos técnicos do ramo, são obtidos com os compostos e composições aqui descritos.These objectives, as well as others apparent to those skilled in the art, are achieved with the compounds and compositions described herein.
RESUMO DO INVENTO presente invento compreende sais de fosfato monalquil diamina tendo um baixo efeito de irritação da pele humana, de fórmula:SUMMARY OF THE INVENTION the present invention comprises monalkyl diamine phosphate salts having a low human skin irritation effect, of the formula:
OX^OX ^
RO—P~0X2 RO — P ~ 0X 2
H 'H '
em que R é um grupo hidrófobo ou o produto de condensação de um grupo hidrófobo com óxido de etileno em que preferivelmente R é alquilo ou alcenilo com uma média de entre cerca de 10 a 18 átomos de carbono e em que X| e X2 são independentemente seleccionados do grupo constituído por hidrogénio, metal alcalino, amónio, amónio substítuido (por exemplo, amónio alcoxilado, alquilamónio, aminas alifáticas r 3,-where R is a hydrophobic group or the condensation product of a hydrophobic group with ethylene oxide where preferably R is alkyl or alkenyl with an average of between about 10 to 18 carbon atoms and where X | and X2 are independently selected from the group consisting of hydrogen, alkali metal, ammonium, substituted ammonium (for example, alkoxylated ammonium, alkylammonium, r 3 aliphatic amines, -
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Case:4119R alcoxiladas, aminas polietoxiladas) e alquileno diamina, desde que pelo menos um de X| e X2 seja uma alquileno diamina totalmente hidroxialquilada.Case: 4119R alkoxylated, polyethoxylated amines) and alkylene diamine, provided that at least one of X | and X 2 is a fully hydroxyalkylated alkylene diamine.
Sao igualmente descritas composiçoes constituídas pelos sais de fosfato dessas monoalquil diaminas.Compositions comprising the phosphate salts of these monoalkyl diamines are also described.
Sais de fosfato de sesquiaquilo não se encontram dentro dos objectivos do presente invento.Sesquiaquyl phosphate salts are not within the scope of the present invention.
Todas as partes, percentagens e rácios aqui utilizados são em peso e todas as medidas são a 252 C, a menos que seja indicada outra coisa.All parts, percentages and ratios used here are by weight and all measurements are at 252 C, unless otherwise stated.
DESCRIÇÃO PORMENORIZADA DO INVENTODETAILED DESCRIPTION OF THE INVENTION
Os compostos tensio-activos do presente invento são da fórmula:The surfactant compounds of the present invention are of the formula:
OXjOXj
II
RO—P—0X2 em que R é um grupo hidrófobo ou ú produto de condensação de um grupo hidrõfobo com óxido de etileno em que R é, preferivelmente, alquilo ou alcenilo com uma média de entre cerca de 10 e 18 átomos de carbono, e em que X·^ e X2 são independentemente escolhidos de um grupo constituído por bidrogénio, metal alcalino, amónio, amónio substituído (por exemplo, amónio alcoxilado, alquilamónio, aminas alifáticas alcoxiladas, aminas polietoxiladas) e alquileno diamina. Preferivelmente, R é o produto de condensação de um grupo hidrófobo com entre cerca de 1 e cerca de 10 moles e preferivelmente entre cerca de 1 e cerca de 4 moles de óxido de etileno.RO — P — 0X 2 where R is a hydrophobic group or a condensation product of a hydrophobic group with ethylene oxide where R is preferably alkyl or alkenyl with an average of between about 10 and 18 carbon atoms, and wherein · X ^ and X 2 are independently selected from the group consisting of bidrogénio, alkali metal, ammonium, substituted ammonium (e.g., alkoxylated ammonium, alkylammonium, alkoxylated aliphatic amines, polyethoxylated amines) and alkylene diamine. Preferably, R is the condensation product of a hydrophobic group with between about 1 and about 10 moles and preferably between about 1 and about 4 moles of ethylene oxide.
Preferivelmente, 0 rácio é peso do sal de fosfato de monalquil diamina para o sal de fosfato de dialquilo é de entre cerca de 99:1 e cerca de 70:30, respectivamente, preferivelmente de entre cerca de 100:0 e cerca de 90:10, sendo o mais preferido um rácio de 100:0. Nao obstante, ao contrário da monoamina, o álcali, ou os saisPreferably, the weight ratio of the monalkyl diamine phosphate salt to the dialkyl phosphate salt is between about 99: 1 and about 70:30, respectively, preferably between about 100: 0 and about 90: 10, with a ratio of 100: 0 being most preferred. However, unlike monoamine, alkali, or salts
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Case:4119R de fosfato de amónio, estes fosfatos de diamina do diester sao unicamente solúveis na água e, por isso, não interferirão com os dispositivos e formulações aqui descritos.Case: 4119R of ammonium phosphate, these diester phosphates of the diester are only soluble in water and, therefore, will not interfere with the devices and formulations described here.
Os agentes tensio-activos do presente invento são particularmente Ateis nos produtos detergentes que contactam directamente com a pele durante muito tempo, tais como produtos de limpeza para o rosto, champôs e barras de detergente sintético e sólido para maquilhagem porque tem um excelente e caracteristico poder de produção de espuma não provocando aspereza na pele. Os agentes tensio-activos podem também ser usados como ingredientes de detergentes líquidos para lavagem de pratos, detergentes em pó e dentífricos e são composições particularmente uteis onde se desejam composiçoes límpidas e não turvas.The surfactants of the present invention are particularly useful in detergent products that directly contact the skin for a long time, such as facial cleansers, shampoos and bars of synthetic and solid detergent for makeup because it has an excellent and characteristic power of foam production without causing roughness to the skin. Surfactants can also be used as liquid dishwashing detergent, powder detergent and toothpaste ingredients and are particularly useful compositions where clear, non-cloudy compositions are desired.
Os grupos de carbono saturados e insaturados com um valor médio de átomos de carbono de 10-18 (R) são hidrocarbonetos de cadeia recta, ramificada ou aliciclica tais como grupos decilo, undecilo, dodecilo, tridecilo, tetradecilo, pentadecilo, hexadecilo, heptadecilo e octadecilo e correspondentes olefinicamente insaturados. Este» grupos hidrocarbonetos estão contidos isoladamente nas composições ou sob a forma de uma combinação de diversos grupos. Grupos de hidrocarboneto saturados com um numero dé átomos de carbono de 10 a 14 e grupos hidrocarboneto insaturados com um numero médio de átomos de carbono de 16 são particularmente preferidos. Também uteis para esta utilização são os grupos hidrocarboento saturados e insaturados de entre cerca de 1 e cerca de 10 unidades e preferivelmente entre cerca de 1 e cerca de 4 unidades de óxido de etileno por molécula.The saturated and unsaturated carbon groups with an average carbon atom value of 10-18 (R) are straight, branched or alicyclic hydrocarbons such as decyl, undecyl, dodecyl, tridecyl, tetradecyl, pentadecyl, hexadecyl, heptadecyl and octadecyl and olefinically unsaturated correspondents. These »hydrocarbon groups are contained alone in the compositions or in the form of a combination of several groups. Hydrocarbon groups saturated with a number of carbon atoms of 10 to 14 and unsaturated hydrocarbon groups with an average number of carbon atoms of 16 are particularly preferred. Also useful for this use are the saturated and unsaturated hydrocarbon groups of between about 1 and about 10 units and preferably between about 1 and about 4 units of ethylene oxide per molecule.
Os metais alcalinos preferidos para X| e X2 de acordo com o invento são, por exemplo, litio, sódio e potássio.The preferred alkali metals for X | and X2 according to the invention are, for example, lithium, sodium and potassium.
alquilamónio ou o alquilamónio substituido para Xj. e X2 de acordo com 0 invento, são catiões produzidos a partir de aminas usadas para neutralizaçao dos correspondentes ácidos fosfóricos por formação de sal após o passo de neutralização no processo de preparação de sais de fosfato de monoalquilo do presente ftBaEBfe). As correspondentes aminas, são aminas primárias, secundárias e terciárias com grupos alquilo de 1 a 4 átomos de carbono que podem ainda seralkylammonium or substituted alkylammonium for Xj. and X2 according to the invention, are cations produced from amines used to neutralize the corresponding phosphoric acids by salt formation after the neutralization step in the process of preparing monoalkyl phosphate salts of the present ftBaEBfe). The corresponding amines are primary, secondary and tertiary amines with alkyl groups of 1 to 4 carbon atoms that can still be
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substituídos, em especial por grupos hidroxilo. Como aminas podem ser mencionadas, por exemplo, dimetilaminoetanolamina, metildietanolamina, trimetilamina, trietilamina, dibutilamina, monoetanolamina, dietanolamina, trietanolamina, isopropildimetilamina e isopropiletanolamina. Aminas preferidas são a monoetanolamina, dietanolamina e trietanolamina. Uma amina particularmente preferida é a trietanolamina. Outras aminas úteis incluem arginina, lisina, mono-, di- ou tei-isopropanolamina, N,N-tris(hidroximetil)aminometano, díglicolamina, glucamina, aminometilpropanol e aminometilpropanediol. Também utilizáveis no presente invento são os copolimeros derivados da adição de óxido de etileno e óxido de propíleno disponíveis como Tetronic®· e Tetronic R® que se pode obter da BASF Corporation e as aminas polietoxiladas disponíveis sob a forma da série Ethomeen® que é fornecida pela Armak Corporation.replaced, in particular by hydroxyl groups. As amines may be mentioned, for example, dimethylaminoethanolamine, methyldiethanolamine, trimethylamine, triethylamine, dibutylamine, monoethanolamine, diethanolamine, triethanolamine, isopropyl dimethylamine and isopropylethanolamine. Preferred amines are monoethanolamine, diethanolamine and triethanolamine. A particularly preferred amine is triethanolamine. Other useful amines include arginine, lysine, mono-, di- or tei-isopropanolamine, N, N-tris (hydroxymethyl) aminomethane, diglycolamine, glucamine, aminomethylpropanol and aminomethylpropanediol. Also usable in the present invention are copolymers derived from the addition of ethylene oxide and propylene oxide available as Tetronic® · and Tetronic R® obtainable from BASF Corporation and the polyethoxylated amines available in the form of the Ethomeen® series which is supplied Armak Corporation.
A alquileno diamina, de acordo com o presente invento tem a seguinte fórmula geral:Alkylene diamine according to the present invention has the following general formula:
Rj^N—R3—NR4R5» em que Rj, R2, R4 e R5 são hidrogénio independente, um grupo alquilo com 1 a 4 átomos de carbono ou um grupo hidroxialquilo ou dihidroxialquilo com 1 a 4 átomos de carbono ou em que R4 e R5 formam, juntamente, um anel heterocíclico de 5 ou 6 membros saturado, que pode ser substituido por um grupo oxo-ou hidroxialquilo e R3 representa um grupo alquileno ou hidroxialquileno com 2 a 4 átomos de carbono, desde que pelo menos um dos Rp R2, R3, R4 e R5 contenha pelo menos um grupo hidroxi.Rj ^ N — R3 — NR4R5 »where Rj, R2, R4 and R5 are hydrogen independent, an alkyl group with 1 to 4 carbon atoms or a hydroxyalkyl or dihydroxyalkyl group with 1 to 4 carbon atoms or where R4 and R5 together form a saturated 5- or 6-membered heterocyclic ring, which can be replaced by an oxo- or hydroxyalkyl group and R3 represents an alkylene or hydroxyalkylene group having 2 to 4 carbon atoms, provided that at least one of the Rp R2, R3, R4 and R5 contain at least one hydroxy group.
Estes compostos são completamente descritos na Patente U.K. 1.513.053, publicada em 7 de Junho de 1978.These compounds are fully described in U.K. 1,513,053, published June 7, 1978.
Uma classe particular e útil de amina, no presente caso, é uma etileno diamina Ν,Ν-tetraquis(hidroxialquil) com a fórmula:A particular and useful class of amine, in the present case, is an ethylene diamine Ν, Ν-tetrakis (hydroxyalkyl) with the formula:
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R [HO—CH-CH2]n R [HO — CH-CH 2 ] n
R [CH2—CHOH]n R [CH 2 —CHOH] n
N—Rj — N [HO—CH—CH2]n [CH2—CHOH]n em que R| é alquileno com dois a quatro átomos de carbono, R é hidrogénio ou um grupo alquilo com um a seis átomos de carbono e n é de um a quatro. A dlamina antecedente tem, preferivelmente, um peso molecular inferior a cerca de 1700, preferivelmente inferior a cerca de 1200, ainda mais preferivelmente inferior a cerca de 800 e com a maior preferência de todas inferior a cerca de 500.N — Rj - N [HO — CH — CH 2 ] n [CH 2 —CHOH] n where R | is alkylene with two to four carbon atoms, R is hydrogen or an alkyl group with one to six carbon atoms and n is one to four. The foregoing dlamine preferably has a molecular weight of less than about 1700, preferably less than about 1200, even more preferably less than about 800 and most preferably of all less than about 500.
Embora outros exemplos sejam fornecidos adiante, a diamina tetraquis (hidroxialquil) etiieno é melhor identificada pelo composto N, N, Ν’, N’-tetraquis(2-hidroxipropil)-etilenodiamina, obtenível comercialmente sob a marca registada Quadrol ou Neutrol TE (ambos fornecidos pela BASE Wyandotte Company).Although other examples are provided below, tetrakis (hydroxyalkyl) ethylene diamine is best identified by the compound N, N, Ν ', N'-tetrakis (2-hydroxypropyl) -ethylenediamine, commercially obtainable under the trademark Quadrol or Neutrol TE (both provided by BASE Wyandotte Company).
Exemplos de sais de fosfato com utilidade no presente invento incluem, sem a eles se limitarem, monococoilfosfato de tetrahidroxipropiletilenodiamina, monolaurllfosfato de tetrahidroxipropiletilenodlamina, monolaurilfosfato de tetrahldropropiletilenodiamlna (monoetoxilado), monoisoestearilfosfato de tetrahidroxipropiletilenodiamina, monostearilfosfato de tetrabidropropiletilenodiamina, monoestearilfosfato de tetrahidroxipropiletilenodiamina (monoetoxilado), monomiristilfosfato de tetrabidroxipropiletilenodiamina, monooleoilfosfato de tetrabidroxipropilenodiamina, monopalmitilfosfato de tetrahidroxipropiletílenodiamina,Examples of phosphate salts useful in the present invention include, but are not limited to, monococoilfosfato of tetrahidroxipropiletilenodiamina, monolaurllfosfato of tetrahidroxipropiletilenodlamina, monolaurilfosfato of tetrahldropropiletilenodiamlna (monoetoxilado) monoisoestearilfosfato of tetrahidroxipropiletilenodiamina, monostearilfosfato of tetrabidropropiletilenodiamina, monoestearilfosfato of tetrahidroxipropiletilenodiamina (monoetoxilado) monomiristilfosfato of tetrabydroxypropylethylenediamine, tetrabydroxypropylenediamine monooleoylphosphate, tetrahydroxypropylethylenediamine monopalmitylphosphate,
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Case:4119R monopalmitilfosfato de tetrahidropropiletilenodiamina (monoetoxilado), monocaprilfosfato de tetrahidroxipropiletilenodiamina, monocaprilfosfato de tetrahidroxipropiletilenodiamina (monoetoxilada), monoundecilenilfosfato de tetrahidroxipropiletilenodiamina, monotridecilenilfosfato de tetrahidroxipropiletilenodiamina, mono(metilmiristil)fosfato de tetrahidroxipropiletilenodiamina, mono(isopropilauril)fosfato de tetrahidroxipropiletilenodiamina, mono(isodecilneopentil)fosfato de tetrahidroxipropilenodiamina, monocetilfosfato de tetrahidroxipropiletilenodiamina e mono(isopropilmiristil)fosfato de tetrahidroxipropiletilenodiamina.Case: 4119R monopalmitilfosfato of tetrahidropropiletilenodiamina (monoetoxilado) monocaprilfosfato of tetrahidroxipropiletilenodiamina, monocaprilfosfato of tetrahidroxipropiletilenodiamina (monoetoxilada) monoundecilenilfosfato of tetrahidroxipropiletilenodiamina, monotridecilenilfosfato of tetrahidroxipropiletilenodiamina, mono (metilmiristil) tetrahidroxipropiletilenodiamina phosphate, mono (isopropilauril) tetrahidroxipropiletilenodiamina phosphate, mono (isodecilneopentil) phosphate tetrahydroxypropylenediamine, tetrahydroxypropylethylenediamine monocetylphosphate and tetrahydroxypropylethylenediamine mono (isopropylmiristyl) phosphate.
COMPOSIÇÕESCOMPOSITIONS
As composições do presente invento compreendem:The compositions of the present invention comprise:
(a) de cerca de 0,1% a cerca de 99% de um ou mais sais de fosfato de monalquil diamina do presente invento; e (b) de cerca de 1,0% a cerca de 99,0% de um veiculo detergente.(a) from about 0.1% to about 99% of one or more monalkyl diamine phosphate salts of the present invention; and (b) from about 1.0% to about 99.0% of a detergent vehicle.
Composições preferidas compreendem uma mistura dos sais de fosfato de monoalquil diamina em que R é seleccionado do grupo constituído por a Cj.4 alquilo ou alcenilo G^-C^g alquilo ou alcenilo (ou o produto de condensação dessas porçoes com entre cerca de 1 e cerca de 10 moles de óxido de etileno) e em que os referidos sais se encontram presentes numa proporção de entre cerca de 80:20 e cerca de 20:80, preferivelmente de cerca de 60:40 a cerca de 40:60 e mais preferivelmente de cerca de 55:45 a cerca de 45:55, respectivamente.Preferred compositions comprise a mixture of the diamine monoalkyl phosphate salts wherein R is selected from the group consisting of Cj.4 alkyl or alkenyl L ^ -C ^ g alkyl or alkenyl (or the condensation product of these portions with between about 1 and about 10 moles of ethylene oxide) and wherein said salts are present in a ratio of between about 80:20 and about 20:80, preferably from about 60:40 to about 40:60 and more preferably from about 55:45 to about 45:55, respectively.
As composições do presente invento podem ser administradas topicamente, isto é, por aplicação directa em camada ou espalhamento da composição sobre tecido epidérmico ou epitelial. Tais composiçoes podem ser formuladas sob a forma de espumas, loções, cremes, unturas, soluções, geleias ou sólidos. Uma composição altamente preferida contém o sal de fosfato de monoalquilo numa matriz de sabão (isto é, líquido e sólido). Estas composições tópicas compreendem uma quantidade segura e eficaz, geralmente de cerca deThe compositions of the present invention can be administered topically, that is, by direct application in layer or spreading the composition on epidermal or epithelial tissue. Such compositions can be formulated in the form of foams, lotions, creams, greases, solutions, jellies or solids. A highly preferred composition contains the monoalkyl phosphate salt in a soap matrix (i.e., liquid and solid). These topical compositions comprise a safe and effective amount, generally about
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0,1% a cerca de 99% e preferivelmente de cerca de 1% e cerca de 10% do sal de fosfato de monoalquilo. Composições em barra contém geralmente níveis muito elevados, isto é, acima de 80%, do sal de fosfato de monoalquil diamina. Geralmente o veiculo é, ou de natureza orgânica ou uma solução ou uma emulsão aquosa e pode ter o sal de fosfato de monoalquil diamina dissolvido ou suspenso nela. 0 veiculo pode incluir emolientes farmaceuticamente aceitáveis, melhoradores de penetração cutanea, agentes corantes, fragrâncias, emulsionantes, agentes espessantes e solventes. Segue-se uma descrição mais pormenorizada de tais formas:0.1% to about 99% and preferably about 1% and about 10% of the monoalkyl phosphate salt. Bar compositions generally contain very high levels, that is, above 80%, of the monoalkyl diamine phosphate salt. Generally the vehicle is either of an organic nature or an aqueous solution or emulsion and may have the monoalkyl diamine phosphate salt dissolved or suspended therein. The carrier can include pharmaceutically acceptable emollients, skin penetration enhancers, coloring agents, fragrances, emulsifiers, thickening agents and solvents. A more detailed description of such forms follows:
1. Loções.1. Lotions.
As loçoes podem compreender uma quantidade segura e eficaz de sal de fosfato de monoalquilo; de cerca de 0,1% a cerca de 25%, preferivelmente de cerca de 3% a cerca de 15% de um emoliente; sendo o saldo constituído por água, um álcool C2 ouC-j ou uma mistura de água e de álcool. Exemplos de emolientes adequados são como segue:Lotions can comprise a safe and effective amount of monoalkyl phosphate salt; from about 0.1% to about 25%, preferably from about 3% to about 15% of an emollient; the balance being water, a C2 or C-j alcohol or a mixture of water and alcohol. Examples of suitable emollients are as follows:
1. Óleos e ceras hidrocarbonadas. Exemplos são óleo mineral, petrolato, parafina, ceresina, ozoquerita, cera microcristalina, polietileno e perhidroesqualano.1. Hydrocarbon oils and waxes. Examples are mineral oil, petrolatum, paraffin, ceresin, ozoquerite, microcrystalline wax, polyethylene and perhydrosqualane.
2. Óleos de silicone, tais como polidimetilsiloxanos, metilfenilpolisiloxanos, copolimeros de silicone-glicol solúveis na água e no álcool.2. Silicone oils, such as polydimethylsiloxanes, methylphenylpolysiloxanes, water-alcohol-soluble silicone-glycol copolymers.
3. Óleos e gorduras triglicéridas, tais como os derivados de fontes vegetais, animais e marinhas. Exemplos disso incluem óleo de castor, óleo de açafrão, óleo de semente de algodão, óleo de milho, azeite, óleo de fígado de bacalhau, óleo de amêndoas, óleo de abacate, óleo de palma, óleo de sésamo e óleo de soja.3. Oils and triglyceride fats, such as those derived from plant, animal and marine sources. Examples of this include castor oil, safflower oil, cottonseed oil, corn oil, olive oil, cod liver oil, almond oil, avocado oil, palm oil, sesame oil and soybean oil.
4. Esteres acetoglicéridos, tais como monoglicérídos acetilados.4. Acetoglyceride esters, such as acetylated monoglycerides.
5. Glicéridos etoxilados, tais como monoestearato de glicerilo etoxilado.5. Ethoxylated glycerides, such as ethoxylated glyceryl monostearate.
6. Esteres alquilo de ácidosgordos com 10 a 20 átomos de carbono. Esteres de metilo, isopropilo e butilo de ácidos gordos são aqui especialmente úteis. Exemplos deles incluem laurato de hexilo, laurato de iso-hexilo, palmitato de iso-hexilo, palmitato de6. Fatty acid alkyl esters with 10 to 20 carbon atoms. Methyl, isopropyl and butyl fatty acid esters are especially useful here. Examples of these include hexyl laurate, isohexyl laurate, isohexyl palmitate,
- 9 4- 9 4
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JJ
Mod. 71 - 20.000 ex. - 90/08Mod. 71 - 20,000 ex. - 8/90
J isopropilo, oleato de decilo, oleato de isodecilo, estearato de hexadecilo, estearato de decilo, isostearato de isopropilo, adipato de di-isopropilo, adipato de di-iso-hexilo, adipato de di-hexildecilo, sebacato de di-isopropilo, lactato de laurilo, lactato de miristilo e lactato de cetilo.J isopropyl, decyl oleate, isodecyl oleate, hexadecyl stearate, decyl stearate, isopropyl isostearate, diisopropyl adipate, diisopropyl adipate, dihexildecyl adipate, diisopropyl sebacate, lactate of lauryl, myristyl lactate and cetyl lactate.
7. Esteres alcenllo de ácidos gordos com 10 a 20 átomos de carbono. Exemplos destes incluem miristato de oleilo, estearato de oleilo e oleato de oleilo.7. Alkenyl esters of fatty acids with 10 to 20 carbon atoms. Examples of these include oleyl myristate, oleyl stearate and oleyl oleate.
8. Ácidos gordos com 9 a 22 átomos de carbono. Exemplos adequados incluem os ácidos pelargónico, laurilico, miristico, palmitico, esteárico, iso-esteárico, hidroxi-esteãrico, oleico, linoleico, ricinoleico, araquidónico, bebénico e erucico.8. Fatty acids with 9 to 22 carbon atoms. Suitable examples include pelargonic, lauryl, myristic, palmitic, stearic, isostearic, hydroxy-stearic, oleic, linoleic, ricinoleic, arachidonic, baby and erucic acids.
9. Álcoois gordos com 10 a 20 átomos de carbono. Laurilo, miristilo, cetilo, hexadecilo, estearilo, isostearilo, hidroxistearilo, oleilo, ricinoleilo, behenilo, reucilo e 2-octil dodecilo são exemplos de álcoois gordos adequados.9. Fatty alcohols with 10 to 20 carbon atoms. Lauryl, myristyl, cetyl, hexadecyl, stearyl, isostearyl, hydroxystearyl, oleyl, ricinoleyl, behenyl, reucyl and 2-octyl dodecyl are examples of suitable fatty alcohols.
10. Esteres de alcóois gordos. Álcoois gordos etoxilados com 10 a 20 átomos de carbono incluem os alcóois de laurilo, cetilo, estearilo, isostearilo, oleilo e colesterol que têm ligados a si entre 1 a 50 grupos de óxido de etileno ou 1 a 50 grupos· de óxido de propileno ou uma sua mistura.10. Fatty alcohol esters. Ethoxylated fatty alcohols with 10 to 20 carbon atoms include the lauryl, cetyl, stearyl, isostearyl, oleyl and cholesterol alcohols that have between 1 to 50 ethylene oxide groups or 1 to 50 propylene oxide groups or its a mixture.
11. Esteres de éter tais como os esteres de acido gordo dos alcóois gordos etoxilados.11. Ether esters such as the fatty acid esters of ethoxylated fatty alcohols.
12. Lanolina e seus derivados. Lanolina, óleo de lanolina, cera de lanolina, alcóois de lanolina, ácidos gordos de lanolina, lanolato de isopropilo, lanolina etoxilada, alcóois de lanolina etoxilada, colesterol etoxilado, alcóois de lanolina propoxilada, lanolina ácetilada, alcóois de lanolina acetilada, linoleato de alcóois de lanolina, ricinoleato de alcóois de lanolina, ricinoleato de alcóois de acetato de lanolina, acetato de esteres alcóolicos etoxilados, bidrogenólise de lanolina, lanolina bidrogenada etoxilada, lanolina sorbitol etoxilada e bases de absorção de lanolina líquida e semõ^ólida são ilustrativos de emolientes derivados da lanolina.12. Lanolin and its derivatives. Lanolin, lanolin oil, lanolin wax, lanolin alcohols, lanolin fatty acids, isopropyl lanolate, ethoxylated lanolin, ethoxylated lanolin alcohols, ethoxylated cholesterol, propoxylated lanolin alcohols, acetylated lanolin, acetylated lanolin alcohols, acetylated lanolin alcohols lanolin, lanolin alcohol ricinoleate, lanolin acetate alcohol ricinoleate, ethoxylated alcohol esters acetate, lanolin hydrogenolysis, ethoxylated hydrogenated lanolin, ethoxylated sorbitol lanolin and liquid lanolin absorption bases and liquid derivatives are illustrative. of lanolin.
13. Derivados de alcóois poli-bidricos e poli-etéreos. Propileno13. Derivatives of polyhydric and polyether etherols. Propylene
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14. Esteres de álcool poli-hídrico, esteres de ácidos mono e di-gordos de etileno glicol, esteres de ácidos mono ou di-gordos de dietileno glicol, esteres de ácidos mono e di-gordos de polietileno glicol (P.M. 200-6000), esteres de ácidos mono e di-gordos de propileno glicol, monoleato de propileno glicol 2000, monostearato de propileno glicol 2000, monostearato de propileno propileno glicol etoxilado, esteres de ácidos mono e di-gordos de glicerilo, esteres de ácidos poli-gordos de poliglicerol, monostearato de gliceril etoxilado, monostearato de 1,3-butileno glicol, distearato de 1,3butileno glicol, ester de ácido gordo de plioxietileno polio, esteres de ácido gordo de sorbitano e esteres de ácido gordo de polioxietileno sorbitano constituem esteres satisfatórios de álcool poli-hidrico.14. Polyhydric alcohol esters, ethylene glycol mono- and di-fatty esters, diethylene glycol mono- or di-fatty esters, polyethylene glycol mono- and di-fatty esters (PM 200-6000) , propylene glycol mono and di-fatty acid esters, propylene glycol 2000 monoleate, propylene glycol 2000 monostearate, ethoxylated propylene glycol monostearate, glyceryl mono and di-fatty acid esters, poly-fatty acid esters polyglycerol, ethoxylated glyceryl monostearate, 1,3-butylene glycol monostearate, 1,3-butylene glycol distearate, polyoxyethylene fatty acid ester, sorbitan fatty acid esters and polyoxyethylene sorbitan fatty acid esters are satisfactory alcohol esters polyhydric.
15. Esteres de cera, tais como cera de abelha, espermacete, miristato de miristilo, estearato de estearilo.15. Wax esters, such as beeswax, spermaceti, myristyl myristate, stearyl stearate.
16. Derivados de cfera de abelhas, por exemplo, polioxietileno sorbitol de cera de abelhas. Estes são produtos de reacçao da cera de abelhas com sorbitol etoxilado com um conteúdo variado de óxido de etileno, que formam uma mistura de eter-esteres.16. Beesphere derivatives, for example, polyoxyethylene sorbitol from beeswax. These are reaction products of beeswax with ethoxylated sorbitol with a varied content of ethylene oxide, which form a mixture of ether-esters.
17. Ceras vegetais, incluindo ceras de carnaúba e de candelária.17. Vegetable waxes, including carnauba and candelaria waxes.
18. Fosfolipidos, tais como a lecitina e os seus derivados.18. Phospholipids, such as lecithin and its derivatives.
19. Esteróis. Colesterol, esteres de ácidos gordos de colesterol são exemplos deles.19. Sterols. Cholesterol, cholesterol fatty acid esters are examples of them.
20. Amidos, tais como amidos de ácidos gordos, amidos de ácidos gordos etoxilados, alcanolamidas de ácido gordo20. Starches, such as fatty acid starches, ethoxylated fatty starches, fatty acid alkanolamides
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sólido.solid.
As loçoes compreendem ainda entre cerca de 1% e cerca de 10%, preferivelmente entre cerca de 2% e cerca de 5% de um emulsionador. Os emulsionadores podem ser não-iónicos, aniónicos ou catiónicos. Exemplos satisfatórios de emulsionadores não-iónicos incluem alcóois de ãcido gordo com 10 a 20 átomos de carbono, alcóois gordos com 10 a 20 átomos de carbono condensados com 2 a 20 moles de óxido de etileno ou óxido de propileno, alquil fenóis com 6 a 12 átomos de carbono na cadeia alquilo condensada com 2 a 20 moles de óxido de etileno, esteres de ãcido mono e di-gordo de óxido etileno, esteres de ácidos mono e di-gordos de etileno glicol em que a porção ácida gorda contem entre 10 a 20 átomos de carbono, dietileno glicol, polietileno glicóis de peso molecular de 200 a 6000, propileno glicóis de peso molecular de 200 a 3000, glicerol, sorbitol, sorbitano, polioxietileno sorbitol, polioxietileno sorbitano e esteres de cera hidrófila. Emulsionadores aniónicos adequados incluem os sabões e ácido gordo, por exemplo sódio, potássio e sabões de trietanolamina, em que a porção de ácido gordo contém entre 10 a 20 átomos de carbono. Outros emulsionadores aniónicos adequados incluem os sulfatos de metal alcalino, amónio ou amónio alquil substituídos, arilsulfonatos de alquilo e sulfonatos de alquil etoxi eter com 10 a 30 átomos de carbono na porção alquilo. Os sulfonatos de eter alquil etoxi contém entre cerca de 1 a 50 unidades de óxido de etileno. Nao obstante, reconhece-se que certos emulsionadores aniónicos podem resultar numa solução turva sendo por essa razão que os emulsionadores aniónicos são os menos preferidos para utilização, no presente caso.Lotions further comprise between about 1% and about 10%, preferably between about 2% and about 5% of an emulsifier. Emulsifiers can be non-ionic, anionic or cationic. Satisfactory examples of non-ionic emulsifiers include fatty acid alcohols with 10 to 20 carbon atoms, fatty alcohols with 10 to 20 carbon atoms condensed with 2 to 20 moles of ethylene oxide or propylene oxide, alkyl phenols with 6 to 12 carbon atoms in the alkyl chain condensed with 2 to 20 moles of ethylene oxide, esters of mono- and di-fatty ethylene oxide, esters of mono- and di-fatty acids of ethylene glycol in which the fatty acid contains between 10 to 20 carbon atoms, diethylene glycol, polyethylene glycols of molecular weight 200 to 6000, propylene glycols of molecular weight 200 to 3000, glycerol, sorbitol, sorbitan, polyoxyethylene sorbitol, polyoxyethylene sorbitan and hydrophilic wax esters. Suitable anionic emulsifiers include soaps and fatty acids, for example sodium, potassium and triethanolamine soaps, wherein the fatty acid portion contains between 10 to 20 carbon atoms. Other suitable anionic emulsifiers include alkali metal, ammonium or substituted alkyl ammonium sulfates, alkyl aryl sulfonates and alkyl ethoxy ether sulfonates having 10 to 30 carbon atoms in the alkyl portion. Ether alkyl ethoxy sulfonates contain between about 1 to 50 ethylene oxide units. However, it is recognized that certain anionic emulsifiers can result in a cloudy solution and that is why anionic emulsifiers are the least preferred for use in the present case.
resto da loção é constituído por água ou um álcool Cg ou Cg, ou uma mistura de água e do álcool. As soluçoes sao formuladas por simples mistura de todos os componentes. Preferivelmente, o sal de fosfato de monoalquilo é dissolvido na mistura. Componentes convencionais facultativos podem também ser incluídos. Um desses aditivos é um agente espessador a um nível de entre cerca de 1% e cerca de 10% da.composição. Exemplos de agentes espessadores adequados incluem; polímeros recticulados de carboxipolimetileno (suficientemente neutralizado), silicato de magnésio de alumínio, carboximetilcelulose, hidroxietilcelulose, $91rest of the lotion consists of water or a Cg or Cg alcohol, or a mixture of water and alcohol. The solutions are formulated by simply mixing all the components. Preferably, the monoalkyl phosphate salt is dissolved in the mixture. Optional conventional components can also be included. One of these additives is a thickening agent at a level of between about 1% and about 10% of the composition. Examples of suitable thickening agents include; crosslinked polymers of carboxypolymethylene (sufficiently neutralized), aluminum magnesium silicate, carboxymethylcellulose, hydroxyethylcellulose, $ 91
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polímeros de ácido acrílico (por exemplo, Acrysol ICS-I, produzido poracrylic acid polymers (eg Acrysol ICS-I, produced by
Rohm & Haas Corporation), polietileno glicóis, goma de tragacanto, goma de caraia, gomas de xantano e bentonite. Polímeros catiónicos, tais como goma catiónica de guar, não são preferidos para uso no presente caso.Rohm & Haas Corporation), polyethylene glycols, tragacanth gum, caraia gum, xanthan and bentonite gums. Cationic polymers, such as guar cationic gum, are not preferred for use in the present case.
2. Cremes.2. Creams.
As composições do presente invento podem também ser formuladas sob a forma de creme. Estes compreendem quantidades eficazes, do sal monoalquil sulfato; entre cerca de 0,1% a 95% de um emoliente preferivelmente de entre cerca de 10% a cerca de 25%; sendo o resto constituído por água. Os emolientes acima descritos podem ser igualmente utilizados nas composições em creme. Facultativamente, a forma de creme contém um emulsionador adequado, conforme anteriormente descrito. Quando se inclui um emulsionador, a composição fica a um nível de entre cerca de 3% e cerca de 50%, preferivelmente entre cerca de 5% e cerca de 20%.The compositions of the present invention can also be formulated in the form of a cream. These comprise effective amounts of the monoalkyl sulfate salt; between about 0.1% to 95% of an emollient, preferably from about 10% to about 25%; the rest being water. The emollients described above can also be used in cream compositions. Optionally, the cream form contains a suitable emulsifier, as previously described. When an emulsifier is included, the composition is at a level of between about 3% and about 50%, preferably between about 5% and about 20%.
3. Soluçoes.3. Solutions.
As composições do presente invento podem igualmente ser formuladas como uma solução. Esta compreende uma quantidade eficaz do sal de fosfato monalquilo, geralmente pelo menos cerca de 0,01% até cerca de 50% e preferivelmente cerca de 0,1% a cerca de 10%; sendo o restante constituído por água ou um solvente orgânico adequado. Adequados materiais orgânicos e úteis como solventes ou partes de um sistema de solventes, são os seguintes: propileno glicol, polietileno glicol (P.M. 200-1000), polipropileno glicol (P.M. 425-2025), butileno glicol, glicerina, esteres de sorbitol, 1,2,6-hexanetriol, etanol, isopropanol, dietil tartarato, butanediol e suas misturas.The compositions of the present invention can also be formulated as a solution. This comprises an effective amount of the monalkyl phosphate salt, generally at least about 0.01% to about 50% and preferably about 0.1% to about 10%; the remainder consisting of water or a suitable organic solvent. Suitable organic materials and useful as solvents or parts of a solvent system are the following: propylene glycol, polyethylene glycol (PM 200-1000), polypropylene glycol (PM 425-2025), butylene glycol, glycerin, sorbitol esters, 1 , 2,6-hexanethriol, ethanol, isopropanol, diethyl tartrate, butanediol and mixtures thereof.
Estas soluções podem ser aplicadas ã pele tal como estão, ou então podem ser formuladas em dispositivos de aperto, conforme descrição ou como um aerossol e pulverizadas sobre a pele a partir de um recipiente aerossol, ou como uma composição para lavagem da boca e utilizada como enxaguamento oral. As composiçoes aerossol compreendem ainda entre cerca de 25% e cerca de 80%, preferivelmente entre cerca de 30% e cerca de 50% de propulsores adequados. Exemplos de tais propulsores são os hidrocarbonetos clorados, fluoretados eThese solutions can be applied to the skin as is, or they can be formulated in tightening devices, as described or as an aerosol and sprayed on the skin from an aerosol container, or as a mouth wash composition and used as a oral rinse. Aerosol compositions further comprise between about 25% and about 80%, preferably between about 30% and about 50% of suitable propellants. Examples of such propellants are chlorinated, fluorinated and hydrocarbons
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clorofluoretados de baixo peso molecular. Óxido nitroso, dióxido de carbono, butano e propano podem também ser usados como propulsores gasosos. Estes propulsores são usados a um nível suficiente para expelir o conteúdo do recipiente.low molecular weight chlorofluorides. Nitrous oxide, carbon dioxide, butane and propane can also be used as gaseous propellants. These propellants are used at a level sufficient to expel the contents of the container.
Embalagens de aperto com espumas são bem conhecidas, conforme e exemplificado pelas descrições das seguintes patentes aqui incorporadas como referência. Patentes U.S. Nos. 3.709.437, Wright, emitida em 9 de Jan., 1973; 3.937.364, Wright, emitida em 10 de Fev., 1976; 4.022.351, Wright, emitida em 10 de Maio, 1977; 4.147.306, Bennett, emitida em 3 de Abr., 1979; 4.184.615, Wright, emitida em 22 de Jan., 1980; 4.598.862, Rice, emitida em 8 de Julho, 1986; e 4.615.467, Grogan e al., emitida em 7 de Out., 1986; e Patente Francesa 2.604.622, Verhulst, publicada em 8 de Abr., 1988.Foam squeeze packs are well known, as exemplified by the descriptions of the following patents incorporated herein by reference. U.S. Patent Nos. 3,709,437, Wright, issued Jan. 9, 1973; 3,937,364, Wright, issued Feb. 10, 1976; 4,022,351, Wright, issued May 10, 1977; 4,147,306, Bennett, issued Apr. 3, 1979; 4,184,615, Wright, issued Jan. 22, 1980; 4,598,862, Rice, issued July 8, 1986; and 4,615,467, Grogan et al., issued on Oct. 7, 1986; and French Patent 2,604,622, Verhulst, published Apr. 8, 1988.
Os acima citados contentores (embalagens) nao utilizam qualquer propulsor e são por isso seguros para o consumidor e para o ambiente. Criam uma espuma a partir de qualquer composição tensio-activa. Embora não haja necessidade de adicionar dilatadores de espuma com a simples finalidade de a estabilizar, tais materiais podem ser desejáveis. Nalgumas composições o uso de dilatadores de espuma pode mesmo ser contraproducente, uma vez que a espuma tem de quebrar para que o recipiente funcione adequadamente. A composição é colocada no reservatório do recipiente (frasco apertável e plástico). Comprimindo-se o recipiente com a mão, força-se a composição a passar através de uma cabeça de espumificação ou outros meios de produção de espuma, em que a composição ê misturada com ar e depois através de meios homogeneizadores que fazem com que a espuma seja mais homogénea e que controlam a consistência da espuma. A espuma é depois descarregada sob a forma de uma espuma arejada uniforme e não pressurizada.The aforementioned containers (packaging) do not use any propellant and are therefore safe for the consumer and the environment. They create a foam from any surfactant composition. Although there is no need to add foam expanders for the sole purpose of stabilizing it, such materials may be desirable. In some compositions, the use of foam expanders can even be counterproductive, since the foam has to break in order for the container to function properly. The composition is placed in the container reservoir (tight and plastic bottle). By compressing the container by hand, the composition is forced to pass through a foaming head or other foaming means, in which the composition is mixed with air and then through homogenizing means that cause the foam more homogeneous and that control the consistency of the foam. The foam is then discharged in the form of a uniform, non-pressurized aerated foam.
A pressão mínima para activar o produtor de espuma de aperto é de cerca de 1 psig a cerca de 2 psig. A pressão mínima está relacionada com o tamanho dos canais existentes no aplicador, a viscosidade da composição, etc..The minimum pressure to activate the squeeze foam maker is about 1 psig to about 2 psig. The minimum pressure is related to the size of the channels in the applicator, the viscosity of the composition, etc.
Em geral, a densidade da espuma deverá situar-se entre cerca de 0,002 e cerca de 0,25 g/cc, preferivelmente entre cercaIn general, the density of the foam should be between about 0.002 and about 0.25 g / cc, preferably between about
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veiculo liquido num preparado para lavagem bocal é geralmente uma mistura de etanol e agua. A quantidade de etanol é geralmente de entre cerca de 5% a cerca de 60%, preferivelmente entre cerca de 5% e cerca de 25% em peso do veículo. Estas composições para lavagem bocal podem também conter outros componentes facultativos tais como agentes emulsionadores conforme descritos anteriormente, agentes aromatizantes, adoçadores e humidificadores. Outras formulações e métodos para se criarem produtos para a lavagem bocal com utilidade no presente invento sao descritos na Patente U.S. 4.323.551 atribuída a Parran, emitida em 6 de Abril de 1982, que é aqui incorporada como referência.liquid vehicle in a nozzle washing preparation is generally a mixture of ethanol and water. The amount of ethanol is generally between about 5% to about 60%, preferably between about 5% and about 25% by weight of the vehicle. These mouthwash compositions may also contain other optional components such as emulsifying agents as described above, flavoring agents, sweeteners and humidifiers. Other formulations and methods for creating mouthwash products useful in the present invention are described in U.S. Patent 4,323,551 issued to Parran, issued April 6, 1982, which is incorporated herein by reference.
4. Geleias.4. Jellies.
Estas composições podem ser formuladas numa forma de geleia por meio de simples mistura de um agente espessador adequado ãs composições de solução conforme descrição anterior. Exemplos de agentes espessadores adequados foram descritos anteriormente quando se referiam ãs loções.These compositions can be formulated in a jelly form by simply mixing a thickening agent suitable for the solution compositions as described above. Examples of suitable thickening agents have been described previously when referring to lotions.
As composições gelificadas compreendem uma quantidade segura e eficaz do sal de monoalquil fosfato, de entre cerca de 0,5% a cerca de 20%, preferivelmente de cerca de 1% a cerca de 10% do agente espessador; sendo o resto água.The gelled compositions comprise a safe and effective amount of the monoalkyl phosphate salt, from about 0.5% to about 20%, preferably from about 1% to about 10% of the thickener; the rest being water.
5. Sólidos.5. Solids.
As composiçoes do presente invento podem também ser formuladas sob uma forma sólida, por exemplo, uma composição do tipo cilindro. Tais composiçoes compreendem uma quantidade eficaz e segura do sal de monoalquil fosfato e entre cerca de 0,01% e cerca de 99%, preferivelmente entre cerca de 60% e cerca de 90%, dos emulientes anteriormente descritos. Esta composição pode ainda compreender entre cerca de 0,1% e cerca de 20%, preferivelmente entre cerca de 5% e cerca de 15% de um agente espessador- adequado e, facultativamente, emulsionadores e água. Os agentes espessadores anteriormente descritos relativamente às loções são igualmente adequados para este caso.The compositions of the present invention can also be formulated in a solid form, for example, a cylinder type composition. Such compositions comprise an effective and safe amount of the monoalkyl phosphate salt and between about 0.01% and about 99%, preferably between about 60% and about 90%, of the emulients described above. This composition can further comprise between about 0.1% and about 20%, preferably between about 5% and about 15% of a suitable thickening agent and, optionally, emulsifiers and water. The thickeners described above for lotions are also suitable for this case.
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II
6. Sabões.6. Soaps.
As composições do presente invento podem também ser formuladas num molde de sabao líquido ou sólido (por exemplo barra). Tais composições compreendem uma quantidade segura e eficaz dos sais de monoalquil fosfato que varia entre cerca de 0,1% e cerca de 99%; e entre cerca de 1% e cerca de 99% de um excipiente tal como os anteriormente descritos. Facultativamente, o sabão contém um emulsionador adequado, conforme anteriormente descrito. Quando se inclui um emulsionador ele encontra-se na composição a um nível de entre cerca de 10% e cerca de 50%.The compositions of the present invention can also be formulated in a liquid or solid soap mold (for example, bar). Such compositions comprise a safe and effective amount of the monoalkyl phosphate salts ranging from about 0.1% to about 99%; and between about 1% and about 99% of an excipient such as those described above. Optionally, the soap contains a suitable emulsifier, as previously described. When an emulsifier is included, it is in the composition at a level of between about 10% and about 50%.
7. Dentífricos.7. Toothpaste.
As composições do presente invento podem também ser formuladas como dentífricos. Tais dentífricos, especialmente pasta de dentes, compreendem uma quantidade segura e eficaz do sal de monoalquil fosfato que varia entre cerca de 0,1% e cerca de 20% em peso da composição. Convencionalmente, as composições de pasta de dentes contem materiais abrasivos, agentes produtores de espumas, ligantes, humedecedores, agentes aromatizantes e adoçadores.The compositions of the present invention can also be formulated as toothpaste. Such toothpastes, especially toothpaste, comprise a safe and effective amount of the monoalkyl phosphate salt ranging from about 0.1% to about 20% by weight of the composition. Conventionally, toothpaste compositions contain abrasive materials, foaming agents, binders, wetting agents, flavoring agents and sweeteners.
n ~ , tr . , , e processos „ , , . n ~, tr. ,, and processes „,,.
Composiçoes dentirricas adequadas para o seu fabrico utilizáveis no presente invento são completamente descritos na Patente U.S. 3.535.421, atribuída a Briner e outros, emitida em 20 de Outubro de 1970, que é aqui incorporada como referência.Denture compositions suitable for their manufacture usable in the present invention are fully described in U.S. Patent 3,535,421, issued to Briner et al., Issued October 20, 1970, which is incorporated herein by reference.
8. Champôs.8. Shampoos.
Composições do presente invento podem também ser formuladas numa forma de champô. Os champôs compreendem uma quantidade segura e eficaz do sal de monoalquil fosfato de diamina variando entre cerca de 0,1% e cerca de 99%; de cerca de 5% a cerca de 60% de um agente tensio-activo sintético; e o resto em água. Um agente tensioactivo secundário pode ser também utilizado. No entanto, tal agente tensio-activo secundário deverá ser neutralizado por uma diamina conforme atrás descrito.Compositions of the present invention can also be formulated in a shampoo form. Shampoos comprise a safe and effective amount of the monoalkyl phosphate diamine salt ranging from about 0.1% to about 99%; from about 5% to about 60% of a synthetic surfactant; and the rest in water. A secondary surfactant can also be used. However, such a secondary surfactant should be neutralized by a diamine as described above.
Estes champôs podem · conter uma variedade de componentes não essenciais facultativos. Tais ingredientes convencionais facultativos sao bem conhecidos da técnica e sao, por exemplo, conservantes, tais como álcool benzilico, etil parabeno,These shampoos can · contain a variety of optional non-essential components. Such optional conventional ingredients are well known in the art and are, for example, preservatives, such as benzyl alcohol, ethyl paraben,
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Case:4119R propil parabeno e imidazolidinilo ureia; agentes tensio-activos catiónicos, tais como cloreto de cetil trimetil amónio, cloreto de estearildimetil benzil amónio e cloreto de di(sebo parcialmente hidrogenado)dimetllamónio; espessadores e modificadores de viscosidade tais como dietanolamida de um ácido gordo de cadeia longa (por exemplo, lauramido PEG 3), polímeros de bloco de óxido de etileno e óxido de propileno, cloreto de sódio, sulfato de sódio, álcool polivinilico e álcool etilico; agentes ajustadores do pH, tais como ácido cítrico, ácido succínico, ácido fosfórico, carbonato de sódio; perfumes; corantes e agentes sequestradores, tais como tetracetato de dissódio etilenodiamina. Geralmente tais agentes sao usados individualmente a um nível de entre cerca de 0,01% e cerca de 10%, preferivelmente de cerca de 0,5% a cerca de 5,0% em peso da composição.Case: 4119R propyl paraben and imidazolidinyl urea; cationic surfactants, such as cetyl trimethyl ammonium chloride, stearyldimethyl benzyl ammonium chloride and di (partially hydrogenated tallow) dimethylammonium chloride; thickeners and viscosity modifiers such as long chain fatty acid diethanolamide (e.g., PEG 3 lauramido), ethylene oxide and propylene oxide block polymers, sodium chloride, sodium sulfate, polyvinyl alcohol and ethyl alcohol; pH adjusting agents, such as citric acid, succinic acid, phosphoric acid, sodium carbonate; Perfumes; dyes and sequestering agents, such as disodium ethylenediamine tetracetate. Generally such agents are used individually at a level of between about 0.01% and about 10%, preferably from about 0.5% to about 5.0% by weight of the composition.
Componentes menores adicionais podem ser acrescentados ãs composições do presente invento a fim de aumentarem o seu atraetivo, versatilidade e armazenagem. Perfumes e corantes solúveis na água, farmaceuticamente aceitáveis .ou corantes alimentares, podem ser adicionados para tornar mais atraentes estas composições. Agentes antifungicos e antimicrobianos são úteis para evitar a contaminação por bolores ou bactéricas e para aumentar a armazenagem das composiçoes. Agentes anti-bacterianos convencionais podem ser incluídos nas presentes composições a níveis de entre cerca de 0,1% e cerca de 4%, preferivelmente de entre cerca de 0,2% e cerca de 1%. Agentes anti-bacterianos adequados para utilização são 3,4-die 3,4',5-tribromosalicilanidos; 4,4’-dicloro-3(trifluorometil)carbanilida; 3,4,4’-triclorocarbanilida; fenoxi etanol ou propano; sais de cloro-hexideno; sais de hexamidina; Irgasan DP 300 (Triclosan); ácido salicilico;' paraclorometaxilenol; Octopirox e misturas desses materiais. Para fins gerais, são desejáveis composiçoes de limpeza da pele com uma variaçao de pH dè cerca de 5,0 a cerca de 8,0. Se necessário, o pH dessas composições pode ser ajustado para baixo utilizando-se ácido citrico ou láctico. Para produtos de limpeza da pele que tratam de superfícies mais sensíveis da pele, tais como os produtos de limpeza vaginais ou do perineo, éAdditional minor components can be added to the compositions of the present invention in order to increase their attractiveness, versatility and storage. Pharmaceutically acceptable water-soluble perfumes and dyes or food dyes can be added to make these compositions more attractive. Antifungal and antimicrobial agents are useful to prevent contamination by molds or bacteria and to increase the storage of the compositions. Conventional anti-bacterial agents can be included in the present compositions at levels of between about 0.1% and about 4%, preferably between about 0.2% and about 1%. Antibacterial agents suitable for use are 3,4-die 3,4 ', 5-tribromosalicylanides; 4,4'-dichloro-3 (trifluoromethyl) carbanilide; 3,4,4'-trichlorocarbanilide; phenoxy ethanol or propane; chlorhexidene salts; hexamidine salts; Irgasan DP 300 (Triclosan); salicylic acid;' parachloromethoxylenol; Octopirox and mixtures of these materials. For general purposes, skin cleansing compositions with a pH range of about 5.0 to about 8.0 are desirable. If necessary, the pH of these compositions can be adjusted downwards using citric or lactic acid. For skin cleansers that treat more sensitive skin surfaces, such as vaginal or perineum cleaners,
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Case:4119R desejável um pH de cerca de 6,5. Estas e outras modificações menores podem ser efectuadas sem se alterar materialmente ou sem se afastar do conceito básico deste invento.Case: a pH of about 6.5 is desirable. These and other minor modifications can be made without changing materially or departing from the basic concept of this invention.
A natureza da espuma produzida determina a utilidade das presentes .composições. Para que uma espuma seja útil como agente de limpeza da pele, deve ter uma consistência uniforme, boa capacidade de se espalhar e boa capacidade de limpeza.The nature of the foam produced determines the usefulness of the present compositions. For a foam to be useful as a skin cleansing agent, it must have a uniform consistency, good spreadability and good cleansing ability.
As caracteristicas de produção de espuma e de humedecimento são orientadas pela tensão de superfície da composição para limpeza da pele. A tensão de superfície para as composições do presente invento varia entre cerca de 20 e cerca de 70 dines/cm. Para composiçoes gerais de limpeza da pele é preferida uma variação de cerca de 23 a cerca de 50 dines/cm. Composições liquidas com uma tensão de superfície com valores inferiores a esses limites possuem maiores características de alastramento e de melhor humedecimento com uma formação de espuma aperfeiçoada. Composições capazes de formar espuma com superfícies de tnesão superiores proporciona geralmente - ~ # · espumas mais estáveis mas sao também mais difíceis de provocar espuma e exige mais força para extrudir a espuma.The characteristics of foaming and moistening are guided by the surface tension of the skin cleansing composition. The surface tension for the compositions of the present invention varies between about 20 and about 70 dynes / cm. For general skin cleansing compositions, a range of about 23 to about 50 dynes / cm is preferred. Liquid compositions with a surface tension lower than these limits have greater spreading characteristics and better wetting with improved foam formation. Compositions capable of foaming with higher tensile surfaces generally provide more stable foams, but are also more difficult to foam and require more strength to extrude the foam.
As composições de limpeza da pele produtoras de espumas do presente invento são particularmente vantajosas pelo facto de deixarem uma quantidade mínima de residuo de agente tensio-activo sobre a superfície da pele. Isso tem sido conseguido, em parte, por meio da utilização de uma baixa percentagem de agentes tensio-activos totais nas próprias composições de limpeza da pele e preparando-se espumas com uma densidade anormalmente baixa. As presentes composiçoes proporcionam densidades de espuma que dão uma boa capacidade de limpeza e mais importante deixam uma quantidade negligenciável de residuo tensio-activo sobre a superfície da pele apôs o enxaguamento ou fricção, preservando assim a elasticidade da pele e reduzindo as perdas de humidade transepidérmicas.The foam-producing skin cleansing compositions of the present invention are particularly advantageous in that they leave a minimal amount of surfactant residue on the skin surface. This has been achieved, in part, through the use of a low percentage of total surfactants in the skin cleansing compositions themselves and by preparing foams with an abnormally low density. The present compositions provide foam densities that give a good cleaning capacity and more importantly leave a negligible amount of surfactant residue on the skin surface after rinsing or rubbing, thus preserving the skin's elasticity and reducing transepidermal moisture losses .
A capacidade de limpeza dessas espumas arejadas é uma função directa da capacidade de limpeza do próprio agente tensio-activo da solução que produz a espuma.The cleaning capacity of these aerated foams is a direct function of the cleaning capacity of the surfactant itself in the solution that produces the foam.
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Os seguintes exemplos não limitativos seguintes listram as formas de realizaçao do invento em causa, em que tanto os ingredientes essenciais como os facultativos estão combinados. Deve entender-se que estes exemplos são apenas para fins ilustrativos e não devem ser considerados como limitando o âmbito do invento.The following non-limiting examples follow the embodiments of the invention in question, in which both the essential and optional ingredients are combined. It should be understood that these examples are for illustrative purposes only and are not to be considered as limiting the scope of the invention.
EXEMPLO 1 mole de acido de monolauril fosfato é aquecido sob um banho de vapor a cerca de 50°C, até fundir. 1 mole de Ν,Ν,Ν',N’-tetraquis(2-hidroxipropil)-etilenodiamina (disponível conforme Quadro 1 junto da BASF Corporation) é aquecida numa proveta separada a 50°C até se poder verter.EXAMPLE 1 mole of monolauryl acid phosphate is heated under a steam bath at about 50 ° C, until it melts. 1 mole of Ν, Ν, Ν ', N'-tetrakis (2-hydroxypropyl) -ethylenediamine (available according to Table 1 from BASF Corporation) is heated in a separate beaker at 50 ° C until it can be poured.
fosfato fundido é lentamente adicionado ã Ν,Ν,Ν’,Ν’-tetraquis(2-hidroxipropil)-etilenodiamina. 0 fosfato é adicionado até se atingir um pH de 5,0 a 9,0 (preferivelmente 7,0). 0 resultante monolaurilfosfato de Ν,Ν,Ν*,N’-tetraquis(2-hidroxipropil)-etilenodiamina é depois arrefecido até formar um sólido limpido, amarelo.Fused phosphate is slowly added to ã, Ν, Ν ’, Ν’-tetrakis (2-hydroxypropyl) -ethylenediamine. The phosphate is added until a pH of 5.0 to 9.0 (preferably 7.0) is reached. The resulting Ν, Ν, Ν *, N'-tetrakis (2-hydroxypropyl) -ethylenediamine monolauryl phosphate is then cooled to a clear, yellow solid.
Este sólido pode ser usado sob a forma de uma barra sólida ou como material para produzir um creme líquido ou uma geleia.This solid can be used as a solid bar or as a material to produce a liquid cream or jelly.
A aplicaçao na pele de aproximadamente 0,5 gramas, pr£ porcionará um produto de limpeza com espuma que possui um poder de limpeza e detergencia, que é suave e nao irritante e deixa pouca, ou mesmo nenhuma, película residual sobre a superfície limpa da pele.The application on the skin of approximately 0.5 grams, will provide a foam cleaning product that has a cleaning and detergent power, which is smooth and non-irritating and leaves little, if any, residual film on the clean surface. skin.
Obtêm-se resultados substancialmente semelhantes quando o ácido de monolauril fosfato é substituido por uma quantidade equivalen te de ácido de monococoleofosfato, ácido de monolaurilfosfato, ácido de mono-isostearilfosfato, ácido de monomiristilfosfato, ácido de monoleilfosfato, ácido de monopalmitilfosfato, ácido de monocaprilfosfato, ácido de monoundecilenilfosfato, ácido de monotridecilenilfosfato, ácido de mono(metilmiristil)fosfato, ácido de mono(isopropilauril)fosfato, ácido de mono(isodecilneopentil)fosfato,ácido de monocetilfosfato e ácido de mono(isopropilmiristil)fosfato e suas misturas.Substantially similar results are obtained when the monolauryl phosphate acid is replaced with an equivalent amount of monocollolephosphate acid, monolauryl phosphate acid, mono isostearyl phosphate acid, monomyristyl phosphate acid, monoleyl phosphate acid, monopalmityl phosphate acid, monopalmityl phosphate acid, monopalmityl phosphate monoundecylenylphosphate acid, monotridecylenylphosphate acid, mono (methylmiristyl) phosphate acid, mono (isopropylauryl) phosphate acid, mono (isodecylneopentyl) phosphate, monethylphosphate acid and its mono (isopropyl) phosphate and its monohydrate.
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EXEMPLO IIEXAMPLE II
Composição para limpeza do rosto para administração tópica é preparada combinando-se os ingredientes seguintes:Face cleansing composition for topical administration is prepared by combining the following ingredients:
Ingredientes Percentagem P/PIngredients Percentage P / P
Ν,Ν,Ν’,Ν’-tetraquis (2-hidroxipropil).Ν, Ν, Ν ’, Ν’-tetrakis (2-hydroxypropyl).
etilenodiamina monolaurilfosfato 2,500ethylenediamine monolaurylphosphate 2,500
Butileno Glicol 2,5002,500 Butylene Glycol
Metilparabeno 0.250Methylparaben 0.250
Propilparabeno 0,150Propylparaben 0.150
Potássio coco (proteína animal hidrolisada)1 0,032Coconut potassium (hydrolyzed animal protein) 1 0.032
Glicerina 2,000Glycerin 2,000
Aloe Vera 0,500Aloe Vera 0.500
Fragancia 0,050Fragrance 0.050
CÔr 0,170Color 0.170
Goma de xantano 0,0500.050 xanthan gum
Água q.s.Water q.s.
Vendida como Lamepon S da Henkel CorporationSold as Lamepon S by Henkel Corporation
Vendida como Keltrol T da Kelco CorporationSold as Keltrol T by Kelco Corporation
EXEMPLO III ’EXAMPLE III ’
Uma composição de limpeza facial em creme para administração tópica é preparada por meio da combinação dos seguintes ingredientes:A cream facial cleansing composition for topical administration is prepared by combining the following ingredients:
IngredientesIngredients
Ν,Ν,Ν’,Ν’-tetraquis(2-hidroxipropil) etilenodiamina monolaurilfosfato Ãcido lauricoΝ, Ν, Ν ’, Ν’-tetrakis (2-hydroxypropyl) ethylenediamine monolaurylphosphate lauric acid
Ν,Ν,Ν’,Ν’-tetraquis(2-hidroxipropil)etilenodiaminaΝ, Ν, Ν ’, Ν’-tetrakis (2-hydroxypropyl) ethylenediamine
Polímero de carboxiviniloCarboxyvinyl polymer
GlicerinaGlycerin
Precentagem P/PPercentage P / P
27,00027,000
4,0004,000
4,0004,000
0,2000.200
8,000 (cont.)8,000 (cont.)
6329263292
Case:4119RCase: 4119R
SorbitolSorbitol
ÃguaWater
Vendida como Quadrol por BASE-WyandotteSold as Quadrol by BASE-Wyandotte
Vendida como Carbopol 941 por B.E.Goodrich Company .2,000Sold as Carbopol 941 by B.E.Goodrich Company .2,000
q.s.q.s.
EXEMPLO IVEXAMPLE IV
Uma composição de limpeza facial para administraçao tópica é preparada combinando-se os seguintes ingredientes:A facial cleansing composition for topical administration is prepared by combining the following ingredients:
IngredientesIngredients
Ν,Ν,Ν’,N’-tetraquis(2-hidroxipropil)etilenodiamina monolaurilfosfato Ácido lauricoΝ, Ν, Ν ’, N'-tetrakis (2-hydroxypropyl) ethylenediamine monolaurylphosphate Lauric acid
Potássio coco(proteína animal hidrolisada)Coconut potassium (hydrolyzed animal protein)
Hidroxietil celuloseHydroxyethyl cellulose
Metil parabenoMethyl paraben
Propil parabenoPropyl Paraben
GlicerinaGlycerin
FraganciaFragrance
CÔr ãguaColor water
Percentagem P/PP / P Percentage
3,0003,000
1,0001,000
0,5000.500
2,0002,000
0,1000.100
0,1000.100
3,0003,000
0,1000.100
0,0000.000
q.s.q.s.
EXEMPLO VEXAMPLE V
Uma composição de limpeza facial em geleia para administração tópica é preparada por meio da combinação dos seguintes ingredientes:A jelly facial cleansing composition for topical administration is prepared by combining the following ingredients:
Ingredientes Percentagem P/PIngredients Percentage P / P
Ν,Ν,Ν’,N'-tetraquis(2-hidroxipropil)etilenodiamina monolaurilfosfato 10,000 Polímero de ácido acrílico 0,500 Ν,Ν,Ν’,N’-tetraquis(2-hidroxipropil) etilenodiamina 1,000 Glicerina 5,000 Ácido laurico 2,000 Água q.s.Ν, Ν, Ν ’, N'-tetrakis (2-hydroxypropyl) ethylenediamine monolaurylphosphate 10,000 Acrylic acid polymer 0.500 Ν, Ν, Ν’, N'-tetrakis (2-hydroxypropyl) ethylenediamine 1,000 Glycerin 5,000 lauric acid 2,000 Water q.
- 21 63292- 21 63292
EXEMPLO VIEXAMPLE VI
Uma composição de espuma para barbear para administração tópica & preparada por meio da combinação dos seguintes ingredientesA shaving foam composition for topical & prepared administration by combining the following ingredients
Uma composição de limpeza facial para administração tópica é preparada por meio da combinação dos seguintes ingredientes:A facial cleansing composition for topical administration is prepared by combining the following ingredients:
- 22 63292- 22 63292
Claims (2)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US50015190A | 1990-03-27 | 1990-03-27 | |
US64552091A | 1991-01-24 | 1991-01-24 |
Publications (2)
Publication Number | Publication Date |
---|---|
PT97096A PT97096A (en) | 1991-12-31 |
PT97096B true PT97096B (en) | 1998-08-31 |
Family
ID=27053427
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT9709691A PT97096B (en) | 1990-03-27 | 1991-03-21 | PROCESS FOR THE PREPARATION OF DETERGENT COMPOSITIONS WITH LOW IRRITATING EFFECT ON THE SKIN |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP0521980A4 (en) |
JP (1) | JPH05506018A (en) |
CN (1) | CN1029912C (en) |
AU (1) | AU7581791A (en) |
CA (1) | CA2078442C (en) |
IE (1) | IE911002A1 (en) |
NZ (1) | NZ237587A (en) |
PT (1) | PT97096B (en) |
WO (1) | WO1991014693A1 (en) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5719118A (en) * | 1995-10-30 | 1998-02-17 | Tomah Products, Inc. | Detergent compositions having polyalkoxylated amine foam stabilizers and method for cleaning including stabilized detergent foam |
US6221822B1 (en) | 1995-10-30 | 2001-04-24 | Tomah Products, Inc. | Detergent compositions having polyalkoxylated amine foam stabilizers |
DE19756373A1 (en) | 1997-12-18 | 1999-06-24 | Clariant Gmbh | alkyl phosphates |
CN102504615B (en) * | 2011-11-17 | 2013-08-07 | 中国科学院宁波材料技术与工程研究所 | Antibacterial agent preparation method for antibacterial plastic product |
JP5959932B2 (en) * | 2012-05-18 | 2016-08-02 | 株式会社ダイゾー | Foamable aerosol composition |
EP3661563A4 (en) * | 2017-07-31 | 2021-11-10 | The Ohio State Innovation Foundation | Biomimetic nanomaterials and uses thereof |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2758093A (en) * | 1948-06-22 | 1956-08-07 | Textilana Corp | Laundering compositions containing ortho-phosphoric acid esters |
US3442727A (en) * | 1967-08-03 | 1969-05-06 | Atlas Chem Ind | Emulsified nitric acid blasting composition and method of preparing same |
US3954648A (en) * | 1969-12-22 | 1976-05-04 | Pennwalt Corporation | Coatings removal composition containing an alkali metal hydroxide, an oxygenated organic solvent, and an amine |
JPS6035959B2 (en) * | 1977-06-30 | 1985-08-17 | 日本油脂株式会社 | Dispersed fuel manufacturing method |
US4290904A (en) * | 1980-12-01 | 1981-09-22 | Neutrogena Corporation | Transparent soap |
US4686058A (en) * | 1981-04-13 | 1987-08-11 | Basf Corporation | Thickened-water based hydraulic fluids |
JPS5874798A (en) * | 1981-10-28 | 1983-05-06 | 花王株式会社 | Shampoo composition |
-
1991
- 1991-03-11 EP EP19910906853 patent/EP0521980A4/en not_active Ceased
- 1991-03-11 JP JP91507206A patent/JPH05506018A/en active Pending
- 1991-03-11 AU AU75817/91A patent/AU7581791A/en not_active Abandoned
- 1991-03-11 CA CA 2078442 patent/CA2078442C/en not_active Expired - Fee Related
- 1991-03-11 WO PCT/US1991/001622 patent/WO1991014693A1/en not_active Application Discontinuation
- 1991-03-21 PT PT9709691A patent/PT97096B/en not_active IP Right Cessation
- 1991-03-26 IE IE100291A patent/IE911002A1/en unknown
- 1991-03-26 NZ NZ23758791A patent/NZ237587A/en unknown
- 1991-03-27 CN CN 91102024 patent/CN1029912C/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
PT97096A (en) | 1991-12-31 |
CA2078442A1 (en) | 1991-09-28 |
IE911002A1 (en) | 1991-10-09 |
NZ237587A (en) | 1994-02-25 |
CN1029912C (en) | 1995-10-04 |
WO1991014693A1 (en) | 1991-10-03 |
JPH05506018A (en) | 1993-09-02 |
EP0521980A1 (en) | 1993-01-13 |
EP0521980A4 (en) | 1993-08-25 |
CN1055385A (en) | 1991-10-16 |
AU7581791A (en) | 1991-10-21 |
CA2078442C (en) | 1995-12-05 |
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Effective date: 19910909 |
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Effective date: 19980504 |
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