PT93946A - Processo para a preparacao de sais de azelastina com solubilidade melhorada e de composicoes farmaceuticas que os contem - Google Patents

Processo para a preparacao de sais de azelastina com solubilidade melhorada e de composicoes farmaceuticas que os contem

Info

Publication number: PT93946A
Authority: PT; Portugal
Prior art keywords: azelastine; salts; improved solubility; preparing; contain
Prior art date: 1989-05-05

Application number

PT93946A

Other languages

English (en)

Other versions

PT93946B (pt

Inventor

Helmut Hettche

Reinhard Muckenshnabel

Gerhard Scheffler

Ilona Fleischhauer

Wolgang Morick

Original Assignee

Asta Medica Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-05-05

Filing date

1990-05-03

Publication date

1991-01-08

1990-05-03 Application filed by Asta Medica Ag filed Critical Asta Medica Ag

1991-01-08 Publication of PT93946A publication Critical patent/PT93946A/pt

1996-11-29 Publication of PT93946B publication Critical patent/PT93946B/pt

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Pulmonology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Immunology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Peptides Or Proteins (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Cephalosporin Compounds (AREA)

PT93946A 1989-05-05 1990-05-03 Processo para a preparacao de sais de azelastina com solubilidade melhorada e de composicoes farmaceuticas que os contem PT93946B (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE3914859		1989-05-05

Publications (2)

Publication Number	Publication Date
PT93946A true PT93946A (pt)	1991-01-08
PT93946B PT93946B (pt)	1996-11-29

Family

ID=6380164

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT93946A PT93946B (pt)	1989-05-05	1990-05-03	Processo para a preparacao de sais de azelastina com solubilidade melhorada e de composicoes farmaceuticas que os contem

Country Status (17)

Country	Link
US (4)	US5086050A (pt)
EP (1)	EP0396069B1 (pt)
JP (1)	JPH02295987A (pt)
AT (1)	ATE107643T1 (pt)
AU (1)	AU622022B2 (pt)
CA (1)	CA2016089C (pt)
DD (1)	DD294254A5 (pt)
DE (2)	DE59006184D1 (pt)
DK (1)	DK0396069T3 (pt)
ES (1)	ES2055216T3 (pt)
FI (1)	FI902244A0 (pt)
HU (1)	HU206110B (pt)
IE (1)	IE63662B1 (pt)
NO (1)	NO901985L (pt)
NZ (1)	NZ233546A (pt)
PT (1)	PT93946B (pt)
YU (1)	YU86390A (pt)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5271946A (en) *	1988-04-20	1993-12-21	Asta Pharma Aktiengesellschaft	Controlled release azelastine-containing pharmaceutical compositions
JPH04198180A (ja) *	1990-11-28	1992-07-17	Eezai Kagaku Kk	ベンジルフタラゾン誘導体の製造方法
US5296472A (en) *	1991-12-05	1994-03-22	Vyrex Corporation	Methods for delipidation of skin and cerumen removal
JP4138910B2 (ja)	1997-07-02	2008-08-27	帝國製薬株式会社	経皮吸収性が良好で且つ皮膚刺激性の少ない塩酸アゼラスチン含有経皮製剤
WO1999021565A1 (en) *	1997-10-24	1999-05-06	Cornell Research Foundation, Inc.	Nutritional supplement for cerebral metabolic insufficiencies
FI109332B (fi)	1998-12-17	2002-07-15	Orion Yhtymae Oyj	Toremifeenin liukoisia koostumuksia
FI982733A (fi) *	1998-12-17	2000-06-18	Orion Yhtymae Oyj	Trifenyylietyleeniantiestrogeenien liukoisia koostumuksia
GB2389530B (en)	2002-06-14	2007-01-10	Cipla Ltd	Pharmaceutical compositions
US7694694B2 (en) *	2004-05-10	2010-04-13	The Aerospace Corporation	Phase-change valve apparatuses
US8758816B2 (en) *	2004-11-24	2014-06-24	Meda Pharmaceuticals Inc.	Compositions comprising azelastine and methods of use thereof
SI2377557T1 (sl)	2004-11-24	2017-02-28	Meda Pharmaceuticals Inc.	Sestavki, ki obsegajo azelastin, in postopki njihove uporabe
US20070020330A1 (en)	2004-11-24	2007-01-25	Medpointe Healthcare Inc.	Compositions comprising azelastine and methods of use thereof
WO2012142302A2 (en)	2011-04-13	2012-10-18	Codexis, Inc.	Biocatalytic process for preparing eslicarbazepine and analogs thereof
US10898493B2 (en)	2019-04-12	2021-01-26	LA PharmaTech Inc.	Pharmaceutical compositions and methods for psychiatric symptoms of patients with Alzheimer's disease
US11938139B2 (en)	2019-04-12	2024-03-26	LA PharmaTech Inc.	Pharmaceutical compositions and methods for anxiety, depression and other psychiatric disorders
US11690849B2 (en)	2019-04-12	2023-07-04	LA PharmaTech Inc.	Method of treating dementia
US11318144B2 (en)	2019-04-12	2022-05-03	LA PharmaTech Inc.	Compositions and methods for treating Alzheimer's disease and Parkinson's disease
US10966989B2 (en)	2019-04-12	2021-04-06	LA PharmaTech Inc.	Pharmaceutical compositions and methods for treating mental, behavioral, cognitive disorders
US10639314B1 (en)	2019-04-30	2020-05-05	LA PharmaTech Inc.	Method of treating Alzheimer's disease
US11744833B2 (en)	2019-04-12	2023-09-05	LA PharmaTech Inc.	Pharmaceutical compositions and methods for treatment of insomnia
US11389458B2 (en)	2019-04-12	2022-07-19	LA PharmaTech Inc.	Pharmaceutical compositions and methods for treating parkinson's and huntington's disease
US11351179B1 (en)	2021-08-05	2022-06-07	LA PharmaTech Inc.	Pharmaceutical compositions and methods for treatment of psychiatric disorders

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CH572914A5 (pt) *	1971-01-22	1976-02-27	Asta Werke Ag Chem Fab
US3813384A (en) *	1972-01-17	1974-05-28	Asta Werke Ag Chem Fab	Basically substituted benzyl phthalazone derivatives,acid salts thereof and process for the production thereof
ATE49205T1 (de) *	1984-09-14	1990-01-15	Asta Pharma Ag	Substituierte benzylphthalazinon-derivate.
DE3677322D1 (de) *	1985-11-11	1991-03-07	Asta Pharma Ag	4-benzyl-1-(2h)-phthalazinon-derivate.
JPH0667844B2 (ja) *	1987-03-06	1994-08-31	エーザイ株式会社	虚血性心疾患の治療・予防剤
EP0289939A1 (de) *	1987-05-08	1988-11-09	ASTA Pharma AG	Neue 4-Benzyl-1-(2H)-phthalazinon-Derivate mit einem Aminosäurerest
US5232919A (en) *	1987-11-13	1993-08-03	Asta Pharma Aktiengesellschaft	Azelastine embonate and compositions which contain it
IE64051B1 (en) *	1987-11-13	1995-06-28	Asta Medica Ag	Azelastine embonate process for its preparation and pharmaceutical preparations which contain azelastine embonate as active substance
DE3850044D1 (de) *	1987-11-13	1994-07-14	Asta Medica Ag	Azelastin-Embonat, Verfahren zu seiner Herstellung und pharmazeutische Zubereitungen, die als Wirkstoff Azelastin-Embonat enthalten.
JP2794021B2 (ja) *	1988-11-02	1998-09-03	エーザイ株式会社	アゼラスチン或いはその塩類含有経皮適用製剤

1990
- 1990-04-28 DK DK90108172.9T patent/DK0396069T3/da active
- 1990-04-28 ES ES90108172T patent/ES2055216T3/es not_active Expired - Lifetime
- 1990-04-28 EP EP90108172A patent/EP0396069B1/de not_active Expired - Lifetime
- 1990-04-28 DE DE59006184T patent/DE59006184D1/de not_active Expired - Lifetime
- 1990-04-28 DE DE4013696A patent/DE4013696A1/de not_active Withdrawn
- 1990-04-28 AT AT90108172T patent/ATE107643T1/de not_active IP Right Cessation
- 1990-05-03 NZ NZ233546A patent/NZ233546A/xx unknown
- 1990-05-03 PT PT93946A patent/PT93946B/pt not_active IP Right Cessation
- 1990-05-04 YU YU00863/90A patent/YU86390A/xx unknown
- 1990-05-04 HU HU902678A patent/HU206110B/hu unknown
- 1990-05-04 AU AU54736/90A patent/AU622022B2/en not_active Ceased
- 1990-05-04 IE IE163990A patent/IE63662B1/en not_active IP Right Cessation
- 1990-05-04 FI FI902244A patent/FI902244A0/fi not_active IP Right Cessation
- 1990-05-04 DD DD90340395A patent/DD294254A5/de not_active IP Right Cessation
- 1990-05-04 CA CA002016089A patent/CA2016089C/en not_active Expired - Lifetime
- 1990-05-04 NO NO90901985A patent/NO901985L/no unknown
- 1990-05-07 JP JP2115947A patent/JPH02295987A/ja active Pending
1991
- 1991-02-08 US US07/652,986 patent/US5086050A/en not_active Expired - Lifetime
1996
- 1996-08-02 US US08/691,415 patent/US5859003A/en not_active Expired - Lifetime
1998
- 1998-07-28 US US09/123,431 patent/US5998403A/en not_active Expired - Fee Related
- 1998-08-20 US US09/136,971 patent/US6017909A/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
DE59006184D1 (de)	1994-07-28
ES2055216T3 (es)	1994-08-16
FI902244A0 (fi)	1990-05-04
ATE107643T1 (de)	1994-07-15
NO901985L (no)	1990-11-06
HU206110B (en)	1992-08-28
AU622022B2 (en)	1992-03-26
US5998403A (en)	1999-12-07
DD294254A5 (de)	1991-09-26
AU5473690A (en)	1990-11-08
US5859003A (en)	1999-01-12
EP0396069A1 (de)	1990-11-07
PT93946B (pt)	1996-11-29
US6017909A (en)	2000-01-25
HUT53901A (en)	1990-12-28
JPH02295987A (ja)	1990-12-06
EP0396069B1 (de)	1994-06-22
DE4013696A1 (de)	1990-11-08
IE63662B1 (en)	1995-05-31
US5086050A (en)	1992-02-04
DK0396069T3 (da)	1994-07-25
CA2016089A1 (en)	1990-11-05
IE901639L (en)	1990-11-05
NZ233546A (en)	1991-09-25
HU902678D0 (en)	1990-09-28
NO901985D0 (no)	1990-05-04
YU86390A (en)	1992-05-28
CA2016089C (en)	1998-12-01

Legal Events

Date	Code	Title	Description
1996-11-29	FG3A	Patent granted, date of granting	Effective date: 19960816
2002-11-29	PC3A	Transfer or assignment	Free format text: ASTA MEDICA HEALTH PRODUCTS GMBH & CO. KG DE Effective date: 20020909
2002-11-29	PD3A	Change of proprietorship	Free format text: VIATRIS GMBH & CO. KG DE Effective date: 20020909 Free format text: ASTA MEDICA GMBH DE Effective date: 20020909
2002-11-29	TE3A	Change of address (patent)	Free format text: ASTA MEDICA AKTIENGESELLSCHAFT DE Effective date: 20020909
2005-06-30	TE3A	Change of address (patent)	Free format text: VIATRIS GMBH & CO. KG DE Effective date: 20050506
2007-06-15	PD4A	Change of proprietorship	Owner name: MEDA PHARMA GMBH & CO. KG, DE Effective date: 20070604
2011-08-24	MM4A	Annulment/lapse due to non-payment of fees, searched and examined patent	Free format text: MAXIMUM VALIDITY LIMIT REACHED Effective date: 20110816

Publication	Publication Date	Title
PT93946A (pt)	1991-01-08	Processo para a preparacao de sais de azelastina com solubilidade melhorada e de composicoes farmaceuticas que os contem
BR9407047A (pt)	1996-08-13	Processo para separaçao de uma proteina de uma soluçao aquosa de proteinas
ES2168334T3 (es)	2002-06-16	Composicion para el tratamiento de la piel.
MX9206474A (es)	1993-10-01	Derivados de n-fenilalanil y n-fenilgliclil del dipeptido del acido l-azetidina 2-carboxilico y aldheido de l-arginina, proceso para su preparacion y composicion farmaceutica que los contiene
ATE218154T1 (de)	2002-06-15	Physikalisch modifizierte abbaubare thermoplastische zusammensetzung
IT1221734B (it)	1990-07-12	Ursodesossicolico solfato acido sale sodico
PT84823B (pt)	1989-12-29	Processo para a preparacao de novos derivados de imidazois 1-substituidos com accao inibidora da dopamina-beta-hidroxilase e de composicoes farmaceuticas que os contem
BR0008255A (pt)	2002-01-15	Composição e processo para formar emulsão estável sob cisalhamento
PT99727A (pt)	1992-10-30	Processo para a preparacao de composicoes farmaceuticas estaveis de calcitonina humana
DK0763098T3 (da)	2002-09-09	Fremgangsmåde til fraktionering af vinasse
ATE172757T1 (de)	1998-11-15	Eisenphosphatierung unter verwendung von substituierten monocarbonsäuren
BR9302029A (pt)	1993-11-30	Metodo para produzir uma composicao,metodo para produzir uma solucao aquosa,composicao,e,processo para retardar o crescimento microbial
ES2037763T3 (es)	1993-07-01	Metodo para preparar compuestos no naturales afines a la ceramida.
PT100756A (pt)	1993-09-30	Novos derivados de gangliosidos, processo para a sua preparacao e composicoes farmaceuticas que os contem
ES2053101T3 (es)	1994-07-16	Compuesto detergente para la piel.
ES2041815T3 (es)	1993-12-01	Un procedimiento para la obtencion de derivados de ornitina 5-sustituidos.
SE8502315D0 (sv)	1985-05-09	Improved transamination process for producing amino acids
AR008236A1 (es)	1999-12-29	Forma cristalina anhidra del clorhidrato de acido r(-)-n-(4,4-di(3- metiltien-2-il)but-3-enil)-nipecotico, una composicion farmaceutica y el uso de dicha sal cristalina para la preparacion de una composicion farmaceutica
PT94685A (pt)	1991-03-20	Processo para a preparacao de 2-imidazolinas substituidas e de composicoes farmaceuticas que as contem
PT98700A (pt)	1992-07-31	Processo para a preparacao de acidos aminometanofosfonico e de acidos aminometil-fosfinicos
BR0014057A (pt)	2002-05-21	Processo para preparar ácido metileno bisfosfÈnico substituìdo ou não substituìdo, e, sal do mesmo
BR0207473A (pt)	2004-04-06	Processo para preparar ácido d-pantotênico e/ou seus sais, e, composição para uso como aditivo de alimento para animal e/ou suplemento de alimento para animal
PT90802A (pt)	1989-12-29	Processo para a preparacao de derivados de propanolamina e de composicoes farmaceuticas que os contem
ES2039525T3 (es)	1993-10-01	Metodo perfeccionado para la preparacion de anilinofumarato.
AR008764A1 (es)	2000-02-23	Sales hidratadas de n,n'-diacetilcistina, proceso para su preparacion, y composiciones terapeuticas que comprenden a dichas sales como ingredienteactivo.