PT89923B - Processo para a preparacao de variantes da hiridina - Google Patents

Processo para a preparacao de variantes da hiridina

Info

Publication number: PT89923B
Authority: PT; Portugal
Prior art keywords: hydroidine; variants; preparation; improving; pharmacokinetic properties
Prior art date: 1988-03-08

Application number

PT89923A

Other languages

English (en)

Other versions

PT89923A (pt

Original Assignee

Transgene Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-03-08

Filing date

1989-03-07

Publication date

1994-05-31

1989-03-07 Application filed by Transgene Sa filed Critical Transgene Sa

1989-11-10 Publication of PT89923A publication Critical patent/PT89923A/pt

1994-05-31 Publication of PT89923B publication Critical patent/PT89923B/pt

Links

102000007625 Hirudins Human genes 0.000 abstract 1
108010007267 Hirudins Proteins 0.000 abstract 1
WQPDUTSPKFMPDP-OUMQNGNKSA-N hirudin Chemical compound C([C@@H](C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C=CC(OS(O)(=O)=O)=CC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCCN)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H]1NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@@H]2CSSC[C@@H](C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)N[C@H](C(NCC(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N2)=O)CSSC1)C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]1NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=2C=CC(O)=CC=2)NC(=O)[C@@H](NC(=O)[C@@H](N)C(C)C)C(C)C)[C@@H](C)O)CSSC1)C(C)C)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 WQPDUTSPKFMPDP-OUMQNGNKSA-N 0.000 abstract 1
229940006607 hirudin Drugs 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/855—Proteins from animals other than mammals or birds

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Biochemistry (AREA)
Gastroenterology & Hepatology (AREA)
Biophysics (AREA)
Tropical Medicine & Parasitology (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Hematology (AREA)
Diabetes (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Removal Of Specific Substances (AREA)
External Artificial Organs (AREA)
Separation Using Semi-Permeable Membranes (AREA)

PT89923A 1988-03-08 1989-03-07 Processo para a preparacao de variantes da hiridina PT89923B (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR8802925A FR2628429B1 (fr)	1988-03-08	1988-03-08	Variants de l'hirudine, leurs utilisations et les procedes pour les obtenir

Publications (2)

Publication Number	Publication Date
PT89923A PT89923A (pt)	1989-11-10
PT89923B true PT89923B (pt)	1994-05-31

Family

ID=9364012

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT89923A PT89923B (pt)	1988-03-08	1989-03-07	Processo para a preparacao de variantes da hiridina

Country Status (10)

Country	Link
US (1)	US5087613A (pt)
EP (1)	EP0332523B1 (pt)
JP (1)	JP2961118B2 (pt)
AT (1)	ATE84571T1 (pt)
CA (1)	CA1341429C (pt)
DE (1)	DE68904330T2 (pt)
ES (1)	ES2036809T3 (pt)
FR (1)	FR2628429B1 (pt)
GR (1)	GR3007254T3 (pt)
PT (1)	PT89923B (pt)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8907110D0 (en) *	1988-05-04	1989-05-10	Ciba Geigy Ag	Improvements in the production of polypeptides
US5268296A (en) *	1988-06-11	1993-12-07	Ciba-Geigy Corporation	DNA vector and recombinant host cell for production of hirullin P6 and P18
DE3835815A1 (de) *	1988-10-21	1990-04-26	Hoechst Ag	Neue isohirudine
FR2646437B1 (fr) *	1989-04-28	1991-08-30	Transgene Sa	Nouvelles sequences d'adn, leur application en tant que sequence codant pour un peptide signal pour la secretion de proteines matures par des levures recombinantes, cassettes d'expression, levures transformees et procede de preparation de proteines correspondant
JP3187044B2 (ja) *	1989-12-01	2001-07-11	ビーエーエスエフアクチェンゲゼルシャフト	ヒルジン突然変異蛋白質及びヒルジンポリアルキレングリコール複合体
US6521594B1 (en)	1990-04-06	2003-02-18	La Jolla Cancer Research Foundation	Method and composition for treating thrombosis
US5672585A (en) *	1990-04-06	1997-09-30	La Jolla Cancer Research Foundation	Method and composition for treating thrombosis
US5612311A (en)	1990-04-06	1997-03-18	La Jolla Cancer Research Foundation	Method and composition for treating thrombosis
US5780303A (en) *	1990-04-06	1998-07-14	La Jolla Cancer Research Foundation	Method and composition for treating thrombosis
ZA915658B (en) *	1990-07-24	1992-05-27	Merrell Dow Pharma	Analogs of hirudin having antiplatelet activity
DK0540574T3 (da) *	1990-07-24	1996-09-30	Merrell Pharma Inc	Antikoagulationspeptider
US5574012A (en) *	1990-07-24	1996-11-12	Merrell Pharmaceuticals Inc.	Analogs of hirudin having anti-platelet activity
GB9023149D0 (en) *	1990-10-24	1990-12-05	British Bio Technology	Proteins and nucleic acids
WO1993004082A1 (en) *	1991-08-20	1993-03-04	Baxter International Inc.	Analogs of hirudin
US5837808A (en) *	1991-08-20	1998-11-17	Baxter International Inc.	Analogs of hirudin
GB9209032D0 (en) *	1992-04-25	1992-06-10	Ciba Geigy Ag	New peptide derivatives
HUT73187A (en) *	1993-06-11	1996-06-28	Merrell Pharma Inc	Trifunctional antithrombin and antiplatelet peptides
DE4404168A1 (de) *	1994-02-10	1995-08-17	Hoechst Ag	Hirudinderivate und Verfahren zu deren Herstellung
US8377863B2 (en) *	2007-05-29	2013-02-19	Unigene Laboratories Inc.	Peptide pharmaceutical for oral delivery
AU2016206950B2 (en)	2015-01-12	2021-05-06	Enteris Biopharma, Inc.	Solid oral dosage forms

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA1341417C (fr) *	1984-03-27	2003-01-21	Paul Tolstoshev	Vecteurs d'expression de l'hirudine, cellules transformees et procede de preparation de l'hirudine
DE3429430A1 (de) *	1984-08-10	1986-02-20	Hoechst Ag, 6230 Frankfurt	Gentechnologisches verfahren zur herstellung von hirudin und mittel zur durchfuehrung dieses verfahrens
FR2607517B2 (fr) *	1986-12-01	1989-12-22	Transgene Sa	Vecteurs d'expression de variants de l'hirudine dans les levures, procede et produit obtenu

1988
- 1988-03-08 FR FR8802925A patent/FR2628429B1/fr not_active Expired - Fee Related
1989
- 1989-03-06 DE DE8989400621T patent/DE68904330T2/de not_active Expired - Lifetime
- 1989-03-06 AT AT89400621T patent/ATE84571T1/de not_active IP Right Cessation
- 1989-03-06 EP EP89400621A patent/EP0332523B1/fr not_active Expired - Lifetime
- 1989-03-06 ES ES198989400621T patent/ES2036809T3/es not_active Expired - Lifetime
- 1989-03-07 CA CA000592974A patent/CA1341429C/fr not_active Expired - Fee Related
- 1989-03-07 PT PT89923A patent/PT89923B/pt not_active IP Right Cessation
- 1989-03-08 JP JP1057693A patent/JP2961118B2/ja not_active Expired - Fee Related
- 1989-03-08 US US07/320,530 patent/US5087613A/en not_active Expired - Lifetime
1993
- 1993-03-05 GR GR930400475T patent/GR3007254T3/el unknown

Also Published As

Publication number	Publication date
PT89923A (pt)	1989-11-10
JP2961118B2 (ja)	1999-10-12
EP0332523A1 (fr)	1989-09-13
EP0332523B1 (fr)	1993-01-13
ES2036809T3 (es)	1993-06-01
GR3007254T3 (pt)	1993-07-30
FR2628429A1 (fr)	1989-09-15
ATE84571T1 (de)	1993-01-15
DE68904330D1 (de)	1993-02-25
DE68904330T2 (de)	1993-05-19
CA1341429C (fr)	2003-05-27
US5087613A (en)	1992-02-11
FR2628429B1 (fr)	1990-12-28
JPH029390A (ja)	1990-01-12

Legal Events

Date	Code	Title	Description
1994-05-31	FG3A	Patent granted, date of granting	Effective date: 19931118
2002-11-29	PC3A	Transfer or assignment	Free format text: SCHERING AKTIENGESELLSCHAFT DE Effective date: 20021002
2002-11-29	TE3A	Change of address (patent)	Free format text: TRANSGENE S.A. FR Effective date: 20021002
2009-03-18	MM4A	Annulment/lapse due to non-payment of fees, searched and examined patent	Free format text: MAXIMUM VALIDITY LIMIT REACHED Effective date: 20090307

Publication	Publication Date	Title
PT89923A (pt)	1989-11-10	Processo para a preparacao de variantes da hiridina
DE69009901D1 (de)	1994-07-21	Lichtleiter.
DE68926706D1 (de)	1996-07-25	Übersetzungsverfahren
BR8303522A (pt)	1984-02-07	Processo para a fabricacao de artigos cirurgicos,esteries feito com um copolimero sintetico,absorvivel
BR9104923A (pt)	1992-06-23	Processo para a producao de um bisfenol
BR8903484A (pt)	1990-03-13	Processo e meios para a fabricacao de fechos de correr
PT92213A (pt)	1990-05-31	Processo para a preparacao de conjugados de anticorpo-droga
BR8906363A (pt)	1990-08-21	Processo para producao de tricloromonosilano
DE3850487D1 (de)	1994-08-04	Kontaktfreies profilierungsverfahren.
PT89545A (pt)	1989-10-04	Processo para a preparacao de derivados da isoquinolinona
BR8902031A (pt)	1990-04-10	Processo para producao de policarbonato
IT8805234A0 (it)	1988-11-14	Camma con profilo temprabile.
BR9106967A (pt)	1993-08-31	Processo para a producao de um copolimero,micromonomero,copolimero e artigo cromatografico
PT92670A (pt)	1990-06-29	Processo para a preparacao de complexos de metal com grupos funcionais isotiocianato
BR8807208A (pt)	1989-10-17	Processo aperfeicoado de moldagem
PT90353A (pt)	1989-11-10	Processo para a producao de polipeptideos
BR9100807A (pt)	1991-11-05	Processo de producao de alfa-olefinas lineares
BR8904840A (pt)	1990-05-01	Processo para producao de n-fosfonometilglicina
PT88254A (pt)	1989-06-30	Processo para a preparacao de derivados de eritromicina a modificada em c.12
PT89504A (pt)	1989-10-04	Processo para a preparacao de conjugados de anticorpos com hidrazidas de vinca
BR9006284A (pt)	1991-08-06	Processo para producao de norcanfano dicarbonitrilas
BR8801069A (pt)	1988-10-18	Processo de manufatura de pelicula de resina de poliacetal
BR9100316A (pt)	1991-10-22	Processo para producao de n-fosfono metilglicina
BR8803577A (pt)	1989-02-08	Processo para formacao de uma caracteristica decorativa
BR8904833A (pt)	1990-05-01	Processo para homopolimerizacao ou copolimerizacao