PT889885E - Processo de proteccao selectiva de derivados da bacatina e sua utilizacao na sintese de taxanos - Google Patents

Processo de proteccao selectiva de derivados da bacatina e sua utilizacao na sintese de taxanos

Info

Publication number: PT889885E
Authority: PT; Portugal
Prior art keywords: derivatives; bacatin; selective protection; taxane synthesis; taxane
Prior art date: 1995-12-27

Application number

PT96944097T

Other languages

English (en)

Inventor

Luc Chanteloup

Bruno Chauveau

Christine Corbin

Robert Dhal

Sonia Le Guen

Arnaud Lamy

Antoine Leze

Jean-Pierre Robin

Original Assignee

Rec En Ing Phar Seripharm Soc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-12-27

Filing date

1996-12-27

Publication date

2002-10-31

1996-12-27 Application filed by Rec En Ing Phar Seripharm Soc filed Critical Rec En Ing Phar Seripharm Soc

2002-10-31 Publication of PT889885E publication Critical patent/PT889885E/pt

Links

238000000034 method Methods 0.000 title abstract 3
229940123237 Taxane Drugs 0.000 title 1
230000015572 biosynthetic process Effects 0.000 title 1
238000003786 synthesis reaction Methods 0.000 title 1
DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 title 1
239000000543 intermediate Substances 0.000 abstract 2
-1 2,2,2-trichloroethoxycarbonyl Chemical group 0.000 abstract 1
229930012538 Paclitaxel Natural products 0.000 abstract 1
238000007068 beta-elimination reaction Methods 0.000 abstract 1
229960001592 paclitaxel Drugs 0.000 abstract 1
RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
- C07F7/1872—Preparation; Treatments not provided for in C07F7/20
- C07F7/188—Preparation; Treatments not provided for in C07F7/20 by reactions involving the formation of Si-O linkages
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Epoxy Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

PT96944097T 1995-12-27 1996-12-27 Processo de proteccao selectiva de derivados da bacatina e sua utilizacao na sintese de taxanos PT889885E (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR9515557A FR2743074B1 (fr)	1995-12-27	1995-12-27	Procede de protection selective des derives de la baccatine et son utilisation dans la synthese des taxanes

Publications (1)

Publication Number	Publication Date
PT889885E true PT889885E (pt)	2002-10-31

Family

ID=9486008

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT96944097T PT889885E (pt)	1995-12-27	1996-12-27	Processo de proteccao selectiva de derivados da bacatina e sua utilizacao na sintese de taxanos

Country Status (25)

Country	Link
US (1)	US6180802B1 (pt)
EP (1)	EP0889885B1 (pt)
JP (1)	JP4068663B2 (pt)
KR (1)	KR100510017B1 (pt)
CN (3)	CN1090625C (pt)
AT (1)	ATE218133T1 (pt)
AU (1)	AU716876B2 (pt)
BR (1)	BR9612242A (pt)
CA (1)	CA2238889C (pt)
CZ (1)	CZ20191998A3 (pt)
DE (1)	DE69621463T2 (pt)
DK (1)	DK0889885T3 (pt)
ES (1)	ES2177825T3 (pt)
FR (1)	FR2743074B1 (pt)
HK (2)	HK1044765B (pt)
HU (1)	HUP0000508A3 (pt)
IL (2)	IL125049A (pt)
NO (1)	NO982719D0 (pt)
NZ (1)	NZ325323A (pt)
PL (1)	PL327581A1 (pt)
PT (1)	PT889885E (pt)
RU (1)	RU2162844C2 (pt)
SK (1)	SK88498A3 (pt)
TR (1)	TR199801232T2 (pt)
WO (1)	WO1997024345A1 (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0875508B1 (en) *	1997-05-02	2003-10-22	Pharmachemie B.V.	Method for the preparation of baccatin III and derivatives thereof from 10-deacetylbaccatin III
US7288665B1 (en) *	1997-08-18	2007-10-30	Florida State University	Process for selective derivatization of taxanes
ES2382009T3 (es)	2006-12-01	2012-06-04	Bristol-Myers Squibb Company	Derivados de N-((3-bencil)-2,2-(bis-fenil-)-propan-1-amina como inhibidores de CETP para el tratamiento de aterosclerosis y enfermedades cardiovasculares
CA2696856A1 (en) *	2007-08-22	2009-02-26	6570763 Canada Inc.	Process for converting 9-dihydro-13-acetylbaccatin iii into docetaxel or paclitaxel
PL388144A1 (pl)	2009-05-29	2010-12-06	Przedsiębiorstwo Produkcyjno-Wdrożeniowe Ifotam Spółka Z Ograniczoną Odpowiedzialnością	Solwaty (2R,3S)-3-tert-butoksykarbonylamino-2-hydroksy-3-fenylopropionianu 4-acetoksy-2α-benzoiloksy -5β,20-epoksy-1,7β,10β-trihydroksy-9-okso-taks-11-en-13α-ylu, sposób ich otrzymywania i zastosowanie
CN115260130A (zh) *	2022-07-07	2022-11-01	上海卓鼎生物技术有限公司	一种10-脱乙酰基紫杉醇的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2601675B1 (fr) *	1986-07-17	1988-09-23	Rhone Poulenc Sante	Derives du taxol, leur preparation et les compositions pharmaceutiques qui les contiennent
FR2601676B1 (fr) *	1986-07-17	1988-09-23	Rhone Poulenc Sante	Procede de preparation du taxol et du desacetyl-10 taxol
IL127599A (en) *	1994-01-28	2004-06-01	Upjohn Co	Process for preparing isotaxol analogs

1995
- 1995-12-27 FR FR9515557A patent/FR2743074B1/fr not_active Expired - Fee Related
1996
- 1996-12-27 PL PL96327581A patent/PL327581A1/xx unknown
- 1996-12-27 CN CN96199356A patent/CN1090625C/zh not_active Expired - Fee Related
- 1996-12-27 RU RU98113957/04A patent/RU2162844C2/ru not_active IP Right Cessation
- 1996-12-27 ES ES96944097T patent/ES2177825T3/es not_active Expired - Lifetime
- 1996-12-27 BR BR9612242A patent/BR9612242A/pt not_active Application Discontinuation
- 1996-12-27 KR KR10-1998-0704853A patent/KR100510017B1/ko not_active IP Right Cessation
- 1996-12-27 DK DK96944097T patent/DK0889885T3/da active
- 1996-12-27 CN CNB011409983A patent/CN1243745C/zh not_active Expired - Fee Related
- 1996-12-27 IL IL12504996A patent/IL125049A/xx not_active IP Right Cessation
- 1996-12-27 NZ NZ325323A patent/NZ325323A/xx unknown
- 1996-12-27 SK SK884-98A patent/SK88498A3/sk unknown
- 1996-12-27 CN CNB011409991A patent/CN1244567C/zh not_active Expired - Fee Related
- 1996-12-27 HU HU0000508A patent/HUP0000508A3/hu not_active Application Discontinuation
- 1996-12-27 DE DE69621463T patent/DE69621463T2/de not_active Expired - Lifetime
- 1996-12-27 CA CA002238889A patent/CA2238889C/fr not_active Expired - Fee Related
- 1996-12-27 AU AU13815/97A patent/AU716876B2/en not_active Ceased
- 1996-12-27 US US09/077,099 patent/US6180802B1/en not_active Expired - Fee Related
- 1996-12-27 TR TR1998/01232T patent/TR199801232T2/xx unknown
- 1996-12-27 AT AT96944097T patent/ATE218133T1/de not_active IP Right Cessation
- 1996-12-27 CZ CZ982019A patent/CZ20191998A3/cs unknown
- 1996-12-27 EP EP96944097A patent/EP0889885B1/fr not_active Expired - Lifetime
- 1996-12-27 JP JP52408197A patent/JP4068663B2/ja not_active Expired - Fee Related
- 1996-12-27 PT PT96944097T patent/PT889885E/pt unknown
- 1996-12-27 WO PCT/FR1996/002097 patent/WO1997024345A1/fr active IP Right Grant
1998
- 1998-06-12 NO NO982719A patent/NO982719D0/no unknown
2000
- 2000-09-28 IL IL138769A patent/IL138769A/en not_active IP Right Cessation
2002
- 2002-08-20 HK HK02106058.4A patent/HK1044765B/zh not_active IP Right Cessation
- 2002-11-29 HK HK02108638.9A patent/HK1047099B/zh not_active IP Right Cessation

Also Published As

Publication number	Publication date
JP2000502696A (ja)	2000-03-07
CN1090625C (zh)	2002-09-11
CN1244567C (zh)	2006-03-08
IL138769A (en)	2006-04-10
CZ20191998A3 (cs)	1998-09-16
RU2162844C2 (ru)	2001-02-10
FR2743074A1 (fr)	1997-07-04
AU1381597A (en)	1997-07-28
NZ325323A (en)	1999-11-29
WO1997024345A1 (fr)	1997-07-10
IL125049A (en)	2003-10-31
ES2177825T3 (es)	2002-12-16
NO982719L (no)	1998-06-12
PL327581A1 (en)	1998-12-21
EP0889885A1 (fr)	1999-01-13
CN1206412A (zh)	1999-01-27
DE69621463D1 (de)	2002-07-04
DE69621463T2 (de)	2002-11-28
SK88498A3 (en)	1998-11-04
KR100510017B1 (ko)	2005-12-16
CN1356325A (zh)	2002-07-03
JP4068663B2 (ja)	2008-03-26
CN1243745C (zh)	2006-03-01
TR199801232T2 (xx)	1998-09-21
EP0889885B1 (fr)	2002-05-29
KR19990076733A (ko)	1999-10-15
HK1047099B (zh)	2006-09-29
HK1044765A1 (en)	2002-11-01
HUP0000508A2 (en)	2000-07-28
AU716876B2 (en)	2000-03-09
BR9612242A (pt)	1999-07-13
CN1356326A (zh)	2002-07-03
HUP0000508A3 (en)	2001-05-28
HK1044765B (zh)	2006-09-29
IL125049A0 (en)	1999-01-26
CA2238889A1 (fr)	1997-07-10
DK0889885T3 (da)	2002-09-16
ATE218133T1 (de)	2002-06-15
US6180802B1 (en)	2001-01-30
HK1047099A1 (pt)	2003-02-07
NO982719D0 (no)	1998-06-12
CA2238889C (fr)	2008-06-10
FR2743074B1 (fr)	1998-03-27

Publication	Publication Date	Title
FR2601676B1 (fr)	1988-09-23	Procede de preparation du taxol et du desacetyl-10 taxol
FR2703049B1 (fr)	1995-04-21	Procédé de purification des taxoïdes.
CY1105399T1 (el)	2010-04-28	Μεθοδος επιλεκτικης υποκαταστασεως των ταξανων
DE59606920D1 (de)	2001-06-21	Chirale methylphenyloxazolidinone
NO981823D0 (no)	1998-04-23	Mellomprodukter for hemisyntese av taxaner og fremstilling derav
ES2158327T3 (es)	2001-09-01	Derivados de benzo(g)quinolina.
BR0007643A (pt)	2001-10-16	Processo para obter ésteres de (nitroximetil) fenila de derivados de aspirina, e, (hidroximetil) feniléter de derivados de aspirina
PT889885E (pt)	2002-10-31	Processo de proteccao selectiva de derivados da bacatina e sua utilizacao na sintese de taxanos
YU63696A (sh)	1999-07-28	Novi fenilamidin-derivati, postupci za njihovo pripremanje i njihova primena kao lekova
NO974155L (no)	1997-11-07	Ny fremgangsmåte for fremstilling av 2,3-dihydrobenzofuranolderivater
HUP9903318A2 (hu)	2000-06-28	Intermedierek taxol előállítására
NO20002600D0 (no)	2000-05-19	Mellomprodukter og fremgangsmÕter for anvendelse ved semisyntesen av paclitaxel og analoger
PT817784E (pt)	2003-10-31	Processo para a sintese de nucleosidos analogos
PT946538E (pt)	2003-12-31	Derivados de indano ou de di-hidroindole
IT8919959A0 (it)	1989-03-31	Nuovo processo per la sintesi della n metil 3,4 dimetossifeniletilamina.