PT888386E - Complexo factor viii/vwf estavel - Google Patents
Complexo factor viii/vwf estavelInfo
- Publication number
- PT888386E PT888386E PT97906928T PT97906928T PT888386E PT 888386 E PT888386 E PT 888386E PT 97906928 T PT97906928 T PT 97906928T PT 97906928 T PT97906928 T PT 97906928T PT 888386 E PT888386 E PT 888386E
- Authority
- PT
- Portugal
- Prior art keywords
- vwf
- factor viii
- stable
- complex factor
- complexes
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
- Y10T436/25375—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AT0049496A AT403764B (de) | 1996-03-15 | 1996-03-15 | Stabiler faktor viii/vwf-komplex |
Publications (1)
Publication Number | Publication Date |
---|---|
PT888386E true PT888386E (pt) | 2003-03-31 |
Family
ID=3492100
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT97906928T PT888386E (pt) | 1996-03-15 | 1997-03-13 | Complexo factor viii/vwf estavel |
Country Status (10)
Country | Link |
---|---|
US (3) | US6228613B1 (pt) |
EP (1) | EP0888386B2 (pt) |
JP (1) | JP2000506869A (pt) |
AT (2) | AT403764B (pt) |
CA (1) | CA2248960C (pt) |
DE (1) | DE59708667D1 (pt) |
DK (1) | DK0888386T4 (pt) |
ES (1) | ES2186870T5 (pt) |
PT (1) | PT888386E (pt) |
WO (1) | WO1997034930A1 (pt) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AT403764B (de) * | 1996-03-15 | 1998-05-25 | Immuno Ag | Stabiler faktor viii/vwf-komplex |
AT406867B (de) * | 1997-02-27 | 2000-10-25 | Immuno Ag | Verfahren zur gewinnung von hochreinem vwf oder faktor viii/vwf-komplex |
AT406373B (de) | 1997-02-27 | 2000-04-25 | Immuno Ag | Verfahren zur reinigung von faktor viii/vwf-komplex mittels kationenaustauscherchromatographie |
US6531577B1 (en) | 1997-12-15 | 2003-03-11 | Hemasure Denmark A/S | von Willebrand factor (vWF)-containing preparation, process for preparing vWF-containing preparations, and use of such preparations |
AT408443B (de) * | 1998-02-27 | 2001-11-26 | Immuno Ag | Verfahren zur gewinnung von gereinigtem faktor viii:c/vwf-komplex |
US6605222B1 (en) * | 1998-05-20 | 2003-08-12 | Baxter Aktiengesellschaft | Method for producing a factor VIII/von Willebrand factor complex |
AT409335B (de) * | 1998-11-10 | 2002-07-25 | Immuno Ag | Pharmazeutisches präparat enthaltend einen rezeptor-antagonisten zur behandlung von blutgerinnungsstörungen |
EP2309275A1 (en) * | 1999-07-05 | 2011-04-13 | K.U.Leuven Research & Development | Detection of Von-Willebrand factor (vwf) activity |
EP1148063A1 (de) * | 2000-04-18 | 2001-10-24 | Octapharma AG | Haemostatisch aktives vWF enthaltendes Präparat und Verfahren zu seiner Herstellung |
DE10246125A1 (de) * | 2002-10-01 | 2004-04-15 | Aventis Behring Gmbh | Konzentrat eines Faktor VIII:C-haltigen von-Willebrand-Faktors und das dazu gehörige Verfahren |
JP3830501B2 (ja) * | 2003-01-17 | 2006-10-04 | 株式会社ティーティーシー | アフィニティートラップリアクター、及びそれを用いたアンジオスタチン様断片のヒト血漿からの一段階精製プロセス |
WO2005012354A1 (en) * | 2003-07-31 | 2005-02-10 | Zlb Behring Gmbh | Method for extending the half-life of fviii |
EP1593388A1 (en) * | 2004-05-05 | 2005-11-09 | ZLB Behring GmbH | Therapeutic plasma protein-concentrates containing von willebrand factor as high molecular weight multimers |
MX2007002085A (es) * | 2004-08-20 | 2007-07-19 | Prometic Biosciences Ltd | Esquemas de aislamiento y purificacion consecutivos de proteinas mediante cromatografia de afinidad. |
US7875288B2 (en) * | 2006-03-30 | 2011-01-25 | The Research Foundation Of State University Of New York | Method for treating blood coagulation disorders |
US7875289B2 (en) * | 2006-03-30 | 2011-01-25 | The Research Foundation Of State University Of New York | Compositions of less immunogenic and long-circulating protein-lipid complexes |
PL2126106T3 (pl) | 2007-02-23 | 2018-03-30 | Sk Chemicals Co., Ltd. | Sposób produkcji i oczyszczania czynnika VIII i jego pochodnych |
ITLU20070007A1 (it) * | 2007-05-07 | 2008-11-08 | Kedrion Spa | Processo cromatografico per l'ottenimento di un complesso fviii/vwf con differenti rapporti tra le due proteine da utilizzare nella terapia della emofilia a e nella malattia di von willebrand. |
KR101748878B1 (ko) * | 2007-12-28 | 2017-06-19 | 박스알타 인코퍼레이티드 | 단백질의 역압 여과 |
EP2291523B1 (en) * | 2008-06-24 | 2014-12-17 | CSL Behring GmbH | Factor viii, von willebrand factor or complexes thereof with prolonged in vivo half-life |
BRPI0919693A2 (pt) * | 2008-10-21 | 2020-08-11 | Baxter Healthcare S.A | formulação farmacêutica estável liofilizada |
GB0915480D0 (en) | 2009-09-04 | 2009-10-07 | Arecor Ltd | Stable formulation of factor viii |
AU2011343813B2 (en) * | 2010-12-15 | 2015-05-21 | Takeda Pharmaceutical Company Limited | Eluate collection using conductivity gradient |
DK3412305T3 (da) * | 2011-06-10 | 2021-03-01 | Baxalta GmbH | Behandling af koagulationssygdom ved administration af rekombinant vwf |
CA2850579A1 (en) | 2011-10-18 | 2013-04-25 | Carsten Horn | Method for improving the stability of purified factor viii after reconstitution |
ES2657291T3 (es) | 2013-04-22 | 2018-03-02 | Csl Ltd. | Un complejo covalente de factor de von Willebrand y factor VIII asociado por un puente disulfuro |
TW201828974A (zh) * | 2016-11-11 | 2018-08-16 | 瑞士商Csl貝林重組技能公司 | 用於血管外施予以治療或預防凝血疾病之截短型類血友病因子(von Willebrand factor)多肽類 |
JP7307047B2 (ja) | 2017-07-07 | 2023-07-11 | 武田薬品工業株式会社 | 組換えvwfの投与による重度のフォンヴィレブランド病を患う患者における消化管出血の治療 |
CN114072420B (zh) * | 2019-07-04 | 2024-06-11 | 康诺贝林伦瑙有限公司 | 用于增加凝血因子viii的体外稳定性的截短的血管性血友病因子(vwf) |
WO2022218962A1 (en) * | 2021-04-13 | 2022-10-20 | Grifols Worldwide Operations Limited | Liquid composition comprising factor viii or factor viii/von willebrand factor complex |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8403473D0 (en) * | 1984-02-09 | 1984-03-14 | Special Trustees For St Thomas | Purification of factor viii |
US5149787A (en) † | 1984-05-22 | 1992-09-22 | The Blood Center Research Foundation | Method for maintaining intact, non-degraded factor VIII/von-Willebrand factor during blood processing |
US4707441A (en) | 1984-08-06 | 1987-11-17 | Technicon Instruments Corp. | Binding assays in automated apparatus with liposome compatible surfactants |
FR2570276B1 (fr) | 1984-09-18 | 1987-09-04 | Immunotech Sa | Procede d'obtention du complexe fviii/vwf a usage therapeutique et produits en resultant |
US5250421A (en) * | 1986-01-03 | 1993-10-05 | Genetics Institute, Inc. | Method for producing factor VIII:C-type proteins |
AU606925B2 (en) | 1987-01-30 | 1991-02-21 | Biogen, Inc. | A method for producing factor viii in high yield |
FR2632309B1 (fr) | 1988-06-07 | 1990-08-24 | Lille Transfusion Sanguine | Procede de purification par voie chromatographique de proteines, notamment de facteur viii, et les produits obtenus |
US5110907A (en) † | 1989-08-01 | 1992-05-05 | Alpha Therapeutic Corporation | Factor viii complex purification using heparin affinity chromatography |
FR2651437A1 (fr) | 1989-09-05 | 1991-03-08 | Lille Transfusion Sanguine | Procede de preparation de concentre du complexe facteur viii-facteur von willebrand de la coagulation sanguine a partir de plasma total. |
JP2931655B2 (ja) | 1990-09-12 | 1999-08-09 | サントル・レジョナル・ド・トランスフユジョン・サンギン・ド・リール | 全血漿から血液疑固▲viii▼因子―フオン・ビルブラント因子複合体濃縮物の製造方法 |
FR2673632A1 (fr) | 1991-03-08 | 1992-09-11 | Lille Transfusion Sanguine | Procede de preparation de concentre de facteur von willebrand humain de tres haute purete, approprie a un usage therapeutique. |
DE4204694C3 (de) | 1992-02-01 | 1995-10-12 | Octapharma Ag | Verfahren zur Gewinnung von hochreinem, virusinaktiviertem Faktor VIII mittels Anionenaustauscher-Chromatographie |
AT399818B (de) | 1992-04-24 | 1995-07-25 | Immuno Ag | Verfahren zur herstellung einer hochgereinigten virussicheren faktor viii-präparation |
IT1256622B (it) | 1992-12-04 | 1995-12-12 | Sclavo Spa | Processo per l'estrazione del complesso fattore viii-fattore von willebrand (fviii:c-fvw) da plasma umano totale. |
DE4435392B4 (de) | 1994-10-04 | 2008-02-07 | Immuno Ag | Verfahren zur Trennung von vWF in hochmolekularen vWF und niedermolekularen vWF |
DE4435485C1 (de) * | 1994-10-04 | 1996-03-21 | Immuno Ag | Verfahren zur Gewinnung von hochreinem von Willebrand-Faktor |
DE19616540A1 (de) | 1995-11-10 | 1997-05-15 | Immuno Ag | Verwendung von von Willebrand-Faktor und pharmazeutische Zubereitung |
US6005077A (en) | 1995-11-10 | 1999-12-21 | Immuno Aktiengesellschaft | Use of von willebrand factor and pharmaceutical formulation |
AT403764B (de) * | 1996-03-15 | 1998-05-25 | Immuno Ag | Stabiler faktor viii/vwf-komplex |
-
1996
- 1996-03-15 AT AT0049496A patent/AT403764B/de not_active IP Right Cessation
-
1997
- 1997-03-13 DK DK97906928T patent/DK0888386T4/da active
- 1997-03-13 DE DE59708667T patent/DE59708667D1/de not_active Expired - Lifetime
- 1997-03-13 PT PT97906928T patent/PT888386E/pt unknown
- 1997-03-13 JP JP9532968A patent/JP2000506869A/ja active Pending
- 1997-03-13 CA CA002248960A patent/CA2248960C/en not_active Expired - Lifetime
- 1997-03-13 WO PCT/AT1997/000055 patent/WO1997034930A1/de active IP Right Grant
- 1997-03-13 ES ES97906928T patent/ES2186870T5/es not_active Expired - Lifetime
- 1997-03-13 AT AT97906928T patent/ATE227310T1/de active
- 1997-03-13 US US09/142,768 patent/US6228613B1/en not_active Expired - Lifetime
- 1997-03-13 EP EP97906928A patent/EP0888386B2/de not_active Expired - Lifetime
-
2001
- 2001-05-07 US US09/849,484 patent/US6924151B2/en not_active Expired - Fee Related
-
2005
- 2005-05-19 US US11/132,326 patent/US7498146B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
ES2186870T5 (es) | 2009-06-19 |
ATE227310T1 (de) | 2002-11-15 |
DK0888386T4 (da) | 2009-05-11 |
US6924151B2 (en) | 2005-08-02 |
ES2186870T3 (es) | 2003-05-16 |
EP0888386B1 (de) | 2002-11-06 |
DK0888386T3 (da) | 2003-02-17 |
CA2248960C (en) | 2009-12-15 |
US6228613B1 (en) | 2001-05-08 |
DE59708667D1 (de) | 2002-12-12 |
EP0888386B2 (de) | 2009-04-01 |
US20050209154A1 (en) | 2005-09-22 |
EP0888386A1 (de) | 1999-01-07 |
US20020025556A1 (en) | 2002-02-28 |
CA2248960A1 (en) | 1997-09-25 |
ATA49496A (de) | 1997-10-15 |
AT403764B (de) | 1998-05-25 |
WO1997034930A1 (de) | 1997-09-25 |
JP2000506869A (ja) | 2000-06-06 |
US7498146B2 (en) | 2009-03-03 |
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