PT85960A - Process for the preparation of new polypeptides and their applications - Google Patents

Process for the preparation of new polypeptides and their applications

Info

Publication number
PT85960A
PT85960A PT85960A PT8596087A PT85960A PT 85960 A PT85960 A PT 85960A PT 85960 A PT85960 A PT 85960A PT 8596087 A PT8596087 A PT 8596087A PT 85960 A PT85960 A PT 85960A
Authority
PT
Portugal
Prior art keywords
arg
thr
glu
tyr
val
Prior art date
Application number
PT85960A
Other languages
Portuguese (pt)
Other versions
PT85960B (en
Inventor
Tamas Bartfai
Original Assignee
Trion Forskning & Utveckling
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Trion Forskning & Utveckling filed Critical Trion Forskning & Utveckling
Publication of PT85960A publication Critical patent/PT85960A/en
Publication of PT85960B publication Critical patent/PT85960B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/235—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Bordetella (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/82—Proteins from microorganisms
    • Y10S530/825—Bacteria

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

The following new polypeptides are described: a) H-X<1>-Asp-Asp-Pro-Pro-Ala-Thr-Val-Tyr-Arg-Tyr-Asp-Ser-Arg-Pro-Pro-Glu -Asp-X<2>-Y, b) H-X<1>-Ser-Glu-Tyr-Leu-Ala-His-Arg-Arg-Ile-Pro-Pro-Glu-Asn-Ile-Arg-Val -Thr-Arg-Val-X<2>-Y, c) H-X<1>-Ala-Phe-Val-Ser-Thr-Ser-Ser-Ser-Arg-Arg-Tyr-Thr-Glu-Val-Tyr-X<2 >-Y, d) H-X<1>-Gly-Ile-Thr-Gly-Glu-Thr-Thr-Thr-Thr-Thr-Glu-Tyr-Ser-Asn-Ala-Arg -Tyr-Val-X<2>-Y-, and e) H-X<1>-Leu-Glu-His-Arg-Met-Gln-Glu-Ala-Val-Glu-Ala-Glu-Arg-Ala-Gly-Arg -Gly-Thr-Gly-His-Phe-Ile-X<2 >- Y in which X<1> and X<2> each represents an optional coupling-facilitating amino acid residue, and Y represents -OH or -NH2. Additionally, there is described an artificial pertussis toxin antigen, which mainly consists of at least one peptide sequence reacting with antibodies induced by the native pertussis toxin selected from the above polypeptides a) to e) and parts thereof. The above described artificial pertussis toxin antigen is included as a diagnostic antigen in a diagnostic immunoassay kit for the determination of antibodies induced by the native pertussis toxin in a sample of biological fluid, and as an immunizing component in a vaccine composition against whooping cough, respectively. Furthermore there is described an intradermal skin test composition comprising the above described artificial pertussis toxin antigen.
PT85960A 1986-10-20 1987-10-20 PROCESS FOR THE PREPARATION OF NEW PEPTIDES AND THEIR APPLICATIONS PT85960B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE8604445A SE455946B (en) 1986-10-20 1986-10-20 NEW PERTUSSISTOXIN POLYPEPTIDES AND ANTIGENS AND TEST KITS, VACCINES AND INTRADERMAL SKIN TEST COMPOSITIONS

Publications (2)

Publication Number Publication Date
PT85960A true PT85960A (en) 1987-11-01
PT85960B PT85960B (en) 1990-07-31

Family

ID=20365987

Family Applications (1)

Application Number Title Priority Date Filing Date
PT85960A PT85960B (en) 1986-10-20 1987-10-20 PROCESS FOR THE PREPARATION OF NEW PEPTIDES AND THEIR APPLICATIONS

Country Status (12)

Country Link
US (1) US5225193A (en)
EP (1) EP0266325B1 (en)
JP (1) JP2635641B2 (en)
AT (1) ATE80895T1 (en)
AU (1) AU624066B2 (en)
DE (1) DE3781863T2 (en)
DK (1) DK312088A (en)
FI (1) FI891872A (en)
IE (1) IE872802L (en)
PT (1) PT85960B (en)
SE (1) SE455946B (en)
WO (1) WO1988002754A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0279151B1 (en) * 1986-12-22 1993-04-28 Trion Forskning- Och Utvecklings Aktiebolag Pertussis toxin polypeptide and its uses
US5000952A (en) * 1988-08-02 1991-03-19 The Board Of Trustees Of The Leland Stanford, Jr. University Polypeptide pertussis toxin vaccine
IT1229766B (en) * 1989-05-19 1991-09-10 Sclavo Spa SYNTHETIC PEPTIDES CAPABLE OF STIMULATING A CELLULAR IMMUNITY.
US5786189A (en) * 1989-11-29 1998-07-28 Smithkline Beecham Biologicals (S.A.) Vaccine
DE4430601A1 (en) * 1994-08-22 1996-02-29 Beiersdorf Ag Cell adhesion peptides for modifying the adhesion behavior of eukaryotic cells to one another
SI3231444T1 (en) 2014-05-12 2020-04-30 Verona Pharma Plc New treatment

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6019733B2 (en) * 1977-06-10 1985-05-17 科研製薬株式会社 proteinaceous active substance
JPS5767592A (en) * 1980-10-11 1982-04-24 Kaken Pharmaceut Co Ltd Protein having reassociating properties and its preparation
JPS5767591A (en) * 1980-10-11 1982-04-24 Kaken Pharmaceut Co Ltd Protein element substance and its preparation
JPS58222032A (en) * 1982-06-18 1983-12-23 Teijin Ltd Subunit protein in pertussal toxin
GB8412207D0 (en) * 1984-05-12 1984-06-20 Wellcome Found Antigenic preparations
FR2590483B1 (en) * 1985-11-22 1988-12-09 Pasteur Institut PURIFIED ANTIGENS HAVING VACCINATION PROPERTIES AGAINST B. PERTUSSIS, IN PARTICULAR RECOMBINANT DNA MEANS, AND VACCINE COMPOSITIONS CONTAINING THEM
CA1340373C (en) * 1986-01-28 1999-02-02 Rino Rappuoli Cloning and sequencing of the dna fragment which codes for the five subunits of the pertussis toxin, a hybrid plasmid containing the dna fragment and micro-organisms transformed by the hybrid plasmid and capable of expressing all or some of the subunits of the pertussis toxin
US4883761A (en) * 1986-03-25 1989-11-28 The United States Of America As Represented By The Department Of Health And Human Services Pertussis toxin gene: cloning and expression of protective antigen
US4762710A (en) * 1986-06-16 1988-08-09 The United States Of America As Represented By The Department Of Health And Human Services Novel method of preparing toxoid by oxidation and metal ions
EP0279151B1 (en) * 1986-12-22 1993-04-28 Trion Forskning- Och Utvecklings Aktiebolag Pertussis toxin polypeptide and its uses
EP0362278A4 (en) * 1987-06-05 1990-05-14 Us Health Autocrine motility factors in cancer diagnosis and management.
US5000952A (en) * 1988-08-02 1991-03-19 The Board Of Trustees Of The Leland Stanford, Jr. University Polypeptide pertussis toxin vaccine

Also Published As

Publication number Publication date
IE872802L (en) 1988-04-20
AU8152487A (en) 1988-05-06
US5225193A (en) 1993-07-06
SE8604445D0 (en) 1986-10-20
SE455946B (en) 1988-08-22
DK312088A (en) 1988-08-10
WO1988002754A1 (en) 1988-04-21
FI891872A0 (en) 1989-04-19
ATE80895T1 (en) 1992-10-15
PT85960B (en) 1990-07-31
DE3781863T2 (en) 1993-03-11
JP2635641B2 (en) 1997-07-30
FI891872A (en) 1989-04-19
DE3781863D1 (en) 1992-10-29
EP0266325A1 (en) 1988-05-04
EP0266325B1 (en) 1992-09-23
AU624066B2 (en) 1992-06-04
DK312088D0 (en) 1988-06-08
SE8604445L (en) 1988-04-21
JPH02500977A (en) 1990-04-05

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Effective date: 20020731

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 20020731