PT819122E - Derivados de 1,3-di-hidro-1-(fenilalquil)-2h-imidazol-2-ona com actividade de pde iv e de citoquina - Google Patents

Derivados de 1,3-di-hidro-1-(fenilalquil)-2h-imidazol-2-ona com actividade de pde iv e de citoquina

Info

Publication number
PT819122E
PT819122E PT96909150T PT96909150T PT819122E PT 819122 E PT819122 E PT 819122E PT 96909150 T PT96909150 T PT 96909150T PT 96909150 T PT96909150 T PT 96909150T PT 819122 E PT819122 E PT 819122E
Authority
PT
Portugal
Prior art keywords
phenylalquil
ona
pde
cytokine
dihydro
Prior art date
Application number
PT96909150T
Other languages
English (en)
Inventor
Gaston Stanislas Marcell Diels
Eddy Jean Edgard Freyne
Jose Ignacio Vesubi Andres-Gil
Francisco Javi Fernandez-Gadea
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of PT819122E publication Critical patent/PT819122E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/30—Oxygen or sulfur atoms
    • C07D233/32—One oxygen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/30—Oxygen or sulfur atoms
    • C07D233/32—One oxygen atom
    • C07D233/36—One oxygen atom with hydrocarbon radicals, substituted by nitrogen atoms, attached to ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/30—Oxygen or sulfur atoms
    • C07D233/32—One oxygen atom
    • C07D233/38—One oxygen atom with acyl radicals or hetero atoms directly attached to ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/70—One oxygen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
PT96909150T 1995-04-06 1996-03-28 Derivados de 1,3-di-hidro-1-(fenilalquil)-2h-imidazol-2-ona com actividade de pde iv e de citoquina PT819122E (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP95200868 1995-04-06
EP95202898 1995-10-26

Publications (1)

Publication Number Publication Date
PT819122E true PT819122E (pt) 2002-08-30

Family

ID=26139205

Family Applications (1)

Application Number Title Priority Date Filing Date
PT96909150T PT819122E (pt) 1995-04-06 1996-03-28 Derivados de 1,3-di-hidro-1-(fenilalquil)-2h-imidazol-2-ona com actividade de pde iv e de citoquina

Country Status (27)

Country Link
US (2) US5994376A (pt)
EP (1) EP0819122B1 (pt)
JP (1) JP4562101B2 (pt)
KR (1) KR100406628B1 (pt)
CN (1) CN1068591C (pt)
AR (1) AR002732A1 (pt)
AT (1) ATE214052T1 (pt)
AU (1) AU702947B2 (pt)
CA (1) CA2216653C (pt)
CY (1) CY2328B1 (pt)
CZ (1) CZ293127B6 (pt)
DE (1) DE69619661T2 (pt)
DK (1) DK0819122T3 (pt)
ES (1) ES2174064T3 (pt)
HK (1) HK1007880A1 (pt)
HR (1) HRP960155A2 (pt)
HU (1) HU223324B1 (pt)
IL (1) IL117807A (pt)
MX (1) MX9707652A (pt)
MY (1) MY119254A (pt)
NO (1) NO314339B1 (pt)
NZ (1) NZ304877A (pt)
PL (1) PL187375B1 (pt)
PT (1) PT819122E (pt)
SI (1) SI0819122T1 (pt)
TW (1) TW332201B (pt)
WO (1) WO1996031485A1 (pt)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5703098A (en) * 1994-12-30 1997-12-30 Celgene Corporation Immunotherapeutic imides/amides
TW332201B (en) 1995-04-06 1998-05-21 Janssen Pharmaceutica Nv 1,3-Dihydro-1-(phenylalkyl)-2H-imidazol-2-one derivatives
PL194673B1 (pl) * 1996-10-02 2007-06-29 Janssen Pharmaceutica Nv Pochodna 2-cyjanoiminoimidazolu, sposób jej wytwarzania i zastosowanie oraz kompozycja farmaceutyczna
TR199903249T2 (xx) 1997-07-10 2000-09-21 Janssen Pharmaceutica N.V. �l-5 inhibit�rleri olarak 6-Azaurasil t�revleri.
US6017926A (en) * 1997-12-17 2000-01-25 Merck & Co., Inc. Integrin receptor antagonists
DK1068194T3 (da) * 1998-04-01 2004-03-15 Janssen Pharmaceutica Nv PDE IV-hæmmende pyridinderivater
WO1999052847A1 (en) * 1998-04-14 1999-10-21 Smithkline Beecham Corporation Phosphodiesterase isoenzyme denominated 4 (pde 4) inhibiting compounds
US6172118B1 (en) * 1998-04-14 2001-01-09 Smithkline Beecham Corporation Compounds
AR021362A1 (es) 1998-11-23 2002-07-17 Janssen Pharmaceutica Nv Derivados de 6-azauracilo inhibidores de la il-5
NZ512748A (en) 1998-12-18 2004-05-28 Janssen Pharmaceutica Nv IL-5 inhibiting 6-azauracil derivatives
AU2001290884B2 (en) 2000-09-13 2005-12-15 Merck & Co., Inc. Alpha V integrin receptor antagonists
MXPA03010672A (es) * 2001-05-23 2004-03-02 Tanabe Seiyaku Co Composicion para el tratamiento regenerativo de enfermedades del cartilago.
CA2447619A1 (en) * 2001-05-23 2002-11-28 Tanabe Seiyaku Co., Ltd. A composition for accelerating bone fracture healing
US6706739B2 (en) * 2001-08-21 2004-03-16 National Health Research Institute Imidazolidinone compounds
SE0200667D0 (sv) * 2002-03-05 2002-03-05 A & Science Invest Ab Novel use of cytokine inhibitors
GB0326407D0 (en) * 2003-11-12 2003-12-17 Glaxo Group Ltd Chemical compounds
GB0412865D0 (en) * 2004-06-09 2004-07-14 Glaxo Group Ltd Chemical compounds
JP4657297B2 (ja) * 2004-07-05 2011-03-23 ドン ファ ファーマシューティカル カンパニー リミテッド アレルギー性炎症疾患の予防及び治療用組成物
AR057455A1 (es) * 2005-07-22 2007-12-05 Merck & Co Inc Inhibidores de la transcriptasa reversa de vih y composicion farmaceutica
US8354434B2 (en) * 2006-01-30 2013-01-15 Purdue Pharma L.P. Cyclourea compounds as calcium channel blockers
US7674811B2 (en) 2006-03-14 2010-03-09 Ranbaxy Laboratories Limited 5-lipoxygenase inhibitors
US7390772B2 (en) * 2006-05-18 2008-06-24 International Flavor & Fragrances Inc. 1-phenyl-spiro[2.5]octane-1-carbonitrile analogues their use in fragrance formulations
WO2008157425A2 (en) * 2007-06-14 2008-12-24 The Regents Of The University Of California Compounds for inhibiting protein aggregation, and methods for making and using them
KR101846136B1 (ko) * 2010-03-12 2018-04-05 오메로스 코포레이션 Pde10 억제제 및 관련 조성물 및 방법
NZ630803A (en) 2014-04-28 2016-03-31 Omeros Corp Optically active pde10 inhibitor
NZ716494A (en) 2014-04-28 2017-07-28 Omeros Corp Processes and intermediates for the preparation of a pde10 inhibitor
US9879002B2 (en) 2015-04-24 2018-01-30 Omeros Corporation PDE10 inhibitors and related compositions and methods
US9920045B2 (en) 2015-11-04 2018-03-20 Omeros Corporation Solid state forms of a PDE10 inhibitor

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL285394A (pt) * 1961-11-17
US3184060A (en) 1963-02-13 1965-05-18 Owens Illinois Glass Co Packaging tacky latex emulsion paints in containers manufactured from polyolefinic maerials
IE913855A1 (en) * 1990-11-06 1992-05-22 Smithkline Beecham Corp Imidazolidinone compounds
BR9307570A (pt) * 1992-12-02 1999-05-25 Pfizer Diéteres de catecol como inibidores seletivos de pdeiv
TW263495B (pt) * 1992-12-23 1995-11-21 Celltech Ltd
GB9304920D0 (en) * 1993-03-10 1993-04-28 Celltech Ltd Chemical compounds
TW332201B (en) 1995-04-06 1998-05-21 Janssen Pharmaceutica Nv 1,3-Dihydro-1-(phenylalkyl)-2H-imidazol-2-one derivatives

Also Published As

Publication number Publication date
CZ293127B6 (cs) 2004-02-18
IL117807A (en) 2001-06-14
EP0819122A1 (en) 1998-01-21
NO974602L (no) 1997-10-06
JP4562101B2 (ja) 2010-10-13
EP0819122B1 (en) 2002-03-06
DE69619661T2 (de) 2002-10-31
CA2216653C (en) 2009-05-26
US6403805B1 (en) 2002-06-11
TW332201B (en) 1998-05-21
ES2174064T3 (es) 2002-11-01
NZ304877A (en) 1999-06-29
CA2216653A1 (en) 1996-10-10
JPH11503136A (ja) 1999-03-23
SI0819122T1 (en) 2002-06-30
DK0819122T3 (da) 2002-07-01
MY119254A (en) 2005-04-30
DE69619661D1 (de) 2002-04-11
AU5275596A (en) 1996-10-23
CY2328B1 (en) 2004-02-06
PL187375B1 (pl) 2004-06-30
HUP9801575A2 (hu) 1999-01-28
KR100406628B1 (ko) 2004-05-31
US20020068830A1 (en) 2002-06-06
CN1068591C (zh) 2001-07-18
AU702947B2 (en) 1999-03-11
NO974602D0 (no) 1997-10-06
NO314339B1 (no) 2003-03-10
HK1007880A1 (en) 1999-04-30
WO1996031485A1 (en) 1996-10-10
HRP960155A2 (en) 1997-10-31
CZ314997A3 (cs) 1998-12-16
CN1181072A (zh) 1998-05-06
US5994376A (en) 1999-11-30
PL322654A1 (en) 1998-02-16
HU223324B1 (hu) 2004-06-28
AR002732A1 (es) 1998-04-29
HUP9801575A3 (en) 1999-03-01
ATE214052T1 (de) 2002-03-15
IL117807A0 (en) 1996-08-04
MX9707652A (es) 1997-11-29
KR19980703449A (ko) 1998-11-05

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