PT738715E - Arilalquil-piridazinonas - Google Patents

Arilalquil-piridazinonas

Info

Publication number
PT738715E
PT738715E PT96105702T PT96105702T PT738715E PT 738715 E PT738715 E PT 738715E PT 96105702 T PT96105702 T PT 96105702T PT 96105702 T PT96105702 T PT 96105702T PT 738715 E PT738715 E PT 738715E
Authority
PT
Portugal
Prior art keywords
cooa
substd
halo
opt
alkyl
Prior art date
Application number
PT96105702T
Other languages
English (en)
Inventor
Beier Dr Norbert
Rochus Jonas
Wolf Dr Michael
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of PT738715E publication Critical patent/PT738715E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/04—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having less than three double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Curing Cements, Concrete, And Artificial Stone (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Pyridine Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
PT96105702T 1995-04-20 1996-04-11 Arilalquil-piridazinonas PT738715E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19514568A DE19514568A1 (de) 1995-04-20 1995-04-20 Arylalkyl-pyridazinone

Publications (1)

Publication Number Publication Date
PT738715E true PT738715E (pt) 2003-06-30

Family

ID=7759974

Family Applications (1)

Application Number Title Priority Date Filing Date
PT96105702T PT738715E (pt) 1995-04-20 1996-04-11 Arilalquil-piridazinonas

Country Status (21)

Country Link
US (2) US6399611B1 (pt)
EP (1) EP0738715B1 (pt)
JP (1) JP4005157B2 (pt)
KR (1) KR100428879B1 (pt)
CN (1) CN1159299C (pt)
AT (1) ATE231842T1 (pt)
AU (1) AU705025B2 (pt)
CA (1) CA2174472C (pt)
CZ (1) CZ291868B6 (pt)
DE (2) DE19514568A1 (pt)
DK (1) DK0738715T3 (pt)
ES (1) ES2191070T3 (pt)
HU (1) HU226198B1 (pt)
NO (1) NO307931B1 (pt)
PT (1) PT738715E (pt)
RU (1) RU2159236C2 (pt)
SI (1) SI0738715T1 (pt)
SK (1) SK284167B6 (pt)
TW (1) TW475927B (pt)
UA (1) UA43853C2 (pt)
ZA (1) ZA963154B (pt)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19533975A1 (de) * 1995-09-14 1997-03-20 Merck Patent Gmbh Arylalkyl-diazinone
JP4017214B2 (ja) * 1996-06-11 2007-12-05 興和創薬株式会社 ５−フェニル−３−ピリダジノン誘導体
EP0924204A4 (en) * 1996-08-27 2002-10-23 Nikken Chemicals Co Ltd 2-PHENYLMORPHOLIN-5-ONE DERIVATIVES AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME
DE19850701A1 (de) * 1998-11-04 2000-05-11 Merck Patent Gmbh Benzoylpyridazine
EP2193808A1 (en) 1999-08-21 2010-06-09 Nycomed GmbH Synergistic combination
DE10064997A1 (de) * 2000-12-23 2002-06-27 Merck Patent Gmbh Benzoylpyridazine
WO2002072103A1 (en) * 2001-02-12 2002-09-19 Merck Patent Gmbh Use of type 4 phosphodiesterase inhibitors in myocardial diseases
US6872382B1 (en) 2001-05-21 2005-03-29 Alcon, Inc. Use of selective PDE IV inhibitors to treat dry eye disorders
US20040146561A1 (en) 2001-05-23 2004-07-29 Naoki Sakurai Compositions for promoting healing of bone fracture
JP4510383B2 (ja) * 2001-05-23 2010-07-21 田辺三菱製薬株式会社 軟骨疾患修復治療用組成物
DE10150517A1 (de) * 2001-10-12 2003-04-17 Merck Patent Gmbh Verwendung von Phosphodiesterase IV-Inhibitoren
US20040259863A1 (en) * 2001-10-31 2004-12-23 Hans-Michael Eggenweiler Type 4 phosphodiesterase inhibitors and uses thereof
US7074959B2 (en) * 2002-08-01 2006-07-11 New Mexico Highlands University Methods and systems for remediating hydrazine-contaminated equipment and/or surfaces
EA200501548A1 (ru) 2003-04-01 2006-02-24 Апплайд Резеч Системз Арс Холдинг Н.В. Ингибиторы фосфодиэстераз при бесплодии
US20080227790A1 (en) * 2004-02-04 2008-09-18 Altana Pharma Ag Pyridazinone Derivatives and their Use as Pde4 Inhibitors
US7494990B2 (en) 2004-02-04 2009-02-24 Nycomed Gmbh 2-(piperidin-4-yl)-4,5-dihydro-2H-pyridazin-3-one derivatives as PDE4 inhibitors
KR20090096690A (ko) * 2006-12-14 2009-09-14 아스텔라스세이야쿠 가부시키가이샤 Ｃｒｔｈ2 길항제 및 항알레르기제로 유용한 폴리사이클릭 산 화합물
US8466198B2 (en) * 2008-09-02 2013-06-18 Bruce Kneller Compositions comprising creatine salts and methods of use thereof
PL2298090T3 (pl) * 2009-08-26 2016-07-29 Jeffrey M Golini Kompozycja farmaceutyczna lub nutraceutyczna
US11395820B2 (en) 2016-03-16 2022-07-26 H. Lee Moffitt Cancer Center And Research Institute, Inc. Small molecules against cereblon to enhance effector t cell function
US11730726B2 (en) 2018-07-11 2023-08-22 H. Lee Moffitt Cancer Center And Research Institute, Inc. Dimeric immuno-modulatory compounds against cereblon-based mechanisms

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1604863A (pt) * 1967-11-22 1972-04-17
US3975388A (en) * 1971-02-22 1976-08-17 Bdh Pharmaceuticals Limited Pyridazinones
DE2845456A1 (de) 1978-10-19 1980-08-14 Merck Patent Gmbh 6-arylpyridazin-3-one und verfahren zu ihrer herstellung
US4397854A (en) * 1981-05-14 1983-08-09 Warner-Lambert Company Substituted 6-phenyl-3(2H)-pyridazinones useful as cardiotonic agents
US4734415A (en) * 1982-08-13 1988-03-29 Warner-Lambert Company Substituted 4,5-dihydro-6-(substituted)-phenyl-3(2H)-pyridazinones and 6-(substituted) phenyl-3(2H)-pyridazinones
NZ208107A (en) * 1983-05-11 1986-12-05 Byk Gulden Lomberg Chem Fab 6-aryl-3(2h)-pyridazinones and pharmaceutical compositions
US4666902A (en) * 1983-06-20 1987-05-19 Cassella Aktiengesellschaft Tetrahydropyridazinone derivatives, processes for their preparation and their use
US4816454A (en) * 1984-09-21 1989-03-28 Cassella Aktiengesellschaft 4,5-dihydro-3(2H)-pyridazinones and their pharmacological use
JPS61158969A (ja) * 1984-12-24 1986-07-18 ワーナー‐ランバート・コンパニー ４，５‐ジヒドロ‐４，４‐ジアルキル‐６‐（置換）フエニル‐３（２ｈ）‐ピリダジノン類
DE3704879A1 (de) * 1987-02-17 1988-08-25 Merck Patent Gmbh Pyridazinonderivate
GB8903130D0 (en) 1989-02-11 1989-03-30 Orion Yhtymae Oy Substituted pyridazinones
JPH03141264A (ja) * 1989-08-10 1991-06-17 Glaxo Inc 強心活性およびベータ遮断活性を有するピリダジノン
DE4237656A1 (de) * 1992-06-13 1993-12-16 Merck Patent Gmbh Benzimidazolderivate
JP2806192B2 (ja) * 1992-11-02 1998-09-30 日本曹達株式会社 血小板凝集抑制剤
DE19502699A1 (de) 1995-01-28 1996-08-01 Merck Patent Gmbh Arylalkyl-thiadiazinone

Also Published As

Publication number Publication date
JPH08291145A (ja) 1996-11-05
AU705025B2 (en) 1999-05-13
SK48796A3 (en) 1997-02-05
ES2191070T3 (es) 2003-09-01
US20020111356A1 (en) 2002-08-15
EP0738715B1 (de) 2003-01-29
HUP9601034A2 (en) 1996-12-30
CZ291868B6 (cs) 2003-06-18
NO307931B1 (no) 2000-06-19
RU2159236C2 (ru) 2000-11-20
SI0738715T1 (en) 2003-10-31
US6531473B2 (en) 2003-03-11
EP0738715A3 (de) 1998-06-17
HU9601034D0 (en) 1996-06-28
NO961578L (no) 1996-10-21
NO961578D0 (no) 1996-04-19
AU5071196A (en) 1996-10-31
HUP9601034A3 (en) 1999-03-01
ATE231842T1 (de) 2003-02-15
KR100428879B1 (ko) 2004-07-15
DK0738715T3 (da) 2003-05-26
CN1159299C (zh) 2004-07-28
CZ113296A3 (en) 1996-11-13
JP4005157B2 (ja) 2007-11-07
DE19514568A1 (de) 1996-10-24
TW475927B (en) 2002-02-11
EP0738715A2 (de) 1996-10-23
US6399611B1 (en) 2002-06-04
DE59610081D1 (de) 2003-03-06
CA2174472A1 (en) 1996-10-21
ZA963154B (en) 1996-12-06
KR960037662A (ko) 1996-11-19
HU226198B1 (en) 2008-06-30
UA43853C2 (uk) 2002-01-15
CN1142493A (zh) 1997-02-12
SK284167B6 (sk) 2004-10-05
CA2174472C (en) 2008-10-21

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