PT672116E - Mutantes por supressao como vacinas contra a colera - Google Patents

Mutantes por supressao como vacinas contra a colera

Info

Publication number
PT672116E
PT672116E PT93916907T PT93916907T PT672116E PT 672116 E PT672116 E PT 672116E PT 93916907 T PT93916907 T PT 93916907T PT 93916907 T PT93916907 T PT 93916907T PT 672116 E PT672116 E PT 672116E
Authority
PT
Portugal
Prior art keywords
breeding
vaccine
cholera
mutants
cholerae
Prior art date
Application number
PT93916907T
Other languages
English (en)
Inventor
Kevin Killeen
John J Mekalanos
David Beattie
Yichen Lu
Original Assignee
Harvard College
Avant Immunotherapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Harvard College, Avant Immunotherapeutics Inc filed Critical Harvard College
Publication of PT672116E publication Critical patent/PT672116E/pt

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/02Bacterial antigens
    • A61K39/107Vibrio
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/28Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Vibrionaceae (F)
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72Receptors; Cell surface antigens; Cell surface determinants for hormones
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20Bacteria; Culture media therefor
    • C12N1/205Bacterial isolates
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/01Preparation of mutants without inserting foreign genetic material therein; Screening processes therefor
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52Bacterial cells; Fungal cells; Protozoal cells
    • A61K2039/522Bacterial cells; Fungal cells; Protozoal cells avirulent or attenuated
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/54Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A61K2039/541Mucosal route
    • A61K2039/542Mucosal route oral/gastrointestinal
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12RINDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00Microorganisms ; Processes using microorganisms
    • C12R2001/01Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/63Vibrio
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00Chemistry: molecular biology and microbiology
    • Y10S435/8215Microorganisms
    • Y10S435/822Microorganisms using bacteria or actinomycetales
    • Y10S435/909Vibrio

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Communicable Diseases (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Oncology (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
PT93916907T 1992-07-06 1993-07-01 Mutantes por supressao como vacinas contra a colera PT672116E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US90938292A 1992-07-06 1992-07-06

Publications (1)

Publication Number Publication Date
PT672116E true PT672116E (pt) 2003-10-31

Family

ID=25427152

Family Applications (1)

Application Number Title Priority Date Filing Date
PT93916907T PT672116E (pt) 1992-07-06 1993-07-01 Mutantes por supressao como vacinas contra a colera

Country Status (16)

Country Link
US (1) US5631010A (pt)
EP (1) EP0672116B1 (pt)
JP (2) JP4179627B2 (pt)
CN (1) CN1083524A (pt)
AT (1) ATE242319T1 (pt)
AU (1) AU4660893A (pt)
BR (1) BR9306707A (pt)
CA (1) CA2139655C (pt)
DE (1) DE69333028T2 (pt)
DK (1) DK0672116T3 (pt)
ES (1) ES2199944T3 (pt)
MX (1) MX9303992A (pt)
PT (1) PT672116E (pt)
TW (1) TW266228B (pt)
WO (1) WO1994001533A1 (pt)
ZA (1) ZA934736B (pt)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5882653A (en) * 1983-03-04 1999-03-16 The University Of Maryland System Vibrio cholerae 01 (CVD111) and non-01 (CVD112 and CVD112RM) serogroup vaccine strains, methods of making same and products thereof
WO1994019482A1 (en) * 1993-02-22 1994-09-01 The General Hospital Corporation Heterologous antigens in live cell vaccine strains
US6203799B1 (en) 1993-07-01 2001-03-20 Presidents And Fellows Of Harvard College Vibrio cholerae mutants which are soft-agar penetration defective and lack a functional CtxA subunit
JP3379582B2 (ja) * 1993-10-08 2003-02-24 ユニバーシティ・オブ・メリーランド・アット・ボルティモア Vibrio cholerae 01(cvd111)および−非01(cvd112およびcvd112rm)血清群ワクチン株、その作製方法、およびその産物
CN1058522C (zh) * 1994-04-01 2000-11-15 中国预防医学科学院流行病学微生物研究所 一种霍乱弧菌新菌株及其活菌苗
US6887483B2 (en) * 1995-12-01 2005-05-03 University Of Iowa Research Foundation Non-toxic mutants of pathogenic gram-negative bacteria
AU7410798A (en) * 1996-11-29 1998-06-22 General Hospital Corporation, The Heterologous antigens in live cell V
JP4086945B2 (ja) * 1996-12-10 2008-05-14 カウンシル・オブ・サイエンティフィック・アンド・インダストリアル・リサーチ 非毒性V.Cholerae株の単離法およびその株由来のコレラワクチンの製造法
US6818222B1 (en) 1997-03-21 2004-11-16 Chiron Corporation Detoxified mutants of bacterial ADP-ribosylating toxins as parenteral adjuvants
EP0887403A3 (en) * 1997-06-27 2000-12-06 Chiron S.P.A. Attenuated Vibrio cholerae strains
EP0928831B1 (en) * 1997-12-10 2006-05-03 Council of Scientific and Industrial Research Cholera organisms, vaccines and preparation thereof
FR2772791B1 (fr) * 1997-12-24 2000-01-28 Staubli Sa Ets Actionneur rotatif electrique pour la formation de la foule sur un metier a tisser, mecanique d'armure et metier a tisser
US6686339B1 (en) 1998-08-20 2004-02-03 Aventis Pasteur Limited Nucleic acid molecules encoding inclusion membrane protein C of Chlamydia
US6693087B1 (en) 1998-08-20 2004-02-17 Aventis Pasteur Limited Nucleic acid molecules encoding POMP91A protein of Chlamydia
EP1105490A1 (en) 1998-08-20 2001-06-13 Aventis Pasteur Limited Nucleic acid molecules encoding inclusion membrane protein c of chlamydia
AU779403B2 (en) * 1999-08-24 2005-01-20 Teva Pharmaceutical Industries Ltd. A vaccine composition and method of using the same
US6592869B2 (en) * 1999-08-24 2003-07-15 Teva Pharmaceutical Industries, Ltd. Vaccine composition and method of using the same
AU1013601A (en) 1999-10-22 2001-05-08 Aventis Pasteur Limited Method of inducing and/or enhancing an immune response to tumor antigens
EP1792995A3 (en) 2000-05-08 2007-06-13 Sanofi Pasteur Limited Chlamydia secretory locus orf and uses thereof
CA2408328C (en) 2000-05-10 2012-04-17 Aventis Pasteur Limited Immunogenic polypeptides encoded by mage minigenes and uses thereof
AU1120102A (en) 2000-11-02 2002-05-15 Univ Singapore AopB gene, protein, homologs, fragments and variants thereof, and their use for cell surface display
US7786278B2 (en) 2002-04-09 2010-08-31 Sanofi Pasteur Limited Modified CEA nucleic acid and expression vectors
JP4668919B2 (ja) * 2003-10-08 2011-04-13 サノフィ パストゥール インコーポレイテッド 修飾cea/b7ベクター
US20060099229A1 (en) * 2004-11-05 2006-05-11 Universiti Sains Malaysia Vibrio cholerae strains VCUSM1 and VCUSM4, method of producing same, and vaccine derivatives thereof
EP1543836A1 (en) * 2003-12-17 2005-06-22 Berna Biotech AG Recombinant Vibrio cholerae strain and vaccine comprising said strain
CA2684742C (en) * 2007-04-24 2014-07-08 Celldex Therapeutics, Inc. V. cholerae hyperexpressing recombinant cholera toxin b subunit showing dual immunogenicity
CN101519440B (zh) * 2008-02-29 2012-02-08 中国科学院海洋研究所 一种交叉保护性疫苗抗原及其制备方法和应用
DK2477649T3 (en) * 2009-09-16 2017-03-06 Msd Wellcome Trust Hilleman Laboratories Pvt Ltd Vaccine against cholera and enterocotoxic E.COLI (ETEC) - DIARY
CN103468623B (zh) * 2011-09-30 2016-01-06 中山百慧基因科技有限公司 基因工程用工具菌及其应用
US11136358B2 (en) 2016-12-16 2021-10-05 Industry-University Cooperation Foundation Hanyang University Erica Campus Plasmid-based CTX phage replication system and vibrio cholerae strain that can be infected by CTX phage and can be used for cholera toxin production
WO2018111018A2 (ko) * 2016-12-16 2018-06-21 한양대학교 에리카산학협력단 플라스미드 기반의 ctx 파지 복제시스템 및 ctx 파지에 감염되고 콜레라 독소를 생산할 수 있는 비브리오 콜레라 균주
EP3651796A4 (en) * 2017-07-12 2021-06-30 The Brigham and Women's Hospital, Inc. WEIGHTED CHOLERA LIVE VACCINE WITH PROBIOTIC PROPERTIES

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4935364A (en) * 1983-03-04 1990-06-19 Swiss Serum And Vaccine Institute Berne Method of isolating restriction fragment deletions in vibrio cholerae and products thereof
US4882278A (en) * 1983-04-29 1989-11-21 President And Fellows Of Harvard College Non-toxinogenic vibrio cholerae mutants
US5098998A (en) * 1987-04-29 1992-03-24 President And Fellows Of Harvard College Cholera vaccines and peptides
ATE145005T1 (de) * 1990-06-05 1996-11-15 Univ Maryland Verfahren zum isolieren von vibrio cholerae- deletionsmutanten und vibrio cholerae enthaltende kulturen

Also Published As

Publication number Publication date
ZA934736B (en) 1994-01-24
MX9303992A (es) 1995-01-31
DE69333028D1 (de) 2003-07-10
CN1083524A (zh) 1994-03-09
EP0672116B1 (en) 2003-06-04
EP0672116A1 (en) 1995-09-20
ES2199944T3 (es) 2004-03-01
DK0672116T3 (da) 2003-10-06
CA2139655C (en) 2008-05-13
ATE242319T1 (de) 2003-06-15
DE69333028T2 (de) 2004-04-22
BR9306707A (pt) 1998-12-08
AU4660893A (en) 1994-01-31
EP0672116A4 (en) 1996-06-12
TW266228B (pt) 1995-12-21
JPH07508885A (ja) 1995-10-05
CA2139655A1 (en) 1994-01-20
JP4179627B2 (ja) 2008-11-12
JP2004159660A (ja) 2004-06-10
WO1994001533A1 (en) 1994-01-20
US5631010A (en) 1997-05-20

Similar Documents

Publication Publication Date Title
PT672116E (pt) Mutantes por supressao como vacinas contra a colera
IL91525A0 (en) Transgenic plants,pharmaceutical compositions containing the same and methods for the preparation thereof
PT625053E (pt) Vacina a base de urease contra a infeccao por helicobacter
WO2001009350A3 (en) Genetically engineered bleb vaccine
ES8707861A1 (es) Un metodo para preparar un conjugado inmunogeno
PT865297E (pt) Composicoes de vacinas para administracao intranasal compreendendo quitosano e suas utilizacoes
FI883876A0 (fi) Menetelmä rokotteen valmistamiseksi streptokokki-infektioita vastaan
HUP9702355A2 (hu) Avirulens Mycoplasma synoviae, és az ezt tartalmazó vakcina
PT603386E (pt) Imunizacao parenterica contra rotavirus
NO996428D0 (no) Anti-Vibrio anguillarum-vaksine (GAVA-3) for forhindring av vibriosen i piggvar og laksefisk og fremgangsmåten for fremstilling av slike vaksiner
IL122829A (en) Isolated strains of staphylococcus aureus and vaccines manufactured therefrom
HUP0002752A2 (hu) Egy szekréciós vektor alkalmazása termékenység-szabályozásra orális vakcinálással
DE3889975D1 (de) Bordetella pertussis-Varianten.
ES2115550A1 (es) Vacuna anti-pasteurella piscicida (di)para la prevencion de la enfermedad pasteurelosis en dorada y lubina y procedimiento de obtencion. .
HUP9800094A2 (hu) Nem patogén mutáns E. coli törzsek, előállításuk és alkalmazásuk