PT3497091T - Derivados de tiofeno condensados úteis como inibidores de napi-iib - Google Patents

Derivados de tiofeno condensados úteis como inibidores de napi-iib

Info

Publication number
PT3497091T
PT3497091T PT177549144T PT17754914T PT3497091T PT 3497091 T PT3497091 T PT 3497091T PT 177549144 T PT177549144 T PT 177549144T PT 17754914 T PT17754914 T PT 17754914T PT 3497091 T PT3497091 T PT 3497091T
Authority
PT
Portugal
Prior art keywords
napi
derivatives useful
thiophene derivatives
condensed thiophene
iib
Prior art date
Application number
PT177549144T
Other languages
English (en)
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of PT3497091T publication Critical patent/PT3497091T/pt

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D333/00Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/66Nitrogen atoms not forming part of a nitro radical
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/38Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4995Pyrazines or piperazines forming part of bridged ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10Spiro-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08Bridged systems
PT177549144T 2016-08-15 2017-08-08 Derivados de tiofeno condensados úteis como inibidores de napi-iib PT3497091T (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201662375169P 2016-08-15 2016-08-15

Publications (1)

Publication Number Publication Date
PT3497091T true PT3497091T (pt) 2020-11-30

Family

ID=59677343

Family Applications (1)

Application Number Title Priority Date Filing Date
PT177549144T PT3497091T (pt) 2016-08-15 2017-08-08 Derivados de tiofeno condensados úteis como inibidores de napi-iib

Country Status (24)

Country Link
US (1) US10934280B2 (pt)
EP (1) EP3497091B1 (pt)
JP (1) JP6653410B2 (pt)
KR (1) KR102266143B1 (pt)
CN (1) CN109563070B (pt)
AU (1) AU2017312783B2 (pt)
BR (1) BR112019000929A2 (pt)
CA (1) CA3033628C (pt)
CY (1) CY1123576T1 (pt)
DK (1) DK3497091T3 (pt)
EA (1) EA037376B1 (pt)
ES (1) ES2830444T3 (pt)
HR (1) HRP20202025T1 (pt)
HU (1) HUE052351T2 (pt)
IL (1) IL264785B (pt)
LT (1) LT3497091T (pt)
MX (1) MX2019001781A (pt)
PL (1) PL3497091T3 (pt)
PT (1) PT3497091T (pt)
RS (1) RS61165B1 (pt)
SA (1) SA519401049B1 (pt)
SI (1) SI3497091T1 (pt)
WO (1) WO2018034883A1 (pt)
ZA (1) ZA201900305B (pt)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20220000864A1 (en) * 2018-11-19 2022-01-06 11949098 Canada Inc. MODULATORS OF RAR-RELATED ORPHAN RECEPTORS (RORs)
JP7194848B2 (ja) * 2019-05-16 2022-12-22 イーライ リリー アンド カンパニー ナトリウム-水素交換体3阻害剤化合物
AR126060A1 (es) 2021-06-08 2023-09-06 Chugai Pharmaceutical Co Ltd Método para producir derivado de dihidropiridazin-3,5-diona
BR112023023708A2 (pt) 2021-06-08 2024-01-30 Chugai Pharmaceutical Co Ltd Formulação contendo derivado de di-hidropiridazino-3,5-diona
WO2023219127A1 (ja) * 2022-05-11 2023-11-16 中外製薬株式会社 嚢胞性疾患を治療または予防するための医薬組成物

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20130029973A1 (en) * 2010-04-28 2013-01-31 Astellas Pharma Inc. Tetrahydrobenzothiophene compound
EA023955B1 (ru) * 2011-10-27 2016-07-29 Астеллас Фарма Инк. Производное аминоалкилзамещенного n-тиенилбензамида
WO2014003153A1 (ja) * 2012-06-28 2014-01-03 協和発酵キリン株式会社 置換アミド化合物
CN105658635B (zh) 2014-08-22 2019-03-08 江苏恒瑞医药股份有限公司 噻吩并环烷基或噻吩并杂环基类衍生物、其制备方法及其在医药上的应用

Also Published As

Publication number Publication date
JP6653410B2 (ja) 2020-02-26
EA201990095A1 (ru) 2019-07-31
EP3497091A1 (en) 2019-06-19
DK3497091T3 (da) 2020-10-19
CA3033628A1 (en) 2018-02-22
ES2830444T3 (es) 2021-06-03
HUE052351T2 (hu) 2021-04-28
AU2017312783A1 (en) 2019-01-24
BR112019000929A2 (pt) 2019-07-09
US20200031813A1 (en) 2020-01-30
KR20190026895A (ko) 2019-03-13
AU2017312783B2 (en) 2020-02-06
SA519401049B1 (ar) 2021-07-14
IL264785B (en) 2021-04-29
LT3497091T (lt) 2020-12-28
KR102266143B1 (ko) 2021-06-17
CA3033628C (en) 2021-01-12
NZ750153A (en) 2021-01-29
CN109563070B (zh) 2021-02-26
EA037376B1 (ru) 2021-03-22
EP3497091B1 (en) 2020-10-07
ZA201900305B (en) 2020-12-23
PL3497091T3 (pl) 2021-02-08
WO2018034883A1 (en) 2018-02-22
JP2019527734A (ja) 2019-10-03
RS61165B1 (sr) 2021-01-29
CN109563070A (zh) 2019-04-02
CY1123576T1 (el) 2022-03-24
MX2019001781A (es) 2019-07-04
US10934280B2 (en) 2021-03-02
SI3497091T1 (sl) 2020-11-30
HRP20202025T1 (hr) 2021-02-19

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