PT3320906T - Tratamento de melanoma e carcinoma pulmonar com a utilização de um inibidor de smad3 - Google Patents
Tratamento de melanoma e carcinoma pulmonar com a utilização de um inibidor de smad3Info
- Publication number
- PT3320906T PT3320906T PT17199116T PT17199116T PT3320906T PT 3320906 T PT3320906 T PT 3320906T PT 17199116 T PT17199116 T PT 17199116T PT 17199116 T PT17199116 T PT 17199116T PT 3320906 T PT3320906 T PT 3320906T
- Authority
- PT
- Portugal
- Prior art keywords
- melanoma
- treatment
- lung carcinoma
- smad3 inhibitor
- smad3
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
- A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/713—Double-stranded nucleic acids or oligonucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dermatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Endocrinology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261719114P | 2012-10-26 | 2012-10-26 |
Publications (1)
Publication Number | Publication Date |
---|---|
PT3320906T true PT3320906T (pt) | 2019-04-30 |
Family
ID=50544039
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT191506419T PT3527213T (pt) | 2012-10-26 | 2013-10-28 | Tratamento de cancro utilizando um inibidor de smad3 |
PT17199116T PT3320906T (pt) | 2012-10-26 | 2013-10-28 | Tratamento de melanoma e carcinoma pulmonar com a utilização de um inibidor de smad3 |
PT138494158T PT2911661T (pt) | 2012-10-26 | 2013-10-28 | Tratamento de cancro pulmonar com a utilização de inibidor de smad3 sis3 |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT191506419T PT3527213T (pt) | 2012-10-26 | 2013-10-28 | Tratamento de cancro utilizando um inibidor de smad3 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT138494158T PT2911661T (pt) | 2012-10-26 | 2013-10-28 | Tratamento de cancro pulmonar com a utilização de inibidor de smad3 sis3 |
Country Status (9)
Country | Link |
---|---|
US (3) | US20140120116A1 (pt) |
EP (3) | EP2911661B1 (pt) |
CN (2) | CN104768546B (pt) |
ES (3) | ES2719435T3 (pt) |
HK (2) | HK1211835A1 (pt) |
HU (3) | HUE044294T2 (pt) |
PL (3) | PL2911661T3 (pt) |
PT (3) | PT3527213T (pt) |
WO (1) | WO2014063659A1 (pt) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2016176306A1 (en) * | 2015-04-27 | 2016-11-03 | Yale University | Novel compositions useful for treating cancer, and methods using same |
US20180221463A1 (en) * | 2017-01-13 | 2018-08-09 | The Chinese University Of Hong Kong | Modified NK Cells and Uses Thereof |
CN108619149A (zh) * | 2018-05-30 | 2018-10-09 | 同济大学 | Sis3在调控纤维化相关疾病中的应用 |
EP3833664A4 (en) * | 2018-08-06 | 2022-06-08 | Moexa Pharmaceuticals Limited | SMAD3 INHIBITORS |
CN110302197A (zh) * | 2019-07-26 | 2019-10-08 | 安徽医科大学第一附属医院 | 一种与恩杂鲁胺治疗敏感性相关的lncRNA及其在恩杂鲁胺治疗***癌中的应用 |
CN112603919A (zh) * | 2019-10-03 | 2021-04-06 | 香港中文大学 | 使用sis3纳米药物治疗癌症 |
Family Cites Families (34)
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US4405712A (en) | 1981-07-01 | 1983-09-20 | The United States Of America As Represented By The Department Of Health And Human Services | LTR-Vectors |
GB8424757D0 (en) | 1984-10-01 | 1984-11-07 | Pasteur Institut | Retroviral vector |
US5506337A (en) | 1985-03-15 | 1996-04-09 | Antivirals Inc. | Morpholino-subunit combinatorial library and method |
US5010175A (en) | 1988-05-02 | 1991-04-23 | The Regents Of The University Of California | General method for producing and selecting peptides with specific properties |
IE66205B1 (en) | 1990-06-14 | 1995-12-13 | Paul A Bartlett | Polypeptide analogs |
US5650489A (en) | 1990-07-02 | 1997-07-22 | The Arizona Board Of Regents | Random bio-oligomer library, a method of synthesis thereof, and a method of use thereof |
JPH07500961A (ja) | 1990-10-01 | 1995-02-02 | ユニバーシティ オブ コネチカット | 細胞による選択的内在化を目的としたウイルス及び細胞の標的設定 |
JP3249516B2 (ja) | 1990-10-31 | 2002-01-21 | ソマティクス セラピー コーポレイション | 遺伝子治療のためのレトロウイルスのベクター |
AU3434393A (en) | 1992-01-17 | 1993-08-03 | Regents Of The University Of Michigan, The | Targeted virus |
US5573905A (en) | 1992-03-30 | 1996-11-12 | The Scripps Research Institute | Encoded combinatorial chemical libraries |
ATE260679T1 (de) | 1992-04-03 | 2004-03-15 | Univ California | Selbstorganisierendes system zur verabreichung von polynukleotiden enthaltend ein amphiphatisches peptid |
JPH07505773A (ja) | 1992-04-03 | 1995-06-29 | ヤング アレキサンダー ティー | 標的化されたウイルスベクターを用いた遺伝子治療 |
US5288514A (en) | 1992-09-14 | 1994-02-22 | The Regents Of The University Of California | Solid phase and combinatorial synthesis of benzodiazepine compounds on a solid support |
WO1994006923A1 (en) | 1992-09-24 | 1994-03-31 | The University Of Connecticut | Modification of a virus to redirect infectivity and enhance targeted delivery of polynucleotides to cells |
US5656609A (en) | 1992-09-24 | 1997-08-12 | University Of Connecticut | Method of enhancing and/or prolonging expression of gene introduced into a cell using colchicine |
US5519134A (en) | 1994-01-11 | 1996-05-21 | Isis Pharmaceuticals, Inc. | Pyrrolidine-containing monomers and oligomers |
US5593853A (en) | 1994-02-09 | 1997-01-14 | Martek Corporation | Generation and screening of synthetic drug libraries |
US5539083A (en) | 1994-02-23 | 1996-07-23 | Isis Pharmaceuticals, Inc. | Peptide nucleic acid combinatorial libraries and improved methods of synthesis |
US5525735A (en) | 1994-06-22 | 1996-06-11 | Affymax Technologies Nv | Methods for synthesizing diverse collections of pyrrolidine compounds |
US5549974A (en) | 1994-06-23 | 1996-08-27 | Affymax Technologies Nv | Methods for the solid phase synthesis of thiazolidinones, metathiazanones, and derivatives thereof |
US5569588A (en) | 1995-08-09 | 1996-10-29 | The Regents Of The University Of California | Methods for drug screening |
US6239114B1 (en) * | 1997-09-26 | 2001-05-29 | Kgk Synergize | Compositions and methods for treatment of neoplastic diseases with combinations of limonoids, flavonoids and tocotrienols |
US6013788A (en) * | 1999-04-09 | 2000-01-11 | Isis Pharmaceuticals Inc. | Antisense modulation of Smad3 expression |
US20030139366A1 (en) | 2000-05-19 | 2003-07-24 | Roberts Anita B. | Inhibition of Smad3 to prevent fibrosis and improve wound healing |
DK2128246T3 (da) | 2001-04-19 | 2014-05-12 | Univ California | Fremgangsmåder og sammensætninger til fremstilling af ortogonale tRNA-aminoacyl-tRNA-syntetasepar. |
JPWO2003037862A1 (ja) * | 2001-10-30 | 2005-02-17 | 日本新薬株式会社 | アミド誘導体及び医薬 |
GB0302315D0 (en) | 2003-02-01 | 2003-03-05 | Univ East Anglia | Novel therapeutic target |
PA8595001A1 (es) * | 2003-03-04 | 2004-09-28 | Pfizer Prod Inc | Nuevos compuestos heteroaromaticos condensados que son inhibidores del factor de crecimiento transforante (tgf) |
AU2005230848B9 (en) * | 2004-03-31 | 2011-06-02 | Genentech, Inc. | Humanized anti-TGF-beta antibodies |
WO2008022467A1 (en) | 2006-08-25 | 2008-02-28 | Mark Lautens | 2-substituted azain doles and 2 substituted thienopyrroles, their precursors and novel processes for the preparation thereof |
WO2008046964A2 (en) * | 2006-10-16 | 2008-04-24 | Panu Jaakkola | Novel useful inhibitors |
WO2009151600A2 (en) | 2008-06-10 | 2009-12-17 | Tufts University | Smad proteins control drosha-mediated mirna maturation |
KR20120000056A (ko) * | 2009-02-11 | 2012-01-03 | 고쿠리츠다이가쿠호우진 도쿄다이가쿠 | 뇌 종양 줄기 세포 분화 촉진제, 및 뇌종양 치료제 |
JO3421B1 (ar) | 2011-06-20 | 2019-10-20 | H Lundbeck As | طريقة لإعطاء 1-((1ار.3س)-6-كلورو-3-فينيل-اندان-1-ايل)-1.2.2-ترايميثيل- بيبيرازين واملاجها لمعالجة انفصام الشخصية |
-
2013
- 2013-02-27 US US13/779,090 patent/US20140120116A1/en not_active Abandoned
- 2013-10-28 PL PL13849415T patent/PL2911661T3/pl unknown
- 2013-10-28 PT PT191506419T patent/PT3527213T/pt unknown
- 2013-10-28 HU HUE17199116 patent/HUE044294T2/hu unknown
- 2013-10-28 ES ES17199116T patent/ES2719435T3/es active Active
- 2013-10-28 WO PCT/CN2013/086053 patent/WO2014063659A1/en active Application Filing
- 2013-10-28 HU HUE13849415A patent/HUE038327T2/hu unknown
- 2013-10-28 PT PT17199116T patent/PT3320906T/pt unknown
- 2013-10-28 HU HUE19150641A patent/HUE056898T2/hu unknown
- 2013-10-28 CN CN201380055232.0A patent/CN104768546B/zh active Active
- 2013-10-28 ES ES13849415.8T patent/ES2660739T3/es active Active
- 2013-10-28 PL PL17199116T patent/PL3320906T3/pl unknown
- 2013-10-28 EP EP13849415.8A patent/EP2911661B1/en not_active Not-in-force
- 2013-10-28 PT PT138494158T patent/PT2911661T/pt unknown
- 2013-10-28 PL PL19150641T patent/PL3527213T3/pl unknown
- 2013-10-28 CN CN201910229234.6A patent/CN110101862B/zh active Active
- 2013-10-28 EP EP17199116.9A patent/EP3320906B1/en active Active
- 2013-10-28 ES ES19150641T patent/ES2893461T3/es active Active
- 2013-10-28 EP EP19150641.9A patent/EP3527213B1/en active Active
-
2015
- 2015-12-23 HK HK15112647.5A patent/HK1211835A1/xx unknown
-
2016
- 2016-03-08 US US15/063,661 patent/US11666565B2/en active Active
-
2018
- 2018-10-16 HK HK18113271.3A patent/HK1254307B/zh unknown
-
2023
- 2023-04-26 US US18/139,826 patent/US20230338361A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
EP2911661B1 (en) | 2017-11-29 |
PL2911661T3 (pl) | 2018-05-30 |
ES2893461T3 (es) | 2022-02-09 |
US20140120116A1 (en) | 2014-05-01 |
PT2911661T (pt) | 2018-03-05 |
US11666565B2 (en) | 2023-06-06 |
HUE044294T2 (hu) | 2019-10-28 |
WO2014063659A1 (en) | 2014-05-01 |
HK1211835A1 (en) | 2016-06-03 |
EP3527213A1 (en) | 2019-08-21 |
ES2719435T3 (es) | 2019-07-10 |
US20160279123A1 (en) | 2016-09-29 |
HK1254307B (zh) | 2020-03-20 |
CN104768546B (zh) | 2019-04-19 |
PT3527213T (pt) | 2021-10-14 |
CN110101862B (zh) | 2022-11-01 |
EP2911661A4 (en) | 2016-07-20 |
EP2911661A1 (en) | 2015-09-02 |
EP3320906A1 (en) | 2018-05-16 |
CN104768546A (zh) | 2015-07-08 |
HUE038327T2 (hu) | 2018-10-29 |
EP3527213B1 (en) | 2021-07-07 |
PL3527213T3 (pl) | 2022-01-03 |
PL3320906T3 (pl) | 2019-07-31 |
HUE056898T2 (hu) | 2023-06-28 |
US20230338361A1 (en) | 2023-10-26 |
EP3320906B1 (en) | 2019-01-09 |
CN110101862A (zh) | 2019-08-09 |
ES2660739T3 (es) | 2018-03-26 |
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