PT3278800T - Composições e métodos para melhorar a função mitocondrial e tratar condições patológicas relacionadas com músculos - Google Patents

Composições e métodos para melhorar a função mitocondrial e tratar condições patológicas relacionadas com músculos

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Publication number
PT3278800T
PT3278800T PT17186188T PT17186188T PT3278800T PT 3278800 T PT3278800 T PT 3278800T PT 17186188 T PT17186188 T PT 17186188T PT 17186188 T PT17186188 T PT 17186188T PT 3278800 T PT3278800 T PT 3278800T
Authority
PT
Portugal
Prior art keywords
compositions
methods
pathological conditions
mitochondrial function
treating muscle
Prior art date
Application number
PT17186188T
Other languages
English (en)
Inventor
Rinsch Christopher
Schneider Bernard
Andreux Penélope
Sandi Carmen
Auwerx Johan
Pirinen Eija
Thomas Charles
Houtkooper Richardus
Blanco-Bose William
Mouchiroud Laurent
Genoux David
Original Assignee
Amazentis Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amazentis Sa filed Critical Amazentis Sa
Publication of PT3278800T publication Critical patent/PT3278800T/pt

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    • AHUMAN NECESSITIES
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    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/195Carboxylic acids, e.g. valproic acid having an amino group
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    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365Lactones
    • A61K31/366Lactones having six-membered rings, e.g. delta-lactones
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    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
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    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
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  • Obesity (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Nutrition Science (AREA)
  • Mycology (AREA)
  • Botany (AREA)
  • Psychiatry (AREA)
  • Physiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Polymers & Plastics (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Biotechnology (AREA)
  • Alternative & Traditional Medicine (AREA)
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  • Child & Adolescent Psychology (AREA)
PT17186188T 2010-12-23 2011-12-23 Composições e métodos para melhorar a função mitocondrial e tratar condições patológicas relacionadas com músculos PT3278800T (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201061426957P 2010-12-23 2010-12-23

Publications (1)

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PT3278800T true PT3278800T (pt) 2019-08-23

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PT17186188T PT3278800T (pt) 2010-12-23 2011-12-23 Composições e métodos para melhorar a função mitocondrial e tratar condições patológicas relacionadas com músculos

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Country Link
US (10) US9872850B2 (pt)
EP (4) EP2654461B1 (pt)
JP (6) JP6054301B2 (pt)
KR (3) KR102072612B1 (pt)
CN (3) CN113142581A (pt)
AU (5) AU2011348068B2 (pt)
BR (1) BR112013016230B1 (pt)
CA (3) CA3108114C (pt)
CO (1) CO6781551A2 (pt)
ES (2) ES2675345T3 (pt)
HK (1) HK1250643B (pt)
IL (2) IL227071A (pt)
MX (1) MX354875B (pt)
PH (1) PH12020500169A1 (pt)
PT (1) PT3278800T (pt)
RU (2) RU2606763C2 (pt)
SG (3) SG10201602286RA (pt)
WO (1) WO2012088519A2 (pt)

Families Citing this family (83)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1929995A1 (en) 2006-12-04 2008-06-11 INSERM (Institut National de la Santé et de la Recherche Médicale) Anaplerotic therapy of Huntington disease and other polyglutamine diseases
KR102072612B1 (ko) 2010-12-23 2020-02-04 아마젠티스 에스에이 미토콘드리아 기능을 개선하고 신경퇴화 질환들 및 인지 장애들을 치료하는 조성물들 및 방법들
US9040082B2 (en) 2011-06-24 2015-05-26 K-Pax Pharmaceuticals, Inc. Compositions and methods for treatment of chronic fatigue
EP2741757B1 (en) 2011-09-11 2018-05-16 Minovia Therapeutics Ltd. Compositions of functional mitochondria and uses thereof
WO2013132487A1 (en) * 2012-03-07 2013-09-12 Ganir (1992) Ltd. Pomegranate extract for use in treating rhinitis and sinusitis
KR20210128511A (ko) 2012-06-27 2021-10-26 아마젠티스 에스에이 우롤리틴 또는 이의 전구체를 투여에 의한 자가포식 향상 또는 장수 증가
WO2014042261A1 (ja) * 2012-09-13 2014-03-20 森下仁丹株式会社 サーチュイン遺伝子活性増強剤ならびにそれを用いた医薬品、化粧品、および食品
CA2894456C (en) 2012-12-13 2022-06-28 Baylor Research Institute Triheptanoin for the treatment of glucose transporter 1 deficiency
AU2014206777A1 (en) * 2013-01-18 2015-07-09 Procell Sprl Urolithin B for muscle growth
ES2510216B1 (es) * 2013-03-20 2015-10-27 Consejo Superior De Investigaciones Científicas (Csic) Microorganismo capaz de convertir ácido elágico y elagitaninos en urolitinas y uso del mismo
US9325581B2 (en) * 2013-04-02 2016-04-26 International Business Machines Corporation Context-aware management of applications at the edge of a network
WO2015035391A1 (en) * 2013-09-09 2015-03-12 Natreon, Inc. Regulation of body weight gain by using dibenzo-alpha-pyrones
EP2862568A1 (en) 2013-10-15 2015-04-22 Centre National de la Recherche Scientifique (CNRS) Compositions comprising urolithins and uses thereof for the stimulation of insulin secretion
CA2929601A1 (en) * 2013-11-14 2015-05-21 Karin Borges Neurodegenerative disorders and methods of treatment and diagnosis thereof
WO2015100213A2 (en) 2013-12-23 2015-07-02 Amazentis Sa Process-scale synthesis of urolithins
KR101640037B1 (ko) * 2013-12-23 2016-07-18 중앙대학교 산학협력단 흰말채나무 추출물, 이의 분획물 또는 이로부터 분리된 신규 화합물을 포함하는 전립선 질환 치료용 조성물
GB201323008D0 (en) 2013-12-24 2014-02-12 Amazentis As Compounds and uses thereof
EP2908137A1 (en) 2014-02-14 2015-08-19 Institut Pasteur Methods for in vitro investigating mitochondrial replication dysfunction in a biological sample, kits and uses thereof, therapeutic methods against progeroid-like syndromes or symptomes and screening method for identifying particular protease inhibitor(s) and/or nitroso-redox stress scavenger compound(s)
US10524488B2 (en) 2014-12-17 2020-01-07 Colgate-Palmolive Company Composition and method for reducing or treating oral inflammation
EP3233188A4 (en) * 2014-12-19 2018-11-07 Halo Life Science, LLC Use of ellagic acid dihydrate in pharmaceutical formulations to regulate blood glucose levels
WO2016099947A1 (en) * 2014-12-19 2016-06-23 Halo Life Science, Llc Use of ellagic acid dihydrate in food products and nutraceuticals
CN114366802A (zh) * 2015-04-22 2022-04-19 西达-赛奈医疗中心 用于治疗2型糖尿病的肠内递送的苦味寡肽
JP6740548B2 (ja) * 2015-05-15 2020-08-19 公立大学法人岡山県立大学 ウロリチン類を含有する育毛剤、及び、ウロリチン類を含有する5αレダクターゼ活性阻害剤
JP2017014154A (ja) * 2015-07-01 2017-01-19 公立大学法人岡山県立大学 ウロリチン類を含有するヒアルロン酸産生促進剤
JP6799767B2 (ja) * 2015-07-07 2020-12-16 公立大学法人岡山県立大学 ウロリチン類を含有するメラニン産生抑制剤
GB201515391D0 (en) 2015-08-28 2015-10-14 Amazentis Sa Compositions
GB201515387D0 (en) * 2015-08-28 2015-10-14 Amazentis Sa Compositions
US11166972B2 (en) * 2015-12-24 2021-11-09 Amazentis Sa Compositions comprising nicotinamide riboside and a urolithin
US20210161890A1 (en) * 2015-12-31 2021-06-03 Bach Pharma, Inc. Compositions and methods for treating brain dysfunction
EP3412274B1 (en) 2016-02-02 2023-11-08 Daicel Corporation Urolithins-containing aqueous solution, dried solid composition thereof and production method therefor, and urolithins stabilizing method
JP6998108B2 (ja) * 2016-03-07 2022-01-18 株式会社ダイセル ウロリチン類を含有するα-グルコシダーゼ活性阻害剤、およびウロリチン類を含有する血糖値上昇抑制剤
JP2017210444A (ja) * 2016-05-26 2017-11-30 株式会社ダイセル ウロリチン類を含有するリパーゼ阻害剤
JP6791478B2 (ja) * 2016-05-26 2020-11-25 株式会社ダイセル ウロリチン類を含有するアンジオテンシン変換酵素阻害剤
JP6948774B2 (ja) * 2016-09-09 2021-10-13 株式会社ダイセル ウロリチン類を含有する前駆脂肪細胞分化抑制剤
EP3354645A1 (en) 2017-01-26 2018-08-01 Patheon Austria GmbH & Co KG Process for preparing urolithins
JP7325170B2 (ja) * 2017-02-01 2023-08-14 ロート製薬株式会社 美容組成物及びミトコンドリアトランスファー促進剤
EP3592424A1 (en) * 2017-03-08 2020-01-15 Amazentis SA Methods for improving mitophagy in subjects
WO2018162651A1 (en) 2017-03-08 2018-09-13 Amazentis Sa Methods for improving mitophagy in subjects
CA3073406A1 (en) * 2017-09-13 2019-03-21 Alexera Ab Methods for identifying therapeutic agents which interact with stk24
JP2019112364A (ja) * 2017-12-26 2019-07-11 花王株式会社 運動調節機能向上剤
WO2019147652A1 (en) * 2018-01-23 2019-08-01 The General Hospital Corporation Compositions and methods for improving mitochondrial function
AU2018408840A1 (en) * 2018-02-19 2020-09-10 Natreon, Inc. Synergistic combinations of Urolithins A and B for improving cognitive capacity or cognitive function
WO2019163176A1 (ja) * 2018-02-21 2019-08-29 株式会社ダイセル ウロリチン類を含有する破骨細胞分化抑制剤
WO2019163437A1 (ja) 2018-02-21 2019-08-29 株式会社ダイセル ウロリチン類を含有する破骨細胞分化抑制剤
JP7124367B2 (ja) * 2018-03-20 2022-08-24 トヨタ自動車株式会社 作業支援システム、情報処理方法およびプログラム
JP7458368B2 (ja) 2018-07-22 2024-03-29 ミノヴィア セラピューティクス リミテッド 筋疾患のミトコンドリア増強療法
RU2712193C1 (ru) * 2018-07-27 2020-01-24 Общество с ограниченной ответственностью научно-технический центр "БиоКлиникум" (ООО НТЦ "БиоКлиникум") Способ лечения поражения нервной системы с помощью рекомбинантной глутаматоксалоацетаттрансаминазы
MY184810A (en) * 2018-09-03 2021-04-23 Univ Kebangsaan Malaysia Ukm A formulation that reduces oxidative stress
CA3127590A1 (en) 2019-01-28 2020-08-06 Mitochondria Emotion, Inc. Mitofusin activators and methods of use thereof
AU2020215510A1 (en) 2019-01-28 2021-07-22 Mitochondria Emotion, Inc. Trans-4-hydroxycyclohexyl phenyl amide mitofusin activators and methods of use thereof
JP2019142863A (ja) * 2019-02-28 2019-08-29 ヒルズ・ペット・ニュートリシャン・インコーポレーテッド 口内炎症を減少または治療するための組成物および方法
TWI706780B (zh) * 2019-03-27 2020-10-11 台灣粒線體應用技術股份有限公司 粒線體用於製備治療阿茲海默症之醫藥組合物的用途
CN110517776B (zh) * 2019-08-16 2023-06-16 四川大学华西医院 一种老年人健康风险评估方法及其应用
RU2712023C1 (ru) * 2019-08-19 2020-01-24 Федеральное государственное бюджетное учреждение науки "Институт общей и экспериментальной биологии Сибирского отделения Российской академии наук" Способ получения уролитина d, обладающего гипогликемическим действием
GB201912107D0 (en) 2019-08-22 2019-10-09 Amazentis Sa Combination
GB201915191D0 (en) 2019-10-21 2019-12-04 Floratek Gmbh Novel heterocyclic compounds
CN110693880A (zh) * 2019-10-24 2020-01-17 广州中医药大学第一附属医院 一种尿石素制剂及其应用
GB201916046D0 (en) 2019-11-04 2019-12-18 Amazentis Sa Diagnostic method
US20230030835A1 (en) * 2019-12-23 2023-02-02 Metagenics, Inc. Polyphenol compositions and uses thereof
CN111658630B (zh) * 2020-07-21 2021-03-23 温州医科大学附属第一医院 玫瑰酸c在制备预防和/或治疗癫痫的药物中的应用
JP2023542320A (ja) 2020-09-25 2023-10-06 ソシエテ・デ・プロデュイ・ネスレ・エス・アー 水性マトリックス中で少なくとも1つのウロリチンを安定化させるためのキサンタンガムを使用する組成物及び方法
CN112401240A (zh) * 2020-12-10 2021-02-26 泓博元生命科技(深圳)有限公司 线粒体运动营养组合物
KR102623664B1 (ko) * 2020-12-10 2024-01-12 서울대학교산학협력단 유로리틴 a를 이용한 당뇨성 알츠하이머병의 치료 조성물 및 치료 방법
CN112675165A (zh) * 2021-01-22 2021-04-20 新疆医科大学 鞣花酸及其代谢物作为天然抑制剂在制备抗细胞焦亡药物的应用
US11820751B2 (en) 2021-01-27 2023-11-21 Vandria Sa Urolithin derivatives and methods of use thereof
CN112957690B (zh) * 2021-02-03 2021-12-14 台州职业技术学院 脑损伤大鼠多功能康复训练装置
CA3224861A1 (en) * 2021-06-22 2022-12-29 Tsi Usa, Llc Compositions containing adenosine triphosphate (atp) and methods of use for cognitive function
WO2023031673A1 (en) * 2021-08-30 2023-03-09 Amazentis Sa Treating long covid-19 with urolithins
WO2023079366A1 (en) * 2021-11-08 2023-05-11 Ultimate Medicine Ag Methods and compositions for treating microglial dysfunction and improving metabolic dysfunction
AU2022423568A1 (en) * 2021-12-20 2024-05-23 Société des Produits Nestlé S.A. Compositions comprising urolithin for treating muscle decline and a kidney dysfunction
WO2023161453A1 (en) 2022-02-24 2023-08-31 Amazentis Sa Uses of urolithins
WO2023180214A1 (en) 2022-03-22 2023-09-28 Amazentis Sa Compositions
CN116920001A (zh) * 2022-03-30 2023-10-24 福建中益制药有限公司 一种降低高尿酸的中药组合物及其制备方法
WO2023228994A1 (ja) * 2022-05-25 2023-11-30 株式会社ダイセル Sirt3遺伝子発現増強用組成物
WO2024058984A2 (en) * 2022-09-16 2024-03-21 MarvelBiome, Inc. Methods and uses of microbiome compositions, components, or metabolites for treating insulin-associated diseases
CN115462488B (zh) * 2022-10-08 2024-01-16 河南师范大学 鞣花酸作为饲料添加剂的应用,功能性饲料及制备方法
CN115581689B (zh) * 2022-10-17 2024-05-14 常州大学 尿石素b酰胺类衍生物的应用
CN115969852B (zh) * 2022-10-17 2024-06-18 常州大学 甲氧基尿石素a酰胺类衍生物的应用
EP4356757A1 (en) 2022-10-18 2024-04-24 Consejo Superior de Investigaciones Científicas (CSIC) Microbial method for reproducing the human urolithin metabotypes in vitro and in vivo
WO2024096818A1 (en) * 2022-10-31 2024-05-10 Delightex Pte. Ltd. Compositions and methods for enhancing mental wellbeing
CN115569131A (zh) * 2022-11-03 2023-01-06 北京工商大学 尿石素a在抗抑郁药物及抗抑郁保健食品中的应用
GB202219317D0 (en) 2022-12-20 2023-02-01 Amazentis Sa Methods for improving mitophagy in subjects
KR102612714B1 (ko) * 2023-01-03 2023-12-11 한림대학교 산학협력단 디티아논에 의해 유도된 도파민 신경 손상 관련 증상의 경감용 조성물 및 신경 손상 관련 증상의 경감 방법

Family Cites Families (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1002893A (en) 1910-02-07 1911-09-12 Joe R Wood Rope-clip.
JPH02304080A (ja) 1989-05-17 1990-12-17 Toyo Pharma- Kk 6H―ジベンゾ[b,d]ピラン―6―オン誘導体,その製法及び用途
US5411757A (en) * 1989-11-09 1995-05-02 Buist; Neil R. M. Palatable balanced amino acid-modified diet
KR20000019718A (ko) * 1998-09-15 2000-04-15 박호군 탄닌 또는 탄닌 유래 페놀성 화합물을 포함하는 동맥경화증, 고지혈증 및 간질환의 예방 및 치료용 조성물
US20030078212A1 (en) * 1998-10-30 2003-04-24 Jia-He Li Pharmaceutical compositions containing poly(adp-ribose) glycohydrolase inhibitors and methods of using the same
US7611738B2 (en) 2005-05-24 2009-11-03 Pom Wonderful, Llc Processes for extracting phytochemicals from pomegranate solids and compositions and methods of use thereof
US7727563B2 (en) * 1999-04-19 2010-06-01 Pom Wonderful, Llc Methods of using pomegranate extracts for treating diabetes related atherosclerotic complications in humans
US20010047032A1 (en) 1999-12-30 2001-11-29 Castillo Gerardo M. Polyhydroxylated aromatic compounds for the treatment of amyloidosis and alpha-synuclein fibril diseases
US6670140B2 (en) * 2001-03-06 2003-12-30 The Procter & Gamble Company Methods for identifying compounds for regulating muscle mass or function using corticotropin releasing factor receptors
US6440436B1 (en) 2001-05-18 2002-08-27 Natreon Inc. Process for preparing purified shilajit composition from native shilajit
US20080039179A1 (en) 2001-06-27 2008-02-14 Seelig Jerald C Gaming display with moveable indicator and methods of use
US6503506B1 (en) 2001-08-10 2003-01-07 Millenium Biotechnologies, Inc. Nutrient therapy for immuno-compromised patients
CN100339090C (zh) * 2002-06-04 2007-09-26 枣庄市清泽源生物科技有限公司 新的石榴叶提取物及其医药用途
WO2005000330A1 (en) 2003-05-28 2005-01-06 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Angiogenic agents from plant extracts, gallic acid, and derivatives
CN1483343A (zh) * 2003-07-31 2004-03-24 枣庄绿宝石榴产品有限公司 一种石榴食用品及其制备方法和应用
NZ529860A (en) * 2003-11-28 2006-10-27 Ovita Ltd Muscle growth regulator mighty and use in promoting muscle mass and treating muscle wasting diseases
DK1734949T3 (en) 2004-03-24 2015-08-24 Univ California Remediation of ellagitannins
US20050282781A1 (en) 2004-06-18 2005-12-22 Shibnath Ghosal Compositions of stable bioactive metabolites of docosahexaenoic (DHA) and eicosapentaenoic (EPA) acids
CN101039683A (zh) * 2004-08-13 2007-09-19 血管技术国际有限公司 使用透明质酸和透明质酸酶抑制剂的组合物和方法
US20080214656A1 (en) * 2004-08-23 2008-09-04 Neurogenex Co., Ltd. Compounds With Diphenoyl-Structure For the Treatment of Immune Diseases
US8183282B2 (en) * 2006-04-26 2012-05-22 The Regents Of The University Of California Therapeutic uses of urolithins
EP2036551B1 (en) * 2006-07-05 2013-11-06 Kao Corporation Catechins for improving muscle power
US20080021340A1 (en) * 2006-07-19 2008-01-24 Mika Sarkela Detection of focal epileptiform activity
US20080031979A1 (en) * 2006-08-04 2008-02-07 Claude Saliou Use of extracts for the treatment of viral disorders
US8894993B2 (en) 2006-08-04 2014-11-25 Natreon Inc. Mitochondria-targeted antioxidants
US20080199546A1 (en) * 2006-10-24 2008-08-21 Krempin David W Anti-resorptive and bone building dietary supplements and methods of use
US8017147B2 (en) 2008-04-07 2011-09-13 Mazed Mohammad A Nutritional supplement for the prevention of cardiovascular disease, alzheimer's disease, diabetes, and regulation and reduction of blood sugar and insulin resistance
US8367072B2 (en) 2006-12-08 2013-02-05 Polifenoles Naturales, S.L. Composition for treating obesity and method of using the same
US7972633B2 (en) 2007-02-07 2011-07-05 Applied Cognitive Sciences, LLC Nutritional supplements for healthy memory and mental function
EP2155186A2 (fr) * 2007-05-11 2010-02-24 Galderma Research & Development Preparations pharmaceutiques ou cosmetiques pour application topique et/ou parenterale, leurs procedes de preparation, et leurs utilisations
CN100589813C (zh) * 2007-05-30 2010-02-17 桂林莱茵生物科技股份有限公司 一种石榴皮提取物及其制备方法
EP2033526A1 (en) * 2007-09-07 2009-03-11 Probelte Pharma, S.A. Nutritional products comprising pomegranate extracts containing ellagitannins and their use
CN101254223A (zh) * 2008-03-04 2008-09-03 东莞市竟恒流通研究所 石榴皮和石榴籽提取物改善***症状的新用途
US7927633B2 (en) 2008-03-28 2011-04-19 Janiece Diane Swilling Adaptogenic tea
CN101273790B (zh) * 2008-04-22 2011-09-28 吐地·艾力 一种石榴原汁的制备方法
WO2009153652A2 (en) * 2008-06-19 2009-12-23 Avesthagen Limited An extract and a process thereof (pomplex)
US20100004334A1 (en) * 2008-07-01 2010-01-07 Mead Johnson Nutrition Company Nutritional Compositions Containing Punicalagins
CN101301319A (zh) 2008-07-09 2008-11-12 中国科学院新疆理化技术研究所 石榴花多酚的制备方法及其应用
US20100055247A1 (en) 2008-08-29 2010-03-04 Tirrito Salvatore J Nutritional Compositions for Athletes
KR101046126B1 (ko) * 2008-11-28 2011-07-01 고려대학교 산학협력단 석류 추출물을 포함하는 신경계 질환 예방 또는 치료용 조성물
KR101099718B1 (ko) * 2008-12-26 2011-12-28 고흥석류친환경영농조합법인 석류 추출물을 함유하는 비만 예방 및 치료용 조성물
JP5385686B2 (ja) 2009-06-05 2014-01-08 サントリーホールディングス株式会社 血小板凝集抑制剤
SG10201500620PA (en) * 2009-07-24 2015-03-30 Amazentis Sa Compounds, compositions and methods for protecting brain health in neurodegenerative disorders
CN101695511B (zh) * 2009-10-29 2012-10-17 新疆维吾尔自治区药物研究所 石榴皮提取物及其生产方法和应用
KR102072612B1 (ko) 2010-12-23 2020-02-04 아마젠티스 에스에이 미토콘드리아 기능을 개선하고 신경퇴화 질환들 및 인지 장애들을 치료하는 조성물들 및 방법들
FR2975008B1 (fr) 2011-05-13 2014-03-07 Inst Biophytis Utilisation de composes et composition pour le traitement de la degenerescence maculaire liee a l'age (dmla)

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