PT3101132T - Anticorpo humano anti-transtirretina - Google Patents

Anticorpo humano anti-transtirretina

Info

Publication number
PT3101132T
PT3101132T PT157435413T PT15743541T PT3101132T PT 3101132 T PT3101132 T PT 3101132T PT 157435413 T PT157435413 T PT 157435413T PT 15743541 T PT15743541 T PT 15743541T PT 3101132 T PT3101132 T PT 3101132T
Authority
PT
Portugal
Prior art keywords
human antibody
transthyretin
transthyretin human
antibody
human
Prior art date
Application number
PT157435413T
Other languages
English (en)
Original Assignee
Km Biologics Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Km Biologics Co Ltd filed Critical Km Biologics Co Ltd
Publication of PT3101132T publication Critical patent/PT3101132T/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/0005Vertebrate antigens
    • A61K39/0007Nervous system antigens; Prions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/005Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies constructed by phage libraries
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896Neurological disorders, e.g. Alzheimer's disease
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/70Mechanisms involved in disease identification
    • G01N2800/7047Fibrils-Filaments-Plaque formation
PT157435413T 2014-01-29 2015-01-23 Anticorpo humano anti-transtirretina PT3101132T (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2014014912 2014-01-29

Publications (1)

Publication Number Publication Date
PT3101132T true PT3101132T (pt) 2021-12-31

Family

ID=53756906

Family Applications (1)

Application Number Title Priority Date Filing Date
PT157435413T PT3101132T (pt) 2014-01-29 2015-01-23 Anticorpo humano anti-transtirretina

Country Status (7)

Country Link
US (2) US10597440B2 (pt)
EP (2) EP3101132B1 (pt)
JP (2) JP6517156B2 (pt)
KR (1) KR102240417B1 (pt)
CN (1) CN106459956B (pt)
PT (1) PT3101132T (pt)
WO (1) WO2015115332A1 (pt)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10464999B2 (en) 2015-01-28 2019-11-05 Prothena Biosciences Limited Anti-transthyretin antibodies
US9879080B2 (en) 2015-01-28 2018-01-30 Prothena Biosciences Limited Anti-transthyretin antibodies
US10633433B2 (en) 2015-01-28 2020-04-28 Prothena Biosciences Limited Anti-transthyretin antibodies
JP7292569B2 (ja) * 2017-10-06 2023-06-19 ノボ ノルディスク エー/エス トランスサイレチンを検出する方法
MX2020003041A (es) 2017-10-06 2020-10-05 Prothena Biosciences Ltd Anticuerpos anti-transtiretina.
MA51223A (fr) 2017-11-29 2020-10-07 Prothena Biosciences Ltd Formulation lyophilisée d'un anticorps monoclonal contre la transthyrétine
EP3814376A4 (en) * 2018-06-26 2022-07-06 Mor Research Applications Ltd. ANTI-TRANSTHYRETIN ANTIBODIES AND THEIR USES
CA3172824A1 (en) 2020-05-12 2021-11-18 Neurimmune Ag Combination therapy for ttr amyloidosis
WO2023099788A1 (en) 2021-12-03 2023-06-08 Neurimmune Ag Novel potency assay for antibody-based drugs and useful means therefor

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050164365A1 (en) 2001-07-06 2005-07-28 Juridical Foundation The Chemosero-Therapeutic Research Institute Genetically modified ecarin and process for producing the same
US20040151721A1 (en) * 2001-10-19 2004-08-05 O'keefe Theresa Humanized anti-CCR2 antibodies and methods of use therefor
US7601351B1 (en) * 2002-06-26 2009-10-13 Human Genome Sciences, Inc. Antibodies against protective antigen
CA2975568A1 (en) 2007-10-25 2009-04-30 The Scripps Research Institute Antibody-mediated disruption of quorum sensing in bacteria
NZ586875A (en) * 2007-12-28 2012-10-26 Elan Pharm Inc Treatment and prophylaxis of amyloidosis with an antibody that binds a specific epitope of human amyloid A peptide
WO2010030203A1 (en) * 2008-09-09 2010-03-18 Biocodex - Incubação De Empresas De Ciências Da Vida, S.A. Monoclonal antibody to human amyloidogenic and modified forms of transthyretin and its use in the detection and treatment of fap and pathologies presenting modified ttr
JP2010195710A (ja) 2009-02-25 2010-09-09 Kumamoto Univ アミロイド線維形成抑制剤及びその利用
AU2013203506B2 (en) 2012-02-24 2016-06-09 Abbvie Stemcentrx Llc Novel modulators and methods of use
US9534048B2 (en) 2012-08-24 2017-01-03 University Health Network Antibodies to TTR and methods of use
EP2953970A4 (en) 2013-02-08 2016-06-29 Misfolding Diagnostics Inc TRANSTYRETIN ANTIBODIES AND USES THEREOF

Also Published As

Publication number Publication date
CN106459956A (zh) 2017-02-22
WO2015115332A1 (ja) 2015-08-06
US11186630B2 (en) 2021-11-30
US10597440B2 (en) 2020-03-24
CN106459956B (zh) 2019-12-17
EP3981874A1 (en) 2022-04-13
EP3101132A4 (en) 2017-09-13
KR20160113208A (ko) 2016-09-28
JP2019191174A (ja) 2019-10-31
JPWO2015115332A1 (ja) 2017-03-23
JP6517156B2 (ja) 2019-05-22
KR102240417B1 (ko) 2021-04-13
EP3101132A1 (en) 2016-12-07
JP6759408B2 (ja) 2020-09-23
US20160340419A1 (en) 2016-11-24
US20200181250A1 (en) 2020-06-11
EP3101132B1 (en) 2021-12-22

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