PT2784157T - Método para conceber proteínas de ligação a rna usando o motivo ppr e sua utilização - Google Patents

Método para conceber proteínas de ligação a rna usando o motivo ppr e sua utilização

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Publication number
PT2784157T
PT2784157T PT128414356T PT12841435T PT2784157T PT 2784157 T PT2784157 T PT 2784157T PT 128414356 T PT128414356 T PT 128414356T PT 12841435 T PT12841435 T PT 12841435T PT 2784157 T PT2784157 T PT 2784157T
Authority
PT
Portugal
Prior art keywords
rna
binding protein
design method
ppr motif
ppr
Prior art date
Application number
PT128414356T
Other languages
English (en)
Inventor
Nakamura Takahiro
Yagi Yusuke
Kobayashi Keiko
Original Assignee
Univ Kyushu Nat Univ Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Kyushu Nat Univ Corp filed Critical Univ Kyushu Nat Univ Corp
Publication of PT2784157T publication Critical patent/PT2784157T/pt

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    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B15/00—ICT specially adapted for analysing two-dimensional or three-dimensional molecular structures, e.g. structural or functional relations or structure alignment
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8216—Methods for controlling, regulating or enhancing expression of transgenes in plant cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8261—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
    • C12N15/8287—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for fertility modification, e.g. apomixis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8261—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
    • C12N15/8287—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for fertility modification, e.g. apomixis
    • C12N15/8289—Male sterility
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5308—Immunoassay; Biospecific binding assay; Materials therefor for analytes not provided for elsewhere, e.g. nucleic acids, uric acid, worms, mites
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G16B20/30—Detection of binding sites or motifs
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G16B20/50—Mutagenesis
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • G16B30/10—Sequence alignment; Homology search
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B35/00—ICT specially adapted for in silico combinatorial libraries of nucleic acids, proteins or peptides
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16C—COMPUTATIONAL CHEMISTRY; CHEMOINFORMATICS; COMPUTATIONAL MATERIALS SCIENCE
    • G16C20/00—Chemoinformatics, i.e. ICT specially adapted for the handling of physicochemical or structural data of chemical particles, elements, compounds or mixtures
    • G16C20/60—In silico combinatorial chemistry
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/85—Fusion polypeptide containing an RNA binding domain
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2522/00—Reaction characterised by the use of non-enzymatic proteins
    • C12Q2522/10—Nucleic acid binding proteins
    • C12Q2522/101—Single or double stranded nucleic acid binding proteins
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Theoretical Computer Science (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Medical Informatics (AREA)
  • Evolutionary Biology (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Plant Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Botany (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Library & Information Science (AREA)
  • Computing Systems (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Tropical Medicine & Parasitology (AREA)
PT128414356T 2011-10-21 2012-10-22 Método para conceber proteínas de ligação a rna usando o motivo ppr e sua utilização PT2784157T (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2011231346 2011-10-21

Publications (1)

Publication Number Publication Date
PT2784157T true PT2784157T (pt) 2019-10-29

Family

ID=48141047

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PT128414356T PT2784157T (pt) 2011-10-21 2012-10-22 Método para conceber proteínas de ligação a rna usando o motivo ppr e sua utilização

Country Status (8)

Country Link
US (7) US9513283B2 (pt)
EP (2) EP2784157B1 (pt)
JP (8) JP6164488B2 (pt)
AU (4) AU2012326971C1 (pt)
DK (1) DK2784157T3 (pt)
ES (1) ES2751126T3 (pt)
PT (1) PT2784157T (pt)
WO (1) WO2013058404A1 (pt)

Families Citing this family (26)

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AU2012326971C1 (en) 2011-10-21 2018-02-08 Kyushu University, National University Corporation Method for designing RNA binding protein utilizing PPR motif, and use thereof
EP2838912A4 (en) * 2012-04-16 2015-11-18 Univ Western Australia PEPTIDES FOR BINDING NUCLEOTIDE TARGETS
NZ714264A (en) * 2013-04-22 2020-10-30 Univ Kyushu Nat Univ Corp Dna-binding protein using ppr motif, and use thereof
EP3613854A1 (en) 2014-03-05 2020-02-26 National University Corporation Kobe University Genomic sequence modification method for specifically converting nucleic acid bases of targeted dna sequence, and molecular complex for use in same
ES2938623T3 (es) 2015-09-09 2023-04-13 Univ Kobe Nat Univ Corp Método para convertir una secuencia del genoma de una bacteria gram-positiva mediante una conversión específica de una base de ácido nucleico de una secuencia de ADN seleccionada como diana y el complejo molecular utilizado en el mismo
JP2019500899A (ja) 2015-11-23 2019-01-17 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア ＣＲＩＳＰＲ／Ｃａｓ９の核送達を通じた細胞ＲＮＡの追跡と操作
KR102061438B1 (ko) 2015-11-27 2019-12-31 고쿠리츠다이가쿠호진 고베다이가쿠 표적화 dna 서열 중의 핵산 염기가 특이적으로 전환되어 있는 단자엽식물 게놈 서열을 전환시키는 방법, 및 그것에 사용되는 분자 복합체
US11136361B2 (en) 2016-06-03 2021-10-05 Kyushu University, National University Corporation Fusion protein for improving protein expression from target mRNA
SG11201810606TA (en) * 2016-06-03 2018-12-28 Univ Kyushu Nat Univ Corp FUSION PROTEIN FOR IMPROVING PROTEIN EXPRESSION FROM TARGET mRNA
CN109563137A (zh) * 2016-08-10 2019-04-02 富士胶片和光纯药株式会社 利用了ppr基序的dna结合性蛋白质及其应用
AU2018265022A1 (en) 2017-05-10 2019-11-21 The Regents Of The University Of California Directed editing of cellular RNA via nuclear delivery of CRISPR/Cas9
CN108932400B (zh) * 2017-05-24 2021-07-23 北京工业大学 一种考虑界面信息的有效的蛋白质-rna复合物结构预测方法
CN108959852B (zh) * 2017-05-24 2021-12-24 北京工业大学 基于氨基酸-核苷酸成对偏好性信息的蛋白质上与rna结合模块的预测方法
KR20210058806A (ko) 2018-06-08 2021-05-24 로카나바이오 인크. Rna 표적화 융합 단백질 조성물 및 사용 방법
US20220220166A1 (en) 2019-05-29 2022-07-14 Editforce, Inc. Ppr protein causing less aggregation and use of the same
WO2020241876A1 (ja) 2019-05-29 2020-12-03 エディットフォース株式会社 効率的なｐｐｒタンパク質の作製方法及びその利用
EP3997227A1 (en) 2019-07-10 2022-05-18 Locanabio, Inc. Rna-targeting knockdown and replacement compositions and methods for use
BR112022019571A2 (pt) 2020-03-31 2022-12-06 Editforce Inc Método para editar um ácido ribonucleico alvo, domínio dyw, proteína dyw, composição para editar ácido ribonucleico em uma célula eucariótica, ácido nucleico, vetor, e, célula
CA3200588A1 (en) 2020-12-01 2022-06-09 David A. Nelles Rna-targeting compositions and methods for treating myotonic dystrophy type 1
AU2021391643A1 (en) 2020-12-01 2023-06-29 Locanabio, Inc. Rna-targeting compositions and methods for treating cag repeat diseases
WO2022221278A1 (en) 2021-04-12 2022-10-20 Locanabio, Inc. Compositions and methods comprising hybrid promoters
WO2022226375A1 (en) 2021-04-23 2022-10-27 Locanabio, Inc. Tissue-targeted modified aav capsids and methods of use thereof
CA3216419A1 (en) 2021-04-23 2022-10-27 Greg NACHTRAB Tissue-targeted modified aav capsids and methods of use thereof
IL308029A (en) 2021-04-30 2023-12-01 Editforce Inc Therapeutic drug for myotonic dystrophy type 1
JP7125727B1 (ja) * 2021-09-07 2022-08-25 国立大学法人千葉大学 核酸配列改変用組成物および核酸配列の標的部位を改変する方法
WO2023154807A2 (en) 2022-02-09 2023-08-17 Locanabio, Inc. Compositions and methods for modulating pre-mrna splicing

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EP1382612B1 (en) 2001-04-25 2011-07-27 Institut National de la Recherche Agronomique Protein participating in restoration from cytoplasmic male sterility to fertility and gene encoding the same
JP4102099B2 (ja) 2001-04-25 2008-06-18 アンスティテュ ナシオナル ドゥ ラ ルシェルシュ アグロノミック 細胞質雄性不稔から可稔への回復に関与するタンパク質及びそれをコードする遺伝子
JP2002355041A (ja) * 2001-04-25 2002-12-10 Mitsubishi Chemicals Corp 細胞質雄性不稔から可稔への回復に関与する遺伝子
US20040117868A1 (en) 2002-01-29 2004-06-17 Jun Imamura Protein participating in restoration from cytoplasmic male sterility to fertility and gene encoding the same
US20060041961A1 (en) 2004-03-25 2006-02-23 Abad Mark S Genes and uses for pant improvement
US8344122B2 (en) 2008-03-12 2013-01-01 Tohoku University Fertility restorer gene and fertility restoration method for CW-type male sterile cytoplasm of rice
WO2011072246A2 (en) 2009-12-10 2011-06-16 Regents Of The University Of Minnesota Tal effector-mediated dna modification
JP2013128413A (ja) * 2010-03-11 2013-07-04 Kyushu Univ Ｐｐｒモチーフを利用したｒｎａ結合性蛋白質の改変方法
AU2012326971C1 (en) * 2011-10-21 2018-02-08 Kyushu University, National University Corporation Method for designing RNA binding protein utilizing PPR motif, and use thereof
EP2838912A4 (en) * 2012-04-16 2015-11-18 Univ Western Australia PEPTIDES FOR BINDING NUCLEOTIDE TARGETS

Also Published As

Publication number Publication date
EP2784157A4 (en) 2015-07-01
US20200294626A1 (en) 2020-09-17
JP6454398B2 (ja) 2019-01-16
US20210249103A1 (en) 2021-08-12
EP2784157A1 (en) 2014-10-01
US20140335521A1 (en) 2014-11-13
JP7381133B2 (ja) 2023-11-15
EP2784157B1 (en) 2019-09-18
JP6164488B2 (ja) 2017-07-19
JP2024010112A (ja) 2024-01-23
JP7157483B2 (ja) 2022-10-20
AU2012326971A1 (en) 2014-06-12
US11742056B2 (en) 2023-08-29
AU2012326971B2 (en) 2017-10-19
JPWO2013058404A1 (ja) 2015-04-02
US20170124252A1 (en) 2017-05-04
US20240047005A1 (en) 2024-02-08
US10679731B2 (en) 2020-06-09
EP3611261A1 (en) 2020-02-19
JP2017148078A (ja) 2017-08-31
JP6934644B2 (ja) 2021-09-15
JP2018078896A (ja) 2018-05-24
ES2751126T3 (es) 2020-03-30
JP2018042569A (ja) 2018-03-22
JP2021130678A (ja) 2021-09-09
DK2784157T3 (da) 2019-10-21
AU2019280013A1 (en) 2020-01-16
JP6270192B2 (ja) 2018-01-31
AU2012326971C1 (en) 2018-02-08
AU2017254874B2 (en) 2019-09-12
US9984202B2 (en) 2018-05-29
AU2019280013B2 (en) 2022-03-31
US10340028B2 (en) 2019-07-02
US9513283B2 (en) 2016-12-06
US20190311783A1 (en) 2019-10-10
WO2013058404A1 (ja) 2013-04-25
US20180247018A1 (en) 2018-08-30
AU2022204654A1 (en) 2022-07-21
AU2017254874A1 (en) 2017-11-16
JP2022177289A (ja) 2022-11-30
JP2017192391A (ja) 2017-10-26
US10943671B2 (en) 2021-03-09
JP6267388B2 (ja) 2018-01-24

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