PT2687532T - Novo derivado de octa-hidrotienoquinolina, composição farmacêutica compreendendo o derivado, e utilização dos mesmos - Google Patents

Novo derivado de octa-hidrotienoquinolina, composição farmacêutica compreendendo o derivado, e utilização dos mesmos

Info

Publication number
PT2687532T
PT2687532T PT127583284T PT12758328T PT2687532T PT 2687532 T PT2687532 T PT 2687532T PT 127583284 T PT127583284 T PT 127583284T PT 12758328 T PT12758328 T PT 12758328T PT 2687532 T PT2687532 T PT 2687532T
Authority
PT
Portugal
Prior art keywords
derivative
pharmaceutical composition
novel
octahydrothienoquinoline
novel octahydrothienoquinoline
Prior art date
Application number
PT127583284T
Other languages
English (en)
Inventor
Nishimura Toshihiro
Teranishi Hirotaka
Yoshida Masako
Ueno Yasunori
Kasai Kiyoshi
Original Assignee
Kissei Pharmaceutical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kissei Pharmaceutical filed Critical Kissei Pharmaceutical
Publication of PT2687532T publication Critical patent/PT2687532T/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D495/00Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4365Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/4523Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/06Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
PT127583284T 2011-03-14 2012-03-12 Novo derivado de octa-hidrotienoquinolina, composição farmacêutica compreendendo o derivado, e utilização dos mesmos PT2687532T (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2011055154 2011-03-14

Publications (1)

Publication Number Publication Date
PT2687532T true PT2687532T (pt) 2017-03-22

Family

ID=46830720

Family Applications (1)

Application Number Title Priority Date Filing Date
PT127583284T PT2687532T (pt) 2011-03-14 2012-03-12 Novo derivado de octa-hidrotienoquinolina, composição farmacêutica compreendendo o derivado, e utilização dos mesmos

Country Status (22)

Country Link
US (1) US9138434B2 (pt)
EP (1) EP2687532B1 (pt)
JP (1) JP5563716B2 (pt)
KR (1) KR101618624B1 (pt)
CN (2) CN103443106B (pt)
AU (1) AU2012227428B2 (pt)
BR (1) BR112013023575B1 (pt)
CA (1) CA2827629C (pt)
DK (1) DK2687532T3 (pt)
ES (1) ES2613658T3 (pt)
HK (1) HK1188791A1 (pt)
HU (1) HUE033449T2 (pt)
IL (1) IL228318A (pt)
MX (1) MX343077B (pt)
MY (1) MY183288A (pt)
PL (1) PL2687532T3 (pt)
PT (1) PT2687532T (pt)
RU (1) RU2573399C2 (pt)
SG (1) SG193400A1 (pt)
TW (1) TWI537274B (pt)
WO (1) WO2012124649A1 (pt)
ZA (1) ZA201306905B (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6166990B2 (ja) * 2012-09-12 2017-07-19 キッセイ薬品工業株式会社 オクタヒドロチエノキノリン誘導体の製造方法及びその製造中間体
EP2930175A4 (en) 2012-12-10 2016-12-21 Kissei Pharmaceutical NOVEL OCTAHYDROPYRIDOQUINAZOLINE DERIVATIVE, PHARMACEUTICAL COMPOSITION CONTAINING THE SAME, AND USES THEREFOR, AND THE DERIVATIVE THEREOF
WO2014112492A1 (ja) * 2013-01-17 2014-07-24 キッセイ薬品工業株式会社 新規なオクタヒドロキノリン誘導体、それを含有する医薬組成物およびそれらの用途
KR102169337B1 (ko) 2018-08-22 2020-10-23 주식회사 도원엔바이로 질소와 인의 흡착형 세라믹 미생물 담체 및 이의 제조방법
EP4177257A1 (en) 2020-07-06 2023-05-10 Kissei Pharmaceutical Co., Ltd. Succinate of octahydrothienoquinoline compound, and crystals thereof
CN116348470A (zh) * 2020-10-07 2023-06-27 橘生药品工业株式会社 八氢噻吩并喹啉化合物的制造方法和其制造中间体

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH507249A (de) 1968-05-31 1971-05-15 Sandoz Ag Verfahren zur Herstellung von 2-Brom-a-ergokryptin
BG17786A3 (pt) 1970-08-14 1973-12-25
US4166182A (en) 1978-02-08 1979-08-28 Eli Lilly And Company 6-n-propyl-8-methoxymethyl or methylmercaptomethylergolines and related compounds
NZ190834A (en) * 1979-01-22 1984-07-06 Lilly Co Eli Trans-dl-5-(alkyl or allyl)-4,4a,5,6,7,8,8a,9-octahydro-21 + pyrrolo(3,4-g)quinolines,
US4526892A (en) * 1981-03-03 1985-07-02 Farmitalia Carlo Erba, S.P.A. Dimethylaminoalkyl-3-(ergoline-8'βcarbonyl)-ureas
US4452808A (en) 1982-12-07 1984-06-05 Smithkline Beckman Corporation 4-Aminoalkyl-2(3H)-indolones
US4501890A (en) * 1983-09-26 1985-02-26 Eli Lilly And Company Trans-(±)-2,4,6-substituted-5,5a,6,7,8,9,9a,10-octahydro-pyrimido[4,5-g]quinolines
US4537893A (en) * 1984-04-27 1985-08-27 Eli Lilly And Company Octahydrothiazolo[4,5-g]quinolines and use as prolactin secretion inhibitors
ATE45735T1 (de) 1984-12-22 1989-09-15 Thomae Gmbh Dr K Tetrahydro-benzthiazole, deren herstellung und deren verwendung als zwischenprodukte oder als arnzneimittel.
US4826986A (en) * 1986-06-16 1989-05-02 Eli Lilly And Company 6-Oxo-trans-octa- and decahydroquinolines
US5057515A (en) * 1989-07-24 1991-10-15 Eli Lilly And Company Method for agonizing a dopamine receptor
US7026484B2 (en) * 2001-02-23 2006-04-11 Ligand Pharmaceuticals Incorporated Tricyclic androgen receptor modulator compounds and methods
JP2005129430A (ja) * 2003-10-27 2005-05-19 Konica Minolta Holdings Inc 光電変換材料用半導体、光電変換素子及び太陽電池

Also Published As

Publication number Publication date
WO2012124649A1 (ja) 2012-09-20
MY183288A (en) 2021-02-18
EP2687532A4 (en) 2014-08-13
KR20140010137A (ko) 2014-01-23
ZA201306905B (en) 2014-12-23
EP2687532A1 (en) 2014-01-22
AU2012227428A1 (en) 2013-09-26
IL228318A0 (en) 2013-11-25
CA2827629A1 (en) 2012-09-20
NZ615293A (en) 2014-08-29
PL2687532T3 (pl) 2017-06-30
CA2827629C (en) 2019-01-08
HUE033449T2 (en) 2017-11-28
BR112013023575A2 (pt) 2016-12-06
RU2013145799A (ru) 2015-04-20
MX343077B (es) 2016-10-24
HK1188791A1 (zh) 2014-05-16
IL228318A (en) 2017-07-31
TW201242970A (en) 2012-11-01
JP5563716B2 (ja) 2014-07-30
SG193400A1 (en) 2013-10-30
MX2013010587A (es) 2013-10-07
CN104829628A (zh) 2015-08-12
TWI537274B (zh) 2016-06-11
JPWO2012124649A1 (ja) 2014-07-24
US20140243311A1 (en) 2014-08-28
ES2613658T3 (es) 2017-05-25
AU2012227428B2 (en) 2016-05-05
CN103443106B (zh) 2015-09-30
BR112013023575A8 (pt) 2018-01-16
CN103443106A (zh) 2013-12-11
RU2573399C2 (ru) 2016-01-20
EP2687532B1 (en) 2016-12-14
DK2687532T3 (en) 2017-02-20
BR112013023575B1 (pt) 2021-12-21
CN104829628B (zh) 2018-01-09
US9138434B2 (en) 2015-09-22
KR101618624B1 (ko) 2016-05-09

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