PT2593556T - Método enzimático de (r)-aminação seletiva - Google Patents

Método enzimático de (r)-aminação seletiva

Info

Publication number
PT2593556T
PT2593556T PT117338376T PT11733837T PT2593556T PT 2593556 T PT2593556 T PT 2593556T PT 117338376 T PT117338376 T PT 117338376T PT 11733837 T PT11733837 T PT 11733837T PT 2593556 T PT2593556 T PT 2593556T
Authority
PT
Portugal
Prior art keywords
enzymatic method
selective amination
amination
selective
enzymatic
Prior art date
Application number
PT117338376T
Other languages
English (en)
Inventor
Schürmann Martin
Peter Helena Peeters Wijnand
Hubertina Johannes Smeets Natascha
Schwab Helmut
Steiner Kerstin
Mykolayivna Lypetska Kateryna
Strohmeier Gernot
Original Assignee
Dpx Holdings Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dpx Holdings Bv filed Critical Dpx Holdings Bv
Publication of PT2593556T publication Critical patent/PT2593556T/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/001—Amines; Imines
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1096—Transferases (2.) transferring nitrogenous groups (2.6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y206/00—Transferases transferring nitrogenous groups (2.6)
    • C12Y206/01—Transaminases (2.6.1)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
PT117338376T 2010-07-14 2011-07-14 Método enzimático de (r)-aminação seletiva PT2593556T (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP10169573 2010-07-14

Publications (1)

Publication Number Publication Date
PT2593556T true PT2593556T (pt) 2017-12-11

Family

ID=43844620

Family Applications (1)

Application Number Title Priority Date Filing Date
PT117338376T PT2593556T (pt) 2010-07-14 2011-07-14 Método enzimático de (r)-aminação seletiva

Country Status (8)

Country Link
US (2) US20140199734A1 (pt)
EP (1) EP2593556B1 (pt)
JP (1) JP5999565B2 (pt)
CN (1) CN103189519B (pt)
ES (1) ES2650245T3 (pt)
MX (1) MX350510B (pt)
PT (1) PT2593556T (pt)
WO (1) WO2012007548A1 (pt)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103189519B (zh) 2010-07-14 2018-01-26 DPx控股有限公司 (r)‑选择性胺化
CN104185634B (zh) * 2012-03-23 2017-05-03 诺华股份有限公司 制备螺旋吲哚酮和其中间体的化学工艺
PL2828256T3 (pl) * 2012-03-23 2019-12-31 Novartis Ag Chemiczny sposób wytwarzania spiroindolonów i ich związków pośrednich
WO2014037376A1 (en) 2012-09-04 2014-03-13 C5 Ligno Technologies In Lund Ab Stereoselective biosynthesis in microbial host cells
EP2909327A1 (en) * 2012-10-18 2015-08-26 Sandoz AG A process for preparing indoline derivatives
KR101493311B1 (ko) 2012-12-13 2015-02-16 연세대학교 산학협력단 광학 활성 아민 및 호모알라닌의 제조방법
WO2014092496A1 (ko) * 2012-12-13 2014-06-19 연세대학교 산학협력단 탈라세믹화를 이용한 광학 활성 아민 화합물의 제조방법
GB201316410D0 (en) * 2013-09-13 2013-10-30 Bial Portela & Ca Sa Processes for preparing peripherally-selective inhibitors of dopamine-?-hydroxylase and intermediates for use therein
CN104630170A (zh) * 2013-11-08 2015-05-20 中国科学院天津工业生物技术研究所 一种来源于里氏木霉的新(r)-转氨酶及其应用
ES2734579T3 (es) * 2013-11-26 2019-12-10 Asymchem Lab Tianjin Co Ltd Transaminasa y utilización de la misma
CN105018440B (zh) * 2014-04-24 2018-06-05 上海弈柯莱生物医药科技有限公司 一种转氨酶及其在合成西他列汀中间体中的应用
CN105734089A (zh) * 2014-12-11 2016-07-06 南京博优康远生物医药科技有限公司 一种不对称合成(r)-3-氨基哌啶衍生物的方法
BR112017020561B1 (pt) * 2015-04-16 2024-01-16 F. Hoffmann-La Roche Ag Transaminase mutante, proteína de fusão, método de produção de amina e uso da transaminase mutante
CN107384887B (zh) * 2017-07-05 2020-08-21 浙江工业大学 一种氨基转移酶、突变体及其制备西他列汀的应用
US10853439B2 (en) 2017-08-08 2020-12-01 Nice Ltd. Systems and methods for fast play back of recorded data
ES2816102T3 (es) 2017-11-17 2021-03-31 Enzymicals Ag Procedimiento de preparación de aminas a partir de compuestos de carbonilo mediante reacción de transaminasa bajo precipitación de sal
CN108866021B (zh) * 2018-05-30 2021-06-08 浙江工业大学 一种转氨酶突变体及在制备西他列汀中间体中的应用
CN111748590B (zh) * 2019-03-29 2024-05-28 弈柯莱(台州)药业有限公司 转氨酶在制备Sacubitril中间体中的应用
CN111117979B (zh) * 2020-01-14 2020-08-21 中国科学院苏州生物医学工程技术研究所 转氨酶突变体、酶制剂、重组载体、重组细胞及其制备方法和应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69841075D1 (de) 1997-04-23 2009-10-01 Kaneka Corp Deoxynukleinsäure welche ein Polypeptid mit stereoselektiver Transaminase Aktivität kodiert, sowie die Deoxynukleinsäure enthaltende Transformanden
DE60013939T2 (de) 1999-03-19 2005-10-06 Sumitomo Chemical Co. Ltd. Stereoselektive Transaminase, deren kodierende Gen und deren Verwendungen
JP4496593B2 (ja) * 1999-03-19 2010-07-07 住友化学株式会社 蛋白質、その遺伝子及びその利用
DE60313866T2 (de) 2002-06-14 2008-04-17 Dsm Ip Assets B.V. Polypeptide mit alpha-h alpha amino acid amide racemase aktivitität und nukleinsäuren kodierend dafür
ES2534282T3 (es) 2006-06-29 2015-04-21 Dsm Ip Assets B.V. Un método para lograr la expresión polipeptídica mejorada
EP1897956A1 (en) * 2006-09-06 2008-03-12 Lonza AG Process for preparation of optically active amines by optical resolution of racemic amines employing a bacterial omega-transaminase
MX2012002561A (es) 2009-09-02 2012-04-10 Lonza Ag Un proceso para la identificacion y preparacion de una omega-transaminasa (r)-especifica.
CN103189519B (zh) 2010-07-14 2018-01-26 DPx控股有限公司 (r)‑选择性胺化

Also Published As

Publication number Publication date
JP5999565B2 (ja) 2016-09-28
EP2593556B1 (en) 2017-08-30
US10023886B2 (en) 2018-07-17
WO2012007548A1 (en) 2012-01-19
CN103189519B (zh) 2018-01-26
MX2013000494A (es) 2013-02-15
CN103189519A (zh) 2013-07-03
US20140199734A1 (en) 2014-07-17
MX350510B (es) 2017-09-08
ES2650245T3 (es) 2018-01-17
EP2593556A1 (en) 2013-05-22
JP2013530713A (ja) 2013-08-01
US20160032335A1 (en) 2016-02-04

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