PT2386642E - Sistema de expressão - Google Patents

Sistema de expressão Download PDF

Info

Publication number: PT2386642E
Authority: PT; Portugal
Prior art keywords: expression system; expression
Prior art date: 2006-02-03

Application number

PT111719944T

Other languages

English (en)

Inventor

Ian John Hodgson

Christopher David John Lennon

Bhupendra Vallabh Kara

Original Assignee

Fujifilm Diosynth Biotechnologies Uk Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-02-03

Filing date

2007-02-01

Publication date

2014-02-12

2007-02-01 Application filed by Fujifilm Diosynth Biotechnologies Uk Ltd filed Critical Fujifilm Diosynth Biotechnologies Uk Ltd

2014-02-12 Publication of PT2386642E publication Critical patent/PT2386642E/pt

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
- C12N15/72—Expression systems using regulatory sequences derived from the lac-operon
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
- C12N15/73—Expression systems using phage (lambda) regulatory sequences
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
- C12N15/78—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Pseudomonas
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/185—Escherichia
- C12R2001/19—Escherichia coli

Landscapes

Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
Biotechnology (AREA)
Bioinformatics & Cheminformatics (AREA)
General Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Microbiology (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Plant Pathology (AREA)
Biophysics (AREA)
Physics & Mathematics (AREA)
Mycology (AREA)
Virology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Tropical Medicine & Parasitology (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Peptides Or Proteins (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

PT111719944T 2006-02-03 2007-02-01 Sistema de expressão PT2386642E (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GBGB0602173.7A GB0602173D0 (en)	2006-02-03	2006-02-03	Expression system

Publications (1)

Publication Number	Publication Date
PT2386642E true PT2386642E (pt)	2014-02-12

Family

ID=36100973

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
PT111719944T PT2386642E (pt)	2006-02-03	2007-02-01	Sistema de expressão
PT77126589T PT1984506E (pt)	2006-02-03	2007-02-01	Sistema de expressão

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
PT77126589T PT1984506E (pt)	2006-02-03	2007-02-01	Sistema de expressão

Country Status (15)

Country	Link
US (4)	US8530188B2 (pt)
EP (6)	EP2695943B1 (pt)
JP (5)	JP5221385B2 (pt)
KR (3)	KR101512776B1 (pt)
CN (3)	CN101410523B (pt)
CA (2)	CA2637818C (pt)
DK (4)	DK2386644T3 (pt)
ES (3)	ES2445173T3 (pt)
GB (1)	GB0602173D0 (pt)
HU (1)	HUE027350T2 (pt)
PL (3)	PL1984506T3 (pt)
PT (2)	PT2386642E (pt)
SG (3)	SG169388A1 (pt)
WO (1)	WO2007088371A2 (pt)
ZA (2)	ZA200806238B (pt)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB0602173D0 (en) *	2006-02-03	2006-03-15	Avecia Ltd	Expression system
GB0709061D0 (en)	2007-05-11	2007-06-20	Avecia Biolog Ltd	Expression system
GB0810154D0 (en) *	2008-06-04	2008-07-09	Avecia Biolog Ltd	Expression vector
GB0905331D0 (en) *	2009-03-27	2009-05-13	Avecia Biolog Ltd	Expression process
GB201018664D0 (en)	2010-11-05	2010-12-22	Msd Biolog Uk Ltd	Expression process
GB201021795D0 (en) *	2010-12-21	2011-02-02	Msd Biolog Uk Ltd	Expression Process
GB201209896D0 (en)	2012-06-01	2012-07-18	Fujifilm Diosynth Biotechnologies Uk Ltd	Process
CA2897345A1 (en)	2013-01-31	2014-08-07	Glaxo Group Limited	Method of producing a protein
CN105392889A (zh) *	2013-05-03	2016-03-09	富士胶片戴奥辛思生物技术英国有限公司	表达方法
GB201311837D0 (en)	2013-07-01	2013-08-14	Fujifilm Diosynth Biotechnologies Uk Ltd	Expression Process
GB201319930D0 (en)	2013-11-12	2013-12-25	Fujifilm Diosynth Biotechnologies Uk Ltd	Expression process
WO2016033327A1 (en)	2014-08-28	2016-03-03	Synthetic Biologics, Inc.	E. coli-based production of beta-lactamase
US9791697B2 (en)	2015-12-11	2017-10-17	Panasonic Intellectual Property Management Co., Ltd.	Screen
KR20190012145A (ko)	2016-03-29	2019-02-08	젤터, 인코포레이티드	주변세포질 부피 대 세포질 부피의 비가 0.5:1 내지 10:1인 그람-음성 박테리아에서의 단백질의 발현
SG11201808976WA (en)	2016-05-06	2018-11-29	Glaxosmithkline Ip Dev Ltd	Method of producing a recombinant protein
GB201704659D0 (en) *	2017-03-24	2017-05-10	Fujifilm Diosynth Biotechnologies Uk Ltd	Expression system
WO2021207611A1 (en) *	2020-04-09	2021-10-14	United States Government As Represented By The Department Of Veterans Affairs	Compositions comprising recombinant epo and methods of use thereof
CN115698276A (zh) *	2020-04-15	2023-02-03	阿拉斯加大学安克雷奇分校	用于生产异丁烯的方法和组合物
AU2022413768A1 (en)	2021-12-17	2024-06-13	Fujifilm Diosynth Biotechnologies Uk Limited	Sequences and methods for production of recombinant biological molecules in vesicles

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GB8517071D0 (en) *	1985-07-05	1985-08-14	Hoffmann La Roche	Gram-positive expression control sequence
US5059530A (en) *	1985-09-30	1991-10-22	Suntory Ltd.	Expression vector for human TNF
JPS63267288A (ja)	1986-12-26	1988-11-04	Hoechst Japan Kk	増幅された遺伝子によつて蛋白質を生産する方法およびそのための遺伝子
US5510099A (en) *	1987-05-01	1996-04-23	Stratagene	Mutagenesis testing using transgenic non-human animals carrying test DNA sequences
US5223407A (en) *	1988-08-31	1993-06-29	Allelix Inc.	Excretion of heterologous proteins from e. coli
WO1991013979A1 (en)	1990-03-05	1991-09-19	President And Fellows Of Harvard College	Transgenic mouse overexpressing il-4 and method of use
DE4029844A1 (de) *	1990-09-20	1992-03-26	Boehringer Mannheim Gmbh	Carbamoylsarcosinhydrolase, kloniert
US5589392A (en)	1991-01-14	1996-12-31	Stratagene	Nucleic acid construct encoding a nuclear transport peptide operatively linked to an inducible promoter
GB2253852B (en)	1991-02-26	1995-03-22	Ici Plc	Vector for expression of heterologous polypeptide comprising inducible selection system
ATE195142T1 (de) *	1991-02-26	2000-08-15	Zeneca Ltd	Fermentationsverfahren zur herstellung von peptiden durch einen wirt
EP0671955A4 (en)	1992-02-14	1997-04-09	Stratagene Inc	MUTAGENESE TEST USING NON-HUMAN BEINGS CONTAINING TEST DNA SEQUENCES.
AU4964697A (en)	1996-11-15	1998-06-10	Institute Of Cytosignal Research, Inc.	Methods for detecting and isolating genes
WO1998022581A1 (fr)	1996-11-15	1998-05-28	Institute Of Cytosignal Research, Inc.	Represseur de transcription
AU8453598A (en)	1997-07-25	1999-02-16	Zeneca Limited	Mcp-1 analogs
GB9715660D0 (en)	1997-07-25	1997-10-01	Zeneca Ltd	Proteins
WO2000071716A2 (en) *	1999-05-20	2000-11-30	Scios Inc.	Vascular endothelial growth factor dimers
US20040171824A1 (en)	2001-03-05	2004-09-02	Scrable Heidi Jean	A Lac operator-repressor system
GB0113318D0 (en)	2001-06-01	2001-07-25	Lonza Biologics Plc	Method for production of a protein
GB0227346D0 (en) *	2002-11-22	2002-12-31	Chiron Spa	741
WO2004056964A2 (en)	2002-12-18	2004-07-08	Genpath Pharmaceuticals, Incorporated	Vectors for inducible rna interference
MXPA06005634A (es)	2003-11-19	2006-08-23	Dow Global Technologies Inc	Sistemas mejorados de expresion de proteinas.
WO2005058946A2 (en) *	2003-12-12	2005-06-30	Zymogenetics, Inc.	Methods for enhancing expression of recombinant proteins
US7498166B2 (en)	2004-01-12	2009-03-03	Vertex Pharmaceuticals Incorporated	Dual expression vector system and screening methods
JP4854202B2 (ja) *	2004-03-31	2012-01-18	株式会社日本触媒	新規改変型ｓ−ヒドロキシニトリルリアーゼ
JP2005314252A (ja) *	2004-04-27	2005-11-10	Okayama Univ	糖尿病性腎症の予防・治療剤
JP2005341803A (ja) *	2004-05-31	2005-12-15	Institute Of Physical & Chemical Research	非対称な塩基配列を認識して切断する酵素Ｉ−ＣｓｍＩ及びその製造方法
GB0602173D0 (en) *	2006-02-03	2006-03-15	Avecia Ltd	Expression system
RU2006129690A (ru)	2006-08-16	2008-02-27	Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) (RU)	СПОСОБ ПОЛУЧЕНИЯ L-АМИНОКИСЛОТЫ С ИСПОЛЬЗОВАНИЕМ БАКТЕРИЙ СЕМЕЙСТВА Enterobacteriaceae, В КОТОРОЙ ОСЛАБЛЕНА ЭКСПРЕССИЯ ГЕНА ydiN, ГЕНА ydiB ИЛИ ИХ КОМБИНАЦИИ
US9388425B2 (en)	2006-10-20	2016-07-12	Trustees Of Boston University	Tunable genetic switch for regulating gene expression

2006
- 2006-02-03 GB GBGB0602173.7A patent/GB0602173D0/en not_active Ceased
2007
- 2007-02-01 PL PL07712658T patent/PL1984506T3/pl unknown
- 2007-02-01 EP EP13191424.4A patent/EP2695943B1/en active Active
- 2007-02-01 SG SG201100856-2A patent/SG169388A1/en unknown
- 2007-02-01 EP EP11172432.4A patent/EP2386644B1/en active Active
- 2007-02-01 CA CA2637818A patent/CA2637818C/en active Active
- 2007-02-01 CN CN2007800112768A patent/CN101410523B/zh active Active
- 2007-02-01 DK DK11172432.4T patent/DK2386644T3/en active
- 2007-02-01 EP EP11172434.0A patent/EP2390334B1/en not_active Not-in-force
- 2007-02-01 PT PT111719944T patent/PT2386642E/pt unknown
- 2007-02-01 ES ES11171994.4T patent/ES2445173T3/es active Active
- 2007-02-01 KR KR1020147017744A patent/KR101512776B1/ko active IP Right Grant
- 2007-02-01 PL PL11171994T patent/PL2386642T3/pl unknown
- 2007-02-01 EP EP11172429.0A patent/EP2386643B1/en active Active
- 2007-02-01 SG SG201100858-8A patent/SG169390A1/en unknown
- 2007-02-01 PL PL13191424T patent/PL2695943T3/pl unknown
- 2007-02-01 DK DK07712658.9T patent/DK1984506T3/da active
- 2007-02-01 EP EP07712658.9A patent/EP1984506B1/en active Active
- 2007-02-01 DK DK13191424.4T patent/DK2695943T3/en active
- 2007-02-01 ES ES13191424.4T patent/ES2569075T3/es active Active
- 2007-02-01 PT PT77126589T patent/PT1984506E/pt unknown
- 2007-02-01 DK DK11171994.4T patent/DK2386642T3/en active
- 2007-02-01 US US12/223,527 patent/US8530188B2/en active Active
- 2007-02-01 EP EP11171994.4A patent/EP2386642B1/en active Active
- 2007-02-01 KR KR1020087018552A patent/KR101492844B1/ko active IP Right Grant
- 2007-02-01 CN CN201210056815.2A patent/CN102690834B/zh active Active
- 2007-02-01 SG SG201100857-0A patent/SG169389A1/en unknown
- 2007-02-01 WO PCT/GB2007/000351 patent/WO2007088371A2/en active Application Filing
- 2007-02-01 CN CN201810774783.7A patent/CN108841848B/zh active Active
- 2007-02-01 ES ES07712658.9T patent/ES2436883T3/es active Active
- 2007-02-01 JP JP2008552885A patent/JP5221385B2/ja active Active
- 2007-02-01 CA CA2959915A patent/CA2959915C/en active Active
- 2007-02-01 HU HUE13191424A patent/HUE027350T2/hu unknown
- 2007-02-01 KR KR1020147026047A patent/KR101624345B1/ko active IP Right Grant
2008
- 2008-07-17 ZA ZA200806238A patent/ZA200806238B/xx unknown
2010
- 2010-07-12 ZA ZA2010/04904A patent/ZA201004904B/en unknown
2012
- 2012-11-21 JP JP2012255098A patent/JP5713984B2/ja active Active
2013
- 2013-08-14 US US13/966,600 patent/US9677103B2/en active Active
2014
- 2014-08-21 JP JP2014168362A patent/JP2015006193A/ja active Pending
2016
- 2016-02-23 JP JP2016031742A patent/JP6298481B2/ja active Active
2017
- 2017-03-06 JP JP2017041457A patent/JP6571707B2/ja active Active
- 2017-05-08 US US15/588,851 patent/US11098335B2/en active Active
2021
- 2021-07-16 US US17/377,805 patent/US20210348205A1/en not_active Abandoned

Also Published As

Publication number	Publication date
EP2390334B1 (en)	2016-08-10
CN108841848A (zh)	2018-11-20
KR20080098013A (ko)	2008-11-06
KR101624345B1 (ko)	2016-06-07
US8530188B2 (en)	2013-09-10
EP2695943B1 (en)	2016-01-20
DK1984506T3 (da)	2013-09-16
KR20140119202A (ko)	2014-10-08
CN108841848B (zh)	2022-03-29
US20090170160A1 (en)	2009-07-02
DK2386642T3 (en)	2014-02-17
PT1984506E (pt)	2013-09-06
JP2017136072A (ja)	2017-08-10
JP2016136959A (ja)	2016-08-04
JP6298481B2 (ja)	2018-03-20
EP2386644B1 (en)	2015-12-16
SG169390A1 (en)	2011-03-30
US20210348205A1 (en)	2021-11-11
US20170240943A1 (en)	2017-08-24
JP6571707B2 (ja)	2019-09-04
HUE027350T2 (hu)	2016-09-28
CN102690834B (zh)	2018-09-04
JP2009525038A (ja)	2009-07-09
EP2386644A3 (en)	2012-11-28
EP2386644A2 (en)	2011-11-16
EP2386643A2 (en)	2011-11-16
EP2695943A1 (en)	2014-02-12
KR101512776B1 (ko)	2015-04-16
CA2959915C (en)	2022-11-15
EP2386642A2 (en)	2011-11-16
EP1984506A2 (en)	2008-10-29
CN102690834A (zh)	2012-09-26
CN101410523A (zh)	2009-04-15
JP2013078323A (ja)	2013-05-02
US20140065670A1 (en)	2014-03-06
CA2637818A1 (en)	2007-08-09
PL1984506T3 (pl)	2013-11-29
EP2390334A3 (en)	2012-11-28
SG169389A1 (en)	2011-03-30
EP2386643A3 (en)	2012-11-28
ES2445173T3 (es)	2014-02-28
GB0602173D0 (en)	2006-03-15
ZA200806238B (en)	2010-10-27
US11098335B2 (en)	2021-08-24
ZA201004904B (en)	2011-03-30
WO2007088371A2 (en)	2007-08-09
JP5221385B2 (ja)	2013-06-26
KR101492844B1 (ko)	2015-02-16
CA2959915A1 (en)	2007-08-09
JP2015006193A (ja)	2015-01-15
PL2695943T3 (pl)	2016-07-29
CA2637818C (en)	2017-05-02
ES2569075T3 (es)	2016-05-06
SG169388A1 (en)	2011-03-30
US9677103B2 (en)	2017-06-13
DK2695943T3 (en)	2016-04-18
EP2386642B1 (en)	2013-11-13
DK2386644T3 (en)	2016-03-14
EP1984506B1 (en)	2013-06-05
WO2007088371A3 (en)	2007-10-04
EP2386642A3 (en)	2012-06-13
KR20140090699A (ko)	2014-07-17
PL2386642T3 (pl)	2014-04-30
EP2390334A2 (en)	2011-11-30
CN101410523B (zh)	2012-05-16
EP2386643B1 (en)	2017-04-12
ES2436883T3 (es)	2014-01-07
JP5713984B2 (ja)	2015-05-07

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