PT2365828E - Anticorpos monoclonais para o receptor 2 do factor de crescimento de fibroblastos - Google Patents

Anticorpos monoclonais para o receptor 2 do factor de crescimento de fibroblastos Download PDF

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Publication number
PT2365828E
PT2365828E PT98255235T PT09825523T PT2365828E PT 2365828 E PT2365828 E PT 2365828E PT 98255235 T PT98255235 T PT 98255235T PT 09825523 T PT09825523 T PT 09825523T PT 2365828 E PT2365828 E PT 2365828E
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Portugal
Prior art keywords
growth factor
monoclonal antibodies
factor receptor
fibroblast growth
fibroblast
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Application number
PT98255235T
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English (en)
Inventor
Maximiliano Vasquez
Kyung Jin Kim
Wei-Meng Zhao
Hangil Park
Original Assignee
Galaxy Biotech Llc
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Publication date
Application filed by Galaxy Biotech Llc filed Critical Galaxy Biotech Llc
Publication of PT2365828E publication Critical patent/PT2365828E/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G01N33/57492—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds localized on the membrane of tumor or cancer cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/71—Assays involving receptors, cell surface antigens or cell surface determinants for growth factors; for growth regulators

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hospice & Palliative Care (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
PT98255235T 2008-11-07 2009-11-06 Anticorpos monoclonais para o receptor 2 do factor de crescimento de fibroblastos PT2365828E (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11268608P 2008-11-07 2008-11-07
US16487009P 2009-03-30 2009-03-30

Publications (1)

Publication Number Publication Date
PT2365828E true PT2365828E (pt) 2014-12-12

Family

ID=42153600

Family Applications (3)

Application Number Title Priority Date Filing Date
PT98255235T PT2365828E (pt) 2008-11-07 2009-11-06 Anticorpos monoclonais para o receptor 2 do factor de crescimento de fibroblastos
PT171911183T PT3290052T (pt) 2008-11-07 2009-11-06 Anticorpos monoclonais para o recetor 2 do fator de crescimento de fibroblastos
PT141887851T PT2842573T (pt) 2008-11-07 2009-11-06 Anticorpos monoclonais para o recetor 2 do factor de crescimento de fibroblastos

Family Applications After (2)

Application Number Title Priority Date Filing Date
PT171911183T PT3290052T (pt) 2008-11-07 2009-11-06 Anticorpos monoclonais para o recetor 2 do fator de crescimento de fibroblastos
PT141887851T PT2842573T (pt) 2008-11-07 2009-11-06 Anticorpos monoclonais para o recetor 2 do factor de crescimento de fibroblastos

Country Status (21)

Country Link
US (8) US8101723B2 (pt)
EP (4) EP3783024A1 (pt)
JP (7) JP5627591B2 (pt)
KR (1) KR101699432B1 (pt)
CN (1) CN102131524B (pt)
AU (1) AU2009313357B2 (pt)
BR (1) BRPI0917315B8 (pt)
CA (2) CA3166399A1 (pt)
DK (3) DK2842573T3 (pt)
ES (3) ES2770134T3 (pt)
HK (3) HK1160012A1 (pt)
HR (2) HRP20171640T1 (pt)
HU (1) HUE035700T2 (pt)
LT (2) LT2842573T (pt)
MX (1) MX2011000455A (pt)
NO (1) NO2842573T3 (pt)
PL (3) PL3290052T3 (pt)
PT (3) PT2365828E (pt)
RU (1) RU2546254C9 (pt)
SI (2) SI2842573T1 (pt)
WO (1) WO2010054265A2 (pt)

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Publication number Publication date
SI2842573T1 (en) 2018-01-31
JP2014240385A (ja) 2014-12-25
US20120134994A1 (en) 2012-05-31
EP2365828B1 (en) 2014-10-15
WO2010054265A3 (en) 2010-09-16
US8603987B2 (en) 2013-12-10
CN102131524B (zh) 2014-05-14
CA2733668A1 (en) 2010-05-14
WO2010054265A2 (en) 2010-05-14
LT2842573T (lt) 2017-12-11
MX2011000455A (es) 2011-02-25
RU2546254C9 (ru) 2015-07-10
US8101723B2 (en) 2012-01-24
BRPI0917315A2 (pt) 2015-11-17
US9834609B2 (en) 2017-12-05
HUE035700T2 (en) 2018-05-28
JP6661734B2 (ja) 2020-03-11
JP6960485B2 (ja) 2021-11-05
US20140193899A1 (en) 2014-07-10
EP3783024A1 (en) 2021-02-24
EP2365828A4 (en) 2012-06-06
US20190153105A1 (en) 2019-05-23
US20160362496A1 (en) 2016-12-15
PL2842573T3 (pl) 2018-04-30
RU2546254C2 (ru) 2015-04-10
HK1249053A1 (zh) 2018-10-26
JP2022008996A (ja) 2022-01-14
AU2009313357B2 (en) 2015-06-11
HRP20171640T1 (hr) 2018-01-12
US9382324B2 (en) 2016-07-05
BRPI0917315B1 (pt) 2020-12-08
EP3290052A1 (en) 2018-03-07
PT3290052T (pt) 2020-02-06
JP5627591B2 (ja) 2014-11-19
HK1160012A1 (en) 2012-08-10
CN102131524A (zh) 2011-07-20
DK2842573T3 (en) 2017-10-30
PT2842573T (pt) 2017-12-04
RU2011141890A (ru) 2013-04-27
SI3290052T1 (sl) 2020-07-31
ES2523740T3 (es) 2014-12-01
US20180094063A1 (en) 2018-04-05
JP2020096615A (ja) 2020-06-25
JP6342223B2 (ja) 2018-06-13
US20100196364A1 (en) 2010-08-05
PL3290052T3 (pl) 2020-06-29
JP2023116746A (ja) 2023-08-22
KR101699432B1 (ko) 2017-01-24
DK3290052T3 (da) 2020-02-03
ES2646168T3 (es) 2017-12-12
ES2770134T3 (es) 2020-06-30
HK1207974A1 (en) 2016-02-19
EP3290052B1 (en) 2019-12-25
CA2733668C (en) 2022-08-30
US20230242650A1 (en) 2023-08-03
PL2365828T3 (pl) 2015-04-30
JP2012508184A (ja) 2012-04-05
US10689448B2 (en) 2020-06-23
EP2842573B1 (en) 2017-09-27
LT3290052T (lt) 2020-02-25
EP2365828A2 (en) 2011-09-21
KR20110081141A (ko) 2011-07-13
JP2019052165A (ja) 2019-04-04
EP2842573A1 (en) 2015-03-04
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