PT2297100E - Tetrahydrocyclopenta[b]indole androgen receptor modulators - Google Patents

Tetrahydrocyclopenta[b]indole androgen receptor modulators

Info

Publication number
PT2297100E
PT2297100E PT97475313T PT09747531T PT2297100E PT 2297100 E PT2297100 E PT 2297100E PT 97475313 T PT97475313 T PT 97475313T PT 09747531 T PT09747531 T PT 09747531T PT 2297100 E PT2297100 E PT 2297100E
Authority
PT
Portugal
Prior art keywords
tetrahydrocyclopenta
indole
androgen receptor
receptor modulators
modulators
Prior art date
Application number
PT97475313T
Other languages
Portuguese (pt)
Inventor
Prabhakar Kondaji Jadhav
Venkatesh Krishnan
Euibong Jemes Kim
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of PT2297100E publication Critical patent/PT2297100E/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/94—[b, c]- or [b, d]-condensed containing carbocyclic rings other than six-membered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/06—Anabolic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/26—Androgens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Endocrinology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Neurology (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
PT97475313T 2008-05-16 2009-05-14 Tetrahydrocyclopenta[b]indole androgen receptor modulators PT2297100E (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US5372208P 2008-05-16 2008-05-16

Publications (1)

Publication Number Publication Date
PT2297100E true PT2297100E (en) 2013-01-24

Family

ID=40847864

Family Applications (1)

Application Number Title Priority Date Filing Date
PT97475313T PT2297100E (en) 2008-05-16 2009-05-14 Tetrahydrocyclopenta[b]indole androgen receptor modulators

Country Status (18)

Country Link
US (1) US8486943B2 (en)
EP (1) EP2297100B1 (en)
JP (1) JP5603327B2 (en)
KR (1) KR101278788B1 (en)
CN (1) CN102026974B (en)
AU (1) AU2009246348B2 (en)
BR (1) BRPI0912394A2 (en)
CA (1) CA2724629C (en)
CY (1) CY1113341T1 (en)
DK (1) DK2297100T3 (en)
EA (1) EA019713B1 (en)
ES (1) ES2396612T3 (en)
HR (1) HRP20120917T1 (en)
MX (1) MX2010012436A (en)
PL (1) PL2297100T3 (en)
PT (1) PT2297100E (en)
SI (1) SI2297100T1 (en)
WO (1) WO2009140448A1 (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA98777C2 (en) 2006-11-20 2012-06-25 Эли Лилли Энд Компани Tetrahydrocyclopenta[b]indole compounds as androgen receptor modulators
US8268872B2 (en) 2008-02-22 2012-09-18 Radius Health, Inc. Selective androgen receptor modulators
MX2010009162A (en) 2008-02-22 2010-12-21 Radius Health Inc Selective androgen receptor modulators.
EP2531029B1 (en) 2010-02-04 2016-10-19 Radius Health, Inc. Selective androgen receptor modulators
ME02474B (en) 2010-05-12 2017-02-20 Radius Health Inc Therapeutic regimens
US8642632B2 (en) 2010-07-02 2014-02-04 Radius Health, Inc. Selective androgen receptor modulators
BR112013007685B1 (en) 2010-09-28 2021-11-09 Radius Pharmaceuticals, Inc SELECTIVE ANDROGEN RECEPTOR MODULATOR COMPOUNDS, PHARMACEUTICAL COMPOSITION INCLUDING SUCH COMPOUNDS, METHOD OF IDENTIFYING A COMPOUND CAPABLE OF MODULARING AN ANDROGEN RECEPTOR, USES OF A COMPOUND OR COMPOSITION AND PROCESS FOR PREPARATION OF A COMPOUND
EP4035664A3 (en) 2014-03-28 2022-11-30 Duke University Treating cancer using selective estrogen receptor modulators
US9421264B2 (en) 2014-03-28 2016-08-23 Duke University Method of treating cancer using selective estrogen receptor modulators
JOP20180072A1 (en) * 2014-09-11 2019-01-30 Lilly Co Eli Treatment of androgen deprivation therapy associated symptoms
RU2769527C2 (en) 2016-06-22 2022-04-01 Эллипсес Фарма Лтд Methods of treating ar+ breast cancer
US20180185347A1 (en) * 2016-11-16 2018-07-05 Transition Therapeutics (Ireland 2) Limited Tetrahydrocyclopenta[b]indole compounds and phosphodiesterase inhibitors for the treatment of the signs and symptoms of bhp
KR102322802B1 (en) 2017-01-05 2021-11-04 래디어스 파마슈티컬스, 인코포레이티드 Polymorphic form of RAD1901-2HCL
US11643385B2 (en) 2018-07-04 2023-05-09 Radius Pharmaceuticals, Inc. Polymorphic forms of RAD1901-2HCl
EP4175647A1 (en) * 2020-07-06 2023-05-10 Crescenta Biosciences Antiviral use of fabp4 modulating compounds

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4988820A (en) 1986-02-21 1991-01-29 Bayer Aktiengesellschaft Cycloalkano(1,2-B) indole-sulponamides
GB8924392D0 (en) 1989-10-30 1989-12-20 Bayer Ag Substituted cycloalkano/b/dihydroindole-and-indolesulphonamides
GB9008108D0 (en) 1990-04-10 1990-06-06 Bayer Ag Cycloalkano(b)dihydroindoles and-indolesulphonamides substituted by heterocycles
DE4027278A1 (en) 1990-08-29 1992-03-05 Bayer Ag HETEROCYCLICALLY SUBSTITUTED INDOLSULFONAMIDE
DE4131346A1 (en) 1991-09-20 1993-03-25 Bayer Ag INDOLSULFONAMIDE SUBSTITUTED DIHYDROPYRIDINES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE IN MEDICINAL PRODUCTS
US7160909B2 (en) 2001-08-09 2007-01-09 Eli Lilly And Company Cyclopenta[b]indole derivatives as sPLA2 inhibitors
DE10164564B4 (en) 2001-12-14 2007-05-16 Zentaris Gmbh Tetrahydrocarbazole derivatives as ligands for G-protein coupled receptors (GPCR)
US7534897B2 (en) 2002-05-16 2009-05-19 Shionogi & Co., Ltd. Indole arylsulfonaimide compounds exhibiting PGD 2 receptor antagonism
US20060074124A1 (en) 2003-09-12 2006-04-06 Andrew Napper Methods of treating a disorder
US7019022B2 (en) 2003-12-15 2006-03-28 Merck Frosst Canada & Co. Substituted tetrahydrocarbazole and cyclopentanoindole derivatives
ES2414604T3 (en) 2004-03-03 2013-07-22 Eli Lilly And Company Modulators of the nuclear steroid hormone receptor of indole-substituted bicyclic derivatives
MX2007006178A (en) 2004-11-23 2007-06-20 Ptc Therapeutics Inc Substituted phenols as active agents inhibiting vegf production.
BRPI0608353A2 (en) 2005-02-17 2009-12-01 Wyeth Corp indole, benzothiophene, benzofuran and indene cycloalkyl fused derivatives
BRPI0611705A2 (en) * 2005-06-24 2016-11-16 Lilly Co Eli compound or a pharmaceutically acceptable salt thereof, pharmaceutical composition, and use of compound
WO2007047604A2 (en) 2005-10-18 2007-04-26 Elixir Pharmaceuticals, Inc. Sirt1 inhibition
WO2008019825A1 (en) 2006-08-14 2008-02-21 Santhera Pharmaceuticals (Schweiz) Ag Use of tricyclic indole derivatives for the treatment of muscular diseases
UA98777C2 (en) * 2006-11-20 2012-06-25 Эли Лилли Энд Компани Tetrahydrocyclopenta[b]indole compounds as androgen receptor modulators

Also Published As

Publication number Publication date
WO2009140448A1 (en) 2009-11-19
AU2009246348B2 (en) 2012-04-12
KR101278788B1 (en) 2013-06-25
MX2010012436A (en) 2010-12-06
CN102026974B (en) 2013-08-28
US20110039855A1 (en) 2011-02-17
HRP20120917T1 (en) 2012-12-31
US8486943B2 (en) 2013-07-16
EP2297100A1 (en) 2011-03-23
DK2297100T3 (en) 2012-12-17
CY1113341T1 (en) 2016-06-22
WO2009140448A8 (en) 2010-01-07
JP5603327B2 (en) 2014-10-08
AU2009246348A1 (en) 2009-11-19
CN102026974A (en) 2011-04-20
KR20100132551A (en) 2010-12-17
EP2297100B1 (en) 2012-10-31
JP2011520903A (en) 2011-07-21
SI2297100T1 (en) 2013-02-28
EA201071317A1 (en) 2011-06-30
ES2396612T3 (en) 2013-02-22
BRPI0912394A2 (en) 2016-07-26
EA019713B1 (en) 2014-05-30
CA2724629C (en) 2014-08-19
PL2297100T3 (en) 2013-03-29
AU2009246348A8 (en) 2010-12-16
CA2724629A1 (en) 2009-11-19

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