PT2261378E - Método de prevenção da fusão vírus:células através da inibição da função da região de iniciação de fusão em vírus de rna contendo proteínas do invólucro fusogénico de membrana de classe i - Google Patents

Método de prevenção da fusão vírus:células através da inibição da função da região de iniciação de fusão em vírus de rna contendo proteínas do invólucro fusogénico de membrana de classe i

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Publication number
PT2261378E
PT2261378E PT101820561T PT10182056T PT2261378E PT 2261378 E PT2261378 E PT 2261378E PT 101820561 T PT101820561 T PT 101820561T PT 10182056 T PT10182056 T PT 10182056T PT 2261378 E PT2261378 E PT 2261378E
Authority
PT
Portugal
Prior art keywords
fusion
present
viruses
class
inhibiting
Prior art date
Application number
PT101820561T
Other languages
English (en)
Inventor
Robert F Garry
Russell B Wilson
Original Assignee
Univ Tulane
Autoimmune Technologies Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Tulane, Autoimmune Technologies Llc filed Critical Univ Tulane
Publication of PT2261378E publication Critical patent/PT2261378E/pt

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    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/162Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from virus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • C12Q1/02Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/18Testing for antimicrobial activity of a material
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56983Viruses
    • G01N33/56988HIV or HTLV
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    • C12N2760/14011Filoviridae
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    • C12N2760/18011Paramyxoviridae
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    • C12N2760/18011Paramyxoviridae
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PT101820561T 2003-11-04 2004-11-03 Método de prevenção da fusão vírus:células através da inibição da função da região de iniciação de fusão em vírus de rna contendo proteínas do invólucro fusogénico de membrana de classe i PT2261378E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US51718103P 2003-11-04 2003-11-04

Publications (1)

Publication Number Publication Date
PT2261378E true PT2261378E (pt) 2013-12-09

Family

ID=34572923

Family Applications (4)

Application Number Title Priority Date Filing Date
PT101820405T PT2261376E (pt) 2003-11-04 2004-11-03 Método para prevenir a fusão vírus:células inibindo a função da região de iniciação de fusão em vírus de rna tendo proteínas do invólucro fusogénicas de membrana de classe i
PT04810256T PT1692265E (pt) 2003-11-04 2004-11-03 Método de prevenção de infecções virais: fusão celular por meio de inibição da função da região de partida de fusão em vírus arn com proteínas de envelope fusogénicas de membrana de classe i
PT101820561T PT2261378E (pt) 2003-11-04 2004-11-03 Método de prevenção da fusão vírus:células através da inibição da função da região de iniciação de fusão em vírus de rna contendo proteínas do invólucro fusogénico de membrana de classe i
PT101820496T PT2261377E (pt) 2003-11-04 2004-11-03 Método para prevenir a fusão vírus:células inibindo a função da região de iniciação de fusão em vírus de rna tendo proteínas do invólucro fusogénicas de membrana de classe

Family Applications Before (2)

Application Number Title Priority Date Filing Date
PT101820405T PT2261376E (pt) 2003-11-04 2004-11-03 Método para prevenir a fusão vírus:células inibindo a função da região de iniciação de fusão em vírus de rna tendo proteínas do invólucro fusogénicas de membrana de classe i
PT04810256T PT1692265E (pt) 2003-11-04 2004-11-03 Método de prevenção de infecções virais: fusão celular por meio de inibição da função da região de partida de fusão em vírus arn com proteínas de envelope fusogénicas de membrana de classe i

Family Applications After (1)

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PT101820496T PT2261377E (pt) 2003-11-04 2004-11-03 Método para prevenir a fusão vírus:células inibindo a função da região de iniciação de fusão em vírus de rna tendo proteínas do invólucro fusogénicas de membrana de classe

Country Status (13)

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US (5) US7491793B2 (pt)
EP (7) EP2261380B1 (pt)
JP (1) JP5008398B2 (pt)
AT (1) ATE518967T1 (pt)
AU (2) AU2004288218B2 (pt)
BR (1) BRPI0416187A (pt)
CA (1) CA2544848C (pt)
DK (7) DK2261376T3 (pt)
ES (7) ES2400456T3 (pt)
HK (6) HK1152081A1 (pt)
PL (4) PL2261378T3 (pt)
PT (4) PT2261376E (pt)
WO (1) WO2005044992A2 (pt)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT2261376E (pt) 2003-11-04 2013-09-23 Univ Tulane Método para prevenir a fusão vírus:células inibindo a função da região de iniciação de fusão em vírus de rna tendo proteínas do invólucro fusogénicas de membrana de classe i
US7682619B2 (en) 2006-04-06 2010-03-23 Cornell Research Foundation, Inc. Canine influenza virus
US8222204B2 (en) * 2006-05-03 2012-07-17 The Administrators of the Tulane Educational Fund and Autoimmune Technologies, LLC Influenza inhibiting compositions and methods
MX2009013635A (es) * 2007-06-25 2010-05-19 Univ Tulane Composiciones que inhiben la influenza y metodos.
WO2009005783A1 (en) * 2007-06-28 2009-01-08 Blanchette Rockefeller Neurosciences Institute Peptides, compositions and methods for reducing beta-amyloid-mediated apoptosis
US20110305749A1 (en) * 2008-08-28 2011-12-15 Mogens Ryttergaard Duch HIV-1 Envelope Polypeptides for HIV Vaccine
EP2413962A1 (en) 2009-03-30 2012-02-08 Mount Sinai School of Medicine Influenza virus vaccines and uses thereof
US10138276B2 (en) 2009-09-30 2018-11-27 Signablok, Inc. Inhibition of TCR signaling with peptide variants
US20130108653A1 (en) * 2009-12-22 2013-05-02 Shervin Bahrami Bivalent molecules for hiv entry inhibition
CN102939101A (zh) 2010-01-26 2013-02-20 科罗拉多大学董事会,法人 用于通用疫苗的流感病毒组合物和方法
EP2536425B1 (en) * 2010-02-18 2019-06-19 Icahn School of Medicine at Mount Sinai Vaccines for use in the prophylaxis and treatment of influenza virus disease
KR20130075732A (ko) 2010-03-30 2013-07-05 마운트 시나이 스쿨 오브 메디슨 인플루엔자 바이러스 백신 및 이의 용도
WO2012045001A2 (en) * 2010-09-30 2012-04-05 Vanderbilt University Influenza virus antibodies and immunogens and uses therefor
US9060972B2 (en) * 2010-10-30 2015-06-23 George Dacai Liu Recombinant hemagglutinin protein of influenza virus and vaccine containing the same
EP2758075B1 (en) 2011-09-20 2023-05-03 Icahn School of Medicine at Mount Sinai Influenza virus vaccines and uses thereof
US9969794B2 (en) 2012-05-10 2018-05-15 Visterra, Inc. HA binding agents
AU2013362935B2 (en) 2012-12-18 2018-10-04 Icahn School Of Medicine At Mount Sinai Influenza virus vaccines and uses thereof
US8999925B2 (en) * 2013-02-26 2015-04-07 The Administrators Of The Tulane Educational Fund Arenavirus inhibiting peptides and uses therefor
WO2014159960A1 (en) 2013-03-14 2014-10-02 Icahn School Of Medicine At Mount Sinai Antibodies against influenza virus hemagglutinin and uses thereof
US9649375B2 (en) * 2013-03-14 2017-05-16 The Administrators Of The Tulane Educational Fund Immunogenic peptide conjugate and method for inducing an anti-influenza therapeutic antibody response therewith
WO2016049380A1 (en) * 2014-09-24 2016-03-31 University Of Utah Research Foundation Ebolavirus pre-hairpin intermediate mimics and methods of use
US10736956B2 (en) 2015-01-23 2020-08-11 Icahn School Of Medicine At Mount Sinai Influenza virus vaccination regimens
WO2017083627A1 (en) 2015-11-13 2017-05-18 Visterra, Inc. Compositions and methods for treating and preventing influenza
WO2017218624A1 (en) 2016-06-15 2017-12-21 Icahn School Of Medicine At Mount Sinai Influenza virus hemagglutinin proteins and uses thereof
US11254733B2 (en) 2017-04-07 2022-02-22 Icahn School Of Medicine At Mount Sinai Anti-influenza B virus neuraminidase antibodies and uses thereof
US11690907B2 (en) 2018-06-12 2023-07-04 Kbio Holdings Limited Vaccines formed by virus and antigen conjugation
US11696948B2 (en) 2018-06-12 2023-07-11 Kbio Holdings Limited Vaccines formed by virus and antigen conjugation
AU2020248404A1 (en) 2019-03-25 2021-09-30 Visterra, Inc. Compositions and methods for treating and preventing influenza
US20230014151A1 (en) * 2019-09-04 2023-01-19 The Trustees Of Columbia University In The City Of New York Combination antiviral therapy for measles
US11479582B2 (en) 2020-10-16 2022-10-25 King Faisal University Anti-SARS-CoV-2 fusion peptides
JP2022116482A (ja) * 2021-01-29 2022-08-10 東亞合成株式会社 SARS-CoV-2由来のアミノ酸配列およびその利用

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU1711888A (en) 1987-04-24 1988-12-02 Biogen, Inc. Immunotherapeutic methods and compositions
US5747239A (en) 1990-02-16 1998-05-05 United Biomedical, Inc. Synthetic peptides specific for the detection of antibodies to HCV, diagnosis of HCV infection and preventions thereof as vaccines
US5567805A (en) 1990-03-09 1996-10-22 Administrators Of The Tulane Educational Fund The cellular receptor for the CS3 peptide of human immunodeficiency virus
WO1994017826A1 (en) 1993-02-01 1994-08-18 Smithkline Beecham Corporation Vaccinal polypeptides
US5464933A (en) 1993-06-07 1995-11-07 Duke University Synthetic peptide inhibitors of HIV transmission
US6479055B1 (en) * 1993-06-07 2002-11-12 Trimeris, Inc. Methods for inhibition of membrane fusion-associated events, including respiratory syncytial virus transmission
US6037348A (en) 1996-02-09 2000-03-14 Eli Lilly And Company Inhibition of viral replication
JPH11209281A (ja) * 1998-01-21 1999-08-03 Daikin Ind Ltd ヘマグルチニン結合活性及びシアリダーゼ活性に対する阻害剤、及び、これを用いてウイルス又は微生物の感染を治療及び/又は予防する方法
IL127331A0 (en) 1998-11-30 1999-09-22 Yeda Res & Dev Peptide-based vaccine for influenza
EP1167382A1 (en) * 1999-03-31 2002-01-02 Otsuka Pharmaceutical Co., Ltd. Influenza virus hemagglutinin-binding peptides
US6750008B1 (en) 1999-07-09 2004-06-15 Trimeris, Inc. Methods and compositions for inhibition of membrane fusion-associated events, including HIV transmission
AU7089600A (en) * 1999-08-30 2001-03-26 U.S. Army Medical Research Institute Of Infectious Diseases Monoclonal antibodies and vaccines against epitopes on the ebola virus glycoprotein
AU3334001A (en) 2000-02-10 2001-08-20 Panacos Pharmaceuticals Inc Assay for detection of viral fusion inhibitors
GB0022969D0 (en) 2000-09-19 2000-11-01 Chiron Spa Influenza a virus subtype H16
JP5180422B2 (ja) * 2000-09-22 2013-04-10 ホワイトヘッド インスチチュート フォアー バイオメディカル リサーチ Hiv浸入のペプチドインヒビター
US7731975B2 (en) * 2001-01-31 2010-06-08 The United States Of America As Represented By The Secretary Of The Army Chimeric filovirus glycoprotein
US7774144B2 (en) * 2001-10-26 2010-08-10 Samuel Bogoch System and method for identifying complex patterns of amino acids
US7894999B2 (en) * 2001-03-27 2011-02-22 Samuel Bogoch Systems and methods for identifying Replikin Scaffolds and uses of said Replikin Scaffolds
US7420028B2 (en) * 2001-03-27 2008-09-02 Samuel Bogoch Replikins and methods of identifying replikin-containing sequences
JP4651213B2 (ja) * 2001-03-27 2011-03-16 株式会社グライコメディクス インフルエンザウイルス・ヘマグルチニン結合性ペプチド
US7442761B2 (en) * 2003-06-06 2008-10-28 Samuel Bogoch Replikin peptides and uses thereof
KR100906102B1 (ko) * 2001-03-27 2009-07-07 사무엘 보고치 레플리킨 펩타이드 및 그의 이용
US7452963B2 (en) * 2001-03-27 2008-11-18 Samuel Bogoch Replikin peptides and antibodies therefore
US7189800B2 (en) * 2001-03-27 2007-03-13 Samuel Bogoch Replikin peptides in rapid replication of glioma cells and in influenza epidemics
WO2004002415A2 (en) * 2002-06-27 2004-01-08 Dana-Farber Cancer Institute, Inc. Compositions and methods for modulating a cytotoxic t lymphocyte immune response
WO2005016238A2 (en) * 2003-05-08 2005-02-24 Duke University Severe acute respiratory syndrome
EP1633775A2 (en) * 2003-06-13 2006-03-15 Crucell Holland B.V. Antigenic peptides of sars coronavirus and uses thereof
EP1648927A1 (en) * 2003-07-21 2006-04-26 THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES Soluble fragments of the sars-cov spike glycoprotein
PT2261376E (pt) 2003-11-04 2013-09-23 Univ Tulane Método para prevenir a fusão vírus:células inibindo a função da região de iniciação de fusão em vírus de rna tendo proteínas do invólucro fusogénicas de membrana de classe i

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EP2261375A2 (en) 2010-12-15
DK2261378T3 (da) 2014-01-20
CA2544848A1 (en) 2005-05-19
HK1152081A1 (en) 2012-02-17
EP2261378B1 (en) 2013-10-09
EP2261374A2 (en) 2010-12-15
ATE518967T1 (de) 2011-08-15
EP1692265B1 (en) 2011-08-03
WO2005044992A2 (en) 2005-05-19
DK1692265T3 (da) 2011-11-21
WO2005044992A3 (en) 2006-12-07
PL2261376T3 (pl) 2014-04-30
HK1152084A1 (en) 2012-02-17
HK1152082A1 (en) 2012-02-17
AU2010201046A1 (en) 2010-04-08
ES2372633T3 (es) 2012-01-25
AU2004288218B2 (en) 2009-12-24
US7491793B2 (en) 2009-02-17
HK1152086A1 (en) 2012-02-17
EP2261377A2 (en) 2010-12-15
AU2004288218A1 (en) 2005-05-19
EP2261376B1 (en) 2013-07-10
EP2261374B1 (en) 2012-06-06
EP2261375B1 (en) 2013-01-23
EP2261378A2 (en) 2010-12-15
JP2007514408A (ja) 2007-06-07
PT1692265E (pt) 2011-10-11
US20090264362A1 (en) 2009-10-22
PL2261378T3 (pl) 2014-03-31
ES2427847T3 (es) 2013-11-04
US9725487B2 (en) 2017-08-08
DK2261380T3 (da) 2013-10-07
DK2261376T3 (da) 2013-10-07
JP5008398B2 (ja) 2012-08-22
EP2261376A3 (en) 2011-02-23
US20140045743A1 (en) 2014-02-13
US20120289458A1 (en) 2012-11-15
HK1152085A1 (en) 2012-02-17
EP2261376A2 (en) 2010-12-15
EP2261378A3 (en) 2011-06-15
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PT2261376E (pt) 2013-09-23
EP2261380B1 (en) 2013-07-17
EP2261380A3 (en) 2011-02-23
DK2261374T3 (da) 2012-09-10
EP2261375A3 (en) 2011-06-22
AU2010201046B2 (en) 2013-06-27
US20060280754A1 (en) 2006-12-14
HK1152083A1 (en) 2012-02-17
US20150239940A1 (en) 2015-08-27
EP2261374A3 (en) 2011-03-02
PL1692265T3 (pl) 2011-12-30
DK2261377T3 (da) 2014-01-06
EP2261377A3 (en) 2011-05-18
PL2261377T3 (pl) 2014-03-31
US9056900B2 (en) 2015-06-16
ES2425600T3 (es) 2013-10-16
ES2435941T3 (es) 2013-12-26
US8598116B2 (en) 2013-12-03
BRPI0416187A (pt) 2007-01-23
EP1692265A2 (en) 2006-08-23
EP1692265A4 (en) 2007-08-29
ES2392891T3 (es) 2012-12-14
ES2400456T3 (es) 2013-04-10
EP2261380A2 (en) 2010-12-15
CA2544848C (en) 2015-12-29
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DK2261375T3 (da) 2013-04-22
ES2437858T3 (es) 2014-01-14

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