PT2101791E - Polinucleótidos anti-conexina como composições para cicatrização dificultada de feridas - Google Patents
Polinucleótidos anti-conexina como composições para cicatrização dificultada de feridas Download PDFInfo
- Publication number
- PT2101791E PT2101791E PT07853353T PT07853353T PT2101791E PT 2101791 E PT2101791 E PT 2101791E PT 07853353 T PT07853353 T PT 07853353T PT 07853353 T PT07853353 T PT 07853353T PT 2101791 E PT2101791 E PT 2101791E
- Authority
- PT
- Portugal
- Prior art keywords
- wound healing
- impaired wound
- healing compositions
- anticonnexin
- polynucleotides
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering N.A.
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/30—Special therapeutic applications
- C12N2320/35—Special therapeutic applications based on a specific dosage / administration regimen
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Heart & Thoracic Surgery (AREA)
- Dermatology (AREA)
- Cardiology (AREA)
- Obesity (AREA)
- Neurology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Neurosurgery (AREA)
- Hematology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US87440406P | 2006-12-11 | 2006-12-11 |
Publications (1)
Publication Number | Publication Date |
---|---|
PT2101791E true PT2101791E (pt) | 2014-12-18 |
Family
ID=39386432
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT07853353T PT2101791E (pt) | 2006-12-11 | 2007-12-11 | Polinucleótidos anti-conexina como composições para cicatrização dificultada de feridas |
Country Status (16)
Country | Link |
---|---|
US (5) | US8063023B2 (pt) |
EP (3) | EP2543377A1 (pt) |
JP (3) | JP5431949B2 (pt) |
KR (1) | KR101521306B1 (pt) |
CN (2) | CN103520197B (pt) |
AU (1) | AU2007333535B2 (pt) |
BR (1) | BRPI0721094A2 (pt) |
CA (1) | CA2672220A1 (pt) |
DK (1) | DK2101791T3 (pt) |
ES (1) | ES2527131T3 (pt) |
HK (1) | HK1136213A1 (pt) |
PL (1) | PL2101791T3 (pt) |
PT (1) | PT2101791E (pt) |
RU (1) | RU2521329C2 (pt) |
SI (1) | SI2101791T1 (pt) |
WO (1) | WO2008073479A2 (pt) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1959981B1 (en) | 2005-02-03 | 2019-10-16 | Coda Therapeutics Limited | Anti-connexin 43 compounds for treating chronic wounds |
JP5960944B2 (ja) | 2006-11-15 | 2016-08-02 | コーダ セラピューティクス, インコーポレイテッド | 創傷治癒のための改善された方法および組成物 |
DK2101791T3 (en) | 2006-12-11 | 2015-01-05 | Coda Therapeutics Inc | ANTICONNEXIN POLYNUCLEOTIDES AS COMPOSITIONS AGAINST DEGRADED HEALTH |
US20080249044A1 (en) * | 2007-04-03 | 2008-10-09 | Masaya Tanaka | Nucleic acid external skin formulation |
JP2011506446A (ja) * | 2007-12-11 | 2011-03-03 | コーダ セラピューティクス, インコーポレイテッド | 損傷した創傷治癒組成物および治療 |
CA2709153A1 (en) * | 2007-12-11 | 2009-06-18 | Coda Therapeutics, Inc. | Impaired wound healing compositions and treatments |
CA2710380A1 (en) | 2007-12-21 | 2009-07-09 | Coda Therapeutics, Inc. | Use of anti-connexin 43 poly nucleotide for the treatment of fibrotic conditions |
US20110092449A1 (en) * | 2007-12-21 | 2011-04-21 | Bradford James Duft | Treatment of fibrotic conditions |
WO2012076985A2 (en) * | 2010-12-06 | 2012-06-14 | The University Of British Columbia | Granzyme b inhibitor compositions, methods and uses for promoting wound healing |
GB201117538D0 (en) * | 2011-10-11 | 2011-11-23 | Royal Veterinary College The | Methods |
CA2866115C (en) | 2012-03-01 | 2020-03-24 | Firststring Research, Inc. | Topical gels containing alpha connexin c-terminal (act) peptides |
CA2868534A1 (en) * | 2012-03-27 | 2013-10-03 | Coda Therapeutics, Inc. | Compositions and treatments based on cadherin modulation |
US9156896B2 (en) * | 2013-03-15 | 2015-10-13 | Coda Therapeutics, Inc. | Wound healing compositions and treatments |
EP3116996A4 (en) * | 2014-03-14 | 2018-01-10 | Ocunexus Therapeutics, Inc. | Treatment of resistant lesions |
EP3183346A4 (en) | 2014-08-22 | 2018-10-24 | Auckland Uniservices Limited | Channel modulators |
US10450569B2 (en) * | 2015-08-13 | 2019-10-22 | Somagenics, Inc. | Methods and compositions of short small hairpin RNAS and microRNAS for wound healing |
EP3518847B1 (en) * | 2016-09-27 | 2023-03-01 | Smith & Nephew plc | Wound closure devices with dissolvable portions |
CN111201247A (zh) | 2017-04-28 | 2020-05-26 | 奥克兰联合服务有限公司 | 治疗方法和新颖构建体 |
CN108588075A (zh) * | 2018-05-03 | 2018-09-28 | 天德悦(北京)生物科技有限责任公司 | 人Cx43基因干扰序列、shRNA-Cx43病毒及低表达Cx43蛋白的细胞系 |
RU2754383C1 (ru) * | 2020-12-07 | 2021-09-01 | Федеральное Государственное Бюджетное Учреждение "Национальный Медицинский Исследовательский Центр Эндокринологии" Министерства Здравоохранения Российской Федерации (Фгбу "Нмиц Эндокринологии" Минздрава России) | Способ лечения неинфицированного послеоперационного раневого дефекта стопы при отсутствии признаков критической ишемии конечности у больных с нейропатической и нейроишемической формой синдрома диабетической стопы |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0539594Y2 (pt) | 1988-08-05 | 1993-10-07 | ||
US5004810A (en) | 1988-09-30 | 1991-04-02 | Schering Corporation | Antiviral oligomers |
US5166195A (en) | 1990-05-11 | 1992-11-24 | Isis Pharmaceuticals, Inc. | Antisense inhibitors of the human immunodeficiency virus phosphorothioate oligonucleotides |
GB9425930D0 (en) | 1994-12-22 | 1995-02-22 | Procter & Gamble | Silicone compositions |
WO1998024797A1 (en) | 1996-12-02 | 1998-06-11 | Dyad Pharmaceutical Corporation | Antisense inhibition of human adhesion molecules |
RU2147240C1 (ru) * | 1998-02-16 | 2000-04-10 | Рязанский областной клинический кожно-венерологический диспансер | Препарат для лечения длительно незаживающих инфицированных язв и ран |
DK2314321T3 (da) * | 1999-01-27 | 2014-09-08 | Coda Therapeutics Inc | Formuleringer, der omfatter antisense-nukleotider til connexiner |
US7250397B2 (en) | 2000-02-23 | 2007-07-31 | Zealand Pharma A/S | Antiarrhythmic peptides |
US20050119211A1 (en) | 2001-05-18 | 2005-06-02 | Sirna Therapeutics, Inc. | RNA mediated inhibition connexin gene expression using short interfering nucleic acid (siNA) |
JP2005509621A (ja) | 2001-10-17 | 2005-04-14 | ユニバーシティ オブ ウェールズ カレッジ オブ メディスン | ギャップ結合ならびにedhf |
EA006860B1 (ru) | 2002-01-29 | 2006-04-28 | Уайт | Композиции и способы модулирования гемиканалов коннексина |
EA015670B9 (ru) | 2003-12-03 | 2012-01-30 | Коуда Терапьютикс (Нз) Лтд. | Антисмысловые соединения, нацеленные на коннексины, и способы их применения |
DE102004027422A1 (de) | 2004-06-04 | 2005-12-29 | Boehringer Ingelheim Microparts Gmbh | Vorrichtung zur Aufnahme von Blut und Abtrennung von Blutbestandteilen |
AU2005319155B2 (en) | 2004-12-21 | 2013-01-31 | Musc Foundation For Research Development | Compositions and methods for promoting wound healing and tissue regeneration |
EP1959981B1 (en) | 2005-02-03 | 2019-10-16 | Coda Therapeutics Limited | Anti-connexin 43 compounds for treating chronic wounds |
JP5960944B2 (ja) | 2006-11-15 | 2016-08-02 | コーダ セラピューティクス, インコーポレイテッド | 創傷治癒のための改善された方法および組成物 |
DK2101791T3 (en) | 2006-12-11 | 2015-01-05 | Coda Therapeutics Inc | ANTICONNEXIN POLYNUCLEOTIDES AS COMPOSITIONS AGAINST DEGRADED HEALTH |
EP2162117B1 (en) | 2007-05-31 | 2018-02-21 | Anterios, Inc. | Nucleic acid nanoparticles and uses therefor |
JP2011506446A (ja) | 2007-12-11 | 2011-03-03 | コーダ セラピューティクス, インコーポレイテッド | 損傷した創傷治癒組成物および治療 |
CA2709153A1 (en) | 2007-12-11 | 2009-06-18 | Coda Therapeutics, Inc. | Impaired wound healing compositions and treatments |
-
2007
- 2007-12-11 DK DK07853353.6T patent/DK2101791T3/en active
- 2007-12-11 PT PT07853353T patent/PT2101791E/pt unknown
- 2007-12-11 ES ES07853353.6T patent/ES2527131T3/es active Active
- 2007-12-11 EP EP20120182487 patent/EP2543377A1/en not_active Ceased
- 2007-12-11 SI SI200731570T patent/SI2101791T1/sl unknown
- 2007-12-11 JP JP2009541370A patent/JP5431949B2/ja not_active Expired - Fee Related
- 2007-12-11 KR KR1020097014484A patent/KR101521306B1/ko active IP Right Grant
- 2007-12-11 RU RU2009126594/15A patent/RU2521329C2/ru not_active IP Right Cessation
- 2007-12-11 EP EP20070853353 patent/EP2101791B1/en active Active
- 2007-12-11 PL PL07853353T patent/PL2101791T3/pl unknown
- 2007-12-11 EP EP20120182489 patent/EP2543378A1/en not_active Ceased
- 2007-12-11 BR BRPI0721094-9A2A patent/BRPI0721094A2/pt not_active Application Discontinuation
- 2007-12-11 CA CA002672220A patent/CA2672220A1/en not_active Abandoned
- 2007-12-11 CN CN201310392821.XA patent/CN103520197B/zh not_active Expired - Fee Related
- 2007-12-11 WO PCT/US2007/025446 patent/WO2008073479A2/en active Application Filing
- 2007-12-11 AU AU2007333535A patent/AU2007333535B2/en not_active Ceased
- 2007-12-11 CN CN200780051207.XA patent/CN101835476B/zh not_active Expired - Fee Related
- 2007-12-11 US US12/001,498 patent/US8063023B2/en not_active Expired - Fee Related
-
2010
- 2010-03-23 HK HK10103066.1A patent/HK1136213A1/xx not_active IP Right Cessation
-
2011
- 2011-11-11 US US13/295,020 patent/US8685940B2/en not_active Expired - Fee Related
-
2013
- 2013-02-11 US US13/764,674 patent/US9029339B2/en not_active Expired - Fee Related
- 2013-06-03 JP JP2013117401A patent/JP5911454B2/ja not_active Expired - Fee Related
-
2015
- 2015-01-05 JP JP2015000248A patent/JP2015063565A/ja active Pending
- 2015-05-11 US US14/709,382 patent/US9637745B2/en active Active
-
2017
- 2017-05-01 US US15/583,898 patent/US20170240905A1/en not_active Abandoned
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