PT1590467E - Utilização de sequências reguladoras para expressão específica transiente em células determinadas neuronais - Google Patents

Utilização de sequências reguladoras para expressão específica transiente em células determinadas neuronais Download PDF

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Publication number
PT1590467E
PT1590467E PT04705802T PT04705802T PT1590467E PT 1590467 E PT1590467 E PT 1590467E PT 04705802 T PT04705802 T PT 04705802T PT 04705802 T PT04705802 T PT 04705802T PT 1590467 E PT1590467 E PT 1590467E
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Prior art keywords
neuronal
cells
regulatory sequences
methods
transient expression
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PT04705802T
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English (en)
Inventor
Sebastien Couillard-Despres
Claudia Karl
Hans-Georg Kuhn
Ludwig Aigner
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Hoffmann La Roche
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Publication of PT1590467E publication Critical patent/PT1590467E/pt

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    • C12N2830/00—Vector systems having a special element relevant for transcription
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    • C12N2840/00—Vectors comprising a special translation-regulating system
    • C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron

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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
PT04705802T 2003-01-28 2004-01-28 Utilização de sequências reguladoras para expressão específica transiente em células determinadas neuronais PT1590467E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP03002027 2003-01-28

Publications (1)

Publication Number Publication Date
PT1590467E true PT1590467E (pt) 2010-01-05

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PT04705802T PT1590467E (pt) 2003-01-28 2004-01-28 Utilização de sequências reguladoras para expressão específica transiente em células determinadas neuronais

Country Status (8)

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US (4) US20070107071A1 (pt)
EP (1) EP1590467B1 (pt)
AT (1) ATE446371T1 (pt)
DE (1) DE602004023692D1 (pt)
DK (1) DK1590467T3 (pt)
ES (1) ES2334231T3 (pt)
PT (1) PT1590467E (pt)
WO (1) WO2004067751A1 (pt)

Families Citing this family (20)

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Publication number Priority date Publication date Assignee Title
DE10339727A1 (de) * 2003-08-22 2005-03-17 Max-Delbrück-Centrum für Molekulare Medizin Verfahren zur Bestimmung der adulten Neurogenese
CN1989244B (zh) 2004-02-09 2013-04-03 柏格丹由里 用于治疗cns病症的tgf-r信号传递抑制剂
US20090055941A1 (en) 2005-03-22 2009-02-26 Agency For Science, Technology And Research Novel Neural Cell Specific Promoter And Baculovirus And Method For Gene Delivery
WO2006128149A1 (en) * 2005-05-26 2006-11-30 Lexicon Genetics Incorporated Methods and compositions for defining gene function
US20110296540A1 (en) * 2008-12-03 2011-12-01 Rene Hen Assay for screening antidepressants
EP2449112A1 (en) 2009-07-01 2012-05-09 Transposagen Biopharmaceuticals, Inc. Genetically modified rat models for severe combined immunodeficiency (scid)
US20110135613A1 (en) * 2009-12-03 2011-06-09 The J. David Gladstone Institutes Methods for treating apolipoprotein e4-associated disorders
EP2330418A1 (en) 2009-12-04 2011-06-08 SYGNIS Bioscience GmbH & Co KG Methods of quantitative determination of neurogenesis in vivo
US9074222B2 (en) * 2013-01-25 2015-07-07 The University Of British Columbia DCX mini-promoters
JP2016523125A (ja) 2013-05-30 2016-08-08 グラハム エイチ． クリーシー 局所神経性刺激
US11229789B2 (en) 2013-05-30 2022-01-25 Neurostim Oab, Inc. Neuro activator with controller
CN106062182A (zh) * 2014-01-17 2016-10-26 住友化学株式会社 用于制备睫状缘干细胞的方法
MX2017005186A (es) * 2014-10-20 2017-07-26 Neuralstem Inc Celulas madre neurales estables que comprenden un polinucleótido exógeno que codifica un factor de crecimiento y métodos de uso de las mismas.
US11077301B2 (en) 2015-02-21 2021-08-03 NeurostimOAB, Inc. Topical nerve stimulator and sensor for bladder control
WO2018026517A1 (en) * 2016-08-04 2018-02-08 Exxonmobil Research And Engineering Company Increasing scales, capacities, and/or efficiencies in swing adsorption processes with hydrocarbon gas feeds
TWI808079B (zh) 2017-04-03 2023-07-11 美商編碼製藥公司 組織選擇性轉基因表現
CA3082390C (en) 2017-11-07 2023-01-31 Neurostim Oab, Inc. Non-invasive nerve activator with adaptive circuit
JP2022538419A (ja) 2019-06-26 2022-09-02 ニューロスティム テクノロジーズ エルエルシー 適応回路を備えた非侵襲性神経活性化装置
CA3152451A1 (en) 2019-12-16 2021-06-24 Michael Bernard Druke Non-invasive nerve activator with boosted charge delivery
JP2023517230A (ja) * 2020-03-11 2023-04-24 リモーター セラピューティクス インコーポレイテッド 中枢神経系全体にわたってタンパク質を散在させるための方法および材料

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2861892A (en) 1991-10-04 1993-05-03 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The Astrocyte-specific transcription of human genes
US5661032A (en) 1994-03-18 1997-08-26 Mcgill University Tα1 α-tubulin promoter and expression vectors
US6245564B1 (en) 1997-01-23 2001-06-12 Cornell Research Foundation, Inc. Method for separating cells
EP0918091A1 (en) * 1997-11-21 1999-05-26 Institut National De La Sante Et De La Recherche Medicale (Inserm) A gene called XLIS and the XLIS gene product, called doublecortin and their applications
US8263402B1 (en) 1998-10-19 2012-09-11 Cornell Research Foundation, Inc. Method for isolating and purifying oligodendrocytes and oligodendrocyte progenitor cells
US7785882B2 (en) 2000-01-18 2010-08-31 Cornell Research Foundation, Inc. Neuronal progenitor cells from hippocampal tissue and a method for isolating and purifying them

Also Published As

Publication number Publication date
EP1590467A1 (en) 2005-11-02
US20090170099A1 (en) 2009-07-02
ES2334231T3 (es) 2010-03-08
US7947448B2 (en) 2011-05-24
DK1590467T3 (da) 2010-01-18
US20110016547A1 (en) 2011-01-20
US8841430B2 (en) 2014-09-23
US20110020790A1 (en) 2011-01-27
ATE446371T1 (de) 2009-11-15
WO2004067751A1 (en) 2004-08-12
EP1590467B1 (en) 2009-10-21
DE602004023692D1 (de) 2009-12-03
US8815505B2 (en) 2014-08-26
US20070107071A1 (en) 2007-05-10

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