PT1301196E - Estimulacao do crescimento osseo com derivados peptidicos de trombina - Google Patents

Estimulacao do crescimento osseo com derivados peptidicos de trombina

Info

Publication number
PT1301196E
PT1301196E PT01954752T PT01954752T PT1301196E PT 1301196 E PT1301196 E PT 1301196E PT 01954752 T PT01954752 T PT 01954752T PT 01954752 T PT01954752 T PT 01954752T PT 1301196 E PT1301196 E PT 1301196E
Authority
PT
Portugal
Prior art keywords
growth
trombin
osseo
stimulation
peptidic derivatives
Prior art date
Application number
PT01954752T
Other languages
English (en)
Inventor
Darrell H Carney
Roger S Crowther
David J Simmons
Jinping Yang
William R Redin
Original Assignee
Univ Texas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Texas filed Critical Univ Texas
Publication of PT1301196E publication Critical patent/PT1301196E/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10—Peptides having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/4833—Thrombin (3.4.21.5)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Organic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
PT01954752T 2000-07-19 2001-07-18 Estimulacao do crescimento osseo com derivados peptidicos de trombina PT1301196E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US21930000P 2000-07-19 2000-07-19

Publications (1)

Publication Number Publication Date
PT1301196E true PT1301196E (pt) 2004-04-30

Family

ID=22818711

Family Applications (1)

Application Number Title Priority Date Filing Date
PT01954752T PT1301196E (pt) 2000-07-19 2001-07-18 Estimulacao do crescimento osseo com derivados peptidicos de trombina

Country Status (14)

Country Link
US (3) US6914050B2 (pt)
EP (1) EP1301196B1 (pt)
JP (2) JP3691484B2 (pt)
CN (1) CN100350971C (pt)
AT (1) ATE254925T1 (pt)
AU (2) AU7697701A (pt)
CA (1) CA2416487A1 (pt)
DE (1) DE60101339T2 (pt)
DK (1) DK1301196T3 (pt)
ES (1) ES2213707T3 (pt)
HK (1) HK1055250A1 (pt)
PT (1) PT1301196E (pt)
TR (1) TR200400260T4 (pt)
WO (1) WO2002005836A2 (pt)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5895766A (en) 1995-09-20 1999-04-20 Micron Technology, Inc. Method of forming a field effect transistor
JP4424575B2 (ja) 1998-05-18 2010-03-03 ユニバーシティー カレッジ ロンドン 新規ポリペプチドホルモン・フォスファトニン
AU7697701A (en) 2000-07-19 2002-01-30 Univ Texas Stimulation of bone growth with thrombin peptide derivatives
US6911425B2 (en) 2000-08-16 2005-06-28 Acologix, Inc. Integrin binding motif containing peptides and methods of treating skeletal diseases
AU8326801A (en) * 2000-08-16 2002-02-25 Big Bear Bio Inc Dental products comprising bone growth enhancing peptide
CN1622826A (zh) * 2002-01-17 2005-06-01 德克萨斯***大学董事会 用凝血酶肽衍生物刺激骨生长和软骨形成
AU2003256343B2 (en) 2002-07-02 2006-12-21 Orthologic Corp. Thrombin peptide derivatives
CA2491135A1 (en) 2002-07-02 2004-01-15 The Board Of Regents, The University Of Texas System Thrombin peptide derivative dimers
US7169405B2 (en) * 2003-08-06 2007-01-30 Warsaw Orthopedic, Inc. Methods and devices for the treatment of intervertebral discs
CA2539445A1 (en) * 2003-09-30 2005-04-07 Snow Brand Milk Products Co., Ltd. Agent for promoting osteogenesis and/or inhibiting bone resorption
JP4740532B2 (ja) * 2003-09-30 2011-08-03 雪印乳業株式会社 骨形成促進及び骨吸収抑制剤
US7399826B1 (en) 2003-10-02 2008-07-15 Ali Sadat M Peptide for promoting healing of fractures
JP5044829B2 (ja) 2003-12-31 2012-10-10 ザ ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム トロンビンペプチド誘導体のための医薬組成物
WO2007011610A2 (en) 2005-07-18 2007-01-25 Acologix, Inc. Protein formulation for promoting hard tissue formation
US8642059B2 (en) * 2006-04-24 2014-02-04 Warsaw Orthopedic, Inc. Controlled release systems and methods for intervertebral discs
US7879027B2 (en) * 2006-04-24 2011-02-01 Warsaw Orthopedic, Inc. Controlled release devices for fusion of osteal structures
US8642060B2 (en) * 2006-04-24 2014-02-04 Warsaw Orthopedic, Inc. Controlled release systems and methods for osteal growth
US7771414B2 (en) * 2006-04-24 2010-08-10 Warsaw Orthopedic, Inc. Controlled release devices for therapeutic treatments of spinal discs
CA2674384C (en) 2007-01-22 2016-11-15 Acologix, Inc. A peptide composition and a method of promoting cartilage formation
WO2008100567A2 (en) * 2007-02-15 2008-08-21 Orthologic Corp. Thrombin peptide derivatives for treating fractures in osteopenic patients
WO2009120300A2 (en) * 2008-03-26 2009-10-01 Orthologic Corp. Method of treating degenerative diseases
WO2009120307A2 (en) * 2008-03-26 2009-10-01 Orthologic Corp. Method of treating peripheral arterial disease
US20110105400A1 (en) * 2008-03-26 2011-05-05 Orthologic Corp. Methods for treating acute myocardial infarction
CA2722621A1 (en) * 2008-03-26 2009-10-01 Orthologic Corp. Thrombin derived peptides for smooth muscle relaxation
WO2010033862A2 (en) * 2008-09-19 2010-03-25 The Board Of Regents, The University Of Texas System Methods for treating cancer
CN102250253A (zh) * 2010-05-17 2011-11-23 中国人民解放军军事医学科学院军事兽医研究所 一种含凝血酶片段融合肽
RU2551119C1 (ru) * 2013-11-29 2015-05-20 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Национальный исследовательский Томский политехнический университет" Времяпролетный спектрометр ионов
US10220078B2 (en) 2014-06-11 2019-03-05 The Board Of Regents Of The University Of Texas System Methods of using thrombin derivatives to treat medulloblastoma

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4563489A (en) * 1984-02-10 1986-01-07 University Of California Biodegradable organic polymer delivery system for bone morphogenetic protein
US4637931A (en) * 1984-10-09 1987-01-20 The United States Of America As Represented By The Secretary Of The Army Polyactic-polyglycolic acid copolymer combined with decalcified freeze-dried bone for use as a bone repair material
US5352664A (en) * 1986-10-31 1994-10-04 Board Of Regents, The University Of Texas System Thrombin derived polypeptides; compositions and methods for use
JPH04279520A (ja) 1990-05-31 1992-10-05 Eisai Co Ltd 骨内部埋め込み用製剤
US5563124A (en) 1991-04-22 1996-10-08 Intermedics Orthopedics/ Denver, Inc. Osteogenic product and process
US5876452A (en) 1992-02-14 1999-03-02 Board Of Regents, University Of Texas System Biodegradable implant
TW369414B (en) 1994-09-30 1999-09-11 Yamanouchi Pharma Co Ltd Bone formation transplant
JPH1033657A (ja) 1996-07-23 1998-02-10 Dainippon Ink & Chem Inc 生体内分解性材料及びその製造方法
US6001352A (en) 1997-03-31 1999-12-14 Osteobiologics, Inc. Resurfacing cartilage defects with chondrocytes proliferated without differentiation using platelet-derived growth factor
EP0896825B1 (en) 1997-08-14 2002-07-17 Sulzer Innotec Ag Composition and device for in vivo cartilage repair comprising nanocapsules with osteoinductive and/or chondroinductive factors
AU7697701A (en) * 2000-07-19 2002-01-30 Univ Texas Stimulation of bone growth with thrombin peptide derivatives
AU2001273561B2 (en) 2000-07-20 2004-10-28 Orthologic Corp. Stimulation of cartilage growth with agonists of the non-proteolytically activated thrombin receptor

Also Published As

Publication number Publication date
DK1301196T3 (da) 2004-03-29
JP2004503596A (ja) 2004-02-05
WO2002005836A3 (en) 2002-12-19
US20020128202A1 (en) 2002-09-12
JP3691484B2 (ja) 2005-09-07
US7304035B2 (en) 2007-12-04
US20020182205A1 (en) 2002-12-05
US6894027B2 (en) 2005-05-17
CA2416487A1 (en) 2002-01-24
CN100350971C (zh) 2007-11-28
ES2213707T3 (es) 2004-09-01
TR200400260T4 (tr) 2004-03-22
EP1301196A2 (en) 2003-04-16
EP1301196B1 (en) 2003-11-26
AU2001276977B2 (en) 2005-05-19
AU7697701A (en) 2002-01-30
DE60101339D1 (de) 2004-01-08
CN1635899A (zh) 2005-07-06
US20050227923A1 (en) 2005-10-13
HK1055250A1 (en) 2004-01-02
JP2005053894A (ja) 2005-03-03
WO2002005836A2 (en) 2002-01-24
ATE254925T1 (de) 2003-12-15
US6914050B2 (en) 2005-07-05
DE60101339T2 (de) 2004-09-09

Similar Documents

Publication Publication Date Title
PT1301196E (pt) Estimulacao do crescimento osseo com derivados peptidicos de trombina
PT946151E (pt) Forma de dosagem de dose crescente
ATE411833T1 (de) Vorrichtung zum abliefern von pharmazeutika an das innenohr
CY1106046T1 (el) Μεθοδος για την θεραπευτικη αγωγη ινωσεως με χρησιμοποιηση ενος ανταγωνιστου της αλφα-4-υπομοναδος της ιντεγκρινης
DE69929418D1 (de) Implantierbare medizinische vorrichtung
DE60042252D1 (de) Implantierbare medizinische Vorrichtung
IL182262A0 (en) Self-fixating scaffolds
DE602004021799D1 (de) Implantierbare medizinische vorrichtung mit begrenzter expansion
DE69724844D1 (de) Medizinische Vorrichtung zur Gewebestimulierung
DE602004028743D1 (de) System und dessen verfahren für eine implantierbare stimulationsleitung mit integrierter optischer faser
ATE277174T1 (de) Stimulation des knorpelwachstums mit agonisten des nicht-proteolytisch aktivierten thrombin rezeptors
SE9704112L (sv) Anordning för att åstadkomma tillförlitlig förankring av gängförsett implantat i ben
DK0998287T3 (da) Anvendelse af levobupivacain
DE69630879D1 (de) Biologisch abbaubare vorrichtung
CO5050343A1 (es) Combinacion de fentolamina y apomorfina para el tratamiento de la funcion y disfuncion sexual humana
BR9708525A (pt) Método de tratamento de insuficência cardíaca com antagonistas de endotelina
PT961592E (pt) Implante, em particular implante de raiz dentaria
SE9403650L (sv) Anordning för benvävnadstillväxt
ATE306278T1 (de) Behandlung von knochenleiden mit adrenomedullin
EA200100041A1 (ru) Способ лечения
FI20000571A (fi) Menetelmä ihmiskehon stimuloimiseksi ultraäänen avulla