PT1282612E - Actividades heteroaromaticas da glucoquinase a vase de alcinilo-fenilo - Google Patents
Actividades heteroaromaticas da glucoquinase a vase de alcinilo-feniloInfo
- Publication number
- PT1282612E PT1282612E PT01949294T PT01949294T PT1282612E PT 1282612 E PT1282612 E PT 1282612E PT 01949294 T PT01949294 T PT 01949294T PT 01949294 T PT01949294 T PT 01949294T PT 1282612 E PT1282612 E PT 1282612E
- Authority
- PT
- Portugal
- Prior art keywords
- alcinyl
- phenylase
- glucokinase
- vase
- heteroaromatic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/88—Nitrogen atoms, e.g. allantoin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US20154600P | 2000-05-03 | 2000-05-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT1282612E true PT1282612E (pt) | 2005-04-29 |
Family
ID=22746271
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT01949294T PT1282612E (pt) | 2000-05-03 | 2001-04-25 | Actividades heteroaromaticas da glucoquinase a vase de alcinilo-fenilo |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US6388071B2 (pt) |
| EP (1) | EP1282612B1 (pt) |
| JP (1) | JP3788935B2 (pt) |
| KR (1) | KR100502033B1 (pt) |
| CN (1) | CN1176915C (pt) |
| AR (1) | AR032453A1 (pt) |
| AT (1) | ATE286036T1 (pt) |
| AU (2) | AU2001270494B2 (pt) |
| BR (1) | BR0110573A (pt) |
| CA (1) | CA2407416C (pt) |
| DE (1) | DE60108108T2 (pt) |
| EC (1) | ECSP014054A (pt) |
| ES (1) | ES2233660T3 (pt) |
| MX (1) | MXPA02010745A (pt) |
| PE (1) | PE20011310A1 (pt) |
| PT (1) | PT1282612E (pt) |
| WO (1) | WO2001083465A2 (pt) |
| ZA (1) | ZA200208542B (pt) |
Families Citing this family (73)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE0102299D0 (sv) * | 2001-06-26 | 2001-06-26 | Astrazeneca Ab | Compounds |
| SE0102300D0 (sv) * | 2001-06-26 | 2001-06-26 | Astrazeneca Ab | Compounds |
| SE0102764D0 (sv) | 2001-08-17 | 2001-08-17 | Astrazeneca Ab | Compounds |
| EP1336607A1 (en) * | 2002-02-19 | 2003-08-20 | Novo Nordisk A/S | Amide derivatives as glucokinase activators |
| GB2409678B (en) * | 2001-12-19 | 2005-09-21 | Hoffmann La Roche | Crystals of glucokinase and methods of growing them and ligands of glucokinase |
| US6911545B2 (en) | 2001-12-19 | 2005-06-28 | Hoffman-La Roche Inc. | Crystals of glucokinase and methods of growing them |
| US20030171411A1 (en) * | 2001-12-21 | 2003-09-11 | Kodra Janos Tibor | Amide derivatives as therapeutic agents |
| KR101116627B1 (ko) | 2002-06-27 | 2012-10-09 | 노보 노르디스크 에이/에스 | 치료제로서 아릴 카르보닐 유도체 |
| CN1678311A (zh) | 2002-06-27 | 2005-10-05 | 诺沃挪第克公司 | 用作治疗剂的芳基羰基衍生物 |
| EP1549626A1 (en) | 2002-10-03 | 2005-07-06 | Novartis AG | Substituted (thiazol-2-yl) -amide or sulfonamide as glycokinase activators useful in the treatment of type 2 diabetes |
| GB0226931D0 (en) | 2002-11-19 | 2002-12-24 | Astrazeneca Ab | Chemical compounds |
| GB0226930D0 (en) | 2002-11-19 | 2002-12-24 | Astrazeneca Ab | Chemical compounds |
| PE20040801A1 (es) | 2002-12-12 | 2004-11-25 | Hoffmann La Roche | Derivados de pirazina y piridina 5-sustituidos como activadores de glucoquinasa |
| ATE506354T1 (de) * | 2003-01-06 | 2011-05-15 | Lilly Co Eli | Substituierte arylcyclopropylacetamide als glucokinaseaktivatoren |
| PL378117A1 (pl) | 2003-02-11 | 2006-03-06 | Prosidion Limited | Tricyklopodstawione związki amidowe |
| SI1723128T1 (sl) | 2004-01-06 | 2013-04-30 | Transtech Pharma, Inc. | Heteroaril uree in njihova uporaba kot aktivatorji glukokinaze |
| JP2007523905A (ja) * | 2004-02-18 | 2007-08-23 | アストラゼネカ アクチボラグ | 化合物 |
| WO2005080359A1 (en) * | 2004-02-18 | 2005-09-01 | Astrazeneca Ab | Benzamide derivatives and their use as glucokinae activating agents |
| RU2006138426A (ru) * | 2004-04-02 | 2008-05-10 | Новартис АГ (CH) | Производные тиазолопиридина, содержащие их фармацевтические композиции и способы лечения состояний, опосредованных глюкокиназой |
| CA2560689C (en) * | 2004-04-02 | 2011-03-01 | Novartis Ag | Sulfonamide-thiazolpyridine derivatives as glucokinase activators useful in the treatment of type 2 diabetes |
| TW200600086A (en) * | 2004-06-05 | 2006-01-01 | Astrazeneca Ab | Chemical compound |
| JP2008516935A (ja) | 2004-10-16 | 2008-05-22 | アストラゼネカ アクチボラグ | フェノキシベンズアミド化合物の製造方法 |
| GB0423043D0 (en) * | 2004-10-16 | 2004-11-17 | Astrazeneca Ab | Compounds |
| GB0423044D0 (en) * | 2004-10-16 | 2004-11-17 | Astrazeneca Ab | Compounds |
| CA2590720A1 (en) * | 2004-12-03 | 2006-06-08 | Lone Jeppesen | Heteroaromatic glucokinase activators |
| EP1891069A1 (en) * | 2005-05-24 | 2008-02-27 | AstraZeneca AB | 2-phenyl substituted imidazol [4,5b]pyridine/ pyrazine and purine derivatives as glucokinase modulators |
| TW200714597A (en) * | 2005-05-27 | 2007-04-16 | Astrazeneca Ab | Chemical compounds |
| KR20080024211A (ko) | 2005-07-08 | 2008-03-17 | 노보 노르디스크 에이/에스 | 디시클로알킬 우레아 글루코키나제 활성제 |
| AU2006268406C1 (en) * | 2005-07-09 | 2011-02-24 | Astrazeneca Ab | Heteroaryl benzamide derivatives for use as GLK activators in the treatment of diabetes |
| EP2027113A1 (en) * | 2005-07-09 | 2009-02-25 | AstraZeneca AB | Heteroaryl benzamide derivatives for use as glk activators in the treatment of diabetes |
| JP2009500442A (ja) * | 2005-07-09 | 2009-01-08 | アストラゼネカ アクチボラグ | ２型糖尿病を処置するためのグルコキナーゼのモジュレーターとしての２−ヘテロシクリルオキシベンゾイルアミノヘテロシクリル化合物 |
| US8106090B2 (en) | 2005-07-20 | 2012-01-31 | Eli Lilly And Company | 1-amino linked compounds |
| US9202182B2 (en) * | 2005-08-11 | 2015-12-01 | International Business Machines Corporation | Method and system for analyzing business architecture |
| KR20080040046A (ko) | 2005-08-31 | 2008-05-07 | 아스텔라스세이야쿠 가부시키가이샤 | 티아졸 유도체 |
| JP2007063225A (ja) | 2005-09-01 | 2007-03-15 | Takeda Chem Ind Ltd | イミダゾピリジン化合物 |
| NZ566877A (en) | 2005-09-29 | 2010-05-28 | Sanofi Aventis | Phenyl-1,2,4-oxadiazolone derivatives, processes for their preparation and their use as pharmaceuticals |
| GT200600428A (es) * | 2005-09-30 | 2007-05-21 | Compuestos organicos | |
| GT200600429A (es) * | 2005-09-30 | 2007-04-30 | Compuestos organicos | |
| JP2009514835A (ja) * | 2005-11-03 | 2009-04-09 | プロシディオン・リミテッド | トリシクロ置換型アミド |
| WO2007123581A1 (en) | 2005-11-17 | 2007-11-01 | Eli Lilly And Company | Glucagon receptor antagonists, preparation and therapeutic uses |
| JP2009515997A (ja) * | 2005-11-18 | 2009-04-16 | タケダ サン ディエゴ インコーポレイテッド | グルコキナーゼ活性剤 |
| TW200738621A (en) * | 2005-11-28 | 2007-10-16 | Astrazeneca Ab | Chemical process |
| JP5302012B2 (ja) | 2006-03-08 | 2013-10-02 | タケダ カリフォルニア インコーポレイテッド | グルコキナーゼ活性剤 |
| US8211925B2 (en) | 2006-04-28 | 2012-07-03 | Transtech Pharma, Inc. | Benzamide glucokinase activators |
| PE20110235A1 (es) | 2006-05-04 | 2011-04-14 | Boehringer Ingelheim Int | Combinaciones farmaceuticas que comprenden linagliptina y metmorfina |
| WO2007143434A2 (en) | 2006-05-31 | 2007-12-13 | Takeda San Diego, Inc. | Indazole and isoindole derivatives as glucokinase activating agents |
| RU2009105818A (ru) | 2006-07-24 | 2010-08-27 | Ф.Хоффманн-Ля Рош Аг (Ch) | Пиразолы в качестве активаторов глюкокиназы |
| TW200825063A (en) * | 2006-10-23 | 2008-06-16 | Astrazeneca Ab | Chemical compounds |
| CL2007003061A1 (es) * | 2006-10-26 | 2008-08-01 | Astrazeneca Ab | Compuestos derivados de 3,5-dioxi-benzamida; proceso de preparacion; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar una enfermedad mediada a traves de glk, tal como la diabetes tipo 2. |
| US8163779B2 (en) | 2006-12-20 | 2012-04-24 | Takeda San Diego, Inc. | Glucokinase activators |
| US20100094009A1 (en) * | 2006-12-21 | 2010-04-15 | Mccabe James | Novel crystalline compound useful as glk activator |
| TW200831081A (en) | 2006-12-25 | 2008-08-01 | Kyorin Seiyaku Kk | Glucokinase activator |
| US8940900B2 (en) | 2007-02-28 | 2015-01-27 | Advinus Therapeutics Private Limited | 2,2,2-tri-substituted acetamide derivatives as glucokinase activators, their process and pharmaceutical application |
| TW200902489A (en) * | 2007-03-07 | 2009-01-16 | Kyorin Seiyaku Kk | Glucokinase-activating substance |
| US8173645B2 (en) | 2007-03-21 | 2012-05-08 | Takeda San Diego, Inc. | Glucokinase activators |
| AR070107A1 (es) * | 2008-01-15 | 2010-03-17 | Lilly Co Eli | R-2-(4-ciclopropansulfonil-fenil)-n-pirazin-2-il-3-(tetrahidropiran-4-il)-propionamida en forma cristalina, composicion farmaceutica que la comprende y su uso para la manufactura de un medicamento util para la prevencion o tratamiento de hiperglicemia |
| CN101918363B (zh) | 2008-01-18 | 2012-09-05 | 安斯泰来制药株式会社 | 苯乙酰胺衍生物 |
| US7741327B2 (en) | 2008-04-16 | 2010-06-22 | Hoffmann-La Roche Inc. | Pyrrolidinone glucokinase activators |
| US8258134B2 (en) | 2008-04-16 | 2012-09-04 | Hoffmann-La Roche Inc. | Pyridazinone glucokinase activators |
| EP2275414B1 (en) | 2008-04-28 | 2015-06-10 | Kyorin Pharmaceutical Co., Ltd. | Cyclopentylacrylamide derivative |
| AU2009278929B2 (en) | 2008-08-04 | 2012-07-05 | Astrazeneca Ab | Pyrazolo [3,4] pyrimidin-4-yl derivatives and their uses to treat diabetes and obesity |
| UA104742C2 (uk) | 2008-12-19 | 2014-03-11 | Эли Лилли Энд Компани | Похідні арилциклопропілацетаміду, застосовні як активатори глюкокінази |
| GB0902406D0 (en) * | 2009-02-13 | 2009-04-01 | Astrazeneca Ab | Crystalline polymorphic form |
| GB0902434D0 (en) * | 2009-02-13 | 2009-04-01 | Astrazeneca Ab | Chemical process |
| AR076220A1 (es) | 2009-04-09 | 2011-05-26 | Astrazeneca Ab | Derivados de pirazol [4,5 - e] pirimidina |
| AR076221A1 (es) * | 2009-04-09 | 2011-05-26 | Astrazeneca Ab | Derivado de pirazol [4,5-e] pirimidina y su uso para tratar diabetes y obesidad |
| US8222416B2 (en) | 2009-12-14 | 2012-07-17 | Hoffmann-La Roche Inc. | Azaindole glucokinase activators |
| JP5909482B2 (ja) | 2010-03-31 | 2016-04-26 | ザ スクリプス リサーチ インスティテュート | 細胞の再プログラム |
| US8877754B2 (en) * | 2010-09-06 | 2014-11-04 | Boehringer Ingelheim International Gmbh | Compounds, pharmaceutical compositions and uses thereof |
| WO2014035872A1 (en) * | 2012-08-27 | 2014-03-06 | Amgen Inc. | Tricyclic alkynes that interact with glucokinase regulatory protein |
| EP2878339A1 (en) | 2013-12-02 | 2015-06-03 | Siena Biotech S.p.A. | SIP3 antagonists |
| EP3053834B1 (en) | 2015-02-04 | 2019-03-27 | Tetra Laval Holdings & Finance S.A. | Forming assembly and method for forming a plurality of sealed packs for pourable food products starting from a tube of packaging material |
| AU2019287437A1 (en) | 2018-06-12 | 2020-09-10 | Vtv Therapeutics Llc | Therapeutic uses of glucokinase activators in combination with insulin or insulin analogs |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS61115054A (ja) * | 1984-11-08 | 1986-06-02 | Taisho Pharmaceut Co Ltd | スチレンアルカン酸誘導体 |
| WO1996040113A2 (en) * | 1995-06-07 | 1996-12-19 | Sugen, Inc. | Phosphatase inhibitors |
| DK0994108T3 (da) * | 1997-06-24 | 2003-08-18 | Zeria Pharm Co Ltd | Fremgangsmåde til fremstilling af 2-hydroxybenzamidderivater |
-
2001
- 2001-04-25 JP JP2001580894A patent/JP3788935B2/ja not_active Expired - Fee Related
- 2001-04-25 US US09/841,983 patent/US6388071B2/en not_active Expired - Fee Related
- 2001-04-25 WO PCT/EP2001/004654 patent/WO2001083465A2/en active IP Right Grant
- 2001-04-25 KR KR10-2002-7014725A patent/KR100502033B1/ko not_active IP Right Cessation
- 2001-04-25 MX MXPA02010745A patent/MXPA02010745A/es active IP Right Grant
- 2001-04-25 DE DE60108108T patent/DE60108108T2/de not_active Expired - Lifetime
- 2001-04-25 CN CNB018089127A patent/CN1176915C/zh not_active Expired - Fee Related
- 2001-04-25 PT PT01949294T patent/PT1282612E/pt unknown
- 2001-04-25 AT AT01949294T patent/ATE286036T1/de not_active IP Right Cessation
- 2001-04-25 AU AU2001270494A patent/AU2001270494B2/en not_active Ceased
- 2001-04-25 EP EP01949294A patent/EP1282612B1/en not_active Expired - Lifetime
- 2001-04-25 CA CA002407416A patent/CA2407416C/en not_active Expired - Fee Related
- 2001-04-25 BR BR0110573-6A patent/BR0110573A/pt not_active IP Right Cessation
- 2001-04-25 ES ES01949294T patent/ES2233660T3/es not_active Expired - Lifetime
- 2001-04-25 AU AU7049401A patent/AU7049401A/xx active Pending
- 2001-04-27 PE PE2001000383A patent/PE20011310A1/es not_active Application Discontinuation
- 2001-04-30 AR ARP010102035A patent/AR032453A1/es not_active Application Discontinuation
- 2001-05-03 EC EC2001004054A patent/ECSP014054A/es unknown
-
2002
- 2002-10-22 ZA ZA200208542A patent/ZA200208542B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2407416A1 (en) | 2001-11-08 |
| DE60108108T2 (de) | 2005-12-08 |
| ECSP014054A (es) | 2002-01-25 |
| ZA200208542B (en) | 2004-01-22 |
| JP2003531898A (ja) | 2003-10-28 |
| EP1282612B1 (en) | 2004-12-29 |
| CN1432004A (zh) | 2003-07-23 |
| JP3788935B2 (ja) | 2006-06-21 |
| WO2001083465A3 (en) | 2002-05-16 |
| KR100502033B1 (ko) | 2005-07-25 |
| ES2233660T3 (es) | 2005-06-16 |
| CN1176915C (zh) | 2004-11-24 |
| EP1282612A2 (en) | 2003-02-12 |
| DE60108108D1 (de) | 2005-02-03 |
| AR032453A1 (es) | 2003-11-12 |
| BR0110573A (pt) | 2003-04-01 |
| US20010053851A1 (en) | 2001-12-20 |
| CA2407416C (en) | 2006-07-18 |
| US6388071B2 (en) | 2002-05-14 |
| AU2001270494B2 (en) | 2005-11-10 |
| PE20011310A1 (es) | 2001-12-31 |
| MXPA02010745A (es) | 2003-03-10 |
| WO2001083465A2 (en) | 2001-11-08 |
| ATE286036T1 (de) | 2005-01-15 |
| AU7049401A (en) | 2001-11-12 |
| KR20020093117A (ko) | 2002-12-12 |
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