PT1185548E - Processo para a secagem de cristais proteicos - Google Patents

Processo para a secagem de cristais proteicos

Info

Publication number
PT1185548E
PT1185548E PT00903580T PT00903580T PT1185548E PT 1185548 E PT1185548 E PT 1185548E PT 00903580 T PT00903580 T PT 00903580T PT 00903580 T PT00903580 T PT 00903580T PT 1185548 E PT1185548 E PT 1185548E
Authority
PT
Portugal
Prior art keywords
drying
water
crystal suspension
protein
protein crystal
Prior art date
Application number
PT00903580T
Other languages
English (en)
Inventor
Deusser Rolf
Kraemer Peter
Thurow Horst
Original Assignee
Sanofi Aventis Deutschland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis Deutschland filed Critical Sanofi Aventis Deutschland
Publication of PT1185548E publication Critical patent/PT1185548E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/30—Extraction; Separation; Purification by precipitation
    • C07K1/306—Extraction; Separation; Purification by precipitation by crystallization
    • C—CHEMISTRY; METALLURGY
    • C30—CRYSTAL GROWTH
    • C30B—SINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
    • C30B29/00—Single crystals or homogeneous polycrystalline material with defined structure characterised by the material or by their shape
    • C30B29/54—Organic compounds
    • C30B29/58—Macromolecular compounds
    • C—CHEMISTRY; METALLURGY
    • C30—CRYSTAL GROWTH
    • C30B—SINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
    • C30B33/00—After-treatment of single crystals or homogeneous polycrystalline material with defined structure

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Metallurgy (AREA)
  • Analytical Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Drying Of Solid Materials (AREA)
  • Extraction Or Liquid Replacement (AREA)
PT00903580T 1999-01-27 2000-01-15 Processo para a secagem de cristais proteicos PT1185548E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19903125A DE19903125B4 (de) 1999-01-27 1999-01-27 Verfahren zur Trocknung von Kristallen von Insulin oder Insulinanaloga

Publications (1)

Publication Number Publication Date
PT1185548E true PT1185548E (pt) 2006-06-30

Family

ID=7895502

Family Applications (1)

Application Number Title Priority Date Filing Date
PT00903580T PT1185548E (pt) 1999-01-27 2000-01-15 Processo para a secagem de cristais proteicos

Country Status (20)

Country Link
US (1) US6408536B1 (pt)
EP (1) EP1185548B1 (pt)
JP (1) JP4465120B2 (pt)
KR (1) KR100652471B1 (pt)
CN (1) CN1211397C (pt)
AT (1) ATE323101T1 (pt)
AU (1) AU764353B2 (pt)
BR (1) BRPI0007713B8 (pt)
CA (1) CA2361397C (pt)
CY (1) CY1105256T1 (pt)
CZ (1) CZ300915B6 (pt)
DE (2) DE19903125B4 (pt)
DK (1) DK1185548T3 (pt)
ES (1) ES2259994T3 (pt)
HK (1) HK1044548B (pt)
HU (1) HU226697B1 (pt)
PL (1) PL197694B1 (pt)
PT (1) PT1185548E (pt)
RU (1) RU2235730C2 (pt)
WO (1) WO2000044767A2 (pt)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19903125B4 (de) * 1999-01-27 2006-01-05 Sanofi-Aventis Deutschland Gmbh Verfahren zur Trocknung von Kristallen von Insulin oder Insulinanaloga
GB0219815D0 (en) * 2002-08-24 2002-10-02 Accentus Plc Preparation of small crystals
DE102004049241A1 (de) * 2004-10-09 2006-04-20 Sanofi-Aventis Deutschland Gmbh Trockner und Verfahren zum Steuern eines Trockners
EP1870649A1 (en) 2006-06-20 2007-12-26 Octapharma AG Lyophilisation targetting defined residual moisture by limited desorption energy levels
US20090271021A1 (en) * 2008-04-28 2009-10-29 Popp Shane M Execution system for the monitoring and execution of insulin manufacture
KR20150000862A (ko) * 2011-11-16 2015-01-05 바이엘 인텔렉쳐 프로퍼티 게엠베하 여과, 건조 및 저장 장치
US11472835B2 (en) 2017-09-26 2022-10-18 Biocon Biologics India Limited Integrated automated filtration for separation, washing and drying of peptide crystals

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4139637A (en) * 1972-12-28 1979-02-13 Maurice Rouchy Quinone derivatives useful as medicaments
US4133716A (en) * 1976-11-22 1979-01-09 Crc Compagnia Ricerca Chimca, S.A. Method for the biosynthesis of a microbial insecticide
US5234503A (en) * 1987-02-02 1993-08-10 A.E. Saley Manufacturing Co. Integrated process for producing crystalline fructose and a high-fructose, liquid-phase sweetener
DE3717370A1 (de) * 1987-05-22 1988-12-01 Hoechst Ag Mischkristalle aus insulin und insulinderivaten, verfahren zur herstellung dieser mischkristalle, diese mischkristalle enthaltende pharmazeutische mittel und ihre verwendung zur behandlung von diabetes mellitus
DE4013388A1 (de) * 1990-04-26 1991-10-31 Titus Hans Joachim Zentrifugen-trockner
US5526581A (en) * 1992-10-30 1996-06-18 Philip Morris Incorporated Process for adjusting the moisture content of organic materials
ES2161726T3 (es) * 1993-04-27 2001-12-16 Hoechst Ag Formas amorfas monoesfericas de derivados de insulina.
US5597893A (en) * 1994-10-31 1997-01-28 Eli Lilly And Company Preparation of stable insulin analog crystals
US5544425A (en) * 1995-05-17 1996-08-13 Mallinckrodt Medical, Inc. Aggressive convective drying in a nutsche type filter/dryer
GB9522302D0 (en) * 1995-10-31 1996-01-03 Univ Liverpool Growth promoters
US5932212A (en) * 1996-05-24 1999-08-03 Altus Biologics, Inc. Crosslinked protein crystal formulations and their use as catalysts in organic solvents
US5743840A (en) * 1996-06-24 1998-04-28 Carr Separations, Inc. Centrifuge with a heating jacket for drying collected solids
JP3764174B2 (ja) * 1997-03-20 2006-04-05 ノボ ノルディスク アクティーゼルスカブ 肺用組成物において使用するための亜鉛非含有のインスリン結晶
DE19903125B4 (de) * 1999-01-27 2006-01-05 Sanofi-Aventis Deutschland Gmbh Verfahren zur Trocknung von Kristallen von Insulin oder Insulinanaloga

Also Published As

Publication number Publication date
BRPI0007713B8 (pt) 2021-05-25
CA2361397A1 (en) 2000-08-03
KR20010090012A (ko) 2001-10-17
HK1044548A1 (en) 2002-10-25
EP1185548B1 (de) 2006-04-12
CA2361397C (en) 2010-02-23
AU2541800A (en) 2000-08-18
DE19903125A1 (de) 2000-08-10
JP2002535415A (ja) 2002-10-22
PL197694B1 (pl) 2008-04-30
AU764353B2 (en) 2003-08-14
CZ300915B6 (cs) 2009-09-09
US6408536B1 (en) 2002-06-25
CN1344273A (zh) 2002-04-10
JP4465120B2 (ja) 2010-05-19
CN1211397C (zh) 2005-07-20
CZ20012630A3 (cs) 2001-10-17
WO2000044767A3 (de) 2001-11-08
HUP0105427A2 (hu) 2002-04-29
HK1044548B (zh) 2006-01-20
KR100652471B1 (ko) 2006-12-01
DK1185548T3 (da) 2006-08-14
HU226697B1 (en) 2009-07-28
DE19903125B4 (de) 2006-01-05
ES2259994T3 (es) 2006-11-01
EP1185548A2 (de) 2002-03-13
BR0007713A (pt) 2001-11-27
WO2000044767A2 (de) 2000-08-03
HUP0105427A3 (en) 2003-12-29
ATE323101T1 (de) 2006-04-15
CY1105256T1 (el) 2010-03-03
PL350169A1 (en) 2002-11-18
DE50012577D1 (de) 2006-05-24
BRPI0007713B1 (pt) 2016-06-14
RU2235730C2 (ru) 2004-09-10

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