PT117309A - Sistema integrado de biorreator e processo de controlo, aprendizagem e monitorização da cultura celular utilizando o mesmo - Google Patents

Sistema integrado de biorreator e processo de controlo, aprendizagem e monitorização da cultura celular utilizando o mesmo

Info

Publication number
PT117309A
PT117309A PT117309A PT11730921A PT117309A PT 117309 A PT117309 A PT 117309A PT 117309 A PT117309 A PT 117309A PT 11730921 A PT11730921 A PT 11730921A PT 117309 A PT117309 A PT 117309A
Authority
PT
Portugal
Prior art keywords
learning
integrated
control
monitoring
cell culture
Prior art date
Application number
PT117309A
Other languages
English (en)
Inventor
Cristina Rodrigues Pascoal Faria Paula
Manuel Fernandes Alves Nuno
Sofia Monteiro De Moura Carla
Pedro Almeida Meneses João
Original Assignee
Inst Politecnico De Leiria
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inst Politecnico De Leiria filed Critical Inst Politecnico De Leiria
Priority to PT117309A priority Critical patent/PT117309A/pt
Priority to EP21199958.6A priority patent/EP4112714A1/en
Publication of PT117309A publication Critical patent/PT117309A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M37/00—Means for sterilizing, maintaining sterile conditions or avoiding chemical or biological contamination
    • C12M37/02—Filters
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M1/00—Apparatus for enzymology or microbiology
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C1/00—Magnetic separation
    • B03C1/02—Magnetic separation acting directly on the substance being separated
    • B03C1/025—High gradient magnetic separators
    • B03C1/031—Component parts; Auxiliary operations
    • B03C1/033—Component parts; Auxiliary operations characterised by the magnetic circuit
    • B03C1/0335—Component parts; Auxiliary operations characterised by the magnetic circuit using coils
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M1/00—Apparatus for enzymology or microbiology
    • C12M1/34—Measuring or testing with condition measuring or sensing means, e.g. colony counters
    • C12M1/3407—Measure of electrical or magnetical factor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M27/00—Means for mixing, agitating or circulating fluids in the vessel
    • C12M27/10—Rotating vessel
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M37/00—Means for sterilizing, maintaining sterile conditions or avoiding chemical or biological contamination
    • C12M37/04—Seals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/48—Automatic or computerized control

Landscapes

  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Sustainable Development (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Computer Hardware Design (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Abstract

A PRESENTE INVENÇÃO DESCREVE UM SISTEMA INTEGRADO DE BIORREATOR (1), QUE COMPREENDE UMA COMPONENTE EXTERNA (2), UMA COMPONENTE INTERNA (3) E UMA ESTRUTURA DE SUPORTE (4) QUE COMPREENDE UMA PLATAFORMA COMPUTACIONAL DE CONTROLO, APRENDIZAGEM E OTIMIZAÇÃO DA APLICAÇÃO DE ESTÍMULOS. A PRESENTE INVENÇÃO AINDA DESCREVE UM PROCESSO DE CONTROLO, APRENDIZAGEM E MONITORIZAÇÃO DA CULTURA CELULAR UTILIZANDO O REFERIDO SISTEMA INTEGRADO DE BIORREATOR (1), QUE PERMITE A OTIMIZAÇÃO DA APLICAÇÃO DE DIFERENTES ESTÍMULOS EM CÉLULAS COLOCADAS EM MODELOS TRIDIMENSIONAIS (3436) ALOCADOS NA COMPONENTE INTERNA (3), DE FORMA A MIMETIZAR AS CONDIÇÕES NATIVAS DO TECIDO BIOLÓGICO. ESTA INVENÇÃO RESOLVE OS PROBLEMAS REFERENTES À NECESSIDADE DE OTIMIZAR, CONTROLAR E MONITORIZAR, EM TEMPO REAL, OS PARÂMETROS ENVOLVIDOS NA ESTIMULAÇÃO DE DIFERENTES CÉLULAS EM APLICAÇÕES DA ENGENHARIA DE TECIDOS REDUZINDO, ASSIM, O TEMPO ENVOLVIDO EM PROCESSOS DE DIFERENCIAÇÃO E / OU PROLIFERAÇÃO, PARAMETRIZÁVEIS PARA DIFERENTES LINHAS CELULARES
PT117309A 2021-06-29 2021-06-29 Sistema integrado de biorreator e processo de controlo, aprendizagem e monitorização da cultura celular utilizando o mesmo PT117309A (pt)

Priority Applications (2)

Application Number Priority Date Filing Date Title
PT117309A PT117309A (pt) 2021-06-29 2021-06-29 Sistema integrado de biorreator e processo de controlo, aprendizagem e monitorização da cultura celular utilizando o mesmo
EP21199958.6A EP4112714A1 (en) 2021-06-29 2021-09-29 Integrated bioreactor system and process for control, learning and monitoring of cell culture using the same

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PT117309A PT117309A (pt) 2021-06-29 2021-06-29 Sistema integrado de biorreator e processo de controlo, aprendizagem e monitorização da cultura celular utilizando o mesmo

Publications (1)

Publication Number Publication Date
PT117309A true PT117309A (pt) 2022-12-29

Family

ID=84272909

Family Applications (1)

Application Number Title Priority Date Filing Date
PT117309A PT117309A (pt) 2021-06-29 2021-06-29 Sistema integrado de biorreator e processo de controlo, aprendizagem e monitorização da cultura celular utilizando o mesmo

Country Status (2)

Country Link
EP (1) EP4112714A1 (pt)
PT (1) PT117309A (pt)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6114164A (en) * 1998-12-07 2000-09-05 The Regents Of The University Of Michigan System and method for emulating an in vivo environment of a muscle tissue specimen
US20100178680A1 (en) * 2004-06-30 2010-07-15 Regenetech, Inc. Rotatable perfused time varying electromagnetic force bioreactor and method of using the same
US20070048253A1 (en) * 2004-06-30 2007-03-01 Goodwin Thomas J Natively glycosylated mammalian biological molecules produced by electromagnetically stimulating living mammalian cells
EP2836585A4 (en) * 2012-04-09 2015-12-23 Thomas J Goodwin ALTERNATIVE ION MAGNETIC RESONANCE MULTIPLE CHAMBER CULTURE APPARATUS (AIMR) AND METHODS OF USE

Also Published As

Publication number Publication date
EP4112714A1 (en) 2023-01-04

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Legal Events

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BB1A Laying open of patent application

Effective date: 20210921