PT1169326E - Novo processo para a preparacao de acido alendronico - Google Patents

Novo processo para a preparacao de acido alendronico

Info

Publication number
PT1169326E
PT1169326E PT00913437T PT00913437T PT1169326E PT 1169326 E PT1169326 E PT 1169326E PT 00913437 T PT00913437 T PT 00913437T PT 00913437 T PT00913437 T PT 00913437T PT 1169326 E PT1169326 E PT 1169326E
Authority
PT
Portugal
Prior art keywords
alendronic acid
preparation
new process
reacting
group
Prior art date
Application number
PT00913437T
Other languages
English (en)
Inventor
Ramy Lidor-Hadas
Revital Lifshitz
Original Assignee
Teva Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teva Pharma filed Critical Teva Pharma
Publication of PT1169326E publication Critical patent/PT1169326E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3839—Polyphosphonic acids
    • C07F9/3873—Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
  • Peptides Or Proteins (AREA)
PT00913437T 1999-02-17 2000-02-11 Novo processo para a preparacao de acido alendronico PT1169326E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US25163499A 1999-02-17 1999-02-17

Publications (1)

Publication Number Publication Date
PT1169326E true PT1169326E (pt) 2004-10-29

Family

ID=22952795

Family Applications (1)

Application Number Title Priority Date Filing Date
PT00913437T PT1169326E (pt) 1999-02-17 2000-02-11 Novo processo para a preparacao de acido alendronico

Country Status (29)

Country Link
US (2) US6201148B1 (pt)
EP (1) EP1169326B1 (pt)
JP (1) JP3930251B2 (pt)
KR (1) KR100665633B1 (pt)
AT (1) ATE271057T1 (pt)
AU (1) AU770312B2 (pt)
BG (1) BG64851B1 (pt)
BR (1) BR0010112A (pt)
CA (1) CA2363317C (pt)
CZ (1) CZ296921B6 (pt)
DE (1) DE60012165T2 (pt)
DK (1) DK1169326T3 (pt)
EA (1) EA003861B1 (pt)
EE (1) EE04593B1 (pt)
ES (1) ES2222188T3 (pt)
HK (1) HK1041004B (pt)
HR (1) HRP20010606B1 (pt)
HU (1) HUP0200342A3 (pt)
IL (1) IL144941A0 (pt)
IS (1) IS6050A (pt)
MX (1) MXPA01008332A (pt)
NO (1) NO20013984L (pt)
NZ (1) NZ513551A (pt)
PL (1) PL350126A1 (pt)
PT (1) PT1169326E (pt)
SK (1) SK285163B6 (pt)
WO (1) WO2000049026A1 (pt)
YU (1) YU59401A (pt)
ZA (1) ZA200106816B (pt)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100665633B1 (ko) * 1999-02-17 2007-01-10 테바 파마슈티컬 인더스트리즈 리미티드 알렌드론산을 제조하는 신규한 방법
ES2153794B1 (es) * 1999-08-06 2001-10-16 Medichem Sa Procedimiento para la obtencion del acido 4-amino-1-hidroxibutiliden-1,1-bisfosfonico y de su sal monosodica trihidratada.
TR200101250A2 (tr) * 2001-05-10 2003-04-21 E�S Eczaciba�I �Zg�N K�Myasal �R�Nler Sanay� A.�. 4-amino-1-hidroksibutiliden-1,1-bifosfonik asit veya tuzlarının hazırlanmasına ilişkin proses
CN1620284B (zh) 2001-12-24 2010-04-28 特瓦制药工业有限公司 含有用粉末或粒状材料的压缩环状体包鞘的有效成分片芯的剂型,及其生产工艺和工具
US20040052843A1 (en) * 2001-12-24 2004-03-18 Lerner E. Itzhak Controlled release dosage forms
ITMI20020908A1 (it) 2002-04-29 2003-10-29 Chemi Spa Processo di preparazione di sodio alendronato
HUP0300227A2 (hu) * 2003-01-28 2004-09-28 Richter Gedeon Vegyészeti Gyár Rt. Eljárás nagy tisztaságú 2-szubsztituált -1-(hidroxi-etilidén)-1,1-biszfoszfonsavak és sóik előállítására
WO2007083240A2 (en) * 2006-01-20 2007-07-26 Aurobindo Pharma Limited An improved process for the preparation of bisphosphonic acids

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US562A (en) * 1838-01-09 Scale beam and weight
US22A (en) * 1836-09-05 Spbcificatioh
DE3016289A1 (de) * 1980-04-28 1981-10-29 Henkel KGaA, 4000 Düsseldorf Verfahren zur herstellung von omega -amino-1-hydroxyalkyliden-1,1-bis-phosphonsaeuren
IT1201087B (it) * 1982-04-15 1989-01-27 Gentili Ist Spa Bifosfonati farmacologicamente attivi,procedimento per la loro preparazione e relative composizioni farmaceutiche
US4621107A (en) * 1982-08-12 1986-11-04 Lagow Richard J Fluorinated elastomeric materials
IT1196315B (it) * 1984-10-29 1988-11-16 Gentili Ist Spa Procedimento per la preparazione di acidi difosfonici
GB2248063A (en) * 1990-09-18 1992-03-25 Merck & Co Inc Phthalimido alkanoyl phosphonates
US5039819A (en) * 1990-09-18 1991-08-13 Merck & Co., Inc. Diphosphonate intermediate for preparing an antihypercalcemic agent
US5159108A (en) * 1990-09-18 1992-10-27 Merck & Co., Inc. Process for preparing an antihypercalcemic agent
CA2197267C (en) * 1997-02-11 2000-02-08 Yong Tao Process for the production of 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof
KR100665633B1 (ko) * 1999-02-17 2007-01-10 테바 파마슈티컬 인더스트리즈 리미티드 알렌드론산을 제조하는 신규한 방법

Also Published As

Publication number Publication date
ATE271057T1 (de) 2004-07-15
MXPA01008332A (es) 2003-01-08
EE04593B1 (et) 2006-02-15
AU3488600A (en) 2000-09-04
KR100665633B1 (ko) 2007-01-10
CA2363317C (en) 2008-04-29
JP2002537303A (ja) 2002-11-05
WO2000049026A1 (en) 2000-08-24
ES2222188T3 (es) 2005-02-01
PL350126A1 (en) 2002-11-04
CA2363317A1 (en) 2000-08-24
NZ513551A (en) 2003-02-28
BR0010112A (pt) 2001-12-26
EA200100894A1 (ru) 2002-04-25
SK11862001A3 (sk) 2002-02-05
US6201148B1 (en) 2001-03-13
BG64851B1 (bg) 2006-06-30
US20020052527A1 (en) 2002-05-02
DK1169326T3 (da) 2004-10-04
AU770312B2 (en) 2004-02-19
YU59401A (sh) 2004-05-12
DE60012165D1 (de) 2004-08-19
EA003861B1 (ru) 2003-10-30
JP3930251B2 (ja) 2007-06-13
IL144941A0 (en) 2002-06-30
EP1169326A1 (en) 2002-01-09
ZA200106816B (en) 2002-08-19
CZ20012942A3 (cs) 2002-01-16
CZ296921B6 (cs) 2006-07-12
HK1041004A1 (en) 2002-06-28
NO20013984D0 (no) 2001-08-16
BG105825A (en) 2002-04-30
SK285163B6 (sk) 2006-07-07
EP1169326B1 (en) 2004-07-14
HRP20010606A2 (en) 2002-10-31
DE60012165T2 (de) 2005-08-25
NO20013984L (no) 2001-10-17
KR20010102162A (ko) 2001-11-15
HUP0200342A2 (en) 2002-06-29
HRP20010606B1 (en) 2005-08-31
IS6050A (is) 2001-08-16
HK1041004B (zh) 2005-01-21
EP1169326A4 (en) 2002-05-22
EE200100436A (et) 2002-12-16
HUP0200342A3 (en) 2005-02-28

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