PT1019195E - Aparelho de elevado gradiente magnetico e metodo de separacao de celulas ou purificacao - Google Patents

Aparelho de elevado gradiente magnetico e metodo de separacao de celulas ou purificacao

Info

Publication number
PT1019195E
PT1019195E PT98955422T PT98955422T PT1019195E PT 1019195 E PT1019195 E PT 1019195E PT 98955422 T PT98955422 T PT 98955422T PT 98955422 T PT98955422 T PT 98955422T PT 1019195 E PT1019195 E PT 1019195E
Authority
PT
Portugal
Prior art keywords
channel
separating material
cells
container
purification
Prior art date
Application number
PT98955422T
Other languages
English (en)
Inventor
Srikanth Ranga Chary
Richard Merrill Schwartz
Donald David Briggs
Shang-Chih Jen
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of PT1019195E publication Critical patent/PT1019195E/pt

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C1/00—Magnetic separation
    • B03C1/02—Magnetic separation acting directly on the substance being separated
    • B03C1/035—Open gradient magnetic separators, i.e. separators in which the gap is unobstructed, characterised by the configuration of the gap
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/84—Manufacture, treatment, or detection of nanostructure
    • Y10S977/888—Shaping or removal of materials, e.g. etching
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure

Landscapes

  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Water Treatment By Electricity Or Magnetism (AREA)
PT98955422T 1997-10-10 1998-10-09 Aparelho de elevado gradiente magnetico e metodo de separacao de celulas ou purificacao PT1019195E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/948,357 US6241894B1 (en) 1997-10-10 1997-10-10 High gradient magnetic device and method for cell separation or purification

Publications (1)

Publication Number Publication Date
PT1019195E true PT1019195E (pt) 2003-01-31

Family

ID=25487708

Family Applications (1)

Application Number Title Priority Date Filing Date
PT98955422T PT1019195E (pt) 1997-10-10 1998-10-09 Aparelho de elevado gradiente magnetico e metodo de separacao de celulas ou purificacao

Country Status (9)

Country Link
US (1) US6241894B1 (pt)
EP (1) EP1019195B1 (pt)
AT (1) ATE223759T1 (pt)
AU (1) AU1226999A (pt)
DE (1) DE69807905T2 (pt)
DK (1) DK1019195T3 (pt)
ES (1) ES2184332T3 (pt)
PT (1) PT1019195E (pt)
WO (1) WO1999019071A1 (pt)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6913697B2 (en) 2001-02-14 2005-07-05 Science & Technology Corporation @ Unm Nanostructured separation and analysis devices for biological membranes
DE10127069A1 (de) * 2001-05-23 2002-11-28 Bio Medical Apherese Systeme G Magnetfilter zur Abtrennung von strömenden magnetischen Objekten
EP1331035A1 (en) * 2002-01-23 2003-07-30 F. Hoffmann-La Roche AG Apparatus for retaining magnetic particles within a flow-through cell
US7318902B2 (en) * 2002-02-04 2008-01-15 Colorado School Of Mines Laminar flow-based separations of colloidal and cellular particles
ATE531257T1 (de) 2002-09-27 2011-11-15 Gen Hospital Corp Mikrofluidische vorrichtung zur zelltrennung und verwendungen davon
US20120077206A1 (en) 2003-07-12 2012-03-29 Accelr8 Technology Corporation Rapid Microbial Detection and Antimicrobial Susceptibility Testing
CA2532414C (en) 2003-07-12 2017-03-14 Accelr8 Technology Corporation Sensitive and rapid biodetection
US20050266394A1 (en) * 2003-12-24 2005-12-01 Massachusette Institute Of Technology Magnetophoretic cell clarification
US20050266433A1 (en) * 2004-03-03 2005-12-01 Ravi Kapur Magnetic device for isolation of cells and biomolecules in a microfluidic environment
US20060171846A1 (en) * 2005-01-10 2006-08-03 Marr David W M Microfluidic systems incorporating integrated optical waveguides
US20070196820A1 (en) 2005-04-05 2007-08-23 Ravi Kapur Devices and methods for enrichment and alteration of cells and other particles
US8921102B2 (en) 2005-07-29 2014-12-30 Gpb Scientific, Llc Devices and methods for enrichment and alteration of circulating tumor cells and other particles
US20070059716A1 (en) * 2005-09-15 2007-03-15 Ulysses Balis Methods for detecting fetal abnormality
WO2007044642A2 (en) * 2005-10-06 2007-04-19 President And Fellows Of Harvard College And Children's Medical Center Corporation Device and method for combined microfluidic-micromagnetic separation of material in continuous flow
US8119976B2 (en) * 2007-07-03 2012-02-21 Colorado School Of Mines Optical-based cell deformability
US9487812B2 (en) 2012-02-17 2016-11-08 Colorado School Of Mines Optical alignment deformation spectroscopy
US9885644B2 (en) 2006-01-10 2018-02-06 Colorado School Of Mines Dynamic viscoelasticity as a rapid single-cell biomarker
US9878326B2 (en) * 2007-09-26 2018-01-30 Colorado School Of Mines Fiber-focused diode-bar optical trapping for microfluidic manipulation
US20080007838A1 (en) * 2006-07-07 2008-01-10 Omnitech Partners, Inc. Field-of-view indicator, and optical system and associated method employing the same
US20090062828A1 (en) * 2007-09-04 2009-03-05 Colorado School Of Mines Magnetic field-based colloidal atherectomy
US10722250B2 (en) 2007-09-04 2020-07-28 Colorado School Of Mines Magnetic-field driven colloidal microbots, methods for forming and using the same
DE102007043281A1 (de) 2007-09-11 2009-05-28 Sebastian Dr. med. Chakrit Bhakdi Vorrichtung, Materialien und Verfahren zur Hochgradientenmagnetseparation biologischen Materials
DE102008047855A1 (de) * 2008-09-18 2010-04-22 Siemens Aktiengesellschaft Trenneinrichtung zur Trennung von in einer durch einen Trennkanal strömenden Suspension transportierten magnetisierbaren und nichtmagnetisierbaren Teilchen
WO2010123594A2 (en) * 2009-01-15 2010-10-28 Children's Medical Center Corporation Device for filtration of fluids there through and accompanying method
US8083069B2 (en) * 2009-07-31 2011-12-27 General Electric Company High throughput magnetic isolation technique and device for biological materials
TWI362964B (en) 2009-12-23 2012-05-01 Ind Tech Res Inst Magnetic separation device and method for separating magnetic substances in bio-samples
US10254204B2 (en) 2011-03-07 2019-04-09 Accelerate Diagnostics, Inc. Membrane-assisted purification
EP2683831B1 (en) * 2011-03-07 2015-09-23 Accelerate Diagnostics, Inc. Rapid cell purification systems
TWI407101B (zh) 2011-04-11 2013-09-01 Ind Tech Res Inst 磁分離單元、磁性分離裝置以及分離生化試樣內磁性物質之方法
BR112013024148B1 (pt) * 2011-04-27 2022-01-25 Becton, Dickinson And Company Dispositivo, método e sistema para separar partes marcadas magneticamente em uma amostra, método de separar partes marcadas magneticamente em uma amostra
WO2014066553A1 (en) 2012-10-26 2014-05-01 Becton, Dickinson And Company Devices and methods for manipulating components in a fluid sample
CA2942831A1 (en) 2013-03-15 2014-09-18 The Trustees Of Princeton University Methods and devices for high throughput purification
US9677109B2 (en) 2013-03-15 2017-06-13 Accelerate Diagnostics, Inc. Rapid determination of microbial growth and antimicrobial susceptibility
US20150064153A1 (en) 2013-03-15 2015-03-05 The Trustees Of Princeton University High efficiency microfluidic purification of stem cells to improve transplants
CN110186835B (zh) 2013-03-15 2022-05-31 Gpb科学有限公司 颗粒的片上微流体处理
US9884326B2 (en) * 2013-06-28 2018-02-06 National Institute Of Advanced Industrial Science And Technology Matrix for magnetic separator and magnetic separator
KR20170132856A (ko) 2015-03-30 2017-12-04 액셀러레이트 다이어그노스틱스, 아이엔씨. 신속한 미생물 동정 및 항균제 감수성 시험을 위한 기기 및 시스템
US10253355B2 (en) 2015-03-30 2019-04-09 Accelerate Diagnostics, Inc. Instrument and system for rapid microorganism identification and antimicrobial agent susceptibility testing
US10976232B2 (en) 2015-08-24 2021-04-13 Gpb Scientific, Inc. Methods and devices for multi-step cell purification and concentration
GB201519668D0 (en) * 2015-11-06 2015-12-23 Ge Healthcare Bio Sciences Ab Method and chromatography media
TWI673105B (zh) 2015-11-18 2019-10-01 財團法人工業技術研究院 磁分離器
WO2018024819A1 (en) * 2016-08-05 2018-02-08 Haute Ecole D'ingenierie Et De Gestion Du Canton De Vaud (Heig-Vd) Device for removing particles from a material in movement
BR102016022548B1 (pt) * 2016-09-28 2022-03-22 José Pancrácio Ribeiro Matriz magnética ondulada para separador magnético de alta intensidade
CN111065399B (zh) 2017-09-01 2023-11-28 Gpb科学有限公司 使用微流体制备治疗活性细胞的方法
WO2020058136A1 (en) * 2018-09-20 2020-03-26 Hemotune Ag Assembly for magnetic separation-based body fluid purification
EP4103518A4 (en) * 2020-02-11 2023-11-01 Khalifa University of Science and Technology SYSTEMS AND METHODS FOR IMPROVING THE EFFICIENCY OF SEPARATION PROCESSES
US11529636B2 (en) 2020-10-09 2022-12-20 Cláudio Henrique Teixeira Ribeiro Magnetic matrices and methods of using the same
CN112553043A (zh) * 2020-12-09 2021-03-26 深圳先进技术研究院 用于胎儿有核红细胞分离纯化的微流控芯片

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB236808A (en) * 1924-12-02 1925-07-16 Krupp Fried Grusonwerk Ag Improvements in or relating to zone poles for magnetic separators
US4212651A (en) * 1979-05-30 1980-07-15 The United States Of America As Represented By The United States Department Of Energy High gradient magnetic beneficiation of dry pulverized coal via upwardly directed recirculating fluidization
US4387286A (en) 1980-03-26 1983-06-07 Inoue-Japax Research Incorporated Apparatus for controlling splashes and purification of a machining liquid
US4560484A (en) * 1980-04-25 1985-12-24 Purdue Research Foundation Method and apparatus for magnetically separating particles from a liquid
US4743364A (en) 1984-03-16 1988-05-10 Kyrazis Demos T Magnetic separation of electrically conducting particles from non-conducting material
US4710472A (en) * 1985-09-25 1987-12-01 The United States Of America As Represented By The Secretary Of The Navy Magnetic separation device
US5512332A (en) * 1985-10-04 1996-04-30 Immunivest Corporation Process of making resuspendable coated magnetic particles
US4795698A (en) * 1985-10-04 1989-01-03 Immunicon Corporation Magnetic-polymer particles
US5076950A (en) * 1985-12-20 1991-12-31 Syntex (U.S.A.) Inc. Magnetic composition for particle separation
EP0339980B1 (en) * 1988-04-26 1994-07-20 Nippon Telegraph And Telephone Corporation Magnetic micro-particles, method and apparatus for collecting specimens for use in labelling immune reactions, and method and device for preparing specimens
US5536475A (en) 1988-10-11 1996-07-16 Baxter International Inc. Apparatus for magnetic cell separation
US5385707A (en) 1988-12-28 1995-01-31 Stefan Miltenyi Metal matrices for use in high gradient magnetic separation of biological materials and method for coating the same
EP0452342B1 (en) * 1988-12-28 1994-11-30 MILTENYI, Stefan Methods and materials for high gradient magnetic separation of biological materials
US5081030A (en) * 1989-04-25 1992-01-14 The Johns Hopkins University Release of cells from affinity matrices
WO1994011078A1 (en) * 1992-11-16 1994-05-26 Immunivest Corporation Magnetic immobilization and manipulation of biological entities
US5466574A (en) 1991-03-25 1995-11-14 Immunivest Corporation Apparatus and methods for magnetic separation featuring external magnetic means
GB9106284D0 (en) * 1991-03-25 1991-05-08 Cryogenic Consult Improvements in and relating to magnetic separators
EP0589636B1 (en) 1992-09-24 2000-08-02 Amersham Pharmacia Biotech UK Limited Magnetic separation method and apparatus therefor
US5514340A (en) * 1994-01-24 1996-05-07 Magnetix Biotechnology, Inc. Device for separating magnetically labelled cells
US5520158A (en) * 1995-01-12 1996-05-28 Gasmaster International, Inc. Magnetic field fuel treatment device
EP0819250B1 (en) * 1995-04-06 2006-09-20 Miltenyi Biotec Inc. Multiparameter cell separation using releasable colloidal magnetic particles
WO1997016835A1 (en) 1995-11-03 1997-05-09 David Sarnoff Research Center Magnet

Also Published As

Publication number Publication date
EP1019195B1 (en) 2002-09-11
AU1226999A (en) 1999-05-03
DK1019195T3 (da) 2002-12-30
US6241894B1 (en) 2001-06-05
ATE223759T1 (de) 2002-09-15
DE69807905D1 (de) 2002-10-17
DE69807905T2 (de) 2003-05-22
ES2184332T3 (es) 2003-04-01
WO1999019071A1 (en) 1999-04-22
EP1019195A1 (en) 2000-07-19

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