PL431580A1 - Preparation for regeneration and moistening of nasal mucosa - Google Patents

Preparation for regeneration and moistening of nasal mucosa

Info

Publication number
PL431580A1
PL431580A1 PL431580A PL43158019A PL431580A1 PL 431580 A1 PL431580 A1 PL 431580A1 PL 431580 A PL431580 A PL 431580A PL 43158019 A PL43158019 A PL 43158019A PL 431580 A1 PL431580 A1 PL 431580A1
Authority
PL
Poland
Prior art keywords
range
regeneration
preparation
nasal mucosa
moistening
Prior art date
Application number
PL431580A
Other languages
Polish (pl)
Inventor
Michał Ławicki
Tomasz Gnatowski
Witold Witkowski
Original Assignee
Axpharm Spółka Z Ograniczoną Odpowiedzialnością
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Axpharm Spółka Z Ograniczoną Odpowiedzialnością filed Critical Axpharm Spółka Z Ograniczoną Odpowiedzialnością
Priority to PL431580A priority Critical patent/PL431580A1/en
Priority to DE102019129085.6A priority patent/DE102019129085A1/en
Publication of PL431580A1 publication Critical patent/PL431580A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A61K31/355—Tocopherols, e.g. vitamin E
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/723—Xanthans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/61—Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/886—Aloeaceae (Aloe family), e.g. aloe vera
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Microbiology (AREA)
  • Botany (AREA)
  • Otolaryngology (AREA)
  • Mycology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Pulmonology (AREA)
  • Organic Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

Przedmiotem zgłoszenia jest preparat do regeneracji i nawilżania błony śluzowej nosa o pH od 5,800 do 6,200 i lepkości od 75,00 cP do 85,000 i powtarzalnej, jednorazowej dawce o wielkości od 0,01 ml do 0,30 ml, który zawiera rozpuszczone w wodzie: witaminę A w zakresie od 0,050 g do 0,250 g, witaminę E w zakresie od 0,2000 g do 2,000 g i Aloe vera w zakresie od 0,1000 g do 1,000 g oraz solubilizator w postaci Polisorbatu 80 w zakresie od 4,000 g do 6,000 g, substancję zwiększającą lepkość w postaci gumy ksantanowej w zakresie od 0,150 g do 0,250 g, substancję korygującą ciśnienie osmotyczne/nawilżającą/humektant w postaci glicerolu 86% w zakresie od 1,800 g do 3,600 g, konserwant w postaci chlorbutanolu w zakresie od 0,010 g do 1,000 g, substancje poprawiającą zapach w postaci olejku eukaliptusowego w zakresie od 0,050 g do 0,100 g, substancję regulującą pH w postaci sodu wodorotlenku oraz wodę dopełniając wagę do 100,000 g.The subject of the application is a preparation for the regeneration and moisturizing of the nasal mucosa with a pH from 5,800 to 6,200 and a viscosity from 75.00 cP to 85,000 and a repeat single dose of 0.01 ml to 0.30 ml, containing dissolved in water: vitamin A in the range of 0.050 g to 0.250 g, vitamin E in the range of 0.2000 g to 2.000 g and Aloe vera in the range of 0.1000 g to 1,000 g and Polysorbate 80 solubilizer in the range of 4.000 g to 6.000 g, viscosity enhancer in the form of xanthan gum in the range from 0.150 g to 0.250 g, osmotic pressure correcting agent / moisturizing / glycerol humectant 86% in the range from 1.800 g to 3.600 g, preservative in the form of chlorbutanol in the range from 0.010 g to 1,000 g , an aroma-improving substance in the form of eucalyptus oil in the range of 0.050 g to 0.100 g, a pH adjusting substance in the form of sodium hydroxide, and water to make up the weight to 100,000 g.

PL431580A 2019-10-23 2019-10-23 Preparation for regeneration and moistening of nasal mucosa PL431580A1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
PL431580A PL431580A1 (en) 2019-10-23 2019-10-23 Preparation for regeneration and moistening of nasal mucosa
DE102019129085.6A DE102019129085A1 (en) 2019-10-23 2019-10-28 Preparation for the regeneration and moistening of the nasal mucosa

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL431580A PL431580A1 (en) 2019-10-23 2019-10-23 Preparation for regeneration and moistening of nasal mucosa

Publications (1)

Publication Number Publication Date
PL431580A1 true PL431580A1 (en) 2020-03-23

Family

ID=69845728

Family Applications (1)

Application Number Title Priority Date Filing Date
PL431580A PL431580A1 (en) 2019-10-23 2019-10-23 Preparation for regeneration and moistening of nasal mucosa

Country Status (2)

Country Link
DE (1) DE102019129085A1 (en)
PL (1) PL431580A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114159353A (en) * 2022-01-07 2022-03-11 贵州省畜牧兽医研究所 Honeycomb nose moistening cream for repairing nasal mucosa and preparation method thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4826683A (en) * 1987-01-09 1989-05-02 Bates Harry L Decongestant
US20030059440A1 (en) * 1998-09-01 2003-03-27 Tim Clarot Composition and method for moisturizing nasal tissue
US6630163B1 (en) * 1999-04-22 2003-10-07 Howard Murad Method of treating dermatological disorders with fruit extracts
US20060120967A1 (en) * 2004-12-07 2006-06-08 Qpharma, Llc Solution forms of cyclodextrins for nasal or throat delivery of essential oils
CN108096408A (en) * 2016-11-17 2018-06-01 中国科学院大连化学物理研究所 A kind of nasal spray and its preparation and application

Also Published As

Publication number Publication date
DE102019129085A1 (en) 2021-04-29

Similar Documents

Publication Publication Date Title
US4603131A (en) Method and composition for treating and preventing irritation of the mucous membranes of the nose
CA2842454C (en) Nasal spray
AU2013266067B2 (en) Xylitol-based anti-mucosal compositions and related methods and compositions
US9999590B2 (en) Diclofenac formulations
CO5271759A1 (en) FORMULATION IN SOLUTION CONTAINING A MIXTURE OF SOLVENTS
PL431580A1 (en) Preparation for regeneration and moistening of nasal mucosa
BR0307786A (en) Pharmaceutical composition, method for preparing same, methods for inhibiting the rate of precipitation of the solution agent in the GI tract, and for reducing inter-patient variability with respect to bioavailability and / or plasma concentrations of the agent, and use of a water soluble ether cellulose or an ester of a water soluble ether cellulose
BR112013003581A2 (en) gastro resistant pharmaceutical or nutraceutical formulation comprising one or more salts of alginic acid
EA200600528A1 (en) METHOD OF OBTAINING WATER SOLUBLE DITERPENES AND THEIR APPLICATION
NZ594592A (en) Paediatric solutions comprising a beta-blocker
MX2020005942A (en) Oral thin film with high active agent loading.
DE102014116903A1 (en) Cineole-containing composition for nasal administration
US20050107330A1 (en) Pharmaceutical composition for the treatment of rhinitis
RU2006101686A (en) COMPOSITIONS FOR LOCAL APPLICATION RESTORING THE STRUCTURE OF NAILS
AR064263A1 (en) PHARMACEUTICAL COMPOSITIONS THAT INCLUDE A COMPOSITE BISFOSFATO
RU2013111633A (en) STABLE LIQUID PHARMACEUTICAL COMPOSITION OF THE COMPLEX 3- (2,2,2-TRIMETHYLHYDRAZINY) PROPIONATE-2-ETHYL-6-METHYL-3-HYDROXYpyridine, possessing antioxidants
RU2014127074A (en) COMPOSITION FOR EFFECTIVE DELIVERY OF LIPIDS TO THE TARPHIC FILM OF A HUMAN USING A SALT-SENSITIVE EMULSION SYSTEM
CN105726416A (en) Gel with mosquito repelling, swelling subsiding and itching relieving functions
TW201642844A (en) Pharmaceutical composition for external use
WO2019125330A2 (en) Nasal decongestant compositions comprising dexpanthenol and sodium hyaluronate
JP2009503062A (en) Composition, package and process for reducing malrubin and snoring
RU2013147613A (en) LOCAL DISINFECTANT OF IODINE CONTAINING LOW CONTENT OF SURFACE-ACTIVE SUBSTANCE
JP2007169232A (en) Ophthalmic composition
JP2011144123A (en) Skin care preparation
FI946057A (en) Preparation for topical use