PL423653A1 - Method for simultaneous detection of ({[(2R)-1-(6-amino-9H-purin-9-yl)propan-2-yl]oxy}methyl)phosphonic acid and creatinine (2-imino-1-methylimidazolidin-4-one) and the test for detection of ({[(2R)-1-(6-amino-9H-purin-9-yl)propan-2-yl]oxy}methyl)phosphonic acid in urine and simultaneous initial assessment of kidney function - Google Patents

Method for simultaneous detection of ({[(2R)-1-(6-amino-9H-purin-9-yl)propan-2-yl]oxy}methyl)phosphonic acid and creatinine (2-imino-1-methylimidazolidin-4-one) and the test for detection of ({[(2R)-1-(6-amino-9H-purin-9-yl)propan-2-yl]oxy}methyl)phosphonic acid in urine and simultaneous initial assessment of kidney function

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Publication number
PL423653A1
PL423653A1 PL423653A PL42365317A PL423653A1 PL 423653 A1 PL423653 A1 PL 423653A1 PL 423653 A PL423653 A PL 423653A PL 42365317 A PL42365317 A PL 42365317A PL 423653 A1 PL423653 A1 PL 423653A1
Authority
PL
Poland
Prior art keywords
purin
propan
oxy
amino
methyl
Prior art date
Application number
PL423653A
Other languages
Polish (pl)
Inventor
Kamila Borowczyk
Grażyna Chwatko
Rafał Głowacki
Paweł Kubalczyk
Patrycja Olejarz
Original Assignee
Univ Lodzki
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Lodzki filed Critical Univ Lodzki
Priority to PL423653A priority Critical patent/PL423653A1/en
Publication of PL423653A1 publication Critical patent/PL423653A1/en

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Abstract

Przedmiotem zgłoszenia jest sposób wykrywania kwasu ({[(2R)-1-(6-amino-9H-puryn-9-ylo)propan-2-ylo]oksy}metylo)fosfonowego i kreatyniny w moczu oraz test do detekcji kwasu ({[(2R)-1-(6-amino-9H-puryn-9-ylo)propan-2-ylo]oksy}metylo)fosfonowego w moczu i wstępnej oceny funkcjonowania nerek. Test ten przeznaczony jest do badania próbek moczu pacjentów poddanych terapii po zakażeniu wirusem zapalenia wątroby tupu B (HBV) i/lub wirusem upośledzenia odporności u ludzi (HIV) stosujących leki zawierające jako substancję czynną kwas ({[(2R)-1-(6-amino-9H-puryn-9-ylo)propan-2-ylo]oksy}metylo)fosfonowy. Sposób i test polega na analizie chromatograficznej z zastosowaniem aparatu do wysokosprawnej chromatografii cieczowej wyposażonego w detektor spektrofotometryczny z matrycą diodową z możliwością zmiany długości fali w czasie trwania pomiaru. Opracowany test charakteryzuje się dobrą dokładnością, precyzją, nieskomplikowaną procedurą przygotowania próbki, oraz krótkim czasem analizy.The subject of the application is a method for detecting ({[(2R) -1- (6-amino-9H-purin-9-yl) propan-2-yl] oxy} methyl) phosphonic acid and creatinine in urine and an acid detection test ({ [(2R) -1- (6-amino-9H-purin-9-yl) propan-2-yl] oxy} methyl) phosphonic urine and initial assessment of renal function. This test is intended for testing urine samples of patients undergoing therapy after infection with the hepatitis B virus (HBV) and / or immunodeficiency virus in humans (HIV) using drugs containing the active substance acid ({[(2R) -1- (6 amino-9H-purin-9-yl) propan-2-yl] oxy} methyl) phosphonic acid. The method and test is based on chromatographic analysis using a high-performance liquid chromatography apparatus equipped with a spectrophotometric detector with a diode matrix with the option of changing the wavelength during the measurement. The developed test is characterized by good accuracy, precision, uncomplicated procedure of sample preparation, and short analysis time.

PL423653A 2017-11-30 2017-11-30 Method for simultaneous detection of ({[(2R)-1-(6-amino-9H-purin-9-yl)propan-2-yl]oxy}methyl)phosphonic acid and creatinine (2-imino-1-methylimidazolidin-4-one) and the test for detection of ({[(2R)-1-(6-amino-9H-purin-9-yl)propan-2-yl]oxy}methyl)phosphonic acid in urine and simultaneous initial assessment of kidney function PL423653A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PL423653A PL423653A1 (en) 2017-11-30 2017-11-30 Method for simultaneous detection of ({[(2R)-1-(6-amino-9H-purin-9-yl)propan-2-yl]oxy}methyl)phosphonic acid and creatinine (2-imino-1-methylimidazolidin-4-one) and the test for detection of ({[(2R)-1-(6-amino-9H-purin-9-yl)propan-2-yl]oxy}methyl)phosphonic acid in urine and simultaneous initial assessment of kidney function

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL423653A PL423653A1 (en) 2017-11-30 2017-11-30 Method for simultaneous detection of ({[(2R)-1-(6-amino-9H-purin-9-yl)propan-2-yl]oxy}methyl)phosphonic acid and creatinine (2-imino-1-methylimidazolidin-4-one) and the test for detection of ({[(2R)-1-(6-amino-9H-purin-9-yl)propan-2-yl]oxy}methyl)phosphonic acid in urine and simultaneous initial assessment of kidney function

Publications (1)

Publication Number Publication Date
PL423653A1 true PL423653A1 (en) 2019-06-03

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Family Applications (1)

Application Number Title Priority Date Filing Date
PL423653A PL423653A1 (en) 2017-11-30 2017-11-30 Method for simultaneous detection of ({[(2R)-1-(6-amino-9H-purin-9-yl)propan-2-yl]oxy}methyl)phosphonic acid and creatinine (2-imino-1-methylimidazolidin-4-one) and the test for detection of ({[(2R)-1-(6-amino-9H-purin-9-yl)propan-2-yl]oxy}methyl)phosphonic acid in urine and simultaneous initial assessment of kidney function

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PL (1) PL423653A1 (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017147186A1 (en) * 2016-02-22 2017-08-31 Ursure, Inc. System and method for detecting therapeutic agents to monitor adherence to a treatment regimen

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017147186A1 (en) * 2016-02-22 2017-08-31 Ursure, Inc. System and method for detecting therapeutic agents to monitor adherence to a treatment regimen

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
JULLIEN V., DETERMINATION OF TENOFOVIR IN HUMAN PLASMA BY HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY WITH SPECTROFLUORIMETRIC DETECTION, 2003 *
KOU H., QUANTIFICATION OF TENOFOVIR IN HUMAN PLASMA BY SOLID-PHASE EXTRACTION AND HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY COUPLED WITH UV DETECTION, 2012 *
ZUO Y., SIMULTANEOUS DETERMINATION OF CREATININE AND URIC ACID IN HUMAN URINE BY HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY, 2008 *

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