PL418144A1 - Nowy marker obecności mikroprzerzutów i podwyższonego ryzyka nawrotu raka jelita grubego, sposób wykrywania obecności mikroprzerzutów i podwyższonego ryzyka nawrotu raka jelita grubego oraz geny normalizacyjne do normalizacji wyników ekspresji miRNA w tkance raka jelita grubego - Google Patents

Nowy marker obecności mikroprzerzutów i podwyższonego ryzyka nawrotu raka jelita grubego, sposób wykrywania obecności mikroprzerzutów i podwyższonego ryzyka nawrotu raka jelita grubego oraz geny normalizacyjne do normalizacji wyników ekspresji miRNA w tkance raka jelita grubego

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Publication number
PL418144A1
PL418144A1 PL418144A PL41814416A PL418144A1 PL 418144 A1 PL418144 A1 PL 418144A1 PL 418144 A PL418144 A PL 418144A PL 41814416 A PL41814416 A PL 41814416A PL 418144 A1 PL418144 A1 PL 418144A1
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Poland
Prior art keywords
mir
large intestine
micrometastases
increased risk
intestine cancer
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PL418144A
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English (en)
Inventor
Marcin Skrzypski
Maciej Bobowicz
Jacek Jassem
Janusz Jaśkiewicz
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Gdański Uniwersytet Medyczny
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Application filed by Gdański Uniwersytet Medyczny filed Critical Gdański Uniwersytet Medyczny
Priority to PL418144A priority Critical patent/PL418144A1/pl
Priority to EP17001302.3A priority patent/EP3276009A1/en
Publication of PL418144A1 publication Critical patent/PL418144A1/pl

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/118—Prognosis of disease development
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/178—Oligonucleotides characterized by their use miRNA, siRNA or ncRNA

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Przedmiotem zgłoszenia są nowe markery obecności mikroprzerzutów i podwyższonego ryzyka nawrotu raka jelita grubego, u chorych po radykalnym leczeniu chirurgicznym, polegający na jednoczesnej ocenie ilości (ekspresji) wymienionych miRNA w materiale biologicznym. Przedmiotem zgłoszenia są również geny normalizacyjne do normalizacji wyników ekspresji miRNA w tkance raka jelita grubego, które stanowią następującą sygnaturę ekspresji: miR-24T, miR-126, miR-200c, miR-26a, let-7g, miR-27a, miR-152, miR-324-3p, miR-197, miR-1274B, miR-720, miR-1274A, miR-1825, miR-93#, miR-664, miR-30e-3p, miR-1285, miR-335#. Przedmiotem zgłoszenia są również są sposoby wykrywania obecności mikroprzerzutów i podwyższonego ryzyka nawrotu raka jelita grubego, u chorych po radykalnym leczeniu chirurgicznym, polegający na badaniu zaburzeń ekspresji genów.
PL418144A 2016-07-29 2016-07-29 Nowy marker obecności mikroprzerzutów i podwyższonego ryzyka nawrotu raka jelita grubego, sposób wykrywania obecności mikroprzerzutów i podwyższonego ryzyka nawrotu raka jelita grubego oraz geny normalizacyjne do normalizacji wyników ekspresji miRNA w tkance raka jelita grubego PL418144A1 (pl)

Priority Applications (2)

Application Number Priority Date Filing Date Title
PL418144A PL418144A1 (pl) 2016-07-29 2016-07-29 Nowy marker obecności mikroprzerzutów i podwyższonego ryzyka nawrotu raka jelita grubego, sposób wykrywania obecności mikroprzerzutów i podwyższonego ryzyka nawrotu raka jelita grubego oraz geny normalizacyjne do normalizacji wyników ekspresji miRNA w tkance raka jelita grubego
EP17001302.3A EP3276009A1 (en) 2016-07-29 2017-07-28 Microrna expression markers for crc development

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL418144A PL418144A1 (pl) 2016-07-29 2016-07-29 Nowy marker obecności mikroprzerzutów i podwyższonego ryzyka nawrotu raka jelita grubego, sposób wykrywania obecności mikroprzerzutów i podwyższonego ryzyka nawrotu raka jelita grubego oraz geny normalizacyjne do normalizacji wyników ekspresji miRNA w tkance raka jelita grubego

Publications (1)

Publication Number Publication Date
PL418144A1 true PL418144A1 (pl) 2018-02-12

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PL418144A PL418144A1 (pl) 2016-07-29 2016-07-29 Nowy marker obecności mikroprzerzutów i podwyższonego ryzyka nawrotu raka jelita grubego, sposób wykrywania obecności mikroprzerzutów i podwyższonego ryzyka nawrotu raka jelita grubego oraz geny normalizacyjne do normalizacji wyników ekspresji miRNA w tkance raka jelita grubego

Country Status (2)

Country Link
EP (1) EP3276009A1 (pl)
PL (1) PL418144A1 (pl)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109825596B (zh) * 2019-04-19 2022-03-15 中国医学科学院肿瘤医院 食管癌样本的内参miRNA及其应用
CN111057769A (zh) * 2020-01-20 2020-04-24 广东医科大学 一种检测与结直肠癌易感相关的miR-218基因位点的试剂盒及其应用方法
CN113035358A (zh) * 2021-04-08 2021-06-25 南京市第一医院 一种预测早期结肠癌患者预后风险的模型构建方法
CN113981096A (zh) * 2021-11-30 2022-01-28 无锡市疾病预防控制中心 一种用于诊断结直肠癌的血浆miRNA标志物及其应用
CN114317743A (zh) * 2021-12-23 2022-04-12 广西百谷生物科技有限公司 一种用于结直肠癌预后的miRNA检测试剂盒

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AU2011311881A1 (en) * 2010-10-08 2013-05-02 Baylor Research Institute MicroRNAs (miRNA) as biomakers for the identification of familial and non-familial colorectal cancer
US20140141986A1 (en) * 2011-02-22 2014-05-22 David Spetzler Circulating biomarkers
EP2771487A1 (en) * 2011-10-27 2014-09-03 Asuragen, INC. Mirnas as diagnostic biomarkers to distinguish benign from malignant thyroid tumors
EP2804959A2 (en) * 2012-01-16 2014-11-26 Herlev Hospital Micrornas for prediction of treatment efficacy and prognosis of cancer patients

Also Published As

Publication number Publication date
EP3276009A1 (en) 2018-01-31

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