PL407710A1 - Method for producing the eye drops preparation in the form of a suspension containing brinzolamidum and the preparation produced by this method - Google Patents

Method for producing the eye drops preparation in the form of a suspension containing brinzolamidum and the preparation produced by this method

Info

Publication number
PL407710A1
PL407710A1 PL407710A PL40771014A PL407710A1 PL 407710 A1 PL407710 A1 PL 407710A1 PL 407710 A PL407710 A PL 407710A PL 40771014 A PL40771014 A PL 40771014A PL 407710 A1 PL407710 A1 PL 407710A1
Authority
PL
Poland
Prior art keywords
preparation
suspension containing
producing
eye drops
brinzolamidum
Prior art date
Application number
PL407710A
Other languages
Polish (pl)
Inventor
Maria Melissa
Grzegorz Huszcza
Wioleta Maruszak
Łukasz Kaczmarek
Andrzej Kutner
Magdalena Dąbrowska
Original Assignee
Instytut Farmaceutyczny
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Instytut Farmaceutyczny filed Critical Instytut Farmaceutyczny
Priority to PL407710A priority Critical patent/PL407710A1/en
Priority to PCT/PL2015/000052 priority patent/WO2015147665A1/en
Publication of PL407710A1 publication Critical patent/PL407710A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/14—Alkali metal chlorides; Alkaline earth metal chlorides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents

Abstract

Przedmiotem wynalazku jest sposób wytwarzania preparatu kropli do oczu w postaci zawiesiny zawierającej brynzolamid, polegający na tym, że substancja czynna jest rozpuszczana, a następnie strącana za pomocą środka strącającego, w postaci cząstek o odpowiedniej wielkości w wyniku zmiany pH środowiska, która to operacja przeprowadzana jest w roztworze zawierającym główne składniki kompozycji połączone w warunkach aseptycznych. Ujawniono również preparat kropli do oczu w postaci zawiesiny zawierającej brynzolamid i substancje pomocnicze: polimer kwasu akrylowego, wersenian disodowy, chlorek benzalkoniowy, mannitol, wodorotlenek sodu, kwas solny, wodorowęglan sodu i wodę do sporządzania kropli do oczu, wolny od substancji zmniejszających napięcie powierzchniowe.The subject of the invention is a method for producing an eye drop preparation in the form of a suspension containing brinzolamide, in which the active substance is dissolved and then precipitated by means of a precipitation agent, in the form of particles of appropriate size as a result of changing the pH of the environment, which operation is carried out in a solution containing the main components of the composition combined under aseptic conditions. An eye drop preparation in the form of a suspension containing brinzolamide and excipients was also disclosed: acrylic acid polymer, disodium edetate, benzalkonium chloride, mannitol, sodium hydroxide, hydrochloric acid, sodium bicarbonate and water for preparing eye drops, free of surface tension reducing substances.

PL407710A 2014-03-28 2014-03-28 Method for producing the eye drops preparation in the form of a suspension containing brinzolamidum and the preparation produced by this method PL407710A1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
PL407710A PL407710A1 (en) 2014-03-28 2014-03-28 Method for producing the eye drops preparation in the form of a suspension containing brinzolamidum and the preparation produced by this method
PCT/PL2015/000052 WO2015147665A1 (en) 2014-03-28 2015-03-27 Process for manufacturing brinzolamide ophthalmic suspension and eye drops formulation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL407710A PL407710A1 (en) 2014-03-28 2014-03-28 Method for producing the eye drops preparation in the form of a suspension containing brinzolamidum and the preparation produced by this method

Publications (1)

Publication Number Publication Date
PL407710A1 true PL407710A1 (en) 2015-10-12

Family

ID=53051892

Family Applications (1)

Application Number Title Priority Date Filing Date
PL407710A PL407710A1 (en) 2014-03-28 2014-03-28 Method for producing the eye drops preparation in the form of a suspension containing brinzolamidum and the preparation produced by this method

Country Status (2)

Country Link
PL (1) PL407710A1 (en)
WO (1) WO2015147665A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR3088196B1 (en) * 2018-11-08 2022-03-25 Abdeslem Alain Kitkit DEVICE FOR IMPROVING SIGHT CONSISTS OF A SOLUTION IN A BOTTLE WITH A TREATMENT AND WASH

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6071904A (en) * 1996-12-11 2000-06-06 Alcon Laboratories, Inc. Process for manufacturing ophthalmic suspensions
EP2506878A2 (en) * 2009-12-03 2012-10-10 Lupin Limited Process for preparing pharmaceutical ophthalmic compositions
WO2012053011A2 (en) * 2010-10-18 2012-04-26 Usv Limited Ophthalmic compositions comprising brinzolamide
US20130065888A1 (en) * 2011-08-15 2013-03-14 Biserka Cetina-Cizmek Ophthalmic formulations and processes for their preparation
WO2013175285A1 (en) * 2012-05-21 2013-11-28 Aurobindo Pharma Limited Process for preparing ophthalmic suspension of brinzolamde

Also Published As

Publication number Publication date
WO2015147665A1 (en) 2015-10-01

Similar Documents

Publication Publication Date Title
NZ608202A (en) Agent for treatment of dry eye characterized by combining p2y2 receptor agonist and hyaluronic acid or salt thereof, method for treating dry eye, and use of the p2y2 receptor agonist and hyaluronic acid or salt thereof
MX2014013315A (en) Pharmaceutical nanoparticles showing improved mucosal transport.
EA201501122A1 (en) NEW AGONISTS OF SOMATOSTATIN RECEPTORS OF SUB-TYPE 4 (SSTR4)
SG10201811186XA (en) Purification of proteins
MX343620B (en) Polymorphic form of pridopidine hydrochloride.
DOP2013000181A (en) GLUCAGON RECEIVER MODULATORS
EA201691147A1 (en) ION WATER COMPOSITIONS
EA201691216A1 (en) COMPOUNDS OF LINACLOTIDE WITH Slow Release
PE20161498A1 (en) REACTIVE COMPOSITION BASED ON SODIUM BICARBONATE AND PROCEDURE FOR ITS PRODUCTION
EA201790427A1 (en) SUBSTITUTED BICYCLIC COMPOUNDS
CL2017000773A1 (en) Process for the production of potassium sulfate granules and the potassium sulfate granulate obtained from it, as well as its use.
TN2015000356A1 (en) Bicyclic compounds
ES2509966T1 (en) Compositions having increased concentrations of carboxymethyl cellulose
MX2016003065A (en) Atrasentan mandelate salts for the treatement of kidney diseases.
EA201992382A2 (en) ORAL TABLET PHARMACEUTICAL COMPOSITION FOR DOUBLE USE ON THE BASIS OF SULPHATE SALTS AND METHODS OF ITS APPLICATION
MX2016010215A (en) Compositions and methods for treating and preventing macular degeneration.
FR3022257B1 (en) PROCESS FOR PRODUCING A STABLE AQUEOUS SOLUTION OF BETA-AMYLASE, AQUEOUS SOLUTION OBTAINED AND USES THEREOF
EA201591704A1 (en) NEW SUSTAINABLE SALTS OF PENTADECEPEPTIDE, METHOD OF THEIR PRODUCTION, THEIR APPLICATION IN THE PRODUCTION OF PHARMACEUTICAL COMPOSITIONS AND THEIR APPLICATION IN THERAPY
PL407710A1 (en) Method for producing the eye drops preparation in the form of a suspension containing brinzolamidum and the preparation produced by this method
IN2014MU01233A (en)
NZ728136A (en) Method for producing aqueous ophthalmic composition, and aqueous ophthalmic composition
PH12018501046B1 (en) Crystal of monovalent cation salt of 3-hydroxyisovaleric acid and process for producing the crystals
PL408208A1 (en) Method for thickening of a glass making batch
MX2012006828A (en) Aqueous dispersions.
IN2014MU00328A (en)