PL403256A1 - Method for introduction of acetal and acetal-ester protecting group and its use to protect a hydroxyl function - Google Patents
Method for introduction of acetal and acetal-ester protecting group and its use to protect a hydroxyl functionInfo
- Publication number
- PL403256A1 PL403256A1 PL403256A PL40325613A PL403256A1 PL 403256 A1 PL403256 A1 PL 403256A1 PL 403256 A PL403256 A PL 403256A PL 40325613 A PL40325613 A PL 40325613A PL 403256 A1 PL403256 A1 PL 403256A1
- Authority
- PL
- Poland
- Prior art keywords
- acetal
- hydroxyl function
- introduction
- protect
- protecting group
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/167—Purine radicals with ribosyl as the saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/067—Pyrimidine radicals with ribosyl as the saccharide radical
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Przedmiotem wynalazku jest sposób wprowadzania acetalowych i acetaloestrowych grup ochronnych funkcji hydroksylowej. Sposób ten znajduje zastosowanie w szczególności w procesach syntezy RNA. Sposób polega na reakcji związku organicznego zawierającego co najmniej jedną grupę hydroksylową, rozpuszczalnego w rozpuszczalniku aprotycznym, ze związkiem o wzorze ogólnym: R1-S-CH2-O-R2 w obecności SnCl4, w rozpuszczalniku aprotycznym. W drugim aspekcie przedmiotem wynalazku jest sposób ochrony funkcji hydroksylowej w szczególności w pozycji 2' pochodnych nukleozydowych polegający na wprowadzaniu grupy acetalowej lub acetaloestrowej.The subject of the invention is a method of introducing acetal and acetalester protecting groups of the hydroxyl function. This method finds application in particular in RNA synthesis processes. The method consists in the reaction of an organic compound containing at least one hydroxyl group, soluble in an aprotic solvent, with a compound of the general formula: R1-S-CH2-O-R2 in the presence of SnCl4, in an aprotic solvent. In a second aspect, the invention relates to a method of protecting the hydroxyl function in particular in the 2' position of nucleoside derivatives by introducing an acetal or acetal ester group.
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PL403256A PL221806B1 (en) | 2013-03-21 | 2013-03-21 | Method for introduction of acetal and acetal-ester protecting group and its use to protect a hydroxyl function |
EP14723139.3A EP3016964A1 (en) | 2013-03-21 | 2014-03-19 | Method for incorporating protecting acetal and acetal ester groups, and its application for the protection of hydroxyl function |
PCT/PL2014/050012 WO2014148928A1 (en) | 2013-03-21 | 2014-03-19 | Method for incorporating protecting acetal and acetal ester groups, and its application for the protection of hydroxyl function |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PL403256A PL221806B1 (en) | 2013-03-21 | 2013-03-21 | Method for introduction of acetal and acetal-ester protecting group and its use to protect a hydroxyl function |
Publications (2)
Publication Number | Publication Date |
---|---|
PL403256A1 true PL403256A1 (en) | 2014-05-26 |
PL221806B1 PL221806B1 (en) | 2016-05-31 |
Family
ID=50687597
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PL403256A PL221806B1 (en) | 2013-03-21 | 2013-03-21 | Method for introduction of acetal and acetal-ester protecting group and its use to protect a hydroxyl function |
Country Status (3)
Country | Link |
---|---|
EP (1) | EP3016964A1 (en) |
PL (1) | PL221806B1 (en) |
WO (1) | WO2014148928A1 (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11897914B2 (en) | 2021-11-29 | 2024-02-13 | Hongene Biotech Corporation | Synthesis of 2′ protected nucleosides |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1193598A (en) * | 1982-05-06 | 1985-09-17 | Rafael Foguet | 2-amino-benzoic acid derivatives and processes for their production |
US5986084A (en) | 1997-08-18 | 1999-11-16 | Pitsch; Stefan | Ribonucleoside-derivative and method for preparing the same |
CN1315955A (en) * | 1998-07-27 | 2001-10-03 | 明治制果株式会社 | Novel carbapenem derivatives |
FR2931824B1 (en) | 2008-05-29 | 2014-11-28 | Centre Nat Rech Scient | PROCESS FOR RNA SYNTHESIS THROUGH CHEMICAL. |
-
2013
- 2013-03-21 PL PL403256A patent/PL221806B1/en unknown
-
2014
- 2014-03-19 WO PCT/PL2014/050012 patent/WO2014148928A1/en unknown
- 2014-03-19 EP EP14723139.3A patent/EP3016964A1/en not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
PL221806B1 (en) | 2016-05-31 |
EP3016964A1 (en) | 2016-05-11 |
WO2014148928A1 (en) | 2014-09-25 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AR128490A2 (en) | COMPOUND DERIVED FROM CARBOXAMIDE FOR THE CONTROL OF ENDOPARASITES | |
CL2012001821A1 (en) | Compounds derived from 5-alkynyl-pyrimidines, kinase inhibitors; pharmaceutical compositions containing them; and its use for the treatment and / or prevention of cancer, infections, inflammatory and autoimmune diseases. | |
BR112015022804A2 (en) | new octahidro-pyrrol [3,4-c] -pyrrol derivatives and their analogues as autotaxin inhibitors | |
PE20151423A1 (en) | TETRAHYDROPYRANIL DERIVATIVES INHIBITORS OF HCV | |
CO6321282A2 (en) | PIPERIDINYLINDOL DERIVATIVES AS INHIBITORS OF ALDOSTERONA SINTASA | |
BR112014017749A8 (en) | 3,5-DISUBSTITUTED ALKYNYLBENZENE COMPOUND AND SALT THEREOF | |
BRPI1009333B8 (en) | beta-secretase inhibitor compounds, their uses, as well as pharmaceutical composition | |
BR112014000178A2 (en) | topical compositions | |
NZ716840A (en) | Combination formulation of two antiviral compounds | |
UY35467A (en) | ORGANIC COMPOUNDS | |
IN2014DN08100A (en) | ||
UY32648A (en) | NEW DERIVATIVES OF PYRIMIDINE AND ITS USE IN THE TREATMENT OF DISEASES | |
ECSP11011183A (en) | ORGANIC COMPOUNDS | |
ECSP11011184A (en) | ORGANIC COMPOUNDS | |
BR112013031405A2 (en) | substituted pyridopyrazines as new syk inhibitors | |
CL2016000382A1 (en) | Processes to prepare antiviral compounds | |
MX350810B (en) | 4'-azido, 3'-fluoro substituted nucleoside derivatives as inhibitors of hcv rna replication. | |
UY32494A (en) | NEW 2,4-DIAMINOPIRIMIDINES, PHARMACEUTICAL SALTS OF THE SAME, COMPOSITIONS CONTAINING AND APPLICATIONS | |
CO6630184A2 (en) | Pharmaceutical formulations comprising derivatives of 1 (beta-d-glucopyranosyl) -2-thienyl methylbenzene as sglt inhibitors | |
BR112015012825A2 (en) | substituted pyridopyrazines as syk inhibitors | |
ECSP109968A (en) | CYCLIC DEPSIPEPTIDES | |
ECSP13012716A (en) | COMPOUNDS AND ITS USES | |
UY31905A (en) | DERIVATIVES OF BENZOXAZINONA, PREPARATION PROCESSES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND APPLICATIONS. | |
MY171201A (en) | New carbamate glycolipid and use thereof | |
BR112015018478B8 (en) | Use of one or more esters, use of solvent, use of dioxolane-derived esters, coating composition, and casting binder system |