PL401098A1 - Method for measuring the low fluid volume in the microfluidic circuit - Google Patents

Method for measuring the low fluid volume in the microfluidic circuit

Info

Publication number
PL401098A1
PL401098A1 PL401098A PL40109812A PL401098A1 PL 401098 A1 PL401098 A1 PL 401098A1 PL 401098 A PL401098 A PL 401098A PL 40109812 A PL40109812 A PL 40109812A PL 401098 A1 PL401098 A1 PL 401098A1
Authority
PL
Poland
Prior art keywords
image
microfluidic system
drop
fluid
measuring
Prior art date
Application number
PL401098A
Other languages
Polish (pl)
Inventor
Piotr Garstecki
Mateusz Tomala
Adam Warchulski
Original Assignee
Scope Fluidics Spółka Z Ograniczoną Odpowiedzialnością
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scope Fluidics Spółka Z Ograniczoną Odpowiedzialnością filed Critical Scope Fluidics Spółka Z Ograniczoną Odpowiedzialnością
Priority to PL401098A priority Critical patent/PL401098A1/en
Priority to PCT/EP2013/070988 priority patent/WO2014056951A1/en
Publication of PL401098A1 publication Critical patent/PL401098A1/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01B—MEASURING LENGTH, THICKNESS OR SIMILAR LINEAR DIMENSIONS; MEASURING ANGLES; MEASURING AREAS; MEASURING IRREGULARITIES OF SURFACES OR CONTOURS
    • G01B11/00—Measuring arrangements characterised by the use of optical techniques
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502769—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
    • B01L3/502784—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/14—Process control and prevention of errors
    • B01L2200/143—Quality control, feedback systems
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/0241—Drop counters; Drop formers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Dispersion Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • Pathology (AREA)
  • Length Measuring Devices By Optical Means (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)

Abstract

Przedmiotem wynalazku jest sposób pomiaru małych objętości płynu w układzie mikroprzepływowym poprzez analizę obrazu układu mikroprzepływowego zasilanego w płyny z układu dozującego, korzystnie pompy, obejmujący uzyskanie obrazu układu mikroprzepływowego z kamery, zwłaszcza z kamery cyfrowej, charakteryzujący się tym, że zawiera następujące kroki: a) uzyskanie dwuwymiarowego obrazu kanału układu mikroprzepływowego z co najmniej jedną kroplą płynu, b) wyznaczenie długości kropli płynu poprzez analizę tego obrazu, c) wyznaczenie objętości kropli płynu z zastosowaniem modelu matematycznego wiążącego objętości kropli z jej długością na obrazie, przy zadanej geometrii układu mikroprzepływowego.The subject of the invention is a method of measuring small volumes of fluid in a microfluidic system by analyzing an image of a microfluidic system fed with fluids from a dispensing system, preferably a pump, comprising obtaining a microfluidic system image from a camera, especially a digital camera, characterized by the following steps: a) obtaining a two-dimensional image of the channel of a microfluidic system with at least one drop of fluid, b) determining the length of the fluid drop by analyzing this image, c) determining the volume of the fluid drop using a mathematical model linking the volume of the drop with its length in the image, given the geometry of the microfluidic system.

PL401098A 2012-10-08 2012-10-08 Method for measuring the low fluid volume in the microfluidic circuit PL401098A1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
PL401098A PL401098A1 (en) 2012-10-08 2012-10-08 Method for measuring the low fluid volume in the microfluidic circuit
PCT/EP2013/070988 WO2014056951A1 (en) 2012-10-08 2013-10-08 Analytical method

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL401098A PL401098A1 (en) 2012-10-08 2012-10-08 Method for measuring the low fluid volume in the microfluidic circuit

Publications (1)

Publication Number Publication Date
PL401098A1 true PL401098A1 (en) 2014-04-14

Family

ID=49518926

Family Applications (1)

Application Number Title Priority Date Filing Date
PL401098A PL401098A1 (en) 2012-10-08 2012-10-08 Method for measuring the low fluid volume in the microfluidic circuit

Country Status (2)

Country Link
PL (1) PL401098A1 (en)
WO (1) WO2014056951A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117058415A (en) 2016-10-28 2023-11-14 贝克曼库尔特有限公司 Substance preparation evaluation system
CN117191141A (en) * 2023-11-07 2023-12-08 南通市海视光电有限公司 Chemical industry sight glass flow detection method based on machine vision technology

Also Published As

Publication number Publication date
WO2014056951A1 (en) 2014-04-17

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