PL3838274T3 - Pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxaline derivative for use in the treatment of cns disorders - Google Patents

Pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxaline derivative for use in the treatment of cns disorders

Info

Publication number
PL3838274T3
PL3838274T3 PL20215786.3T PL20215786T PL3838274T3 PL 3838274 T3 PL3838274 T3 PL 3838274T3 PL 20215786 T PL20215786 T PL 20215786T PL 3838274 T3 PL3838274 T3 PL 3838274T3
Authority
PL
Poland
Prior art keywords
pyrido
pyrrolo
treatment
cns disorders
quinoxaline derivative
Prior art date
Application number
PL20215786.3T
Other languages
Polish (pl)
Inventor
Peng Li
Wei Yao
Original Assignee
Intra-Cellular Therapies, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Intra-Cellular Therapies, Inc. filed Critical Intra-Cellular Therapies, Inc.
Publication of PL3838274T3 publication Critical patent/PL3838274T3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
    • C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
    • C07D241/40—Benzopyrazines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/16—Peri-condensed systems
PL20215786.3T 2016-01-26 2017-01-26 Pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxaline derivative for use in the treatment of cns disorders PL3838274T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662287264P 2016-01-26 2016-01-26
US201662440130P 2016-12-29 2016-12-29

Publications (1)

Publication Number Publication Date
PL3838274T3 true PL3838274T3 (en) 2024-04-02

Family

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Family Applications (2)

Application Number Title Priority Date Filing Date
PL20215786.3T PL3838274T3 (en) 2016-01-26 2017-01-26 Pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxaline derivative for use in the treatment of cns disorders
PL17744910T PL3407888T3 (en) 2016-01-26 2017-01-26 Pyridopyrroloquinoxaline compounds, their compositions and uses

Family Applications After (1)

Application Number Title Priority Date Filing Date
PL17744910T PL3407888T3 (en) 2016-01-26 2017-01-26 Pyridopyrroloquinoxaline compounds, their compositions and uses

Country Status (17)

Country Link
US (3) US10245260B2 (en)
EP (2) EP3838274B1 (en)
JP (3) JP6995761B2 (en)
KR (1) KR20180099905A (en)
CN (2) CN113786407A (en)
AU (1) AU2017211791B2 (en)
BR (1) BR112018015283B1 (en)
CA (1) CA3011983A1 (en)
DK (2) DK3838274T3 (en)
ES (1) ES2863471T3 (en)
HU (2) HUE053737T2 (en)
IL (3) IL260653B2 (en)
MX (2) MX2018009158A (en)
PL (2) PL3838274T3 (en)
PT (2) PT3407888T (en)
RU (1) RU2743513C2 (en)
WO (1) WO2017132408A1 (en)

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MX2016007219A (en) 2013-12-03 2016-09-16 Intra-Cellular Therapies Inc Novel methods.
US10077267B2 (en) 2014-04-04 2018-09-18 Intra-Cellular Therapies, Inc. Organic compounds
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WO2017172795A1 (en) 2016-03-28 2017-10-05 Intra-Cellular Therapies, Inc. Novel compositions and methods
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US10961245B2 (en) * 2016-12-29 2021-03-30 Intra-Cellular Therapies, Inc. Substituted heterocycle fused gamma-carbolines for treatment of central nervous system disorders
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MX2021013640A (en) 2017-03-24 2022-08-31 Intra Cellular Therapies Inc Novel compositions and methods.
IL272249B2 (en) * 2017-07-26 2023-11-01 Intra Cellular Therapies Inc Organic compounds
BR112020001654A2 (en) * 2017-07-26 2020-07-21 Intra-Cellular Therapies, Inc. organic compounds
WO2019183341A1 (en) 2018-03-23 2019-09-26 Intra-Cellular Therapies, Inc. Organic compounds
US20210009592A1 (en) * 2018-03-23 2021-01-14 Intra-Cellular Therapies, Inc. Organic compounds
WO2019237037A1 (en) * 2018-06-08 2019-12-12 Intra-Cellular Therapies, Inc. Novel methods
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CA3108558A1 (en) 2018-08-31 2020-03-05 Intra-Cellular Therapies, Inc. Novel methods
US20220056030A1 (en) * 2018-12-17 2022-02-24 Intra-Cellular Therapies, Inc. Organic compound
KR20210104834A (en) * 2018-12-17 2021-08-25 인트라-셀룰라 써래피스, 인코퍼레이티드. Substituted Heterocycle Fusion Gamma-Carboline Synthesis
CN113227045B (en) * 2018-12-17 2024-04-26 细胞内治疗公司 Synthesis of substituted heterocycle fused gamma-carbolines
US20220048910A1 (en) * 2018-12-21 2022-02-17 Intra-Cellular Therapies, Inc. Organic compounds
EP3897643B1 (en) * 2018-12-21 2023-11-15 Intra-Cellular Therapies, Inc. A pyridopyrroloquinoxaline compound and its medical use
JP2022518495A (en) * 2019-01-23 2022-03-15 イントラ－セルラー・セラピーズ・インコーポレイテッド How to treat addiction
JP2022526596A (en) * 2019-04-04 2022-05-25 イントラ－セルラー・セラピーズ・インコーポレイテッド How to treat neuropathic pain
WO2021062307A1 (en) * 2019-09-25 2021-04-01 Intra-Cellular Therapies, Inc. Novel methods
US11753419B2 (en) 2019-12-11 2023-09-12 Intra-Cellular Therapies, Inc. 4-((6bR,10aS)-3-methyl-2,3,6b,9,10,10a-hexahydro-1H-pyrido[3′,4′:4,5]pyrrolo[1,2,3-de]quinoxalin-8(7H)-yl)-1-(4-((6bR,10aS)-3-methyl-2,3,6b,9,10,10a-hexahydro-1H-pyrido[3′4′:4,5]pyrrolo[1,2,3-de]quinoxalin-8(7H)-yl)phenyl)butan-1-one for treating conditions of the central nervous system and cardiac disorders
MX2023004102A (en) * 2020-10-09 2023-04-27 Shujing Biopharma Co Ltd Heterocyclic substituted fused î³-carboline derivative, preparation method therefor, intermediate thereof and use thereof.

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