PL377354A1 - Tetrahydro-4H-pirydo[1,2-a]pirymidyny i związki pokrewne użyteczne jako inhibitory integrazy HIV - Google Patents

Tetrahydro-4H-pirydo[1,2-a]pirymidyny i związki pokrewne użyteczne jako inhibitory integrazy HIV

Info

Publication number: PL377354A1
Authority: PL; Poland
Prior art keywords: compounds; pyrido; pyrimidines; tetrahydro; hiv
Prior art date: 2002-12-27

Application number

PL377354A

Other languages

English (en)

Inventor

Benedetta Crescenzi

Olaf Kinzel

Ester Muraglia

Federica Orvieto

Giovanna Pescatore

Michael Rowley

Vincenzo Summa

Original Assignee

Istituto Di Ricerche Di Biologia Molecolare P. Angeletti Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-12-27

Filing date

2003-12-18

Publication date

2006-01-23

2003-12-18 Application filed by Istituto Di Ricerche Di Biologia Molecolare P. Angeletti Spa filed Critical Istituto Di Ricerche Di Biologia Molecolare P. Angeletti Spa

2006-01-23 Publication of PL377354A1 publication Critical patent/PL377354A1/pl

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems

PL377354A 2002-12-27 2003-12-18 Tetrahydro-4H-pirydo[1,2-a]pirymidyny i związki pokrewne użyteczne jako inhibitory integrazy HIV PL377354A1 (pl)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US43683002P	2002-12-27	2002-12-27
US52877603P	2003-12-12	2003-12-12

Publications (1)

Publication Number	Publication Date
PL377354A1 true PL377354A1 (pl)	2006-01-23

Family

ID=32685467

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL377354A PL377354A1 (pl)	2002-12-27	2003-12-18	Tetrahydro-4H-pirydo[1,2-a]pirymidyny i związki pokrewne użyteczne jako inhibitory integrazy HIV

Country Status (20)

Country	Link
US (2)	US7414045B2 (pl)
EP (1)	EP1578748B1 (pl)
JP (1)	JP4733986B2 (pl)
KR (1)	KR20050087865A (pl)
CN (1)	CN100343253C (pl)
AT (1)	ATE481401T1 (pl)
AU (2)	AU2003292437A1 (pl)
BR (1)	BR0317749A (pl)
CA (1)	CA2509554C (pl)
DE (1)	DE60334248D1 (pl)
EC (1)	ECSP055890A (pl)
HR (1)	HRP20050593A2 (pl)
IS (1)	IS7892A (pl)
MA (1)	MA27583A1 (pl)
MX (1)	MXPA05007010A (pl)
NO (1)	NO20053624L (pl)
NZ (1)	NZ540729A (pl)
PL (1)	PL377354A1 (pl)
RU (1)	RU2329265C2 (pl)
WO (2)	WO2004058757A1 (pl)

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UA87884C2 (uk) *	2004-12-03	2009-08-25	Мерк Энд Ко., Инк.	Безводна кристалічна калієва сіль інгібітора віл-інтегрази
JP2008521929A (ja)	2004-12-03	2008-06-26	メルクエンドカムパニーインコーポレーテッド	抗核形成剤を含有する医薬組成物
RU2403066C2 (ru) *	2004-12-03	2010-11-10	Мерк Шарп Энд Домэ Корп	Применение атазанавира для улучшения фармакокинетики лекарственных средств, метаболизируемых ugt1a1
JP5317257B2 (ja) *	2005-02-21	2013-10-16	塩野義製薬株式会社	Ｈｉｖインテグラーゼ阻害活性を有する２環性カルバモイルピリドン誘導体
CA2600832C (en) *	2005-03-31	2011-12-13	Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A.	Hiv integrase inhibitors
KR101848819B1 (ko) *	2005-04-28	2018-04-16	비이브 헬쓰케어 컴퍼니	Ｈｉｖ 통합효소 억제 활성을 가지는 다환식 카르바모일피리돈 유도체
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US7494984B2 (en) *	2005-08-31	2009-02-24	Bristol-Myers Squibb Company	Substituted imidazo[1,2-a]pyrimidines as HIV viral DNA integrase inhibitors
CA2622639C (en) *	2005-10-04	2012-01-03	Istituto Di Recerche Di Biologia Molecolare P. Angeletti S.P.A.	Hiv integrase inhibitors
EP1942736A2 (en) *	2005-10-27	2008-07-16	Merck & Co., Inc.	Hiv integrase inhibitors
ES2569357T3 (es) *	2005-10-27	2016-05-10	Shionogi & Co., Ltd.	Derivado de carbamoilpiridona policíclico que tiene actividad inhibidora sobre integrasa de HIV
WO2007059125A2 (en) *	2005-11-15	2007-05-24	Bristol-Myers Squibb Company	Hiv integrase inhibitors
WO2007058646A1 (en) *	2005-11-15	2007-05-24	Bristol-Myers Squibb Company	Hiv integrase inhibitors: cyclic pyrimidinone compounds
US7902182B2 (en) *	2005-11-16	2011-03-08	Bristol-Myers Squibb Company	HIV integrase inhibitors
US8039458B2 (en) *	2005-11-17	2011-10-18	Bristol-Myers Squibb Company	HIV integrase inhibitors
WO2007064316A1 (en) *	2005-11-30	2007-06-07	Bristol-Myers Squibb Company	Bicyclic heterocycles as hiv integrase inhibitors
US20070129379A1 (en) *	2005-12-01	2007-06-07	Bristol-Myers Squibb Company	Hiv integrase inhibitors
US20090136570A1 (en) *	2006-01-20	2009-05-28	Bhagwant Rege	Taste-Masked Tablets and Granules
WO2007143446A1 (en) *	2006-05-30	2007-12-13	Bristol-Myers Squibb Company	Spiro-condensed heterotricyclic compounds as hiv integrase inhibitors
US7893055B2 (en) *	2006-06-28	2011-02-22	Bristol-Myers Squibb Company	HIV integrase inhibitors
US7763630B2 (en) *	2007-06-06	2010-07-27	Bristol-Myers Squibb Company	HIV integrase inhibitors
US8129398B2 (en) *	2008-03-19	2012-03-06	Bristol-Myers Squibb Company	HIV integrase inhibitors
CN102239172A (zh) *	2008-10-06	2011-11-09	默沙东公司	Hiv整合酶抑制剂
BRPI0923217A2 (pt) *	2008-12-11	2017-05-23	Glaxosmithkline Llc	processos para a preparação de um composto de piridona, e para a preparação de uma forma cristalina, composto, sal ou um hidrato deste, forma cristalina de um sal de sódio ou um hidrato deste, e, composição farmacêutica.
US8143244B2 (en) *	2009-02-26	2012-03-27	Bristol-Myers Squibb Company	Cyclopropyl fused indolobenzazepine HCV NS5B inhibitors
KR20120103553A (ko) *	2009-07-02	2012-09-19	사노피	신규 １,２,３,４-테트라히드로-피리미도（１,２-ａ）피리미딘-６-온 유도체, 그의 제조법 및 그의 제약 용도
CN102574854B (zh)	2009-10-13	2014-04-16	伊兰科动物健康爱尔兰有限公司	大环整合酶抑制剂
US8383639B2 (en)	2009-10-15	2013-02-26	Bristol-Myers Squibb Company	HIV integrase inhibitors
PT2493312T (pt)	2009-10-26	2021-11-25	Merck Sharp & Dohme	Composições farmacêuticas sólidas contendo um inibidor de integrase
US8716293B2 (en)	2010-04-02	2014-05-06	Janssen R&D Ireland	Macrocyclic integrase inhibitors
UA112517C2 (uk)	2010-07-06	2016-09-26	Новартіс Аг	Тетрагідропіридопіримідинові похідні
BR112014014327A2 (pt)	2011-12-15	2017-06-13	Novartis Ag	uso de inibidores da atividade ou função de pi3k
WO2014099586A1 (en)	2012-12-17	2014-06-26	Merck Sharp & Dohme Corp.	4-pyridinonetriazine derivatives as hiv integrase inhibitors
US9493479B2 (en)	2013-04-16	2016-11-15	Merck Sharp & Dohme Corp.	Substituted pyrido[1,2-a]pyrazines as HIV integrase inhibitors
SI2997033T1 (en)	2013-05-17	2018-04-30	Merck Sharp & Dohme Corp.	FUZYCLE TRICYCLE HETEROCYCLIC COMPOUNDS AS HIV INTEGRATED INHIBITORS
US9951079B2 (en)	2013-06-13	2018-04-24	Merck Sharp & Dohme Corp.	Fused tricyclic heterocyclic compounds as HIV integrase inhibitors
JP6081662B2 (ja)	2013-09-27	2017-02-15	メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋＳｈａｒｐ＆ＤｏｈｍｅＣｏｒｐ．	Ｈｉｖインテグラーゼ阻害薬として有用な置換されたキノリジン誘導体
WO2016187788A1 (en)	2015-05-25	2016-12-01	Merck Sharp & Dohme Corp.	Fused tricyclic heterocyclic compounds useful for treating hiv infection
EP3377066B1 (en)	2015-11-17	2021-04-07	Merck Sharp & Dohme Corp.	Amido-substituted pyridotriazine derivatives useful as hiv integrase inhibitors
US10544155B2 (en)	2015-12-15	2020-01-28	Merck Sharp & Dohme Corp.	Spirocyclic quinolizine derivatives useful as HIV integrase inhibitors
WO2017113288A1 (en)	2015-12-31	2017-07-06	Merck Sharp & Dohme Corp.	Fused tricyclic heterocyclic compounds as hiv integrase inhibitors
JOP20190130A1 (ar)	2016-12-02	2019-06-02	Merck Sharp & Dohme	مركبات حلقية غير متجانسة رباعية الحلقات مفيدة كمثبطات إنزيم مدمج لفيروس نقص المناعة البشرية (hiv)
CN110062627A (zh)	2016-12-02	2019-07-26	默沙东公司	可用作hiv整合酶抑制剂的三环杂环化合物
US10786488B2 (en)	2017-01-26	2020-09-29	Merck Sharp & Dohme Corp.	Substituted quinolizine derivatives useful as HIV integrase inhibitors
MA52802A (fr)	2018-05-31	2021-04-14	Shionogi & Co	Dérivé de pyridone polycyclique
PE20210477A1 (es)	2018-05-31	2021-03-11	Shionogi & Co	Derivado policiclico de carbamoilpiridona

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2003
- 2003-12-18 AU AU2003292437A patent/AU2003292437A1/en not_active Abandoned
- 2003-12-18 EP EP03768014A patent/EP1578748B1/en not_active Expired - Lifetime
- 2003-12-18 BR BR0317749-1A patent/BR0317749A/pt not_active IP Right Cessation
- 2003-12-18 AT AT03768014T patent/ATE481401T1/de not_active IP Right Cessation
- 2003-12-18 AU AU2003292436A patent/AU2003292436B2/en not_active Ceased
- 2003-12-18 RU RU2005123807/04A patent/RU2329265C2/ru not_active IP Right Cessation
- 2003-12-18 JP JP2004563339A patent/JP4733986B2/ja not_active Expired - Fee Related
- 2003-12-18 KR KR1020057012028A patent/KR20050087865A/ko not_active Application Discontinuation
- 2003-12-18 NZ NZ540729A patent/NZ540729A/en unknown
- 2003-12-18 MX MXPA05007010A patent/MXPA05007010A/es active IP Right Grant
- 2003-12-18 US US10/540,449 patent/US7414045B2/en active Active
- 2003-12-18 PL PL377354A patent/PL377354A1/pl not_active Application Discontinuation
- 2003-12-18 CN CNB2003801099211A patent/CN100343253C/zh not_active Expired - Fee Related
- 2003-12-18 CA CA2509554A patent/CA2509554C/en not_active Expired - Fee Related
- 2003-12-18 DE DE60334248T patent/DE60334248D1/de not_active Expired - Lifetime
- 2003-12-18 WO PCT/GB2003/005543 patent/WO2004058757A1/en not_active Application Discontinuation
- 2003-12-18 WO PCT/GB2003/005536 patent/WO2004058756A1/en active Application Filing
2005
- 2005-06-13 IS IS7892A patent/IS7892A/is unknown
- 2005-06-23 EC EC2005005890A patent/ECSP055890A/es unknown
- 2005-06-24 HR HR20050593A patent/HRP20050593A2/hr not_active Application Discontinuation
- 2005-07-21 MA MA28407A patent/MA27583A1/fr unknown
- 2005-07-26 NO NO20053624A patent/NO20053624L/no not_active Application Discontinuation
2008
- 2008-03-12 US US12/075,514 patent/US7968553B2/en active Active

Also Published As

Publication number	Publication date
NZ540729A (en)	2008-03-28
CA2509554A1 (en)	2004-07-15
BR0317749A (pt)	2005-11-22
CA2509554C (en)	2011-02-01
JP2006513200A (ja)	2006-04-20
MXPA05007010A (es)	2005-08-18
US7414045B2 (en)	2008-08-19
EP1578748B1 (en)	2010-09-15
NO20053624D0 (no)	2005-07-26
US20080176869A1 (en)	2008-07-24
ATE481401T1 (de)	2010-10-15
AU2003292436A1 (en)	2004-07-22
AU2003292436B2 (en)	2009-07-30
ECSP055890A (es)	2005-09-20
WO2004058757A1 (en)	2004-07-15
CN1753892A (zh)	2006-03-29
EP1578748A1 (en)	2005-09-28
HRP20050593A2 (en)	2006-03-31
CN100343253C (zh)	2007-10-17
WO2004058756A1 (en)	2004-07-15
DE60334248D1 (de)	2010-10-28
KR20050087865A (ko)	2005-08-31
NO20053624L (no)	2005-09-26
JP4733986B2 (ja)	2011-07-27
US7968553B2 (en)	2011-06-28
RU2329265C2 (ru)	2008-07-20
IS7892A (is)	2005-06-13
RU2005123807A (ru)	2006-01-20
US20060046985A1 (en)	2006-03-02
AU2003292437A1 (en)	2004-07-22
MA27583A1 (fr)	2005-10-03

Legal Events

Date	Code	Title	Description
2011-05-31	REFS	Decisions on refusal to grant patents (taken after the publication of the particulars of the applications)

Publication	Publication Date	Title
PL377354A1 (pl)	2006-01-23	Tetrahydro-4H-pirydo[1,2-a]pirymidyny i związki pokrewne użyteczne jako inhibitory integrazy HIV
NO2020026I1 (no)	2020-08-10	Raltegravir eller et farmasøytisk akseptabelt salt derav, spesielt kaliumsaltet
DK1441734T3 (da)	2007-06-11	Dihydroxypyrimidin-carboxamid-inhibitorer a HIV-integrase
WO2005120516A3 (en)	2007-02-22	Hiv integrase inhibitors
WO2005086700A3 (en)	2006-09-08	Hiv integrase inhibitors
WO2004024078A3 (en)	2004-05-13	Dihydroxypyridopyrazine-1,6-dione compounds useful as hiv integrase inhibitors
WO2007146230A3 (en)	2008-12-11	Non-nucleoside reverse transcriptase inhibitors
WO2007050510A3 (en)	2007-10-04	Hiv integrase inhibitors
ATE517899T1 (de)	2011-08-15	Hiv-integrasehemmer
WO2005115147A3 (en)	2007-04-19	Hiv reverse transcriptase inhibitors
WO2004047725A3 (en)	2004-09-30	8-hydroxy-1-oxo-tetrahydropyrrolopyrazine compounds useful as hiv integrase inhibitors