PL3618811T3 - Proces wytwarzania porowatych cząsteczek krzemionki załadowanych co najmniej jednym związkiem bioaktywnym dostosowanych do dostarczania dopłucnego, donosowego, podjęzykowego i/lub dogardłowego - Google Patents
Proces wytwarzania porowatych cząsteczek krzemionki załadowanych co najmniej jednym związkiem bioaktywnym dostosowanych do dostarczania dopłucnego, donosowego, podjęzykowego i/lub dogardłowegoInfo
- Publication number
- PL3618811T3 PL3618811T3 PL18723453T PL18723453T PL3618811T3 PL 3618811 T3 PL3618811 T3 PL 3618811T3 PL 18723453 T PL18723453 T PL 18723453T PL 18723453 T PL18723453 T PL 18723453T PL 3618811 T3 PL3618811 T3 PL 3618811T3
- Authority
- PL
- Poland
- Prior art keywords
- sublingual
- nasal
- lung
- silica particles
- porous silica
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/143—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1611—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
- A61K9/1676—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5015—Organic compounds, e.g. fats, sugars
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
- C01B33/00—Silicon; Compounds thereof
- C01B33/113—Silicon oxides; Hydrates thereof
- C01B33/12—Silica; Hydrates thereof, e.g. lepidoic silicic acid
- C01B33/124—Preparation of adsorbing porous silica not in gel form and not finely divided, i.e. silicon skeletons, by acidic treatment of siliceous materials
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
- C01P2006/00—Physical properties of inorganic compounds
- C01P2006/14—Pore volume
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
- C01P2006/00—Physical properties of inorganic compounds
- C01P2006/16—Pore diameter
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Inorganic Chemistry (AREA)
- Otolaryngology (AREA)
- Pulmonology (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Dispersion Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE1750544 | 2017-05-04 | ||
EP18723453.9A EP3618811B1 (en) | 2017-05-04 | 2018-05-03 | A process for manufacturing porous silica particles loaded with at least one bioactive compound adapted for lung, nasal, sublingual and/or pharyngeal delivery |
PCT/EP2018/061436 WO2018202818A1 (en) | 2017-05-04 | 2018-05-03 | A process for manufacturing porous silica particles loaded with at least one bioactive compound adapted for lung, nasal, sublingual and/or pharyngeal delivery |
Publications (1)
Publication Number | Publication Date |
---|---|
PL3618811T3 true PL3618811T3 (pl) | 2021-04-06 |
Family
ID=62143135
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PL18723453T PL3618811T3 (pl) | 2017-05-04 | 2018-05-03 | Proces wytwarzania porowatych cząsteczek krzemionki załadowanych co najmniej jednym związkiem bioaktywnym dostosowanych do dostarczania dopłucnego, donosowego, podjęzykowego i/lub dogardłowego |
Country Status (11)
Country | Link |
---|---|
US (1) | US11285107B2 (pl) |
EP (1) | EP3618811B1 (pl) |
JP (1) | JP7048642B2 (pl) |
KR (1) | KR102579524B1 (pl) |
CN (1) | CN110603034A (pl) |
AU (1) | AU2018262708B2 (pl) |
CA (1) | CA3059099C (pl) |
DK (1) | DK3618811T3 (pl) |
ES (1) | ES2837675T3 (pl) |
PL (1) | PL3618811T3 (pl) |
WO (1) | WO2018202818A1 (pl) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP7048642B2 (ja) | 2017-05-04 | 2022-04-05 | ナノロジカ アクティエボラーグ | 肺、鼻、舌下および/または咽頭への送達に適した、少なくとも1つの生物活性化合物をロードした多孔質シリカ粒子の製造方法 |
GB201818164D0 (en) | 2018-11-07 | 2018-12-19 | Vicore Pharma Ab | New composition |
JP7394493B2 (ja) * | 2019-07-31 | 2023-12-13 | レモネックス インコーポレイテッド | 抗癌剤および多孔性シリカ粒子の製造方法 |
GB201916121D0 (en) | 2019-11-06 | 2019-12-18 | Vicore Pharma Ab | New compositions |
GB201916130D0 (en) | 2019-11-06 | 2019-12-18 | Vicore Pharma Ab | New compositions |
GB201916122D0 (en) | 2019-11-06 | 2019-12-18 | Nanologica Ab | New compositions |
GB201916117D0 (en) | 2019-11-06 | 2019-12-18 | Vicore Pharma Ab | New compositions |
WO2021211738A1 (en) * | 2020-04-15 | 2021-10-21 | Sanford Burnham Prebys Medical Discovery Institute | Methods and compositions for antiviral treatment |
US11793808B2 (en) | 2021-02-22 | 2023-10-24 | Mannkind Corp. | Compositions of clofazimine, combinations comprising them, processes for their preparation, uses and methods comprising them |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6254854B1 (en) | 1996-05-24 | 2001-07-03 | The Penn Research Foundation | Porous particles for deep lung delivery |
GB2355711B (en) | 1999-10-27 | 2003-12-24 | Agilent Technologies Inc | Porous silica microsphere scavengers |
US6485707B2 (en) * | 2001-02-15 | 2002-11-26 | Aeropharm Technology Incorporated | Modulated release particles for aerosol delivery |
US6596262B2 (en) * | 2001-02-15 | 2003-07-22 | Aeropharm Technology Incorporated | Modulated release particles for aerosol delivery |
US6544497B2 (en) * | 2001-02-15 | 2003-04-08 | Aeropharm Technology Incorporated | Modulated release particles for aerosol delivery |
GB0118689D0 (en) * | 2001-08-01 | 2001-09-19 | Psimedica Ltd | Pharmaceutical formulation |
US20040242729A1 (en) * | 2003-05-30 | 2004-12-02 | 3M Innovative Properties Company | Stabilized particle dispersions containing surface-modified inorganic nanoparticles |
FI20060428L (fi) * | 2006-05-03 | 2007-11-04 | Esko Kauppinen | Pintamodifioidut aerosolihiukkaset, menetelmä ja laite niiden tuottamiseksi sekä jauheet ja dispersiot jotka sisältävät kyseisiä hiukkasia |
WO2008150537A2 (en) | 2007-06-04 | 2008-12-11 | Alltech Associates, Inc. | Silica particles and methods of making and using the same |
GB0714134D0 (en) * | 2007-07-19 | 2007-08-29 | Norton Healthcare Ltd | Dry-powder medicament |
AU2008296195A1 (en) * | 2007-09-07 | 2009-03-12 | Epigenesis Pharmaceuticals, Llc | (DHEAS) inhalation compositions |
AU2009214118B2 (en) * | 2008-02-11 | 2014-06-12 | Nanologica Ab | Method for manufacturing mesoporous materials, materials so produced and use of mesoporous materials |
EP2251038B1 (en) * | 2008-03-11 | 2017-05-10 | ASKA Pharmaceutical Co., Ltd. | Solid dispersion, pharmaceutical compositions containing the same, and processes for the production of both |
US9757456B2 (en) * | 2010-09-14 | 2017-09-12 | Nanologica Ab | Super-saturating delivery vehicles for poorly water-soluble pharmaceutical and cosmetic active ingredients and suppression of crystallization of pharmaceutical active ingredients |
GB201212866D0 (en) * | 2012-07-20 | 2012-09-05 | Formac Pharmaceuticals Nv | Dry granulates of mesoporous silica powders |
CN106456595A (zh) | 2014-02-10 | 2017-02-22 | 帕塔拉制药有限责任公司 | 用于***性病症的肥大细胞稳定剂治疗 |
JP6426288B2 (ja) * | 2014-07-22 | 2018-11-21 | レモネックス インコーポレイテッドLemonex Inc. | 生理活性物質又はタンパク質伝達用組成物及びその用途 |
WO2016054225A1 (en) | 2014-09-30 | 2016-04-07 | Stc.Unm | Plasmid delivery in the treatment of cancer and other disease states |
WO2017023407A2 (en) | 2015-06-01 | 2017-02-09 | Stc. Unm | Nanobiocomposite compositions and methods |
WO2017149287A1 (en) * | 2016-02-29 | 2017-09-08 | Emplicure Ab | Devices for evaporation and inhalation of active agents |
JP7048642B2 (ja) | 2017-05-04 | 2022-04-05 | ナノロジカ アクティエボラーグ | 肺、鼻、舌下および/または咽頭への送達に適した、少なくとも1つの生物活性化合物をロードした多孔質シリカ粒子の製造方法 |
-
2018
- 2018-05-03 JP JP2019560246A patent/JP7048642B2/ja active Active
- 2018-05-03 CN CN201880029084.8A patent/CN110603034A/zh active Pending
- 2018-05-03 AU AU2018262708A patent/AU2018262708B2/en active Active
- 2018-05-03 KR KR1020197035080A patent/KR102579524B1/ko active IP Right Grant
- 2018-05-03 ES ES18723453T patent/ES2837675T3/es active Active
- 2018-05-03 CA CA3059099A patent/CA3059099C/en active Active
- 2018-05-03 US US16/609,854 patent/US11285107B2/en active Active
- 2018-05-03 DK DK18723453.9T patent/DK3618811T3/da active
- 2018-05-03 EP EP18723453.9A patent/EP3618811B1/en active Active
- 2018-05-03 WO PCT/EP2018/061436 patent/WO2018202818A1/en unknown
- 2018-05-03 PL PL18723453T patent/PL3618811T3/pl unknown
Also Published As
Publication number | Publication date |
---|---|
CA3059099C (en) | 2023-06-27 |
KR20190142386A (ko) | 2019-12-26 |
ES2837675T3 (es) | 2021-07-01 |
AU2018262708A1 (en) | 2019-11-28 |
US20200069588A1 (en) | 2020-03-05 |
CA3059099A1 (en) | 2018-11-08 |
CN110603034A (zh) | 2019-12-20 |
WO2018202818A1 (en) | 2018-11-08 |
EP3618811B1 (en) | 2020-09-30 |
KR102579524B1 (ko) | 2023-09-18 |
DK3618811T3 (da) | 2020-12-21 |
US11285107B2 (en) | 2022-03-29 |
JP2020518620A (ja) | 2020-06-25 |
AU2018262708B2 (en) | 2021-06-03 |
JP7048642B2 (ja) | 2022-04-05 |
EP3618811A1 (en) | 2020-03-11 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
PL3618811T3 (pl) | Proces wytwarzania porowatych cząsteczek krzemionki załadowanych co najmniej jednym związkiem bioaktywnym dostosowanych do dostarczania dopłucnego, donosowego, podjęzykowego i/lub dogardłowego | |
ZA201900979B (en) | Electronic cigarette with mass air flow sensor | |
AU201712950S (en) | Respiratory mask with air delivery aadapter | |
HK1257973A1 (zh) | 確定用於媒體傳輸的媒體傳遞事件位置 | |
HK1220092A1 (zh) | 由材料的薄片形成加熱元件、用於產生霧化器的輸入端和方法,用於氣霧劑遞送裝置的套筒以及用於組裝用於吸烟物品的套筒的方法 | |
PL3298911T3 (pl) | Papieros elektroniczny ze zintegrowaną dyszą do zasysania | |
PL3554295T3 (pl) | Produkt dla osób palących, dla dostarczania na żądanie zwiększonej ilości kompozycji prekursora aerozolowego, wkład, oraz powiązany sposób | |
IL292251A (en) | Use of anti-static materials in air passages in the process of thermal condensation of an aerosol | |
WO2012110258A3 (de) | Rauchfreie zigarette, zigarre oder pfeife | |
AU201812272S (en) | Nicotine Inhaler | |
PL3694349T3 (pl) | Inhalator, w szczególności elektroniczny produkt papierosowy | |
DK3522962T3 (en) | A nasal delivery system | |
EP3081605A4 (en) | EMISSIONSING COATING FILM, METHOD FOR THE MANUFACTURE THEREOF AND FUNCTIONAL CONSTRUCTION MATERIAL FOR WINDOWS AND DOORS THEREWITH | |
GB201909882D0 (en) | Vapour delivery systems | |
CA189046S (en) | Mist inhaler | |
AU201715847S (en) | Air delivery adapter for respiratory mask | |
EP3337944A4 (en) | Evacuation head with ceramic heater for vig unit manufacture | |
ZA202007400B (en) | Media stream delivery | |
EP4048354C0 (en) | INHALER ARTICLE WITH TANGENTIAL AIR FLOW END ELEMENT | |
PL3310731T3 (pl) | Wyrób powlekany sekwencyjnie aktywowaną powłoką niskoemisyjną i/lub sposób jego wytwarzania | |
PL3558037T3 (pl) | Układ napełniania inhalatora aerozolu | |
EP3418256A4 (en) | METHOD FOR MANUFACTURING POROUS SILICA PARTICLE OF C UR-BARK TYPE | |
GB201814913D0 (en) | Airway valve for irregular shaped airway | |
IL229771B (en) | Peptide preparations for the treatment of lung damage, asthma, anaphylaxis, angioedema, systemic syndromes of vascular permeability and nasal congestion | |
PT3074473T (pt) | Mina para dispositivos de escrita, de desenho e/ou de pintura, e processo para a sua produção |