PL348163A1 - Inhibition of the formation of vascular hyperpermeability - Google Patents

Inhibition of the formation of vascular hyperpermeability

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Publication number
PL348163A1
PL348163A1 PL99348163A PL34816399A PL348163A1 PL 348163 A1 PL348163 A1 PL 348163A1 PL 99348163 A PL99348163 A PL 99348163A PL 34816399 A PL34816399 A PL 34816399A PL 348163 A1 PL348163 A1 PL 348163A1
Authority
PL
Poland
Prior art keywords
tyrosine kinase
vascular hyperpermeability
events
formation
vascular
Prior art date
Application number
PL99348163A
Inventor
Lee D Arnold
Peter F Bousquet
Original Assignee
Basf Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basf Ag filed Critical Basf Ag
Publication of PL348163A1 publication Critical patent/PL348163A1/en

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Abstract

Vascular hyperpermeability in individuals is a prelude to a number of physiological events that are often deleterious. Among these events is the formation of edema, diapedesis, aberrant trans-endothelial exchange, extravasation, exudation and effusion, matrix deposition (often with abnormal stromal proliferation) and vascular hypotension. Vascular hyperpermeability and the subsequent events can be inhibited by the administration of a compound that inhibits the enzyme activity of the VEGF tyrosine kinase receptor known as KDR tyrosine kinase. Preferred administered compounds selectively inhibit the function of KDR tyrosine kinase but do not block the activity of Flt-1 tyrosine kinase which is another VEGF tyrosine kinase receptor.
PL99348163A 1998-11-06 1999-11-03 Inhibition of the formation of vascular hyperpermeability PL348163A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US10746298P 1998-11-06 1998-11-06

Publications (1)

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PL348163A1 true PL348163A1 (en) 2002-05-06

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ID=22316735

Family Applications (1)

Application Number Title Priority Date Filing Date
PL99348163A PL348163A1 (en) 1998-11-06 1999-11-03 Inhibition of the formation of vascular hyperpermeability

Country Status (19)

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EP (1) EP1126842A2 (en)
JP (1) JP2002529421A (en)
KR (1) KR20010080952A (en)
CN (1) CN1342077A (en)
AR (1) AR023912A1 (en)
AU (1) AU1908000A (en)
BG (1) BG105476A (en)
BR (1) BR9915139A (en)
CA (1) CA2347916A1 (en)
CO (1) CO5150183A1 (en)
CZ (1) CZ20011564A3 (en)
HU (1) HUP0104302A3 (en)
ID (1) ID29063A (en)
IL (1) IL142583A0 (en)
NO (1) NO20012218L (en)
PL (1) PL348163A1 (en)
SK (1) SK5052001A3 (en)
TR (1) TR200102278T2 (en)
WO (1) WO2000027414A2 (en)

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CN109718253B (en) * 2019-01-16 2021-09-24 中国人民解放军总医院 Use of bacteria capable of metabolizing to produce histamine for preventing or treating altitude sickness

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ID29063A (en) 2001-07-26
HUP0104302A2 (en) 2002-03-28
AR023912A1 (en) 2002-09-04
HUP0104302A3 (en) 2002-11-28
EP1126842A2 (en) 2001-08-29
SK5052001A3 (en) 2002-10-08
AU1908000A (en) 2000-05-29
KR20010080952A (en) 2001-08-25
CA2347916A1 (en) 2000-05-18
CO5150183A1 (en) 2002-04-29
NO20012218L (en) 2001-06-18
CN1342077A (en) 2002-03-27
BG105476A (en) 2002-02-28
WO2000027414A2 (en) 2000-05-18
CZ20011564A3 (en) 2002-04-17
IL142583A0 (en) 2002-03-10
NO20012218D0 (en) 2001-05-04
BR9915139A (en) 2001-08-07
JP2002529421A (en) 2002-09-10
WO2000027414A3 (en) 2000-09-08
TR200102278T2 (en) 2001-12-21

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