PL3186241T3 - Sondy do obrazowania białka huntingtyny - Google Patents

Sondy do obrazowania białka huntingtyny

Info

Publication number
PL3186241T3
PL3186241T3 PL15836970T PL15836970T PL3186241T3 PL 3186241 T3 PL3186241 T3 PL 3186241T3 PL 15836970 T PL15836970 T PL 15836970T PL 15836970 T PL15836970 T PL 15836970T PL 3186241 T3 PL3186241 T3 PL 3186241T3
Authority
PL
Poland
Prior art keywords
probes
imaging
huntington protein
huntington
protein
Prior art date
Application number
PL15836970T
Other languages
English (en)
Inventor
Celia Dominguez
John Wityak
Jonathan Bard
Christopher John Brown
Thomas Martin KRÜLLE
Daniel CLARK-FREW
Sarah HAYES
Original Assignee
Chdi Foundation, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chdi Foundation, Inc. filed Critical Chdi Foundation, Inc.
Publication of PL3186241T3 publication Critical patent/PL3186241T3/pl

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • A61K51/041Heterocyclic compounds
    • A61K51/044Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0459Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • A61K51/041Heterocyclic compounds
    • A61K51/044Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0446Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • A61K51/041Heterocyclic compounds
    • A61K51/044Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0455Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D513/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D513/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/12Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
    • C07D513/14Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05Isotopically modified compounds, e.g. labelled

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Physics & Mathematics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
PL15836970T 2014-08-29 2015-08-28 Sondy do obrazowania białka huntingtyny PL3186241T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462043644P 2014-08-29 2014-08-29
EP15836970.2A EP3186241B1 (en) 2014-08-29 2015-08-28 Probes for imaging huntington protein
PCT/US2015/047396 WO2016033436A1 (en) 2014-08-29 2015-08-28 Probes for imaging huntingtin protein

Publications (1)

Publication Number Publication Date
PL3186241T3 true PL3186241T3 (pl) 2021-05-17

Family

ID=55400644

Family Applications (1)

Application Number Title Priority Date Filing Date
PL15836970T PL3186241T3 (pl) 2014-08-29 2015-08-28 Sondy do obrazowania białka huntingtyny

Country Status (20)

Country Link
US (2) US11071793B2 (pl)
EP (1) EP3186241B1 (pl)
JP (3) JP2017527559A (pl)
KR (1) KR102410760B1 (pl)
CN (2) CN107074817B (pl)
AU (1) AU2015308765B2 (pl)
BR (1) BR112017004136B1 (pl)
CA (1) CA2959531C (pl)
DK (1) DK3186241T3 (pl)
EA (1) EA037275B1 (pl)
ES (1) ES2841746T3 (pl)
HR (1) HRP20202032T1 (pl)
HU (1) HUE052892T2 (pl)
IL (1) IL250805B (pl)
MX (2) MX2017002704A (pl)
PL (1) PL3186241T3 (pl)
PT (1) PT3186241T (pl)
SG (1) SG11201701578YA (pl)
SI (1) SI3186241T1 (pl)
WO (1) WO2016033436A1 (pl)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK3186233T3 (da) 2014-08-29 2021-11-22 Chdi Foundation Inc Prober til billeddannelse af huntingtin-protein
US11104691B2 (en) 2014-08-29 2021-08-31 Chdi Foundation, Inc. Probes for imaging huntingtin protein
AU2015308709B2 (en) 2014-08-29 2020-01-02 Chdi Foundation, Inc. Probes for imaging huntingtin protein
RU2721419C2 (ru) 2015-08-28 2020-05-19 СиЭйчДиАй ФАУНДЕЙШН, ИНК. Зонды визуализации белка гентингтина
JP7086942B2 (ja) 2016-09-12 2022-06-20 インテグラル ヘルス, インコーポレイテッド Gpr120モジュレーターとして有用な単環式化合物
US10865201B2 (en) 2016-09-12 2020-12-15 Valo Health, Inc. Bicyclic compounds useful as GPR120 modulators
WO2020176424A1 (en) 2019-02-25 2020-09-03 Chdi Foundation, Inc. Compounds for targeting mutant huntingtin protein and uses thereof
WO2021127265A1 (en) * 2019-12-18 2021-06-24 Chdi Foundation, Inc. Compounds and probes for imaging huntingtin protein
EP4320114A1 (en) * 2021-04-08 2024-02-14 CHDI Foundation, Inc. Isoindolinone compounds and imaging agents for imaging huntingtin protein

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5726197A (en) * 1992-11-02 1998-03-10 Syntex (U.S.A.) Inc. Isoindolinyl derivatives
CN1156445C (zh) 1999-06-10 2004-07-07 沃尼尔·朗伯公司 采用二氢异吲哚衍生物抑制淀粉样蛋白聚集和使淀粉样蛋白沉积成像的方法
PL371366A1 (pl) * 2002-03-01 2005-06-13 Takeda Pharmaceutical Company Limited Środek przeciwdepresyjny
US7968569B2 (en) 2002-05-17 2011-06-28 Celgene Corporation Methods for treatment of multiple myeloma using 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione
US7320992B2 (en) * 2003-08-25 2008-01-22 Amgen Inc. Substituted 2,3-dihydro-1h-isoindol-1-one derivatives and methods of use
US8110681B2 (en) 2006-03-17 2012-02-07 The United States Of America As Represented By The Secretary, Department Of Health And Human Services Compounds for the treatment of spinal muscular atrophy and other uses
AU2008304231A1 (en) 2007-09-27 2009-04-02 Albany Molecular Research, Inc. Isoindoline compounds for the treatment of spinal muscular atrophy and other uses
WO2009072581A1 (ja) * 2007-12-05 2009-06-11 Aska Pharmaceutical Co., Ltd. ラクタム化合物又はその塩及びppar活性化剤
WO2010104324A2 (ko) * 2009-03-10 2010-09-16 한국과학기술연구원 베타-아밀로이드 집적체 및 피브릴에 우수한 결합 친화도를 가지는 할로겐화 이소인돌론 화합물, 및 이의 제조 방법 및 용도
RU2646754C2 (ru) * 2012-04-25 2018-03-07 Раквалиа Фарма Инк. Производные пирролопиридинона в качестве ttx-s блокаторов
ES2779152T3 (es) * 2013-10-07 2020-08-13 Kadmon Corporation Llc Derivados de (2-(5-isoindolin-2-il)pirimidin-4-il)-amina como inhibidores de Rho-quinasa para tratar enfermedades autoinmunes
DK3186233T3 (da) 2014-08-29 2021-11-22 Chdi Foundation Inc Prober til billeddannelse af huntingtin-protein
US11104691B2 (en) 2014-08-29 2021-08-31 Chdi Foundation, Inc. Probes for imaging huntingtin protein
AU2015308709B2 (en) 2014-08-29 2020-01-02 Chdi Foundation, Inc. Probes for imaging huntingtin protein
RU2721419C2 (ru) 2015-08-28 2020-05-19 СиЭйчДиАй ФАУНДЕЙШН, ИНК. Зонды визуализации белка гентингтина

Also Published As

Publication number Publication date
KR102410760B1 (ko) 2022-06-20
EA037275B1 (ru) 2021-03-03
US20210379211A1 (en) 2021-12-09
EP3186241A4 (en) 2018-04-18
IL250805B (en) 2020-08-31
MX2021005891A (es) 2021-06-23
EP3186241B1 (en) 2020-10-07
CN118005611A (zh) 2024-05-10
CN107074817A (zh) 2017-08-18
IL250805A0 (en) 2017-04-30
DK3186241T3 (da) 2021-01-11
BR112017004136B1 (pt) 2022-05-03
JP2021088584A (ja) 2021-06-10
ES2841746T3 (es) 2021-07-09
HRP20202032T1 (hr) 2021-02-19
EP3186241A1 (en) 2017-07-05
US20170281804A1 (en) 2017-10-05
AU2015308765A1 (en) 2017-03-23
JP7042940B2 (ja) 2022-03-28
JP2020079272A (ja) 2020-05-28
SG11201701578YA (en) 2017-03-30
HUE052892T2 (hu) 2021-05-28
EA201790432A1 (ru) 2017-09-29
CA2959531A1 (en) 2016-03-03
JP6843282B2 (ja) 2021-03-17
SI3186241T1 (sl) 2021-03-31
JP2017527559A (ja) 2017-09-21
US11071793B2 (en) 2021-07-27
KR20170047348A (ko) 2017-05-04
CN107074817B (zh) 2023-12-15
AU2015308765B2 (en) 2020-06-04
PT3186241T (pt) 2021-01-08
MX2017002704A (es) 2017-10-23
WO2016033436A1 (en) 2016-03-03
CA2959531C (en) 2023-01-10
BR112017004136A2 (pt) 2017-12-12

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