PL2760848T3 - Sposoby otrzymywania kabazytakselu powiązane z sililowaniem c(7)-oh i c(13)-oh lub z sililowaniem tylko c(7)-oh - Google Patents
Sposoby otrzymywania kabazytakselu powiązane z sililowaniem c(7)-oh i c(13)-oh lub z sililowaniem tylko c(7)-ohInfo
- Publication number
- PL2760848T3 PL2760848T3 PL12783667T PL12783667T PL2760848T3 PL 2760848 T3 PL2760848 T3 PL 2760848T3 PL 12783667 T PL12783667 T PL 12783667T PL 12783667 T PL12783667 T PL 12783667T PL 2760848 T3 PL2760848 T3 PL 2760848T3
- Authority
- PL
- Poland
- Prior art keywords
- silylation
- cabazitaxel
- involving
- processes
- preparation
- Prior art date
Links
- 238000006884 silylation reaction Methods 0.000 title 2
- BMQGVNUXMIRLCK-OAGWZNDDSA-N cabazitaxel Chemical compound O([C@H]1[C@@H]2[C@]3(OC(C)=O)CO[C@@H]3C[C@@H]([C@]2(C(=O)[C@H](OC)C2=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=3C=CC=CC=3)C[C@]1(O)C2(C)C)C)OC)C(=O)C1=CC=CC=C1 BMQGVNUXMIRLCK-OAGWZNDDSA-N 0.000 title 1
- 229960001573 cabazitaxel Drugs 0.000 title 1
- 238000000034 method Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Epoxy Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN2794DE2011 | 2011-09-26 | ||
| EP12783667.4A EP2760848B1 (en) | 2011-09-26 | 2012-09-21 | Processes for the preparation of cabazitaxel involving c(7)-oh and c(13)-oh silylation or just c(7)-oh silylation |
| PCT/IN2012/000630 WO2013069027A1 (en) | 2011-09-26 | 2012-09-21 | Processes for the preparation of cabazitaxel involving c(7) -oh and c(13) -oh silylation or just c(7) -oh silylation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2760848T3 true PL2760848T3 (pl) | 2019-07-31 |
Family
ID=47146459
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL12783667T PL2760848T3 (pl) | 2011-09-26 | 2012-09-21 | Sposoby otrzymywania kabazytakselu powiązane z sililowaniem c(7)-oh i c(13)-oh lub z sililowaniem tylko c(7)-oh |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US8901327B2 (pl) |
| EP (1) | EP2760848B1 (pl) |
| CN (1) | CN104039771B (pl) |
| ES (1) | ES2712804T3 (pl) |
| PL (1) | PL2760848T3 (pl) |
| WO (1) | WO2013069027A1 (pl) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2688877B1 (en) | 2011-04-12 | 2017-03-08 | Teva Pharmaceuticals International GmbH | Solid state forms of cabazitaxel and processes for preparation thereof |
| TWI526437B (zh) * | 2011-09-09 | 2016-03-21 | 台灣神隆股份有限公司 | 卡巴他賽之結晶型 |
| US20130090484A1 (en) * | 2011-10-11 | 2013-04-11 | Scinopharm Taiwan Ltd. | Process for making an intermediate of cabazitaxel |
| KR101407353B1 (ko) * | 2012-12-04 | 2014-06-17 | 주식회사 삼양바이오팜 | 10-디아세틸바카틴 iii으로부터 카바지탁셀을 고수율로 제조하는 새로운 방법 및 이를 위한 신규 중간체 |
| CN106632158B (zh) * | 2013-08-28 | 2018-11-06 | 江苏恒瑞医药股份有限公司 | 7β,10β-二甲氧基-10-去乙酰基浆果赤霉素III的制备方法 |
| CN103664837B (zh) * | 2013-08-30 | 2016-01-20 | 北京阳光诺和药物研究有限公司 | 一种高纯度卡巴他赛中间体的制备方法 |
| CN104292188A (zh) * | 2014-08-21 | 2015-01-21 | 四川汇宇制药有限公司 | 一种卡巴他赛的合成方法 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5399726A (en) | 1993-01-29 | 1995-03-21 | Florida State University | Process for the preparation of baccatin III analogs bearing new C2 and C4 functional groups |
| FR2696462B1 (fr) | 1992-10-05 | 1994-11-25 | Rhone Poulenc Rorer Sa | Procédé d'obtention de la désacétyl-10 baccatine III. |
| FR2696459B1 (fr) | 1992-10-05 | 1994-11-25 | Rhone Poulenc Rorer Sa | Procédé de préparation de dérivés du taxane. |
| US5453521A (en) | 1992-10-05 | 1995-09-26 | Rhone-Poulenc Rorer S.A. | Process for obtaining 10-deacetylbaccatin III |
| FR2696463B1 (fr) | 1992-10-05 | 1994-11-25 | Rhone Poulenc Rorer Sa | Procédé d'obtention de la désacétyl-10 baccatine III. |
| US6500858B2 (en) | 1994-10-28 | 2002-12-31 | The Research Foundation Of The State University Of New York | Taxoid anti-tumor agents and pharmaceutical compositions thereof |
| US5847170A (en) | 1995-03-27 | 1998-12-08 | Rhone-Poulenc Rorer, S.A. | Taxoids, their preparation and pharmaceutical compositions containing them |
| MA23823A1 (fr) * | 1995-03-27 | 1996-10-01 | Aventis Pharma Sa | Nouveaux taxoides, leur preparation et les compositions qui les contiennent |
| US6372780B2 (en) * | 1995-03-27 | 2002-04-16 | Aventis Pharma S.A. | Methods of treating cell lines expressing multidrug resistance P-glycoprotein |
| FR2771092B1 (fr) | 1997-11-18 | 1999-12-17 | Rhone Poulenc Rorer Sa | Procede de preparation de derives de la classe des taxoides |
| US6124482A (en) | 1998-07-27 | 2000-09-26 | Dabur Research Foundation | Process for isolation of 10-deacetyl baccatin-III |
| US6410757B1 (en) | 1999-02-16 | 2002-06-25 | Bio Research Corporation Of Yokohama | Baccatin derivatives and a process for producing the same |
| WO2005113528A1 (en) | 2004-05-14 | 2005-12-01 | Immunogen, Inc. | A facile method for synthesizing baccatin iii compounds |
| FR2926551A1 (fr) * | 2008-01-17 | 2009-07-24 | Aventis Pharma Sa | Formes cristallines du dimethoxy docetaxel et leurs procedes de preparation |
| US8791279B2 (en) * | 2010-12-13 | 2014-07-29 | Yung Shin Pharm. Ind. Co., Ltd. | Process for preparing taxoids from baccatin derivatives using lewis acid catalyst |
| WO2012088391A1 (en) * | 2010-12-22 | 2012-06-28 | Nektar Therapeutics | Non-ring hydroxy substituted taxanes and methods for synthesizing the same |
| EP2688877B1 (en) * | 2011-04-12 | 2017-03-08 | Teva Pharmaceuticals International GmbH | Solid state forms of cabazitaxel and processes for preparation thereof |
-
2012
- 2012-09-21 PL PL12783667T patent/PL2760848T3/pl unknown
- 2012-09-21 ES ES12783667T patent/ES2712804T3/es active Active
- 2012-09-21 CN CN201280046984.6A patent/CN104039771B/zh active Active
- 2012-09-21 WO PCT/IN2012/000630 patent/WO2013069027A1/en active Application Filing
- 2012-09-21 EP EP12783667.4A patent/EP2760848B1/en active Active
- 2012-09-24 US US13/625,155 patent/US8901327B2/en active Active
-
2014
- 2014-11-05 US US14/533,412 patent/US9000193B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| WO2013069027A1 (en) | 2013-05-16 |
| US9000193B2 (en) | 2015-04-07 |
| CN104039771B (zh) | 2017-10-27 |
| EP2760848A1 (en) | 2014-08-06 |
| ES2712804T3 (es) | 2019-05-14 |
| US20140058119A1 (en) | 2014-02-27 |
| US8901327B2 (en) | 2014-12-02 |
| CN104039771A (zh) | 2014-09-10 |
| US20150057454A1 (en) | 2015-02-26 |
| WO2013069027A9 (en) | 2013-10-17 |
| EP2760848B1 (en) | 2018-11-28 |
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