PL2654780T3 - Aktywne mutanty przeciwciała fc odporne na proteazy - Google Patents
Aktywne mutanty przeciwciała fc odporne na proteazyInfo
- Publication number
- PL2654780T3 PL2654780T3 PL11851794T PL11851794T PL2654780T3 PL 2654780 T3 PL2654780 T3 PL 2654780T3 PL 11851794 T PL11851794 T PL 11851794T PL 11851794 T PL11851794 T PL 11851794T PL 2654780 T3 PL2654780 T3 PL 2654780T3
- Authority
- PL
- Poland
- Prior art keywords
- mutants
- active protease
- resistant antibody
- antibody
- resistant
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/524—CH2 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/53—Hinge
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/72—Increased effector function due to an Fc-modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/734—Complement-dependent cytotoxicity [CDC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201061426619P | 2010-12-23 | 2010-12-23 | |
US201161540882P | 2011-09-29 | 2011-09-29 | |
EP11851794.5A EP2654780B1 (en) | 2010-12-23 | 2011-12-15 | Active protease-resistant antibody fc mutants |
Publications (1)
Publication Number | Publication Date |
---|---|
PL2654780T3 true PL2654780T3 (pl) | 2017-07-31 |
Family
ID=46314374
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PL11851794T PL2654780T3 (pl) | 2010-12-23 | 2011-12-15 | Aktywne mutanty przeciwciała fc odporne na proteazy |
Country Status (31)
Country | Link |
---|---|
US (2) | US8871204B2 (pl) |
EP (1) | EP2654780B1 (pl) |
JP (1) | JP6012624B2 (pl) |
KR (1) | KR101900280B1 (pl) |
CN (1) | CN103260640B (pl) |
AU (1) | AU2011349719B2 (pl) |
BR (1) | BR112013018317A2 (pl) |
CA (1) | CA2822366A1 (pl) |
CO (1) | CO6741179A2 (pl) |
CR (1) | CR20130292A (pl) |
CY (1) | CY1118923T1 (pl) |
DK (1) | DK2654780T3 (pl) |
EA (1) | EA028658B1 (pl) |
EC (1) | ECSP13012712A (pl) |
ES (1) | ES2623912T3 (pl) |
GT (1) | GT201300167A (pl) |
HR (1) | HRP20170595T1 (pl) |
HU (1) | HUE033205T2 (pl) |
IL (1) | IL226987A (pl) |
LT (1) | LT2654780T (pl) |
MX (1) | MX347077B (pl) |
MY (1) | MY162489A (pl) |
NI (1) | NI201300057A (pl) |
NZ (1) | NZ612379A (pl) |
PL (1) | PL2654780T3 (pl) |
PT (1) | PT2654780T (pl) |
RS (1) | RS55906B1 (pl) |
SG (1) | SG191233A1 (pl) |
SI (1) | SI2654780T1 (pl) |
WO (1) | WO2012087746A1 (pl) |
ZA (1) | ZA201305538B (pl) |
Families Citing this family (46)
Publication number | Priority date | Publication date | Assignee | Title |
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ES2848323T3 (es) | 2008-01-31 | 2021-08-06 | Inst Nat Sante Rech Med | Anticuerpos contra CD39 humano y uso de los mismos para inhibir la actividad de las células T reguladoras |
US10053513B2 (en) | 2009-11-30 | 2018-08-21 | Janssen Biotech, Inc. | Antibody Fc mutants with ablated effector functions |
BR112013018317A2 (pt) * | 2010-12-23 | 2017-03-21 | Janssen Biotech Inc | mutantes de fc do anticorpo resistentes a protease ativa |
US10400029B2 (en) | 2011-06-28 | 2019-09-03 | Inhibrx, Lp | Serpin fusion polypeptides and methods of use thereof |
NZ744257A (en) | 2011-06-28 | 2022-10-28 | Inhibrx Inc | Serpin fusion polypeptides and methods of use thereof |
EP2812027A1 (en) | 2012-02-07 | 2014-12-17 | Innate Pharma | Mica binding agents |
TWI635098B (zh) | 2013-02-01 | 2018-09-11 | 再生元醫藥公司 | 含嵌合恆定區之抗體 |
TWI701042B (zh) | 2014-03-19 | 2020-08-11 | 美商再生元醫藥公司 | 用於腫瘤治療之方法及抗體組成物 |
FI3169703T4 (fi) * | 2014-07-16 | 2024-03-01 | Hinrich Abken | Kimeerinen antigeenireseptori ja sen käyttö |
CN104177496B (zh) * | 2014-09-02 | 2015-03-11 | 安源生物科技(上海)有限公司 | 人IgG2抗体铰链区修饰体 |
WO2016055609A1 (en) | 2014-10-10 | 2016-04-14 | Innate Pharma | Cd73 blockade |
BR112017008525A2 (pt) * | 2014-10-27 | 2018-01-30 | Inhibrx Lp | proteína de fusão isolada, e, métodos para tratamento ou alívio de um sintoma de uma doença ou distúrbio, para tratamento ou alívio de uma inflamação ou um sintoma de uma doença ou distúrbio inflamatório e para redução do risco de infecção em um indivíduo. |
ES2809455T3 (es) | 2014-11-17 | 2021-03-04 | Regeneron Pharma | Métodos para tratamiento tumoral usando anticuerpo biespecífico CD3xCD20 |
EP3259288A1 (en) | 2015-02-20 | 2017-12-27 | Innate Pharma | Cd73 blockade |
US10196445B1 (en) | 2015-03-17 | 2019-02-05 | Bristol-Myers Squibb Company | Ipilimumab variant with enhanced ADCC |
ES2846748T3 (es) | 2015-03-30 | 2021-07-29 | Regeneron Pharma | Regiones constantes de cadenas pesadas con unión reducida a receptores Fc gamma |
JP2018517708A (ja) | 2015-06-05 | 2018-07-05 | ニューヨーク・ユニバーシティ | 抗ブドウ球菌生物学的薬剤のための組成物及び方法 |
BR112017028550A2 (pt) * | 2015-07-24 | 2018-09-04 | Gliknik Inc | proteínas de fusão de fragmentos de proteína humana para criar composições de inmunoglobulina fc multimerizadas ordinárias com relação de complemento melhorado |
MX2018001522A (es) | 2015-08-05 | 2018-03-15 | Janssen Biotech Inc | Anticuerpos anti-cd154 y metodos de uso de estos. |
US10544229B2 (en) | 2015-09-30 | 2020-01-28 | Janssen Biotech, Inc. | Agonistic antibodies specifically binding CD40 and methods of use |
WO2017064043A1 (en) | 2015-10-12 | 2017-04-20 | Innate Pharma | Cd73 blocking agents |
AU2016341400B2 (en) * | 2015-10-23 | 2021-04-08 | Apogenix Ag | Single-chain CD137-receptor agonist proteins |
EP3912681A1 (en) | 2016-03-14 | 2021-11-24 | Orega Biotech | Anti-cd39 antibodies |
CN108779178A (zh) | 2016-03-15 | 2018-11-09 | 依奈特制药公司 | 抗mica抗体 |
KR102635635B1 (ko) * | 2016-05-23 | 2024-02-14 | 모멘타 파머슈티컬스 인코포레이티드 | 유전자 조작 Fc 작제물에 관한 조성물 및 방법 |
CN115304669A (zh) * | 2016-06-08 | 2022-11-08 | 上海交通大学医学院 | 增强激动型抗体活性的抗体重链恒定区序列 |
GB2552473A (en) * | 2016-07-21 | 2018-01-31 | Evox Therapeutics Ltd | Surface decoration of extracellular vesicles |
WO2018065552A1 (en) | 2016-10-06 | 2018-04-12 | Innate Pharma | Anti-cd39 antibodies |
CA3051640A1 (en) | 2017-03-16 | 2018-09-20 | Innate Pharma | Compositions and methods for treating cancer |
WO2018183520A1 (en) * | 2017-03-28 | 2018-10-04 | Lyvgen Biopharma Holdings Limited | Therapeutic agents and methods for enhancing immune responses in tumor microenvironment |
JP2020519309A (ja) * | 2017-05-10 | 2020-07-02 | アルバジュナ・セラピューティクス・エセ・エレ | 高い二重のHIV抗ウイルス及び免疫調節活性を有するFc融合タンパク質誘導体 |
RS61883B1 (sr) | 2017-09-19 | 2021-06-30 | Tillotts Pharma Ag | Varijante antitela |
EA202092518A1 (ru) | 2018-06-18 | 2021-08-23 | Иннейт Фарма | Композиции и способы лечения рака |
KR20210054528A (ko) | 2018-08-31 | 2021-05-13 | 리제너론 파아마슈티컬스, 인크. | Cd3/c20 이중특이적 항체에 대한 사이토카인 방출 증후군을 경감시키는 투약 전략 |
BR112021005907A2 (pt) | 2018-09-27 | 2021-08-10 | Xilio Development, Inc. | citocinas mascaradas, ácido nucleico, vetor, célula hospedeira, métodos para produzir uma citocina mascarada, para tratar ou prevenir uma doença neoplásica e para tratar ou prevenir uma doença inflamatória ou autoimune neoplásica, composição, composição farmacêutica e kit |
WO2020114616A1 (en) | 2018-12-07 | 2020-06-11 | Tillotts Pharma Ag | Topical treatment of immune checkpoint inhibitor induced diarrhoea, colitis or enterocolitis using antibodies and fragments thereof |
EP3711772A1 (en) | 2019-03-20 | 2020-09-23 | Oslo Universitetssykehus HF | Recombinant proteins and fusion proteins |
CN113874392A (zh) * | 2019-03-28 | 2021-12-31 | 丹尼斯科美国公司 | 工程化抗体 |
GB201906685D0 (en) | 2019-05-13 | 2019-06-26 | Ultrahuman Six Ltd | Activatable protein constructs and uses thereof |
US20220380457A1 (en) * | 2019-08-23 | 2022-12-01 | City Of Hope | Igg antibody compositions and methods of making the same |
GB2595299B (en) | 2020-05-21 | 2022-08-03 | Mabsolve Ltd | Modified immunoglobulin FC regions |
IL300260A (en) * | 2020-08-07 | 2023-03-01 | Genentech Inc | FLT3 ligand fusion proteins and methods of use |
WO2022167729A1 (en) * | 2021-02-04 | 2022-08-11 | Helsingin Yliopisto | A cross-hybrid fc-fusion polypeptide targeting pd-l1 and methods and uses related thereto |
CN117597365A (zh) * | 2021-05-04 | 2024-02-23 | 再生元制药公司 | 多特异性fgf21受体激动剂及其应用 |
WO2023109928A1 (zh) * | 2021-12-16 | 2023-06-22 | 上海宝济药业有限公司 | 抗免疫球蛋白降解酶酶切的Fc变体 |
WO2024108137A2 (en) * | 2022-11-18 | 2024-05-23 | Seismic Therapeutic, Inc. | Fc fusion molecules and uses thereof |
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WO1994025591A1 (en) | 1993-04-29 | 1994-11-10 | Unilever N.V. | PRODUCTION OF ANTIBODIES OR (FUNCTIONALIZED) FRAGMENTS THEREOF DERIVED FROM HEAVY CHAIN IMMUNOGLOBULINS OF $i(CAMELIDAE) |
EP1082137A4 (en) | 1998-05-06 | 2004-05-19 | Univ Temple | REVERSE OF PERCENTAL RESPONSE BY INTERRUPTING THE MACROPHAGE RECEPTOR FcSg (g) RI |
KR101077001B1 (ko) * | 1999-01-15 | 2011-10-26 | 제넨테크, 인크. | 효과기 기능이 변화된 폴리펩티드 변이체 |
ES2571230T3 (es) | 1999-04-09 | 2016-05-24 | Kyowa Hakko Kirin Co Ltd | Procedimiento para controlar la actividad de una molécula inmunofuncional |
US7129331B2 (en) | 2000-05-31 | 2006-10-31 | Pestka Biomedical Laboratories, Inc. | Phosphorylated polypeptides and uses related thereto |
GB0130228D0 (en) | 2001-12-18 | 2002-02-06 | Hansa Medica Ab | Protein |
US8188231B2 (en) * | 2002-09-27 | 2012-05-29 | Xencor, Inc. | Optimized FC variants |
EP1833510A4 (en) | 2004-12-27 | 2010-02-10 | Progenics Pharmaceuticals Neva | ORAL ADMINISTRATION ANTITOXIN ANTIBODIES AND METHODS OF MAKING AND USING THE SAME |
CA2619825A1 (en) | 2005-08-19 | 2007-03-01 | Centocor, Inc. | Proteolysis resistant antibody preparations |
AU2006299429B2 (en) * | 2005-10-03 | 2012-02-23 | Xencor, Inc. | Fc variants with optimized Fc receptor binding properties |
CA2696011A1 (en) * | 2007-08-10 | 2009-02-19 | Centocor Ortho Biotech Inc. | Immunoglobulin cleavage fragments as disease indicators and compositions for detecting and binding such |
SG193868A1 (en) * | 2007-09-26 | 2013-10-30 | Chugai Pharmaceutical Co Ltd | Modified antibody constant region |
WO2009045894A1 (en) | 2007-09-28 | 2009-04-09 | Centocor, Inc. | Methods and structural conformations of antibody preparations with increased resistance to proteases |
PT2211904T (pt) * | 2007-10-19 | 2016-11-02 | Seattle Genetics Inc | Agentes de ligação a cd19 e seus usos |
CA2758524A1 (en) | 2009-04-21 | 2010-10-28 | Amgen Inc. | Fragmentation resistant igg1 fc-conjugates |
BR112013018317A2 (pt) * | 2010-12-23 | 2017-03-21 | Janssen Biotech Inc | mutantes de fc do anticorpo resistentes a protease ativa |
US8729985B2 (en) | 2012-01-23 | 2014-05-20 | Electro-Mechanical Corporation | Switchgear visible disconnect mechanical interlock |
-
2011
- 2011-12-15 BR BR112013018317A patent/BR112013018317A2/pt not_active Application Discontinuation
- 2011-12-15 MX MX2013007291A patent/MX347077B/es active IP Right Grant
- 2011-12-15 SI SI201131178A patent/SI2654780T1/sl unknown
- 2011-12-15 LT LTEP11851794.5T patent/LT2654780T/lt unknown
- 2011-12-15 AU AU2011349719A patent/AU2011349719B2/en not_active Ceased
- 2011-12-15 HU HUE11851794A patent/HUE033205T2/en unknown
- 2011-12-15 ES ES11851794.5T patent/ES2623912T3/es active Active
- 2011-12-15 SG SG2013046966A patent/SG191233A1/en unknown
- 2011-12-15 KR KR1020137018973A patent/KR101900280B1/ko active IP Right Grant
- 2011-12-15 CA CA2822366A patent/CA2822366A1/en not_active Abandoned
- 2011-12-15 WO PCT/US2011/065174 patent/WO2012087746A1/en active Application Filing
- 2011-12-15 MY MYPI2013701050A patent/MY162489A/en unknown
- 2011-12-15 PL PL11851794T patent/PL2654780T3/pl unknown
- 2011-12-15 RS RS20170386A patent/RS55906B1/sr unknown
- 2011-12-15 JP JP2013546229A patent/JP6012624B2/ja not_active Expired - Fee Related
- 2011-12-15 PT PT118517945T patent/PT2654780T/pt unknown
- 2011-12-15 CN CN201180061808.5A patent/CN103260640B/zh not_active Expired - Fee Related
- 2011-12-15 EP EP11851794.5A patent/EP2654780B1/en active Active
- 2011-12-15 DK DK11851794.5T patent/DK2654780T3/en active
- 2011-12-15 NZ NZ612379A patent/NZ612379A/en not_active IP Right Cessation
- 2011-12-15 EA EA201390958A patent/EA028658B1/ru not_active IP Right Cessation
-
2012
- 2012-07-23 US US13/555,334 patent/US8871204B2/en not_active Expired - Fee Related
-
2013
- 2013-06-17 IL IL226987A patent/IL226987A/en active IP Right Grant
- 2013-06-17 CR CR20130292A patent/CR20130292A/es unknown
- 2013-06-21 NI NI201300057A patent/NI201300057A/es unknown
- 2013-06-21 GT GT201300167A patent/GT201300167A/es unknown
- 2013-06-21 EC ECSP13012712 patent/ECSP13012712A/es unknown
- 2013-06-21 CO CO13148253A patent/CO6741179A2/es unknown
- 2013-07-22 ZA ZA2013/05538A patent/ZA201305538B/en unknown
-
2014
- 2014-09-22 US US14/492,250 patent/US9611328B2/en not_active Expired - Fee Related
-
2017
- 2017-04-13 HR HRP20170595TT patent/HRP20170595T1/hr unknown
- 2017-04-19 CY CY20171100444T patent/CY1118923T1/el unknown
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