PL2593429T3 - Sposób otrzymywania kwasu bifenyl-2-ylokarbaminowego - Google Patents

Sposób otrzymywania kwasu bifenyl-2-ylokarbaminowego

Info

Publication number
PL2593429T3
PL2593429T3 PL11734208T PL11734208T PL2593429T3 PL 2593429 T3 PL2593429 T3 PL 2593429T3 PL 11734208 T PL11734208 T PL 11734208T PL 11734208 T PL11734208 T PL 11734208T PL 2593429 T3 PL2593429 T3 PL 2593429T3
Authority
PL
Poland
Prior art keywords
biphenyl
preparing
ylcarbamic acid
ylcarbamic
acid
Prior art date
Application number
PL11734208T
Other languages
English (en)
Inventor
Pierre-Jean Colson
Original Assignee
Theravance Biopharma R&D Ip Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Theravance Biopharma R&D Ip Llc filed Critical Theravance Biopharma R&D Ip Llc
Publication of PL2593429T3 publication Critical patent/PL2593429T3/pl

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/4523Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40Oxygen atoms
    • C07D211/44Oxygen atoms attached in position 4
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40Oxygen atoms
    • C07D211/44Oxygen atoms attached in position 4
    • C07D211/46Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
PL11734208T 2010-07-13 2011-06-30 Sposób otrzymywania kwasu bifenyl-2-ylokarbaminowego PL2593429T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US36372510P 2010-07-13 2010-07-13
EP11734208.9A EP2593429B1 (en) 2010-07-13 2011-06-30 Process for preparing a biphenyl-2-ylcarbamic acid
PCT/US2011/042530 WO2012009166A1 (en) 2010-07-13 2011-06-30 Process for preparing a biphenyl-2-ylcarbamic acid

Publications (1)

Publication Number Publication Date
PL2593429T3 true PL2593429T3 (pl) 2015-10-30

Family

ID=44514976

Family Applications (1)

Application Number Title Priority Date Filing Date
PL11734208T PL2593429T3 (pl) 2010-07-13 2011-06-30 Sposób otrzymywania kwasu bifenyl-2-ylokarbaminowego

Country Status (22)

Country Link
US (2) US8754225B2 (pl)
EP (1) EP2593429B1 (pl)
JP (2) JP5959117B2 (pl)
KR (1) KR101742253B1 (pl)
CN (1) CN102958916B (pl)
AU (1) AU2011279602B2 (pl)
BR (1) BR112013000877B1 (pl)
CA (1) CA2801101C (pl)
DK (1) DK2593429T3 (pl)
ES (1) ES2544287T3 (pl)
HK (1) HK1184145A1 (pl)
HR (1) HRP20150700T1 (pl)
HU (1) HUE027140T2 (pl)
IL (1) IL223328A (pl)
MX (1) MX2013000456A (pl)
PL (1) PL2593429T3 (pl)
PT (1) PT2593429E (pl)
RS (1) RS54201B1 (pl)
SG (1) SG186708A1 (pl)
SI (1) SI2593429T1 (pl)
SM (1) SMT201500204B (pl)
WO (1) WO2012009166A1 (pl)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI341836B (en) 2004-03-11 2011-05-11 Theravance Inc Biphenyl compounds useful as muscarinic receptor antagonists
CN102470130B (zh) 2009-07-15 2013-09-04 施万制药 联苯化合物的结晶游离碱形式
WO2020047225A1 (en) 2018-08-30 2020-03-05 Theravance Biopharma R&D Ip, Llc Methods for treating chronic obstructive pulmonary disease
CN110526859B (zh) * 2019-08-07 2021-03-12 山东百诺医药股份有限公司 一种瑞维那新中间体及其制备方法和瑞维那新的制备方法
WO2022049604A1 (en) * 2020-09-05 2022-03-10 Cipla Limited Process for preparing revefenacin and intermediates therof
CN112694434B (zh) * 2020-12-29 2023-06-16 浙江和泽医药科技股份有限公司 一种雷芬那辛新中间体及其活性亲电砌块和雷芬那辛的新制备方法
CN113121412A (zh) * 2021-04-20 2021-07-16 扬州中宝药业股份有限公司 一种雷芬那辛中间体的制备方法
WO2023002502A1 (en) * 2021-07-17 2023-01-26 Msn Laboratories Private Ltd, R&D Center Novel process for the preparation of 1-(2-{4-[(4-carbamoylpiperidin-1-yl)methyl]- n-methylbenzamido}ethyl)piperidin-4-yl n-({1,1'-biphenyl}-2-yl)carbamate
WO2023104920A1 (en) 2021-12-09 2023-06-15 Medichem, S.A. Crystalline acetone solvate of revefenacin
CN114276290B (zh) * 2021-12-24 2024-05-28 浙江和泽医药科技股份有限公司 一种雷芬那辛无水晶型及其制备方法
CN115093365B (zh) * 2022-07-25 2023-07-25 沈阳药科大学 一种雷芬那辛的合成方法
CN116514704B (zh) * 2023-07-01 2023-09-29 北京远大九和药业有限公司 一种雷芬那辛中间体及其制备方法
CN117263848A (zh) * 2023-09-19 2023-12-22 山东京卫制药有限公司 一种雷芬那辛的吸入喷雾剂

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6816878B1 (en) * 2000-02-11 2004-11-09 Steven L. Zimmers Alert notification system
PE20040950A1 (es) * 2003-02-14 2005-01-01 Theravance Inc DERIVADOS DE BIFENILO COMO AGONISTAS DE LOS RECEPTORES ADRENERGICOS ß2 Y COMO ANTAGONISTAS DE LOS RECEPTORES MUSCARINICOS
US7228657B2 (en) 2003-07-10 2007-06-12 Controlled Environments Limited Climate control for a greenhouse
DE602004021959D1 (de) * 2003-11-21 2009-08-20 Theravance Inc Verbindungen mit agonistischer wirkung am beta2-adrenergen rezeptor und am muscarinischen rezeptor
TWI341836B (en) * 2004-03-11 2011-05-11 Theravance Inc Biphenyl compounds useful as muscarinic receptor antagonists
US7659403B2 (en) * 2005-03-10 2010-02-09 Theravance, Inc. Biphenyl compounds useful as muscarinic receptor antagonists
TWI372749B (en) 2005-03-10 2012-09-21 Theravance Inc Crystalline forms of a biphenyl compound
CN102470130B (zh) 2009-07-15 2013-09-04 施万制药 联苯化合物的结晶游离碱形式

Also Published As

Publication number Publication date
US20140121378A1 (en) 2014-05-01
JP2015127342A (ja) 2015-07-09
HK1184145A1 (en) 2014-01-17
US8754225B2 (en) 2014-06-17
AU2011279602B2 (en) 2015-04-09
CN102958916B (zh) 2015-03-25
CA2801101A1 (en) 2012-01-19
PT2593429E (pt) 2015-09-24
IL223328A0 (en) 2013-02-03
HUE027140T2 (hu) 2016-08-29
SG186708A1 (en) 2013-02-28
JP5959117B2 (ja) 2016-08-02
BR112013000877A2 (pt) 2016-05-17
MX2013000456A (es) 2013-02-27
RS54201B1 (en) 2015-12-31
AU2011279602A1 (en) 2013-02-21
SI2593429T1 (sl) 2015-10-30
US9035061B2 (en) 2015-05-19
ES2544287T3 (es) 2015-08-28
EP2593429B1 (en) 2015-06-03
SMT201500204B (it) 2015-10-30
EP2593429A1 (en) 2013-05-22
WO2012009166A1 (en) 2012-01-19
CA2801101C (en) 2018-01-16
HRP20150700T1 (hr) 2015-08-14
IL223328A (en) 2015-07-30
KR20130129177A (ko) 2013-11-27
BR112013000877B1 (pt) 2021-07-06
DK2593429T3 (en) 2015-09-07
JP2013532631A (ja) 2013-08-19
CN102958916A (zh) 2013-03-06
US20120016130A1 (en) 2012-01-19
KR101742253B1 (ko) 2017-05-31

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